Simone P Niclou

Simone P Niclou

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Simone P Niclou

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Dual blockade of STAT3 and EGFR, a key to unlock drug resistance in Glioblastoma?

Authors:
Sabrina Fritah Simone P Niclou

Neuro Oncol 2020 Feb 14. Epub 2020 Feb 14.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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http://dx.doi.org/10.1093/neuonc/noaa039DOI Listing
February 2020

Revealing and Harnessing Tumour-Associated Microglia/Macrophage Heterogeneity in Glioblastoma.

Authors:
Yolanda Pires-Afonso Simone P Niclou Alessandro Michelucci

Int J Mol Sci 2020 Jan 21;21(3). Epub 2020 Jan 21.

Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg.

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http://dx.doi.org/10.3390/ijms21030689DOI Listing
January 2020

Longitudinal molecular trajectories of diffuse glioma in adults.

Authors:
Floris P Barthel Kevin C Johnson Frederick S Varn Anzhela D Moskalik Georgette Tanner Emre Kocakavuk Kevin J Anderson Olajide Abiola Kenneth Aldape Kristin D Alfaro Donat Alpar Samirkumar B Amin David M Ashley Pratiti Bandopadhayay Jill S Barnholtz-Sloan Rameen Beroukhim Christoph Bock Priscilla K Brastianos Daniel J Brat Andrew R Brodbelt Alexander F Bruns Ketan R Bulsara Aruna Chakrabarty Arnab Chakravarti Jeffrey H Chuang Elizabeth B Claus Elizabeth J Cochran Jennifer Connelly Joseph F Costello Gaetano Finocchiaro Michael N Fletcher Pim J French Hui K Gan Mark R Gilbert Peter V Gould Matthew R Grimmer Antonio Iavarone Azzam Ismail Michael D Jenkinson Mustafa Khasraw Hoon Kim Mathilde C M Kouwenhoven Peter S LaViolette Meihong Li Peter Lichter Keith L Ligon Allison K Lowman Tathiane M Malta Tali Mazor Kerrie L McDonald Annette M Molinaro Do-Hyun Nam Naema Nayyar Ho Keung Ng Chew Yee Ngan Simone P Niclou Johanna M Niers Houtan Noushmehr Javad Noorbakhsh D Ryan Ormond Chul-Kee Park Laila M Poisson Raul Rabadan Bernhard Radlwimmer Ganesh Rao Guido Reifenberger Jason K Sa Michael Schuster Brian L Shaw Susan C Short Peter A Sillevis Smitt Andrew E Sloan Marion Smits Hiromichi Suzuki Ghazaleh Tabatabai Erwin G Van Meir Colin Watts Michael Weller Pieter Wesseling Bart A Westerman Georg Widhalm Adelheid Woehrer W K Alfred Yung Gelareh Zadeh Jason T Huse John F De Groot Lucy F Stead Roel G W Verhaak

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1775-1DOI Listing
December 2019

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin.

Authors:
Julia Biedermann Matthias Preussler Marina Conde Mirko Peitzsch Susan Richter Ralf Wiedemuth Khalil Abou-El-Ardat Alexander Krüger Matthias Meinhardt Gabriele Schackert William P Leenders Christel Herold-Mende Simone P Niclou Rolf Bjerkvig Graeme Eisenhofer Achim Temme Michael Seifert Leoni A Kunz-Schughart Evelin Schröck Barbara Klink

Cancers (Basel) 2019 Dec 16;11(12). Epub 2019 Dec 16.

Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

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http://dx.doi.org/10.3390/cancers11122028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966450PMC
December 2019

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

Authors:
Pia S Zeiner Corinna Preusse Anna Golebiewska Jenny Zinke Ane Iriondo Arnaud Muller Tony Kaoma Katharina Filipski Monika Müller-Eschner Simon Bernatz Anna-Eva Blank Peter Baumgarten Elena Ilina Anne Grote Martin L Hansmann Marcel A Verhoff Kea Franz Friedrich Feuerhake Joachim P Steinbach Jörg Wischhusen Werner Stenzel Simone P Niclou Patrick N Harter Michel Mittelbronn

Brain Pathol 2019 07 15;29(4):513-529. Epub 2019 Jan 15.

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/bpa.12690
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http://dx.doi.org/10.1111/bpa.12690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849857PMC
July 2019

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Authors:
Nathan Reynders Dayana Abboud Alessandra Baragli Muhammad Zaeem Noman Bernard Rogister Simone P Niclou Nikolaus Heveker Bassam Janji Julien Hanson Martyna Szpakowska Andy Chevigné

Cells 2019 06 18;8(6). Epub 2019 Jun 18.

Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-1526 Luxembourg, Luxembourg.

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http://dx.doi.org/10.3390/cells8060613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627231PMC
June 2019

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.

