Publications by authors named "Simonetta Buglioni"

48Publications

Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer.

Authors:
Frauke Goeman Francesca De Nicola Carla Azzurra Amoreo Stefano Scalera Daniele Marinelli Francesca Sperati Marco Mazzotta Irene Terrenato Matteo Pallocca Ludovica Ciuffreda Eleonora Sperandio Maddalena Barba Laura Pizzuti Domenico Sergi Antonella Amodio Giancarlo Paoletti Eriseld Krasniqi Patrizia Vici Beatrice Casini Enzo Gallo Simonetta Buglioni Maria Grazia Diodoro Edoardo Pescarmona Ilio Vitale Ruggero De Maria Gian Luca Grazi Gennaro Ciliberto Maurizio Fanciulli Marcello Maugeri-Saccà

Clin Transl Med 2020 Dec;10(8):e199

Division of Medical Oncology 2, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.

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December 2020

BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.

Authors:
Fabiana Conciatori Chiara Bazzichetto Carla Azzurra Amoreo Isabella Sperduti Sara Donzelli Maria Grazia Diodoro Simonetta Buglioni Italia Falcone Senji Shirasawa Giovanni Blandino Gianluigi Ferretti Francesco Cognetti Michele Milella Ludovica Ciuffreda

Commun Biol 2020 Oct 1;3(1):546. Epub 2020 Oct 1.

Medical Oncology 1, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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October 2020

Vav1 Down-Modulates Akt2 Expression in Cells from Pancreatic Ductal Adenocarcinoma: Nuclear Vav1 as a Potential Regulator of Akt Related Malignancy in Pancreatic Cancer.

Authors:
Silvia Grassilli Federica Brugnoli Rossano Lattanzio Simonetta Buglioni Valeria Bertagnolo

Biomedicines 2020 Sep 26;8(10). Epub 2020 Sep 26.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.

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September 2020

Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem-Like Cells and Reduces Metastases through Effects on Lipid Anabolism.

Authors:
Rosanna Dattilo Carla Mottini Emanuela Camera Alessia Lamolinara Noam Auslander Ginevra Doglioni Michela Muscolini Wei Tang Melanie Planque Cristiana Ercolani Simonetta Buglioni Isabella Manni Daniela Trisciuoglio Alessandra Boe Sveva Grande Anna Maria Luciani Manuela Iezzi Gennaro Ciliberto Stefan Ambs Ruggero De Maria Sarah-Maria Fendt Eytan Ruppin Luca Cardone

Cancer Res 2020 10 23;80(19):4087-4102. Epub 2020 Jul 23.

Department of Research, Advanced Diagnostics, and Technological Innovations, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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October 2020

p53 and BLC2 Immunohistochemical Expression Across Molecular Subtypes in 1099 Early Breast Cancer Patients With Long-Term Follow-up: An Observational Study.

Authors:
Alessandra Fabi Marcella Mottolese Anna Di Benedetto Francesca Sperati Cristiana Ercolani Simonetta Buglioni Cecilia Nisticò Gianluigi Ferretti Patrizia Vici Letizia Perracchio Paola Malaguti Michelangelo Russillo Claudio Botti Edoardo Pescarmona Francesco Cognetti Irene Terrenato

Clin Breast Cancer 2020 Dec 13;20(6):e761-e770. Epub 2020 May 13.

Biostatistics and Bioinformatic Unit, Scientific Direction, IRCCS, Regina Elena National Cancer Institute, Rome, Italy.

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December 2020

TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients.

Authors:
Roberto Dinami Manuela Porru Carla Azzurra Amoreo Isabella Sperduti Marcella Mottolese Simonetta Buglioni Daniele Marinelli Marcello Maugeri-Saccà Andrea Sacconi Giovanni Blandino Carlo Leonetti Giuliana Di Rocco Alessandra Verdina Francesca Spinella Francesco Fiorentino Gennaro Ciliberto Annamaria Biroccio Pasquale Zizza

J Exp Clin Cancer Res 2020 Jun 15;39(1):111. Epub 2020 Jun 15.

