Siraj M Ali

Siraj M Ali

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Siraj M Ali

Siraj M Ali

Publications by authors named "Siraj M Ali"

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Clinicopathologic Characteristics of BRG1-Deficient Non-Small Cell Lung Cancer.

J Thorac Oncol 2020 Jan 24. Epub 2020 Jan 24.

Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2020.01.002DOI Listing
January 2020

Pan-Cancer Analysis of Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype.

Oncologist 2019 Dec 10;24(12):1526-1533. Epub 2019 Jul 10.

Johns Hopkins University School of Medicine and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Baltimore, Maryland, USA

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http://dx.doi.org/10.1634/theoncologist.2019-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975947PMC
December 2019

Squamous Transformation of Prostate Adenocarcinoma: A Report of Two Cases With Genomic Profiling.

Clin Genitourin Cancer 2019 Dec 4. Epub 2019 Dec 4.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.11.020DOI Listing
December 2019

Clinical and Immunological Implications of Frameshift Mutations in Lung Cancer.

J Thorac Oncol 2019 Oct 22;14(10):1807-1817. Epub 2019 Jun 22.

Leonard M. Miller School of Medicine, University of Miami, Miami, Florida; Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.06.016DOI Listing
October 2019

Novel rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib.

Cold Spring Harb Mol Case Stud 2019 Oct 23;5(5). Epub 2019 Oct 23.

Division of Hematology/Oncology, Departments of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1101/mcs.a004440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824247PMC
October 2019

TKI-resistant -rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations.

Lung Cancer (Auckl) 2019 15;10:81-86. Epub 2019 Aug 15.

Department of Pathology, Rhode Island Hospital and Alpert Medical School at Brown University, Providence, RI 02903, USA.

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http://dx.doi.org/10.2147/LCTT.S212406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699522PMC
August 2019

Primary Spinal Epidural CIC-DUX4 Undifferentiated Sarcoma in a Child.

Pediatr Dev Pathol 2018 Jul-Aug;21(4):411-417. Epub 2017 May 5.

1 Department of Pathology, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, Rhode Island.

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http://journals.sagepub.com/doi/10.1177/1093526617707856
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http://dx.doi.org/10.1177/1093526617707856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575979PMC
May 2019

Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities.

Cancer 2019 04 24;125(7):1185-1199. Epub 2018 Dec 24.

Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California San Diego, San Diego, California.

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http://dx.doi.org/10.1002/cncr.31921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433468PMC
April 2019

TNS1-ALK Fusion in a Recurrent, Metastatic Uterine Mesenchymal Tumor Originally Diagnosed as Leiomyosarcoma.

Acta Med Acad 2019 Apr;48(1):116-120

The Angeles Clinic and Research Institute, Los Angeles, CA, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.5644/ama2006-124.248DOI Listing
April 2019

Differential response to a combination of full-dose osimertinib and crizotinib in a patient with -mutant non-small cell lung cancer and emergent amplification.

Lung Cancer (Auckl) 2019 12;10:21-26. Epub 2019 Mar 12.

Chao Family Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of California, Irvine School of Medicine, Orange, CA, USA,

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http://dx.doi.org/10.2147/LCTT.S190403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419586PMC
March 2019

Novel SPECC1L-MET Fusion Detected in Circulating Tumor DNA in a Patient with Lung Adenocarcinoma following Treatment with Erlotinib and Osimertinib.

J Thorac Oncol 2019 02;14(2):e27-e29

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.

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http://dx.doi.org/10.1016/j.jtho.2018.10.160DOI Listing
February 2019

Variable Response to ALK Inhibitors in NSCLC with a Novel MYT1L-ALK Fusion.

J Thorac Oncol 2019 02;14(2):e29-e30

City of Hope Comprehensive Cancer Center, Duarte, California. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.10.169DOI Listing
February 2019

Detection of Known and Novel FGFR Fusions in Non-Small Cell Lung Cancer by Comprehensive Genomic Profiling.

J Thorac Oncol 2019 01 26;14(1):54-62. Epub 2018 Sep 26.

Department of Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.09.014DOI Listing
January 2019

Dramatic response to alectinib in a lung cancer patient with a novel fusion and an acquired ALK T1151K mutation.

Lung Cancer (Auckl) 2018 8;9:111-116. Epub 2018 Nov 8.

Chao Family Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of California, Irvine School of Medicine, Orange, CA, USA,

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http://dx.doi.org/10.2147/LCTT.S186804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234987PMC
November 2018

Carving out another slice of the pie: Exceptional response to single agent imatinib in an asian female never-smoker with advanced NSCLC with a de-novo PDGFR-α N848 K mutation.