Authors:
Anne Dirkse Anna Golebiewska Thomas Buder Petr V Nazarov Arnaud Muller Suresh Poovathingal Nicolaas H C Brons Sonia Leite Nicolas Sauvageot Dzjemma Sarkisjan Mathieu Seyfrid Sabrina Fritah Daniel Stieber Alessandro Michelucci Frank Hertel Christel Herold-Mende Francisco Azuaje Alexander Skupin Rolf Bjerkvig Andreas Deutsch Anja Voss-Böhme Simone P Niclou

Nat Commun 2019 04 16;10(1):1787. Epub 2019 Apr 16.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526, Luxembourg, Luxembourg.

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http://dx.doi.org/10.1038/s41467-019-09853-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467886PMC
April 2019

Transcriptional and epigenetic mechanisms underlying astrocyte identity.

Authors:
Maria Angeliki S Pavlou Luc Grandbarbe Noel J Buckley Simone P Niclou Alessandro Michelucci

Prog Neurobiol 2019 03 29;174:36-52. Epub 2018 Dec 29.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.12.007DOI Listing
March 2019

A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications.

Authors:
Matthieu Gobin Petr V Nazarov Rolf Warta Marco Timmer Guido Reifenberger Joerg Felsberg Laurent Vallar Anthony J Chalmers Christel C Herold-Mende Roland Goldbrunner Simone P Niclou Eric Van Dyck

Cancer Res 2019 03 23;79(6):1226-1238. Epub 2019 Jan 23.

NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2076DOI Listing
March 2019

RNAi/CRISPR Screens: from a Pool to a Valid Hit.

Authors:
Anne Schuster Hélène Erasimus Sabrina Fritah Petr V Nazarov Eric van Dyck Simone P Niclou Anna Golebiewska

Trends Biotechnol 2019 01 31;37(1):38-55. Epub 2018 Aug 31.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg; Co-senior authors. Electronic address:

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http://dx.doi.org/10.1016/j.tibtech.2018.08.002DOI Listing
January 2019

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses.

Authors:
Francisco Azuaje Tony Kaoma Céline Jeanty Petr V Nazarov Arnaud Muller Sang-Yoon Kim Gunnar Dittmar Anna Golebiewska Simone P Niclou

F1000Res 2018 7;7:1906. Epub 2018 Dec 7.

Luxembourg Institute of Health (LIH), Strassen, Luxembourg.

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http://dx.doi.org/10.12688/f1000research.17149.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406180PMC
December 2018

Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.

Authors:
Carole Sousa Anna Golebiewska Suresh K Poovathingal Tony Kaoma Yolanda Pires-Afonso Silvia Martina Djalil Coowar Francisco Azuaje Alexander Skupin Rudi Balling Knut Biber Simone P Niclou Alessandro Michelucci

EMBO Rep 2018 11 11;19(11). Epub 2018 Sep 11.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg

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http://dx.doi.org/10.15252/embr.201846171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216255PMC
November 2018

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Authors:
Jean Philippe Nesseler Dorthe Schaue William H McBride Mi-Heon Lee Tania Kaprealian Simone P Niclou Philippe Nickers

Adv Radiat Oncol 2019 Apr-Jun;4(2):268-282. Epub 2018 Nov 20.

Department of Radiation Oncology, Centre François Baclesse, Esch-sur-Alzette, Luxembourg.

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183023
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http://dx.doi.org/10.1016/j.adro.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460102PMC
November 2018

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma.

Authors:
Nina Obad Heidi Espedal Radovan Jirik Per Oystein Sakariassen Cecilie Brekke Rygh Morten Lund-Johansen Torfinn Taxt Simone P Niclou Rolf Bjerkvig Olivier Keunen

J Cereb Blood Flow Metab 2018 10 19;38(10):1741-1753. Epub 2017 Jun 19.

7 Norlux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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http://dx.doi.org/10.1177/0271678X17714656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168744PMC
October 2018

Revival of the VEGF ligand family?

Authors:
Simone P Niclou

Neuro Oncol 2018 10;20(11):1421-1422

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg.

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http://dx.doi.org/10.1093/neuonc/noy127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178279PMC
October 2018

EGFL7 enhances surface expression of integrin αβ to promote angiogenesis in malignant brain tumors.

Authors:
Nevenka Dudvarski Stanković Frank Bicker Stefanie Keller David Tw Jones Patrick N Harter Arne Kienzle Clarissa Gillmann Philipp Arnold Anna Golebiewska Olivier Keunen Alf Giese Andreas von Deimling Tobias Bäuerle Simone P Niclou Michel Mittelbronn Weilan Ye Stefan M Pfister Mirko H Schmidt

EMBO Mol Med 2018 09;10(9)

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.15252/emmm.201708420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127886PMC
September 2018

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.

Authors:
Marina Wierz Sandrine Pierson Léa Guyonnet Elodie Viry Audrey Lequeux Anaïs Oudin Simone P Niclou Markus Ollert Guy Berchem Bassam Janji Coralie Guérin Jerome Paggetti Etienne Moussay

Blood 2018 04 13;131(14):1617-1621. Epub 2018 Feb 13.

Laboratory of Experimental Cancer Research, Department of Oncology.