Oncogenomic and Epigenetic Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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June 2020

Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells.

Authors:
Marta Di Martile Chiara Gabellini Marianna Desideri Marta Matraxia Valentina Farini Elisabetta Valentini Simone Carradori Cristiana Ercolani Simonetta Buglioni Daniela Secci Massimiliano Andreazzoli Donatella Del Bufalo Daniela Trisciuoglio

J Exp Clin Cancer Res 2020 Jun 5;39(1):103. Epub 2020 Jun 5.

Preclinical Models and New Therapeutic Agents Unit, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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June 2020

Cross-sectional analysis of circulating tumor DNA in primary colorectal cancer at surgery and during post-surgery follow-up by liquid biopsy.

Authors:
Matteo Allegretti Giuliano Cottone Fabio Carboni Ettore Cotroneo Beatrice Casini Elena Giordani Carla Azzurra Amoreo Simonetta Buglioni Maria Diodoro Edoardo Pescarmona Settimio Zazza Orietta Federici Massimo Zeuli Laura Conti Giovanni Cigliana Francesco Fiorentino Mario Valle Patrizio Giacomini Francesca Spinella

J Exp Clin Cancer Res 2020 Apr 20;39(1):69. Epub 2020 Apr 20.

Oncogenomics Division, Eurofins Genoma Group, Via Castel Giubileo, 11, 00138, Rome, Italy.

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April 2020

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages.

Authors:
Marta Di Martile Valentina Farini Francesca Maria Consonni Daniela Trisciuoglio Marianna Desideri Elisabetta Valentini Simona D'Aguanno Maria Grazia Tupone Simonetta Buglioni Cristiana Ercolani Enzo Gallo Bruno Amadio Irene Terrenato Maria Laura Foddai Antonio Sica Donatella Del Bufalo

J Immunother Cancer 2020 04;8(1)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

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April 2020

microRNA-378a-5p iS a novel positive regulator of melanoma progression.

Authors:
Maria Grazia Tupone Simona D'Aguanno Marta Di Martile Elisabetta Valentini Marianna Desideri Daniela Trisciuoglio Sara Donzelli Andrea Sacconi Simonetta Buglioni Cristiana Ercolani Alessio Biagioni Gabriella Fibbi Luigi Fattore Rita Mancini Gennaro Ciliberto Giovanni Blandino Donatella Del Bufalo

Oncogenesis 2020 Feb 14;9(2):22. Epub 2020 Feb 14.

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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February 2020

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma.

Authors:
Carla Mottini Hideo Tomihara Diego Carrella Alessia Lamolinara Manuela Iezzi Justin K Huang Carla A Amoreo Simonetta Buglioni Isabella Manni Frederick S Robinson Rosalba Minelli Ya'an Kang Jason B Fleming Michael P Kim Christopher A Bristow Daniela Trisciuoglio Antonella Iuliano Donatella Del Bufalo Diego Di Bernardo Davide Melisi Giulio F Draetta Gennaro Ciliberto Alessandro Carugo Luca Cardone

Cancer Res 2019 Nov 5;79(21):5612-5625. Epub 2019 Sep 5.

Department of Tumor Immunology and Immunotherapy, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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November 2019

CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions.

Authors:
Sara Bruschini Simona di Martino Maria Elena Pisanu Luigi Fattore Claudia De Vitis Valentina Laquintana Simonetta Buglioni Eugenio Tabbì Andrea Cerri Paolo Visca Gabriele Alessandrini Francesco Facciolo Christian Napoli Marcella Trombetta Antonio Santoro Anna Crescenzi Gennaro Ciliberto Rita Mancini

J Cell Physiol 2020 03 9;235(3):1877-1887. Epub 2019 Aug 9.

Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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March 2020

PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes.

