Publications by authors named "Simonetta Pazzaglia"

44Publications

Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications.

Cancers (Basel) 2020 Jan 8;12(1). Epub 2020 Jan 8.

Laboratory of Biomedical Technologies, ENEA CR-Casaccia, Via Anguillarese 301, 00123 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12010146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017115PMC
January 2020

Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus.

Neural Regen Res 2019 Jan;14(1):59-61

Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.243703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263010PMC
January 2019

Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Heterozygous Mice.

Front Mol Neurosci 2018 23;11:168. Epub 2018 May 23.

Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974030PMC
May 2018

Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.

Oncotarget 2017 Nov 7;8(60):100958-100974. Epub 2016 Jul 7.

Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), CR-Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731848PMC
November 2017

MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.

Mol Cancer Ther 2016 06 9;15(6):1177-89. Epub 2016 Mar 9.

Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA) CR-Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-15-0371DOI Listing
June 2016

Acceleration of atherogenesis in ApoE-/- mice exposed to acute or low-dose-rate ionizing radiation.

Oncotarget 2015 Oct;6(31):31263-71

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.5075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741603PMC
October 2015

The Patched 1 tumor-suppressor gene protects the mouse lens from spontaneous and radiation-induced cataract.

Am J Pathol 2015 Jan 15;185(1):85-95. Epub 2014 Nov 15.

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2014.09.019DOI Listing
January 2015

Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum.

Stem Cells 2013 Nov;31(11):2506-16

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), CR-Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1485DOI Listing
November 2013

Oncogenic radiation abscopal effects in vivo: interrogating mouse skin.

Int J Radiat Oncol Biol Phys 2013 Aug 5;86(5):993-9. Epub 2013 Jun 5.

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Casaccia Research Centre, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2013.04.040DOI Listing
August 2013

Dose and spatial effects in long-distance radiation signaling in vivo: implications for abscopal tumorigenesis.

Int J Radiat Oncol Biol Phys 2013 Mar 11;85(3):813-9. Epub 2012 Sep 11.

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA) Centro Ricerche (CR) Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2012.07.2372DOI Listing
March 2013

The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse.

G3 (Bethesda) 2012 Sep 1;2(9):1041-6. Epub 2012 Sep 1.

Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/g3.112.003525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429918PMC
September 2012

The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

Cancer Lett 2011 Sep 1;308(2):197-202. Epub 2011 Jun 1.

Laboratory of Radiation Biology and Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile CR-Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2011.05.004DOI Listing
September 2011

Microsatellite instability in radiation-induced murine tumours; influence of tumour type and radiation quality.

Int J Radiat Biol 2010 Jul;86(7):555-68

Health Protection Agency-Centre for Radiation, Chemical and Environmental Hazards, Chilton, Oxfordshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/09553001003734600DOI Listing
July 2010

Genetic heterogeneity of inflammatory response and skin tumorigenesis in phenotypically selected mouse lines.

Cancer Lett 2010 Sep 21;295(1):54-8. Epub 2010 Mar 21.

Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2010.02.013DOI Listing
September 2010

Smoothened antagonists: a promising new class of antitumor agents.

Expert Opin Drug Discov 2009 May;4(5):525-44

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Department of Oncology, IRBM- Merck Research Laboratories Rome, Via Pontina Km 30,600, 00040 Pomezia, Italy +39 06 91093232 ; +39 06 91093549 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460440902852686DOI Listing
May 2009

Physical, heritable and age-related factors as modifiers of radiation cancer risk in patched heterozygous mice.

Int J Radiat Oncol Biol Phys 2009 Mar 7;73(4):1203-10. Epub 2009 Feb 7.

Section of Toxicology and Biomedical Sciences, Biotechnologies, Agro-Industry and Health Protection Department, ENEA CR Casaccia, 00123 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2008.10.068DOI Listing
March 2009

Genetic background modulates gene expression profile induced by skin irradiation in ptch1 mice.

Int J Radiat Oncol Biol Phys 2008 Dec;72(5):1582-6

Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2008.08.008DOI Listing
December 2008

Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12445-50. Epub 2008 Aug 18.

Section of Toxicology and Biomedical Sciences and Italian National Metrological Institute, Biotechnologies, Agro-Industry and Health Protection, Ente per le Nuove Technologie, l'Energia e l'Ambiente Centro Ricerche Casaccia, 00123 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0804186105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517601PMC
August 2008

PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.

Carcinogenesis 2008 Oct 27;29(10):1911-9. Epub 2008 Jul 27.

Section of Toxicology and Biomedical Sciences, Biotechnologies, Agro-Industry and Health Protection Department, Ente per le Nuove Tecnologie, l'Energia e l'Ambiente (ENEA), Centro Ricerche Casaccia, 00123 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgn174DOI Listing
October 2008

Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3.

FASEB J 2007 Jul 19;21(9):2215-25. Epub 2007 Mar 19.

Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale Ricerche, Via Fosso di Fiorano 64, 00143, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.06-7548comDOI Listing
July 2007

Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/+ mice exposed to radiation.

Cancer Res 2006 Jul;66(13):6606-14

Biotechnology and Radiation Protection Unit, Ente per le Nuove Tecnologie, l'Energia e l'Ambiente, CR-Casaccia, Via Anguillarese 301, 00060 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-05-3690DOI Listing
July 2006

Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis.

Cancer Lett 2006 Mar 31;234(2):124-34. Epub 2005 May 31.

Biotechnology Unit, ENEA CR-Casaccia, Via Anguillarese 301, 00060 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2005.03.047DOI Listing
March 2006

Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.

Cancer Res 2004 Jun;64(11):3798-806

Biotechnology Unit, ENEA-Ente per le Nuove tecnologie, l'Energia e l'Ambiente, Centro Ricerche Casaccia, Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-03-3716DOI Listing
June 2004

Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.

Mutat Res 2004 Apr;548(1-2):35-45

Biotechnology Unit, ENEA Casaccia Research Center, Via Anguillarese 301, 00060 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2003.12.017DOI Listing
April 2004

Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice.

Cancer Res 2004 Feb;64(3):934-41

Biotechnology Unit and Radiation Protection Unit, ENEA-Ente per le Nuove Tecnologie, l'Energia e l'Ambiente, Centro Ricerche, Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.can-03-2460DOI Listing
February 2004

Carcinogenesis in laboratory mice after low doses of ionizing radiation.

Radiat Res 2003 Jan;159(1):102-8

Biotechnology Unit, Centro Ricerche ENEA Casaccia, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/0033-7587(2003)159[0102:cilmal]2.0.co;2DOI Listing
January 2003