Sinisa Savic

Sinisa Savic

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Sinisa Savic

Sinisa Savic

Publications by authors named "Sinisa Savic"

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Predicting Severe Infection and Effects of Hypogammaglobulinemia During Therapy With Rituximab in Rheumatic and Musculoskeletal Diseases.

Arthritis Rheumatol 2019 Nov 26;71(11):1812-1823. Epub 2019 Sep 26.

University of Leeds, Chapel Allerton Hospital, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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http://dx.doi.org/10.1002/art.40937DOI Listing
November 2019

Hereditary systemic autoinflammatory diseases and Schnitzler's syndrome.

Rheumatology (Oxford) 2019 Nov;58(Supplement_6):vi31-vi43

National Institute for Health Research-Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK.

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http://dx.doi.org/10.1093/rheumatology/kez448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878846PMC
November 2019

Predicting the Occurrence of Variants in RAG1 and RAG2.

J Clin Immunol 2019 Oct 6;39(7):688-701. Epub 2019 Aug 6.

Department of Clinical Immunology and Allergy, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1007/s10875-019-00670-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754361PMC
October 2019

Ligelizumab for Chronic Spontaneous Urticaria.

N Engl J Med 2019 10;381(14):1321-1332

From the Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin (M. Maurer, M. Metz), the Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden (A. Bauer), the Department of Dermatology, University Hospital Münster, Münster (R.B.), the Department of Dermatology, University Medical Center Mainz, Mainz (P.S.), and the Department of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover (B.W.) - all in Germany; the Dermatology Department, Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Universitat Autònoma Barcelona, Barcelona (A.M.G.-A.); the Division of Allergy and Clinical Immunology, St. Michael's Hospital and University of Toronto, Toronto (G.S.), Service d'Allergie, Centre Hospitalier Université Laval-Centre Hospitalier Universitaire de Québec, Quebec, QC (J.H.), and the Department of Medicine, University of Ottawa, Ottawa (K.K.) - all in Canada; Baker Allergy Asthma and Dermatology Clinic, Portland, OR (D.R.B.); University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology, Rheumatology, and Allergy and Bernstein Clinical Research Center, Cincinnati (J.A.B.); the Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine (C.-Y.C.), and the Department of Dermatology, Chang Gung Memorial Hospital (W.-H.C.), Taipei, Taiwan; the National Research Center-Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow (I.D.), and the Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk (R.M.) - both in Russia; St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London (C.G.), and the National Institute for Health Research-Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, and the Department of Clinical Immunology and Allergy, St. James's University Hospital, Leeds (S.S.) - all in the United Kingdom; the School of Medicine, Western Sydney University, and the Immunology and Allergy Unit, Campbelltown Hospital, Campbelltown, NSW (C.K.), and Sinclair Dermatology and the Epworth Hospital, Melbourne, VIC (R.S.) - all in Australia; the Second Department of Dermatology and Venereology, Attikon University Hospital, Athens (M. Makris); Little Rock Allergy and Asthma Clinic, Little Rock, AR (K.S.); Novartis Pharma, Basel, Switzerland (J.L., T.S., R.J.); Novartis Pharmaceuticals, East Hanover, NJ (A. Barve, K.K.); and Shanghai Novartis Trading, Shanghai, China (E.H.).

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http://dx.doi.org/10.1056/NEJMoa1900408DOI Listing
October 2019

Chlorhexidine allergy in the perioperative setting: a narrative review.

Br J Anaesth 2019 Jul 5;123(1):e95-e103. Epub 2019 Apr 5.

Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergy, Copenhagen University Hospital, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bja.2019.01.033DOI Listing
July 2019

Arthritis in Two Patients With Partial Recombination Activating Gene Deficiency.

Front Pediatr 2019 5;7:235. Epub 2019 Jul 5.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, University of South Florida, St. Petersburg, FL, United States.

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http://dx.doi.org/10.3389/fped.2019.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625222PMC
July 2019

Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.

Clin Immunol 2019 Jun 3;203:23-27. Epub 2019 Apr 3.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.03.010DOI Listing
June 2019

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Front Immunol 2018 16;9:543. Epub 2018 Mar 16.

Center for Chronic Immunodeficiency, Medical Center - University of Freiburg, Freiburg, Germany.

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00
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http://dx.doi.org/10.3389/fimmu.2018.00543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863269PMC
May 2019

A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype.

J Clin Immunol 2019 Apr 4;39(3):249-256. Epub 2019 Apr 4.

Department of Clinical Immunology and Allergy, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1007/s10875-019-00618-3DOI Listing
April 2019

RNAseq Supports the Molecular Genetic Diagnosis of Late-Onset ADA Deficiency.

J Clin Immunol 2019 Apr 16;39(3):270-273. Epub 2019 Apr 16.