Lung Cancer 2018 10 31;124:86-89. Epub 2018 Jul 31.

Division of Hematology-Oncology, Department of Medicine, University of California Irvine School of Medicine, Orange, CA 92868, USA; Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA 92868, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183050
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http://dx.doi.org/10.1016/j.lungcan.2018.07.043DOI Listing
October 2018

Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.

J Clin Oncol 2018 Oct 20:JCO1801148. Epub 2018 Oct 20.

Andrea Necchi, Andrea Anichini, Daniele Raggi, Simona Massa, Maurizio Colecchia, Patrizia Giannatempo, Roberta Mortarini, Elena Farè, Francesco Monopoli, Antonella Messina, Roberto Salvioni, and Luigi Mariani, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori; Alberto Briganti, Roberta Lucianò, Marco Bianchi, Renzo Colombo, Andrea Gallina, Andrea Salonia, and Francesco Montorsi, Vita Salute San Raffaele University and Urological Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital, Milan, Italy; Siraj M. Ali, Russell Madison, Jeffrey S. Ross, and Jon H. Chung, Foundation Medicine, Cambridge, MA; and Jeffrey S. Ross, Upstate Medical University, Syracuse, NY.

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http://ascopubs.org/doi/10.1200/JCO.18.01148
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http://dx.doi.org/10.1200/JCO.18.01148DOI Listing
October 2018

A prolonged response to platinum-based therapy in a patient with metastatic urothelial carcinoma harboring a single rearranged and truncated NF2 gene.

Genes Chromosomes Cancer 2018 08 30;57(8):430-433. Epub 2018 Mar 30.

Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/gcc.22537DOI Listing
August 2018

Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma.

Eur Urol 2018 07;74(1):124-128

Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183025
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http://dx.doi.org/10.1016/j.eururo.2018.03.032DOI Listing
July 2018

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma.

Cancer Discov 2018 07 17;8(7):822-835. Epub 2018 May 17.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030433PMC
July 2018

WAC/RET: A Novel RET Oncogenic Fusion Variant in Non-Small Cell Lung Carcinoma.

J Thorac Oncol 2018 07;13(7):e122-e123

Foundation Medical, Cambridge, Massachusetts.

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http://dx.doi.org/10.1016/j.jtho.2018.03.003DOI Listing
July 2018

Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer.

J Clin Oncol 2018 04 26;36(12):1199-1206. Epub 2018 Jan 26.

Jessica J. Lin, Satoshi Yoda, Beow Y. Yeap, Ibiayi Dagogo-Jack, Nicholas A. Jessop, Ginger Y. Jiang, Long P. Le, Aaron N. Hata, Justin F. Gainor, Anthony J. Iafrate, and Alice T. Shaw, Massachusetts General Hospital, Boston; Alexa B. Schrock, Kyle Gowen, Philip J. Stephens, Jeffrey S. Ross, Siraj M. Ali, and Vincent A. Miller, Foundation Medicine, Cambridge, MA; Viola W. Zhu and Sai-Hong Ignatius Ou, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA; Melissa L. Johnson, Sarah Cannon Research Institute; and Christine M. Lovly, Vanderbilt-Ingram Cancer Center, Nashville, TN.

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http://dx.doi.org/10.1200/JCO.2017.76.2294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903999PMC
April 2018

Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer.

Cold Spring Harb Mol Case Stud 2018 04 2;4(2). Epub 2018 Apr 2.

Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA.

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http://dx.doi.org/10.1101/mcs.a002089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880253PMC
April 2018

EGFR-RAD51 Fusion: A Targetable Partnership Originated from the Tumor Evolution?

J Thorac Oncol 2018 03;13(3):e33-e34

Foundation Medicine, Inc., Cambridge, Massachusetts.

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http://dx.doi.org/10.1016/j.jtho.2017.10.005DOI Listing
March 2018

Reply to Genomic profiles of nasopharyngeal carcinoma: The importance of histological subtyping and Epstein-Barr virus in situ assays.

Cancer 2018 01 22;124(2):435-436. Epub 2017 Nov 22.

OrigiMed Inc, Shanghai, China.

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http://dx.doi.org/10.1002/cncr.31132DOI Listing
January 2018

De novo ERBB2 amplification causing intrinsic resistance to erlotinib in EGFR-L858R mutated TKI-naïve lung adenocarcinoma.