Authors:
Rossano Lattanzio Manuela Iezzi Gianluca Sala Nicola Tinari Marco Falasca Saverio Alberti Simonetta Buglioni Marcella Mottolese Letizia Perracchio Pier Giorgio Natali Mauro Piantelli

BMC Cancer 2019 Jul 30;19(1):747. Epub 2019 Jul 30.

Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University of Chieti-Pescara, Via Luigi Polacchi 11, 66100, Chieti, Italy.

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July 2019

Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.

Authors:
Frauke Goeman Francesca De Nicola Stefano Scalera Francesca Sperati Enzo Gallo Ludovica Ciuffreda Matteo Pallocca Laura Pizzuti Eriseld Krasniqi Giacomo Barchiesi Patrizia Vici Maddalena Barba Simonetta Buglioni Beatrice Casini Paolo Visca Edoardo Pescarmona Marco Mazzotta Ruggero De Maria Maurizio Fanciulli Gennaro Ciliberto Marcello Maugeri-Saccà

J Thorac Oncol 2019 11 16;14(11):1924-1934. Epub 2019 Jul 16.

Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address:

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November 2019

Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb.

Authors:
Simona D'Aguanno Elisabetta Valentini Maria Grazia Tupone Marianna Desideri Marta Di Martile Manuela Spagnuolo Simonetta Buglioni Cristiana Ercolani Italia Falcone Marco De Dominici Michele Milella Maria Giulia Rizzo Bruno Calabretta Carlo Cota Andrea Anichini Daniela Trisciuoglio Donatella Del Bufalo

J Exp Clin Cancer Res 2018 Nov 19;37(1):278. Epub 2018 Nov 19.

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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November 2018

The clinical significance of PD-L1 in advanced gastric cancer is dependent on mutations and ATM expression.

Authors:
Simonetta Buglioni Elisa Melucci Francesca Sperati Matteo Pallocca Irene Terrenato Francesca De Nicola Frauke Goeman Beatrice Casini Carla Azzurra Amoreo Enzo Gallo Maria Grazia Diodoro Edoardo Pescarmona Patrizia Vici Domenico Sergi Laura Pizzuti Luigi Di Lauro Marco Mazzotta Maddalena Barba Maurizio Fanciulli Ilio Vitale Ruggero De Maria Gennaro Ciliberto Marcello Maugeri-Saccà

Oncoimmunology 2018;7(8):e1457602. Epub 2018 Apr 24.

Division of Medical Oncology 2, "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, Rome, Italy.

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April 2018

Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer.

Authors:
Matteo Pallocca Frauke Goeman Francesca De Nicola Elisa Melucci Francesca Sperati Irene Terrenato Laura Pizzuti Beatrice Casini Enzo Gallo Carla Azzurra Amoreo Patrizia Vici Luigi Di Lauro Simonetta Buglioni Maria Grazia Diodoro Edoardo Pescarmona Marco Mazzotta Maddalena Barba Maurizio Fanciulli Ruggero De Maria Gennaro Ciliberto Marcello Maugeri-Saccà

J Transl Med 2018 09 4;16(1):247. Epub 2018 Sep 4.

Division of Medical Oncology 2, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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September 2018

HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma.

Authors:
Dante Lamberti Giulia Cristinziano Manuela Porru Carlo Leonetti Jan B Egan Chang-Xin Shi Simonetta Buglioni Carla A Amoreo Loriana Castellani Mitesh J Borad Stefano Alemà Sergio Anastasi Oreste Segatto

Hepatology 2019 01 14;69(1):131-142. Epub 2018 Dec 14.

Unit of Oncogenomics and Epigenetics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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January 2019

Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer.

Authors:
Francesca De Nicola Frauke Goeman Matteo Pallocca Francesca Sperati Laura Pizzuti Elisa Melucci Beatrice Casini Carla Azzurra Amoreo Enzo Gallo Maria Grazia Diodoro Simonetta Buglioni Marco Mazzotta Patrizia Vici Domenico Sergi Luigi Di Lauro Maddalena Barba Edoardo Pescarmona Gennaro Ciliberto Ruggero De Maria Maurizio Fanciulli Marcello Maugeri-Saccà

Oncogenesis 2018 Jul 22;7(7):55. Epub 2018 Jul 22.