Department of Clinical Immunology and Allergy, St. James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://link.springer.com/10.1007/s10875-019-00625-4
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http://dx.doi.org/10.1007/s10875-019-00625-4DOI Listing
April 2019

Combined Immunodeficiency With Late-Onset Progressive Hypogammaglobulinemia and Normal B Cell Count in a Patient With RAG2 Deficiency.

Front Pediatr 2019 16;7:122. Epub 2019 Apr 16.

Division of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

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http://dx.doi.org/10.3389/fped.2019.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477099PMC
April 2019

Patient and Primary Care Physician Perceptions of Penicillin Allergy Testing and Subsequent Use of Penicillin-Containing Antibiotics: A Qualitative Study.

J Allergy Clin Immunol Pract 2019 Jul - Aug;7(6):1888-1893.e1. Epub 2019 Mar 12.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, United Kingdom; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2019.02.036DOI Listing
March 2019

A novel mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.

Blood 2019 02 11;133(8):820-829. Epub 2018 Dec 11.

School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2018-07-866939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450058PMC
February 2019

Resistant type II cryoglobulinaemic vasculitis successfully treated with bortezomib in a patient with SLE.

BMJ Case Rep 2019 Jan 4;12(1). Epub 2019 Jan 4.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1136/bcr-2018-226083DOI Listing
January 2019

Mechanistic immunological based classification of rheumatoid arthritis.

Autoimmun Rev 2018 Nov 11;17(11):1115-1123. Epub 2018 Sep 11.

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/j.autrev.2018.06.001DOI Listing
November 2018

A Case of Adult-Onset Still's Disease Caused by a Novel Splicing Mutation in Successfully Treated With Tocilizumab.

Front Immunol 2018 4;9:1527. Epub 2018 Jul 4.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.01527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039542PMC
July 2018

Autoinflammatory disease in the lung.

Immunology 2018 Apr 19. Epub 2018 Apr 19.

Cystic Fibrosis Trust Strategic Research Centre, St James's University Hospital, Leeds, UK.

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http://doi.wiley.com/10.1111/imm.12937
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http://dx.doi.org/10.1111/imm.12937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050210PMC
April 2018

Glucose-6-Phosphatase Catalytic Subunit 3 () Deficiency Associated With Autoinflammatory Complications.

Front Immunol 2017 6;8:1485. Epub 2017 Nov 6.

Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681747PMC
November 2017

Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases.

RMD Open 2017 1;3(2):e000550. Epub 2017 Nov 1.

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1136/rmdopen-2017-000550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687541PMC
November 2017

Bialellic Mutations in Tetratricopeptide Repeat Domain 7A (TTC7A) Cause Common Variable Immunodeficiency-Like Phenotype with Enteropathy.

J Clin Immunol 2017 10 14;37(7):617-622. Epub 2017 Aug 14.

Department of Clinical Immunology and Allergy, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1007/s10875-017-0427-1DOI Listing
October 2017

Interleukin-1 Blockade: An Update on Emerging Indications.

BioDrugs 2017 Jun;31(3):207-221

Department of Infectious Diseases and Immunity, Jessa Hospital, Stadsomvaat 11, 3500, Hasselt, Belgium.

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http://dx.doi.org/10.1007/s40259-017-0224-7DOI Listing
June 2017

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

J Allergy Clin Immunol 2017 02 16;139(2):597-606.e4. Epub 2016 Jul 16.

Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292996PMC
February 2017

Autoinflammatory diseases: update on classification diagnosis and management.

J Clin Pathol 2017 Jan 19;70(1):1-8. Epub 2016 Sep 19.

National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St James's University Hospital, Leeds, UK.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2016-203810
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http://dx.doi.org/10.1136/jclinpath-2016-203810DOI Listing
January 2017

The burgeoning field of innate immune-mediated disease and autoinflammation.

J Pathol 2017 Jan 11;241(2):123-139. Epub 2016 Nov 11.

National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU) and Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/path.4812DOI Listing
January 2017

A Case of SLC29A3 Spectrum Disorder-Unresponsive to Multiple Immunomodulatory Therapies.

J Clin Immunol 2016 07 23;36(5):429-33. Epub 2016 May 23.

Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1007/s10875-016-0301-6DOI Listing
July 2016

Anakinra as a diagnostic challenge and treatment option for systemic autoinflammatory disorders of undefined etiology.

JCI Insight 2016 05 5;1(6):e86336. Epub 2016 May 5.

NIH Research-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU) and Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St. James's University Hospital, Beckett Street, Leeds, United Kingdom.

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https://insight.jci.org/articles/view/86336
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http://dx.doi.org/10.1172/jci.insight.86336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033915PMC
May 2016

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency.

J Allergy Clin Immunol 2016 Mar 10;137(3):955-7.e8. Epub 2015 Nov 10.

