Siquan Sun

Siquan Sun

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Siquan Sun

Siquan Sun

Publications by authors named "Siquan Sun"

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Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.

Bioorg Med Chem Lett 2016 10 12;26(20):4888-4891. Epub 2016 Sep 12.

Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.09.029DOI Listing
October 2016

7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases.

Front Pharmacol 2015 24;6:60. Epub 2015 Mar 24.

Neuroscience Therapeutic Area, Janssen Pharmaceutical Research & Development, LLC, San Diego CA, USA.

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http://www.frontiersin.org/Pharmaceutical_Medicine_and_Outco
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http://dx.doi.org/10.3389/fphar.2015.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371701PMC
April 2015

Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.

Bioorg Med Chem Lett 2013 Feb 21;23(4):1070-4. Epub 2012 Dec 21.

Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.12.014DOI Listing
February 2013

Oxysterols direct B-cell migration through EBI2.

Nature 2011 Jul 27;475(7357):519-23. Epub 2011 Jul 27.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.

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http://dx.doi.org/10.1038/nature10226DOI Listing
July 2011

Cathepsin S inhibitors: 2004-2010.

Expert Opin Ther Pat 2011 Mar;21(3):311-37

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://www.tandfonline.com/doi/full/10.1517/13543776.2011.55
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http://dx.doi.org/10.1517/13543776.2011.553800DOI Listing
March 2011

Recent advances in the design of cathepsin S inhibitors.

Curr Top Med Chem 2010 ;10(7):717-32

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 MerryfieldRow, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/156802610791113432DOI Listing
July 2010

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.

Bioorg Med Chem Lett 2010 Jul 25;20(14):4060-4. Epub 2010 May 25.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.086DOI Listing
July 2010

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Bioorg Med Chem Lett 2010 Apr 28;20(7):2370-4. Epub 2010 Jan 28.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.108DOI Listing
April 2010

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.

Bioorg Med Chem Lett 2010 Apr 1;20(7):2375-8. Epub 2010 Feb 1.

Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.104DOI Listing
April 2010

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.

Bioorg Med Chem Lett 2010 Apr 8;20(7):2379-82. Epub 2010 Feb 8.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.103DOI Listing
April 2010

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.

Bioorg Med Chem Lett 2009 Nov 10;19(21):6131-4. Epub 2009 Sep 10.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.014DOI Listing
November 2009

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.

Bioorg Med Chem Lett 2009 Nov 10;19(21):6135-9. Epub 2009 Sep 10.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.013DOI Listing
November 2009

TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders.

Inflamm Allergy Drug Targets 2007 Dec;6(4):223-35

Department of Immunology, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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December 2007

Pyrazole-based cathepsin S inhibitors with improved cellular potency.

Bioorg Med Chem Lett 2007 Oct 22;17(20):5525-8. Epub 2007 Aug 22.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.08.038DOI Listing
October 2007

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.

Bioorg Med Chem Lett 2006 Apr 3;16(8):2209-12. Epub 2006 Feb 3.

Johnson and Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.01.038DOI Listing
April 2006

Cathepsin S inhibitors as novel immunomodulators.

Curr Opin Investig Drugs 2005 May;6(5):473-82

Johnson & Johnson Pharmaceutical Research & Development LLC, San Diego, CA 92121, USA.

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May 2005

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

Bioorg Med Chem Lett 2005 Mar;15(6):1687-91

Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.01.045DOI Listing
March 2005

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

J Med Chem 2004 Sep;47(20):4799-801

Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.

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http://dx.doi.org/10.1021/jm0496133DOI Listing
September 2004

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.

J Pharmacol Exp Ther 2004 Apr 13;309(1):404-13. Epub 2004 Jan 13.

Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1124/jpet.103.061754DOI Listing
April 2004

Identification of a potent and selective noncovalent cathepsin S inhibitor.

J Pharmacol Exp Ther 2004 Jan 17;308(1):268-76. Epub 2003 Oct 17.

Johnson & Johnson Pharmaceutical Research & Development L.L.C., San Diego, California, USA.

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http://dx.doi.org/10.1124/jpet.103.056879DOI Listing
January 2004