Division of Medical Oncology 2, IRCCS "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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July 2018

Multicenter Evaluation of the Idylla NRAS-BRAF Mutation Test in Metastatic Colorectal Cancer.

Authors:
Iván Prieto-Potin Clara Montagut Beatriz Bellosillo Matthew Evans Matthew Smith Linea Melchior Werner Reiltin Michael Bennett Veronica Pennati Francesca Castiglione Karl-Friedrich Bürrig Ulrike Cooper Barbara Dockhorn-Dworniczak Christiana Rossenbach Claudia M Luna-Aguirre Hugo A Barrera-Saldaña José C Machado José L Costa Rinat Yacobi Hilla Tabibian-Keissar Simonetta Buglioni Livia Ronchetti Lotte Douglas-Berger Hendrikus J Dubbink Mohammed Alorini Jean-Christophe Sabourin Federico Rojo

J Mol Diagn 2018 09 26;20(5):664-676. Epub 2018 Jun 26.

Molecular Diagnostics Laboratory, Department of Pathology, CIBERONC, The Fundación Jiménez Díaz University Hospital Health Research Institute, Autonomous University of Madrid, Madrid, Spain. Electronic address:

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September 2018

Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations.

Authors:
Matteo Allegretti Alessandra Fabi Simonetta Buglioni Aline Martayan Laura Conti Edoardo Pescarmona Gennaro Ciliberto Patrizio Giacomini

J Exp Clin Cancer Res 2018 Mar 5;37(1):47. Epub 2018 Mar 5.

Oncogenomics and Epigenetics, IRCSS Regina Elena National Cancer Institute, Rome, Italy.

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March 2018

Histone deacetylase inhibitor ITF2357 leads to apoptosis and enhances doxorubicin cytotoxicity in preclinical models of human sarcoma.

Authors:
Marta Di Martile Marianna Desideri Maria Grazia Tupone Simonetta Buglioni Barbara Antoniani Carlotta Mastroiorio Rita Falcioni Virginia Ferraresi Nicola Baldini Roberto Biagini Michele Milella Daniela Trisciuoglio Donatella Del Bufalo

Oncogenesis 2018 Feb 23;7(2):20. Epub 2018 Feb 23.

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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February 2018

Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

Authors:
Elisa Melucci Beatrice Casini Livia Ronchetti Laura Pizzuti Francesca Sperati Matteo Pallocca Francesca De Nicola Frauke Goeman Enzo Gallo Carla Azzurra Amoreo Domenico Sergi Irene Terrenato Patrizia Vici Luigi Di Lauro Maria Grazia Diodoro Edoardo Pescarmona Maddalena Barba Marco Mazzotta Marcella Mottolese Maurizio Fanciulli Gennaro Ciliberto Ruggero De Maria Simonetta Buglioni Marcello Maugeri-Saccà

J Transl Med 2018 02 5;16(1):22. Epub 2018 Feb 5.

Division of Medical Oncology 2, "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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February 2018

BCL-X overexpression promotes tumor progression-associated properties.

Authors:
Daniela Trisciuoglio Maria Grazia Tupone Marianna Desideri Marta Di Martile Chiara Gabellini Simonetta Buglioni Matteo Pallocca Gabriele Alessandrini Simona D'Aguanno Donatella Del Bufalo

Cell Death Dis 2017 12 13;8(12):3216. Epub 2017 Dec 13.

Preclinical Models and New Therapeutic Agents Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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December 2017

Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification.

Authors:
Cristiana Ercolani Caterina Marchiò Anna Di Benedetto Alessandra Fabi Letizia Perracchio Patrizia Vici Francesca Sperati Simonetta Buglioni Vincenzo Arena Edoardo Pescarmona Anna Sapino Irene Terrenato Marcella Mottolese

J Exp Clin Cancer Res 2017 10 13;36(1):143. Epub 2017 Oct 13.