Lung Cancer 2017 12 24;114:108-110. Epub 2017 Aug 24.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.lungcan.2017.08.018DOI Listing
December 2017

-oriented solvent-front EGFR G796S mutation in tissue and ctDNA in a patient progressing on osimertinib: a case report and review of the literature.

Lung Cancer (Auckl) 2017 6;8:241-247. Epub 2017 Dec 6.

Department of Medicine-Hematology/Oncology, Chao Family Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA, USA.

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https://www.dovepress.com/cis-oriented-solvent-front-egfr-g7
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http://dx.doi.org/10.2147/LCTT.S147129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723122PMC
December 2017

Genomic Profiling of Small-Bowel Adenocarcinoma.

JAMA Oncol 2017 Nov;3(11):1546-1553

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1001/jamaoncol.2017.1051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710195PMC
November 2017

BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer.

J Clin Oncol 2017 Aug 9;35(23):2624-2630. Epub 2017 May 9.

Jeremy C. Jones, Lindsay A. Renfro, Ben Y. Zhang, Pashtoon M. Kasi, Jesse S. Voss, Alexis D. Leal, Joleen M. Hubbard, Benjamin R. Kipp, Robert R. McWilliams, and Axel Grothey, Mayo Clinic, Rochester, MN; Humaid O. Al-Shamsi, Scott Kopetz, and Robert A. Wolff, The University of Texas MD Anderson Cancer Center, Houston, TX; and Alexa B. Schrock, Andrew Rankin, James Sun, Jeffrey Ross, and Siraj M. Ali, Foundation Medicine, Cambridge, MA.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.4394
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http://dx.doi.org/10.1200/JCO.2016.71.4394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549454PMC
August 2017

Open-Label, Multicenter, Phase II Study of Ceritinib in Patients With Non-Small-Cell Lung Cancer Harboring ROS1 Rearrangement.

J Clin Oncol 2017 Aug 18;35(23):2613-2618. Epub 2017 May 18.

Sun Min Lim, Hye Ryun Kim, Hyo Sup Shim, Joo-Hang Kim, and Byoung Chul Cho, Yonsei University College of Medicine; Yun-Gyoo Lee, Yoon La Choi, and Myung-Ju Ahn, Sungkyunkwan University School of Medicine; Bong-Seog Kim, VHS Medical Center; Min Jeong Lee and Maria Kim, Yonsei University Health System, Seoul; Jong-Seok Lee and Jin-Haeng Chung, Seoul National University Bundang Hospital, Bundang; Ki Hyeong Lee, Chungbuk National University, Cheongju; Young Joo Min, University of Ulsan College of Medicine, Ulsan; Eun Kyung Cho, Gachon Medical School, Inchon; Sung Sook Lee, Inje University College of Medicine; Moon Young Choi, Inje University, Busan; Jin-Haeng Chung, Seoul National University College of Medicine, Seongnam, Republic of Korea; and Siraj M. Ali, Foundation Medicine, Cambridge, MA.

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http://dx.doi.org/10.1200/JCO.2016.71.3701DOI Listing
August 2017

Mutation of MET Y1230 as an Acquired Mechanism of Crizotinib Resistance in NSCLC with MET Exon 14 Skipping.

J Thorac Oncol 2017 07;12(7):e89-e90

Memorial Cancer Institute, Memorial Healthcare System, Hollywood, Florida.

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http://dx.doi.org/10.1016/j.jtho.2017.02.017DOI Listing
July 2017

Response to Pembrolizumab in a Patient With Chemotherapy Refractory Bladder Cancer With Small Cell Variant Histology: A Case Report and Review of the Literature.

Clin Genitourin Cancer 2017 06 22;15(3):e521-e524. Epub 2016 Dec 22.

Department of Medical Oncology, Sidney Kimmel Cancer Center, Jefferson University Hospital, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2016.12.012DOI Listing
June 2017

A recurrent endometrial stromal sarcoma harbors the novel fusion .

Gynecol Oncol Rep 2017 May 8;20:51-53. Epub 2017 Mar 8.

Department of Obstetrics and Gynecology and the Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States.

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http://dx.doi.org/10.1016/j.gore.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348601PMC
May 2017

Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re-biopsy?

Lung Cancer 2017 04 9;106:110-114. Epub 2017 Feb 9.

Department of Medicine, Division of Hematology-Oncology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.lungcan.2017.02.005DOI Listing
April 2017

Correlation Between Molecular Subclassifications of Clear Cell Renal Cell Carcinoma and Targeted Therapy Response.

Eur Urol Focus 2016 Jun 9;2(2):204-209. Epub 2015 Dec 9.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2015.11.007DOI Listing
June 2016