Publications by authors named "Simone P Niclou"

87 Publications

Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy.

Authors:
Eliane Klein Ann-Christin Hau Anaïs Oudin Anna Golebiewska Simone P Niclou

Front Oncol 2020 8;10:604121. Epub 2020 Dec 8.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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December 2020

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

Authors:
Anne Schuster Eliane Klein Virginie Neirinckx Arnon Møldrup Knudsen Carina Fabian Ann-Christin Hau Monika Dieterle Anais Oudin Petr V Nazarov Anna Golebiewska Arnaud Muller Daniel Perez-Hernandez Sophie Rodius Gunnar Dittmar Rolf Bjerkvig Christel Herold-Mende Barbara Klink Bjarne Winther Kristensen Simone P Niclou

Nat Commun 2020 12 11;11(1):6366. Epub 2020 Dec 11.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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December 2020

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

Authors:
Anna Golebiewska Ann-Christin Hau Anaïs Oudin Daniel Stieber Yahaya A Yabo Virginie Baus Vanessa Barthelemy Eliane Klein Sébastien Bougnaud Olivier Keunen May Wantz Alessandro Michelucci Virginie Neirinckx Arnaud Muller Tony Kaoma Petr V Nazarov Francisco Azuaje Alfonso De Falco Ben Flies Lorraine Richart Suresh Poovathingal Thais Arns Kamil Grzyb Andreas Mock Christel Herold-Mende Anne Steino Dennis Brown Patrick May Hrvoje Miletic Tathiane M Malta Houtan Noushmehr Yong-Jun Kwon Winnie Jahn Barbara Klink Georgette Tanner Lucy F Stead Michel Mittelbronn Alexander Skupin Frank Hertel Rolf Bjerkvig Simone P Niclou

Acta Neuropathol 2020 12 3;140(6):919-949. Epub 2020 Oct 3.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 84, Val Fleuri, 1526, Luxembourg, Luxembourg.

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December 2020

Temozolomide-Induced RNA Interactome Uncovers Novel LncRNA Regulatory Loops in Glioblastoma.

Authors:
Sabrina Fritah Arnaud Muller Wei Jiang Ramkrishna Mitra Mohamad Sarmini Monika Dieterle Anna Golebiewska Tao Ye Eric Van Dyck Christel Herold-Mende Zhongming Zhao Francisco Azuaje Simone P Niclou

Cancers (Basel) 2020 Sep 10;12(9). Epub 2020 Sep 10.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg L-1526, Luxembourg.

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September 2020

The soluble form of pan-RTK inhibitor and tumor suppressor LRIG1 mediates downregulation of AXL through direct protein-protein interaction in glioblastoma.

Authors:
Virginie Neirinckx Ann-Christin Hau Anne Schuster Sabrina Fritah Katja Tiemann Eliane Klein Petr V Nazarov André Matagne Martyna Szpakowska Max Meyrath Andy Chevigné Mirko H H Schmidt Simone P Niclou

Neurooncol Adv 2019 May-Dec;1(1):vdz024. Epub 2019 Sep 6.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg.

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September 2019

Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?

Authors:
Olivier Keunen Simone P Niclou

Neuro Oncol 2020 07;22(7):903-904

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Strassen, Luxembourg.

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July 2020

Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey.

Authors:
Emilie Le Rhun Michael Weller Simone P Niclou Susan Short Karin Piil Florien Boele Roberta Rudà Marilena Theodorou Dieta Brandsma Martin van den Bent Linda Dirven

Neurooncol Pract 2020 Mar 10;7(2):249-259. Epub 2020 Jan 10.

Department of Neurology, Leiden University Medical Center, the Netherlands.

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March 2020

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.

Authors:
Sophie Rodius Niek de Klein Céline Jeanty Héctor Sánchez-Iranzo Isaac Crespo Mark Ibberson Ioannis Xenarios Gunnar Dittmar Nadia Mercader Simone P Niclou Francisco Azuaje

Sci Rep 2020 02 19;10(1):2896. Epub 2020 Feb 19.

Quantitative Biology Unit, Luxembourg Institute of Health (LIH), Luxembourg, 1445, Strassen, Luxembourg.

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February 2020

Dual blockade of STAT3 and EGFR: a key to unlock drug resistance in glioblastoma?

Authors:
Sabrina Fritah Simone P Niclou

Neuro Oncol 2020 04;22(4):440-441

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg.

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April 2020

Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma.

Authors:
Yolanda Pires-Afonso Simone P Niclou Alessandro Michelucci

Int J Mol Sci 2020 Jan 21;21(3). Epub 2020 Jan 21.

Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.

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January 2020

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin.

Authors:
Julia Biedermann Matthias Preussler Marina Conde Mirko Peitzsch Susan Richter Ralf Wiedemuth Khalil Abou-El-Ardat Alexander Krüger Matthias Meinhardt Gabriele Schackert William P Leenders Christel Herold-Mende Simone P Niclou Rolf Bjerkvig Graeme Eisenhofer Achim Temme Michael Seifert Leoni A Kunz-Schughart Evelin Schröck Barbara Klink

Cancers (Basel) 2019 Dec 16;11(12). Epub 2019 Dec 16.

Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

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December 2019

Longitudinal molecular trajectories of diffuse glioma in adults.

Authors:
Floris P Barthel Kevin C Johnson Frederick S Varn Anzhela D Moskalik Georgette Tanner Emre Kocakavuk Kevin J Anderson Olajide Abiola Kenneth Aldape Kristin D Alfaro Donat Alpar Samirkumar B Amin David M Ashley Pratiti Bandopadhayay Jill S Barnholtz-Sloan Rameen Beroukhim Christoph Bock Priscilla K Brastianos Daniel J Brat Andrew R Brodbelt Alexander F Bruns Ketan R Bulsara Aruna Chakrabarty Arnab Chakravarti Jeffrey H Chuang Elizabeth B Claus Elizabeth J Cochran Jennifer Connelly Joseph F Costello Gaetano Finocchiaro Michael N Fletcher Pim J French Hui K Gan Mark R Gilbert Peter V Gould Matthew R Grimmer Antonio Iavarone Azzam Ismail Michael D Jenkinson Mustafa Khasraw Hoon Kim Mathilde C M Kouwenhoven Peter S LaViolette Meihong Li Peter Lichter Keith L Ligon Allison K Lowman Tathiane M Malta Tali Mazor Kerrie L McDonald Annette M Molinaro Do-Hyun Nam Naema Nayyar Ho Keung Ng Chew Yee Ngan Simone P Niclou Johanna M Niers Houtan Noushmehr Javad Noorbakhsh D Ryan Ormond Chul-Kee Park Laila M Poisson Raul Rabadan Bernhard Radlwimmer Ganesh Rao Guido Reifenberger Jason K Sa Michael Schuster Brian L Shaw Susan C Short Peter A Sillevis Smitt Andrew E Sloan Marion Smits Hiromichi Suzuki Ghazaleh Tabatabai Erwin G Van Meir Colin Watts Michael Weller Pieter Wesseling Bart A Westerman Georg Widhalm Adelheid Woehrer W K Alfred Yung Gelareh Zadeh Jason T Huse John F De Groot Lucy F Stead Roel G W Verhaak

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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December 2019

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Authors:
Nathan Reynders Dayana Abboud Alessandra Baragli Muhammad Zaeem Noman Bernard Rogister Simone P Niclou Nikolaus Heveker Bassam Janji Julien Hanson Martyna Szpakowska Andy Chevigné

Cells 2019 06 18;8(6). Epub 2019 Jun 18.

Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-1526 Luxembourg, Luxembourg.

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June 2019

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Authors:
Jean Philippe Nesseler Dorthe Schaue William H McBride Mi-Heon Lee Tania Kaprealian Simone P Niclou Philippe Nickers

Adv Radiat Oncol 2019 Apr-Jun;4(2):268-282. Epub 2018 Nov 20.

Department of Radiation Oncology, Centre François Baclesse, Esch-sur-Alzette, Luxembourg.

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November 2018

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

Authors:
Anne Dirkse Anna Golebiewska Thomas Buder Petr V Nazarov Arnaud Muller Suresh Poovathingal Nicolaas H C Brons Sonia Leite Nicolas Sauvageot Dzjemma Sarkisjan Mathieu Seyfrid Sabrina Fritah Daniel Stieber Alessandro Michelucci Frank Hertel Christel Herold-Mende Francisco Azuaje Alexander Skupin Rolf Bjerkvig Andreas Deutsch Anja Voss-Böhme Simone P Niclou

Nat Commun 2019 04 16;10(1):1787. Epub 2019 Apr 16.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526, Luxembourg, Luxembourg.

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April 2019

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

Authors:
Francisco Azuaje Tony Kaoma Céline Jeanty Petr V Nazarov Arnaud Muller Sang-Yoon Kim Gunnar Dittmar Anna Golebiewska Simone P Niclou

F1000Res 2018 7;7:1906. Epub 2018 Dec 7.

Luxembourg Institute of Health (LIH), Strassen, Luxembourg.

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December 2018

A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications.

Authors:
Matthieu Gobin Petr V Nazarov Rolf Warta Marco Timmer Guido Reifenberger Joerg Felsberg Laurent Vallar Anthony J Chalmers Christel C Herold-Mende Roland Goldbrunner Simone P Niclou Eric Van Dyck

Cancer Res 2019 03 23;79(6):1226-1238. Epub 2019 Jan 23.

NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

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March 2019

Transcriptional and epigenetic mechanisms underlying astrocyte identity.

Authors:
Maria Angeliki S Pavlou Luc Grandbarbe Noel J Buckley Simone P Niclou Alessandro Michelucci

Prog Neurobiol 2019 03 29;174:36-52. Epub 2018 Dec 29.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg. Electronic address:

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March 2019

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

Authors:
Pia S Zeiner Corinna Preusse Anna Golebiewska Jenny Zinke Ane Iriondo Arnaud Muller Tony Kaoma Katharina Filipski Monika Müller-Eschner Simon Bernatz Anna-Eva Blank Peter Baumgarten Elena Ilina Anne Grote Martin L Hansmann Marcel A Verhoff Kea Franz Friedrich Feuerhake Joachim P Steinbach Jörg Wischhusen Werner Stenzel Simone P Niclou Patrick N Harter Michel Mittelbronn

Brain Pathol 2019 07 15;29(4):513-529. Epub 2019 Jan 15.