Department of Pathology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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October 2017

Fasting glucose and body mass index as predictors of activity in breast cancer patients treated with everolimus-exemestane: The EverExt study.

Authors:
Laura Pizzuti Paolo Marchetti Clara Natoli Teresa Gamucci Daniele Santini Angelo Fedele Scinto Laura Iezzi Lucia Mentuccia Loretta D'Onofrio Andrea Botticelli Luca Moscetti Francesca Sperati Claudio Botti Francesca Ferranti Simonetta Buglioni Giuseppe Sanguineti Simona Di Filippo Luigi di Lauro Domenico Sergi Teresa Catenaro Silverio Tomao Antonio Giordano Marcello Maugeri-Saccà Maddalena Barba Patrizia Vici

Sci Rep 2017 09 6;7(1):10597. Epub 2017 Sep 6.

Division of Medical Oncology 2, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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September 2017

Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase.

Authors:
Franco Di Filippo Simona Di Filippo Anna Maria Ferrari Raffaele Antonetti Alessandro Battaglia Francesca Becherini Laia Bernet Renzo Boldorini Catherine Bouteille Simonetta Buglioni Paolo Burelli Rafael Cano Vincenzo Canzonieri Pierluigi Chiodera Alfredo Cirilli Luigi Coppola Stefano Drago Luca Di Tommaso Privato Fenaroli Roberto Franchini Andrea Gianatti Diana Giannarelli Carmela Giardina Florence Godey Massimo M Grassi Giuseppe B Grassi Siobhan Laws Samuele Massarut Giuseppe Naccarato Maria Iole Natalicchio Sergio Orefice Fabrizio Palmieri Tiziana Perin Manuela Roncella Massimo G Roncalli Antonio Rulli Angelo Sidoni Corrado Tinterri Maria C Truglia Isabella Sperduti

J Exp Clin Cancer Res 2017 05 16;36(1):69. Epub 2017 May 16.

Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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May 2017

Expression of phosphorylated Hippo pathway kinases (MST1/2 and LATS1/2) in HER2-positive and triple-negative breast cancer patients treated with neoadjuvant therapy.

Authors:
Cristiana Ercolani Anna Di Benedetto Irene Terrenato Laura Pizzuti Luigi Di Lauro Domenico Sergi Francesca Sperati Simonetta Buglioni Maria Teresa Ramieri Lucia Mentuccia Teresa Gamucci Letizia Perracchio Edoardo Pescarmona Marcella Mottolese Maddalena Barba Patrizia Vici Ruggero De Maria Marcello Maugeri-Saccà

Cancer Biol Ther 2017 05 7;18(5):339-346. Epub 2017 Apr 7.

c Division of Medical Oncology 2 , "Regina Elena" National Cancer Institute , Via Elio Chianesi, Rome , Italy.

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May 2017

DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

Authors:
Livia Ronchetti Elisa Melucci Francesca De Nicola Frauke Goeman Beatrice Casini Francesca Sperati Matteo Pallocca Irene Terrenato Laura Pizzuti Patrizia Vici Domenico Sergi Luigi Di Lauro Carla Azzurra Amoreo Enzo Gallo Maria Grazia Diodoro Edoardo Pescarmona Ilio Vitale Maddalena Barba Simonetta Buglioni Marcella Mottolese Maurizio Fanciulli Ruggero De Maria Marcello Maugeri-Saccà

Int J Cancer 2017 06 11;140(11):2587-2595. Epub 2017 Mar 11.

Division of Medical Oncology 2, "Regina Elena" National Cancer Institute, Rome, Italy.

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June 2017

A cut-off of 2150 cytokeratin 19 mRNA copy number in sentinel lymph node may be a powerful predictor of non-sentinel lymph node status in breast cancer patients.

Authors:
Irene Terrenato Valerio D'Alicandro Beatrice Casini Letizia Perracchio Francesca Rollo Laura De Salvo Simona Di Filippo Franco Di Filippo Edoardo Pescarmona Marcello Maugeri-Saccà Marcella Mottolese Simonetta Buglioni

PLoS One 2017 10;12(2):e0171517. Epub 2017 Feb 10.

Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy.

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August 2017

Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase.

Authors:
Franco Di Filippo Simona Di Filippo Anna Maria Ferrari Raffaele Antonetti Alessandro Battaglia Francesca Becherini Laia Bernet Renzo Boldorini Catherine Bouteille Simonetta Buglioni Paolo Burelli Rafael Cano Vincenzo Canzonieri Pierluigi Chiodera Alfredo Cirilli Luigi Coppola Stefano Drago Luca Di Tommaso Privato Fenaroli Roberto Franchini Andrea Gianatti Diana Giannarelli Carmela Giardina Florence Godey Massimo M Grassi Giuseppe B Grassi Siobhan Laws Samuele Massarut Giuseppe Naccarato Maria Iole Natalicchio Sergio Orefice Fabrizio Palmieri Tiziana Perin Manuela Roncella Massimo G Roncalli Antonio Rulli Angelo Sidoni Corrado Tinterri Maria C Truglia Isabella Sperduti

J Exp Clin Cancer Res 2016 12 8;35(1):193. Epub 2016 Dec 8.

Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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December 2016

A Real-World Multicentre Retrospective Study of Paclitaxel-Bevacizumab and Maintenance Therapy as First-Line for HER2-Negative Metastatic Breast Cancer.

Authors:
Teresa Gamucci Lucia Mentuccia Clara Natoli Isabella Sperduti Alessandra Cassano Andrea Michelotti Luigi Di Lauro Domenico Sergi Alessandra Fabi Maria G Sarobba Paolo Marchetti Maddalena Barba Emanuela Magnolfi Marcello Maugeri-Saccà Ernesto Rossi Valentina Sini Antonino Grassadonia Domenica Pellegrini Antonino Astone Cecilia Nisticò Franco Angelini Angela Vaccaro Arianna Pellegrino Claudia De Angelis Michela Palleschi Luca Moscetti Ilaria Bertolini Simonetta Buglioni Antonio Giordano Laura Pizzuti Patrizia Vici

J Cell Physiol 2017 Jun 30;232(6):1571-1578. Epub 2016 Nov 30.

Division of Medical Oncology 2, Regina Elena National Cancer Institute, Rome, Italy.

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June 2017

Analysis of the hippo transducers TAZ and YAP in cervical cancer and its microenvironment.

Authors:
Simonetta Buglioni Patrizia Vici Domenico Sergi Laura Pizzuti Luigi Di Lauro Barbara Antoniani Francesca Sperati Irene Terrenato Mariantonia Carosi Teresa Gamucci Cristina Vincenzoni Luciano Mariani Enrico Vizza Aldo Venuti Giuseppe Sanguineti Angiolo Gadducci Maddalena Barba Clara Natoli Ilio Vitale Marcella Mottolese Ruggero De Maria Marcello Maugeri-Saccà

Oncoimmunology 2016 Jun 28;5(6):e1160187. Epub 2016 Mar 28.

Division of Medical Oncology B, "Regina Elena" National Cancer Institute, Rome, Italy; Scientific Direction, "Regina Elena" National Cancer Institute, Rome, Italy.

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June 2016

DNA Damage and Repair Biomarkers in Cervical Cancer Patients Treated with Neoadjuvant Chemotherapy: An Exploratory Analysis.

Authors:
Patrizia Vici Simonetta Buglioni Domenico Sergi Laura Pizzuti Luigi Di Lauro Barbara Antoniani Francesca Sperati Irene Terrenato Mariantonia Carosi Teresa Gamucci Rosanna Dattilo Monica Bartucci Cristina Vincenzoni Luciano Mariani Enrico Vizza Giuseppe Sanguineti Angiolo Gadducci Ilio Vitale Maddalena Barba Ruggero De Maria Marcella Mottolese Marcello Maugeri-Saccà

PLoS One 2016 1;11(3):e0149872. Epub 2016 Mar 1.

