Publications by authors named "Sinan Yasin Ertem"

5 Publications

  • Page 1 of 1

Partially resorbed unremoved silk sutures after tooth extraction: A unique Case report.

Clin Case Rep 2021 Mar 2;9(3):1621-1623. Epub 2021 Feb 2.

Department of Oral and Maxillofacial Surgery School of Dentistry Ankara Yildirim Beyazit University Ankara Turkey.

Suturation may remain in the mouth for a long time due to incomplete information to patients due to inadvertency. Forgotten silk sutures might be sunk and cause irritation into the alveolar mucosa.
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March 2021

Accelerated Calcium Phosphate Mineralization by Peptides with Adjacent Oppositely Charged Residues.

ACS Biomater Sci Eng 2020 07 29;6(7):3791-3798. Epub 2020 Jun 29.

Department of Clinical Sciences, School of Dentistry, Ankara Yildirim Beyazit University, Ankara 06760, Turkey.

Calcium phosphate mineralizing peptides are of special importance for dental and orthopedic applications, such as caries remineralization and improved osteointegration. Uncovering the mechanism of action for such peptides is an ongoing challenge with the aim of a better fundamental understanding of biomineralization processes and developing optimized peptides for clinical use. It has recently been reported that "adjacent oppositely charged residue" motifs are found abundantly in cation binding, inorganic surface binding, or biomineralization-related proteins and may play a key role in the biomineralization events. Despite their medical importance, the role of these motifs has not yet been investigated on calcium phosphate mineral systems. To investigate this, we have designed peptides with different structural properties and different numbers of adjacent oppositely charged residues. We have evaluated their effects on calcium phosphate mineralization kinetics and mineral properties. The kinetics of the mineralization increased proportionally with an increasing number of adjacent oppositely charged residues. Two peptides with relatively high structural stability and two adjacent oppositely charged residues resulted in faster mineralization and more crystalline mineral compared to a peptide with a higher structural degree of freedom that contained only acidic residues. The fastest mineralization and the highest mineral crystallinity were obtained with a peptide containing the highest number of adjacent oppositely charged residues and highest structural degree of freedom. Our findings and observations from previously identified natural or designed peptides indicate that, in addition to structural instability, adjacent oppositely charged residues play a role in the cation binding, inorganic surface binding, and biomineralization of peptides and require further investigation. Lastly, the peptide identified in this study is an agent with potential medical applications involving the treatment of mineralized tissues.
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July 2020

Does Incidence of Temporomandibular Disc Displacement With and Without Reduction Show Similarity According to MRI Results?

J Maxillofac Oral Surg 2020 Dec 20;19(4):603-608. Epub 2019 Dec 20.

Department of Radiology, Ankara Ataturk Training and Research Hospital, Universiteler Mh., Bilkent Cad. No:1, Çankaya, Ankara Turkey.

Purpose: The aim of this study is to assess MRI reports of the patients and to provide retrospective analysis by conducting detailed evaluation of temporomandibular disc position.

Patients And Methods: MRI images of 259 patients from 2008 to 2017 were reviewed retrospectively. Existence of disc displacement in joint with and without reduction, existence of effusion in joint gap, arthritis, degenerative changes in joints and limitation of movement of joint and anatomic characteristics were evaluated.

Results: One hundred and seventeen (45.2%) of the patients had healthy joint connection bilaterally. Anterior disc displacement was observed in 101 (38.9%) of the patients. The number of the patients having disc displacement with reduction was 50 (19.3%) and without reduction was 51 (19.6%) similarly.

Conclusion: The incidence of anterior disc displacement with or without reduction was similar; besides this, the majority of the patients diagnosed with anterior disc displacement were unilateral.
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December 2020

Comparative Three-Dimensional Finite Element Analysis on Miniplate and Lag Screw Fixation to Symphysis Fractures.

J Craniofac Surg 2020 Jun;31(4):983-988

Department of Oral and Maxillofacial Surgery, School of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey.

The purpose of this study was to compare the amount of stress on the fracture site via three-dimensional finite element analysis between lag screw and miniplate systems. Solid mathematical models were created from the CT of a patient and a fracture observed in the symphysis area. On the fracture site mini plates and lag screws applied to the bone to fixate segments. The physiologic mastication chewing forces were applied for simulation. These 2 fixation methods: were evaluated by their amount of stress values. The maximum Von Misses stress lag screw model was 2727 MPa on the apex of the lag screw and 934 MPa on the fracture site of the screw. At the miniplate model, the maximum Von Misses stress was 571 MPa on the head of the miniplate screw, and it was 202 MPa on the fracture site. Thus, lag screw model causes at least 4 times higher stress values than mini plate model. The stress level of lag screw model is higher than miniplate model. However, when the chewing forces are taken into account, the amount of stress in the lag screw system is also acceptable in clinical applications.
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June 2020

Salivary opiorphin in dental pain: A potential biomarker for dental disease.

Arch Oral Biol 2019 Mar 15;99:15-21. Epub 2018 Dec 15.

Department of Clinical Sciences, School of Dentistry, Ankara Yildirim Beyazit University, Ankara, Turkey. Electronic address:

Objectives: Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in high concentrations in saliva, the relationship between salivary opiorphin and orofacial pains is not yet fully understood. We aimed to determine salivary opiorphin concentrations in dental pain related to symptomatic irreversible pulpitis (SIP), and symptomatic apical periodontitis (SAP).

Design: 39 patients participated in this study. The participants were categorized into SIP and SAP based on their diagnosis. All the patients were treated with root canal treatment. Saliva specimens were collected, and pain levels were recorded at pre-treatment, 7 days post-treatment and 30 days post-treatment. Saliva opiorphin levels were measured using a commercially available ELISA kit. Pre-treatment and post-treatment opiorphin levels were evaluated using repeated measures ANOVA. Correlations between VAS scores, opiorphin levels and age were evaluated using Spearman's Rank Correlation.

Results: The average saliva opiorphin level pre-treatment, 7 days post-treatment and 30 days post-treatment were 31.28 ± 7.10 ng/ml, 20.41 ± 2.67 ng/ml and 18.61 ± 2.05 ng/ml respectively. Significantly higher pre-treatment opiorphin levels were observed in the SIP group compared to the SAP group. A strong correlation was observed between the pre-treatment pain levels and the saliva opiorphin concentrations.

Conclusions: Our findings indicate that saliva opiorphin levels increase in inflammation related dental pain. The level of salivary opiorphin is strongly correlated with the reported level of pain. The extent of the inflammation (pulpal vs. periodontal) also affects the opiorphin level.
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March 2019