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany.

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July 2019

Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

Authors:
Carole Sousa Anna Golebiewska Suresh K Poovathingal Tony Kaoma Yolanda Pires-Afonso Silvia Martina Djalil Coowar Francisco Azuaje Alexander Skupin Rudi Balling Knut Biber Simone P Niclou Alessandro Michelucci

EMBO Rep 2018 11 11;19(11). Epub 2018 Sep 11.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg

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November 2018

RNAi/CRISPR Screens: from a Pool to a Valid Hit.

Authors:
Anne Schuster Hélène Erasimus Sabrina Fritah Petr V Nazarov Eric van Dyck Simone P Niclou Anna Golebiewska

Trends Biotechnol 2019 01 31;37(1):38-55. Epub 2018 Aug 31.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg; Co-senior authors. Electronic address:

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January 2019

Revival of the VEGF ligand family?

Authors:
Simone P Niclou

Neuro Oncol 2018 10;20(11):1421-1422

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg.

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October 2018

EGFL7 enhances surface expression of integrin αβ to promote angiogenesis in malignant brain tumors.

Authors:
Nevenka Dudvarski Stanković Frank Bicker Stefanie Keller David Tw Jones Patrick N Harter Arne Kienzle Clarissa Gillmann Philipp Arnold Anna Golebiewska Olivier Keunen Alf Giese Andreas von Deimling Tobias Bäuerle Simone P Niclou Michel Mittelbronn Weilan Ye Stefan M Pfister Mirko H Schmidt

EMBO Mol Med 2018 09;10(9)

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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September 2018

Increased formate overflow is a hallmark of oxidative cancer.

Authors:
Johannes Meiser Anne Schuster Matthias Pietzke Johan Vande Voorde Dimitris Athineos Kristell Oizel Guillermo Burgos-Barragan Niek Wit Sandeep Dhayade Jennifer P Morton Emmanuel Dornier David Sumpton Gillian M Mackay Karen Blyth Ketan J Patel Simone P Niclou Alexei Vazquez

Nat Commun 2018 04 10;9(1):1368. Epub 2018 Apr 10.

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.

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April 2018

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

Authors:
Marina Wierz Sandrine Pierson Léa Guyonnet Elodie Viry Audrey Lequeux Anaïs Oudin Simone P Niclou Markus Ollert Guy Berchem Bassam Janji Coralie Guérin Jerome Paggetti Etienne Moussay

Blood 2018 04 13;131(14):1617-1621. Epub 2018 Feb 13.

Laboratory of Experimental Cancer Research, Department of Oncology.

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April 2018

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

Authors:
Fred Fack Saverio Tardito Guillaume Hochart Anais Oudin Liang Zheng Sabrina Fritah Anna Golebiewska Petr V Nazarov Amandine Bernard Ann-Christin Hau Olivier Keunen William Leenders Morten Lund-Johansen Jonathan Stauber Eyal Gottlieb Rolf Bjerkvig Simone P Niclou

EMBO Mol Med 2017 12;9(12):1681-1695

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg

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December 2017

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

Authors:
Siti Aminah Abdul Rahim Anne Dirkse Anais Oudin Anne Schuster Jill Bohler Vanessa Barthelemy Arnaud Muller Laurent Vallar Bassam Janji Anna Golebiewska Simone P Niclou

Br J Cancer 2017 Sep 10;117(6):813-825. Epub 2017 Aug 10.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.

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September 2017

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

Authors:
Angela Armento Elena I Ilina Tony Kaoma Arnaud Muller Laurent Vallar Simone P Niclou Marcel A Krüger Michel Mittelbronn Ulrike Naumann

Int J Oncol 2017 Aug 21;51(2):702-714. Epub 2017 Jun 21.

Molecular Neuro-Oncology, Hertie Institute for Clinical Brain Research and Center Neurology, University of Tübingen, D-72076 Tübingen, Germany.

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August 2017

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

Authors:
Nina Obad Heidi Espedal Radovan Jirik Per Oystein Sakariassen Cecilie Brekke Rygh Morten Lund-Johansen Torfinn Taxt Simone P Niclou Rolf Bjerkvig Olivier Keunen

J Cereb Blood Flow Metab 2018 10 19;38(10):1741-1753. Epub 2017 Jun 19.

7 Norlux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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October 2018

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.

Authors:
Virginie Neirinckx Hakan Hedman Simone P Niclou

Biochim Biophys Acta Rev Cancer 2017 Aug 1;1868(1):109-116. Epub 2017 Mar 1.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 1526, Luxembourg; K.G. Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen, 5020 Bergen, Norway. Electronic address:

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August 2017