Division of Medical Oncology B, "Regina Elena" National Cancer Institute, Rome, Italy.

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July 2016

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.

Authors:
Marta Di Martile Marianna Desideri Teresa De Luca Chiara Gabellini Simonetta Buglioni Adriana Eramo Giovanni Sette Michele Milella Dante Rotili Antonello Mai Simone Carradori Daniela Secci Ruggero De Maria Donatella Del Bufalo Daniela Trisciuoglio

Oncotarget 2016 Mar;7(10):11332-48

Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy.

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March 2016

HER2 status determination: analyzing the problems to find the solutions.

Authors:
Irene Terrenato Ilaria Pennacchia Simonetta Buglioni Marcella Mottolese Vincenzo Arena

Medicine (Baltimore) 2015 Apr;94(15):e645

From the Biostatistics, Scientific Direction, Regina Elena National Cancer Institute (IT); Pathology Department Catholic University of Sacred Heart (IP, VA); and Pathology Department Regina Elena National Cancer Institute-Rome, Italy (SB, MM).

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April 2015

External Quality Assessment (EQA) program for the preanalytical and analytical immunohistochemical determination of HER2 in breast cancer: an experience on a regional scale.

Authors:
Irene Terrenato Vincenzo Arena Sara Pizzamiglio Ilaria Pennacchia Letizia Perracchio Simonetta Buglioni Cristiana Ercolani Francesca Sperati Leopoldo Costarelli Elena Bonanno Daniela Baldini Silvia Candia Anna Crescenzi Antonella Dal Mas Claudio Di Cristofano Vito Gomes Lucia Rosalba Grillo Paola Pasquini Maria Nicoletta Pericoli Maria Teresa Ramieri Domenica Di Stefano Luigi Ruco Stefania Scarpino Domenico Vitolo Giulia d'Amati Angelo Paradiso Paolo Verderio Marcella Mottolese

J Exp Clin Cancer Res 2013 Aug 21;32:58. Epub 2013 Aug 21.

Pathology Department, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.

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August 2013

Quantitative molecular analysis of sentinel lymph node may be predictive of axillary node status in breast cancer classified by molecular subtypes.

Authors:
Simonetta Buglioni Franco Di Filippo Irene Terrenato Beatrice Casini Enzo Gallo Ferdinando Marandino Carlo L Maini Rossella Pasqualoni Claudio Botti Simona Di Filippo Edoardo Pescarmona Marcella Mottolese

PLoS One 2013 22;8(3):e58823. Epub 2013 Mar 22.

Department of Pathology, Regina Elena National Cancer Institute, Rome, Italy.

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September 2013

HER2 protein and gene variation between primary and metastatic breast cancer: significance and impact on patient care.

Authors:
Alessandra Fabi Anna Di Benedetto Giulio Metro Letizia Perracchio Cecilia Nisticò Franco Di Filippo Cristiana Ercolani Gianluigi Ferretti Elisa Melucci Simonetta Buglioni Isabella Sperduti Paola Papaldo Francesco Cognetti Marcella Mottolese

Clin Cancer Res 2011 Apr 9;17(7):2055-64. Epub 2011 Feb 9.

Medical Oncology, Regina Elena Cancer Institute, Rome, Italy.

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April 2011

A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study.

Authors:
Flavia Novelli Michele Milella Elisa Melucci Anna Di Benedetto Isabella Sperduti Raffaele Perrone-Donnorso Letizia Perracchio Irene Venturo Cecilia Nisticò Alessandra Fabi Simonetta Buglioni Pier Giorgio Natali Marcella Mottolese

Breast Cancer Res 2008 4;10(5):R74. Epub 2008 Sep 4.

Pathology Department, Regina Elena Cancer Institute, Rome, Italy.

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February 2009

Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas.