Section of Ophthalmology and Neuroscience, School of Medicine, St James's University Hospital, University of Leeds, Leeds, United Kingdom; School of Dentistry, University of Leeds, Leeds, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775071PMC
March 2016

Incidence of suspected perioperative anaphylaxis: A multicenter snapshot study.

J Allergy Clin Immunol Pract 2015 May-Jun;3(3):454-5.e1. Epub 2015 Feb 14.

Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2014.12.016DOI Listing
February 2016

Repeat cycles of rituximab on clinical relapse in ANCA-associated vasculitis: identifying B cell biomarkers for relapse to guide retreatment decisions.

Ann Rheum Dis 2015 Sep 8;74(9):1734-8. Epub 2015 Apr 8.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-206496DOI Listing
September 2015

A new case of Fas-associated death domain protein deficiency and update on treatment outcomes.

J Allergy Clin Immunol 2015 Aug 17;136(2):502-5.e4. Epub 2015 Mar 17.

Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.02.002DOI Listing
August 2015

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care.

Allergy Asthma Clin Immunol 2015 21;11(1):21. Epub 2015 Jul 21.

St John's Institute of Dermatology, London, SE1 7EH UK ; Dermatology Centre, Norfolk and Norwich University Hospital, Norwich, NR4 7UY UK.

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http://dx.doi.org/10.1186/s13223-015-0088-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507325PMC
July 2015

Clinical genetics in 2014: New monogenic diseases span the immunological disease continuum.

Nat Rev Rheumatol 2015 Feb 23;11(2):67-8. Epub 2014 Dec 23.

National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St James University, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/nrrheum.2014.215DOI Listing
February 2015

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes.

J Autoimmun 2014 May 31;50:59-66. Epub 2013 Dec 31.

NIHR-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Wellcome Trust Brenner Building, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411130014
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http://dx.doi.org/10.1016/j.jaut.2013.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012140PMC
May 2014

CVID patients with autoimmunity have elevated T cell expression of granzyme B and HLA-DR and reduced levels of Treg cells.

J Clin Pathol 2013 Feb 21;66(2):146-50. Epub 2012 Nov 21.

Cellular Immunology Laboratory, Department of Immunology and Transplant Immunology, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1136/jclinpath-2012-201046DOI Listing
February 2013

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.

Ann Rheum Dis 2012 Dec 7;71(12):2035-43. Epub 2012 Jun 7.

Experimental Rheumatology, National Institute for Health Research–Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, Leeds, West Yorkshire, UK.

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http://dx.doi.org/10.1136/annrheumdis-2011-201197DOI Listing
December 2012

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives.

Best Pract Res Clin Rheumatol 2012 Aug;26(4):505-33

Department of Clinical Immunology, St. James's University Hospital, Leeds, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S15216942120007
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http://dx.doi.org/10.1016/j.berh.2012.07.009DOI Listing
August 2012

Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases.

Curr Opin Rheumatol 2012 Jan;24(1):103-12

Department of Clinical Immunology, NIHR-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1097/BOR.0b013e32834dd2d5DOI Listing
January 2012

The NLRP3 inflammasome, a target for therapy in diverse disease states.

Eur J Immunol 2010 Mar;40(3):631-4

Section of Oncology and Clinical Research, Leeds Institute of Molecular Medicine, Leeds, UK.

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http://dx.doi.org/10.1002/eji.200940162DOI Listing
March 2010

Periodic fever syndrome and autoinflammatory diseases.

F1000 Med Rep 2010 Jan 18;2. Epub 2010 Jan 18.

NIHR-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital Leeds, LS9 7TF UK.

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http://dx.doi.org/10.3410/M2-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948378PMC
January 2010

Inflammation: canakinumab for the cryopyrin-associated periodic syndromes.

Nat Rev Rheumatol 2009 Oct;5(10):529-30

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http://dx.doi.org/10.1038/nrrheum.2009.195DOI Listing
October 2009

Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap).

Biologics 2008 Dec;2(4):733-42

Department of Rheumatology, Division of Immunity, Infection and Inflammation, Institute for Biomedical Research, The University of Birmingham, Birmingham, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727888PMC
http://dx.doi.org/10.2147/btt.s3167DOI Listing
December 2008

Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases.

Expert Rev Clin Immunol 2008 Jul;4(4):425-8

CHU Montpellier, Unité Médicale des Maladies Auto-Inflammatoires, Hôpital Arnaud de Villeneuve, Montpellier, F-34295, France.

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http://dx.doi.org/10.1586/1744666X.4.4.425DOI Listing
July 2008

The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self.

Semin Immunopathol 2007 Sep 6;29(3):303-13. Epub 2007 Sep 6.

The Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James's University Hospital, The University of Leeds, Leeds, UK.

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http://link.springer.com/10.1007/s00281-007-0084-1
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http://dx.doi.org/10.1007/s00281-007-0084-1DOI Listing
September 2007