Authors:
Valentina Folgiero Paolo Avetrani Giulia Bon Selene E Di Carlo Alessandra Fabi Cecilia Nisticò Patrizia Vici Elisa Melucci Simonetta Buglioni Letizia Perracchio Isabella Sperduti Laura Rosanò Ada Sacchi Marcella Mottolese Rita Falcioni

PLoS One 2008 Feb 13;3(2):e1592. Epub 2008 Feb 13.

Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy.

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February 2008

Bio-pathologic characteristics related to chromosome 11 aneusomy and cyclin D1 gene status in surgically resected stage I and II breast cancer: Identification of an adverse prognostic profile.

Authors:
Marcella Mottolese Giulia Orlandi Isabella Sperduti Roberta Merola Simonetta Buglioni Anna Di Benedetto Paola Pinnarò Letizia Perracchio Irene Venturo Francesco Cognetti AnnaMaria Cianciulli

Am J Surg Pathol 2007 Feb;31(2):247-54

Departments of Pathology, Regina Elena Cancer Institute, Rome, Italy.

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February 2007

Chromogenic in situ hybridization to detect HER-2/neu gene amplification in histological and ThinPrep-processed breast cancer fine-needle aspirates: a sensitive and practical method in the trastuzumab era.

Authors:
Amina Vocaturo Flavia Novelli Maria Benevolo Giulia Piperno Ferdinando Marandino Anna Maria Cianciulli Roberta Merola Raffaele Perrone Donnorso Isabella Sperduti Simonetta Buglioni Marcella Mottolese

Oncologist 2006 Sep;11(8):878-86

Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.

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September 2006

Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer.

Authors:
Marcella Mottolese Edit A Nádasi Claudio Botti Anna M Cianciulli Roberta Merola Simonetta Buglioni Maria Benevolo Diana Giannarelli Ferdinando Marandino Raffaele Perrone Donnorso Irene Venturo Pier Giorgio Natali

J Cell Physiol 2005 Jul;204(1):106-12

Department of Pathology, Regina Elena Cancer Institute, Rome, Italy.

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July 2005

Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy.

Authors:
Claudio Botti Simonetta Buglioni Maria Benevolo Diana Giannarelli Paola Papaldo Francesco Cognetti Patrizia Vici Franco Di Filippo Franca Del Nonno Franco Maria Venanzi Pier Giorgio Natali Marcella Mottolese

Clin Cancer Res 2004 Feb;10(4):1360-5

Regina Elena Cancer Institute, Rome, Italy, and University of Camerino, Camerino, Italy.

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February 2004

Transcription and alternative splicing of telomerase reverse transcriptase in benign and malignant breast tumours and in adjacent mammary glandular tissues: implications for telomerase activity.

Authors:
Nadia Zaffaroni Chiara Della Porta Raffaella Villa Claudio Botti Simonetta Buglioni Marcella Mottolese Maria Grazia Daidone

J Pathol 2002 Sep;198(1):37-46

Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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September 2002

Contribution of fluorescence in situ hybridization to immunohistochemistry for the evaluation of HER-2 in breast cancer.

Authors:
Anna M Cianciulli Claudio Botti Angela M Coletta Simonetta Buglioni Raffaella Marzano Maria Benevolo Antonio Cione Marcella Mottolese

Cancer Genet Cytogenet 2002 Feb;133(1):66-71

Department of Clinical Pathology, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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February 2002

Polyclonal Antibodies Against gp185HER2 Peptides: Their Putative Role in the Identification of a Particular HER2 Status in Patients With Breast Cancer.

Authors:
Francesca Di Modugno Simonetta Buglioni Marcella Mottolese Duilia Del Bello Simona Cascioli Alberto Chersi Angela Santoni Paola Nisticò

J Immunother (1991) 2001 May;24(3):221-231

Laboratory of Pathophysiology, CRS Regina Elena Cancer Institute; Laboratory of Pathology, Regina Elena Cancer Institute; Laboratory of Biochemistry, CRS Regina Elena Cancer Institute; and Department of Experimental Medicine and Pathology, University of Rome "La Sapienza", Rome, Italy.

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May 2001