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http://dx.doi.org/10.1182/blood-2017-06-792267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887766PMC
April 2018

Increased formate overflow is a hallmark of oxidative cancer.

Authors:
Johannes Meiser Anne Schuster Matthias Pietzke Johan Vande Voorde Dimitris Athineos Kristell Oizel Guillermo Burgos-Barragan Niek Wit Sandeep Dhayade Jennifer P Morton Emmanuel Dornier David Sumpton Gillian M Mackay Karen Blyth Ketan J Patel Simone P Niclou Alexei Vazquez

Nat Commun 2018 04 10;9(1):1368. Epub 2018 Apr 10.

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.

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http://www.nature.com/articles/s41467-018-03777-w
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http://dx.doi.org/10.1038/s41467-018-03777-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893600PMC
April 2018

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways.

Authors:
Fred Fack Saverio Tardito Guillaume Hochart Anais Oudin Liang Zheng Sabrina Fritah Anna Golebiewska Petr V Nazarov Amandine Bernard Ann-Christin Hau Olivier Keunen William Leenders Morten Lund-Johansen Jonathan Stauber Eyal Gottlieb Rolf Bjerkvig Simone P Niclou

EMBO Mol Med 2017 12;9(12):1681-1695

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
Publisher Site
http://dx.doi.org/10.15252/emmm.201707729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709746PMC
December 2017

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

Authors:
Siti Aminah Abdul Rahim Anne Dirkse Anais Oudin Anne Schuster Jill Bohler Vanessa Barthelemy Arnaud Muller Laurent Vallar Bassam Janji Anna Golebiewska Simone P Niclou

Br J Cancer 2017 Sep 10;117(6):813-825. Epub 2017 Aug 10.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.

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http://dx.doi.org/10.1038/bjc.2017.263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590001PMC
September 2017

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy.

Authors:
Virginie Neirinckx Hakan Hedman Simone P Niclou

Biochim Biophys Acta Rev Cancer 2017 Aug 1;1868(1):109-116. Epub 2017 Mar 1.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 1526, Luxembourg; K.G. Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen, 5020 Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.02.007DOI Listing
August 2017

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors.

Authors:
Angela Armento Elena I Ilina Tony Kaoma Arnaud Muller Laurent Vallar Simone P Niclou Marcel A Krüger Michel Mittelbronn Ulrike Naumann

Int J Oncol 2017 Aug 21;51(2):702-714. Epub 2017 Jun 21.

Molecular Neuro-Oncology, Hertie Institute for Clinical Brain Research and Center Neurology, University of Tübingen, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.3892/ijo.2017.4051DOI Listing
August 2017

The angiogenic switch leads to a metabolic shift in human glioblastoma.

Authors:
Krishna M Talasila Gro V Røsland Hanne R Hagland Eskil Eskilsson Irene H Flønes Sabrina Fritah Francisco Azuaje Nadia Atai Patrick N Harter Michel Mittelbronn Michael Andersen Justin V Joseph Jubayer Al Hossain Laurent Vallar Cornelis J F van Noorden Simone P Niclou Frits Thorsen Karl Johan Tronstad Charalampos Tzoulis Rolf Bjerkvig Hrvoje Miletic

Neuro Oncol 2017 03;19(3):383-393

Department of Biomedicine, University of Bergen, Norway.

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http://dx.doi.org/10.1093/neuonc/now175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464376PMC
March 2017

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

Authors:
Eskil Eskilsson Gro V Rosland Krishna M Talasila Stian Knappskog Olivier Keunen Andrea Sottoriva Sarah Foerster Gergely Solecki Torfinn Taxt Radovan Jirik Sabrina Fritah Patrick N Harter Kristjan Välk Jubayer Al Hossain Justin V Joseph Roza Jahedi Halala S Saed Sara G Piccirillo Inma Spiteri Lina Leiss Philipp Euskirchen Grazia Graziani Thomas Daubon Morten Lund-Johansen Per Øyvind Enger Frank Winkler Christoph A Ritter Simone P Niclou Colin Watts Rolf Bjerkvig Hrvoje Miletic

Neuro Oncol 2016 12 10;18(12):1644-1655. Epub 2016 Jun 10.

Department of Biomedicine, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., T.T., K.V., J.A.H., J.V.J., R.J., H.S.S., L.L., T.D., P.Ø.E., R.B., H.M.); KG Jebsen Brain Tumor Research Center, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., K.V., J.A.H., J.V.J., T.D., P. Ø.E., S.P.N., R.B., H.M.); Department of Clinical Science, University of Bergen, Norway (S.K.); Department of Oncology, Haukeland University Hospital, Bergen, Norway (S.K.); Norlux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg (O.K., S.F., S.P.N., R.B.); Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK (A.S.); Department of Clinical Pharmacy, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany (S.F., C.A.R.); Department of Neurooncology, University Hospital Heidelberg, Germany (G.S., F.W.); Institute of Scientific Instruments, ASCR, Brno, Czech Republic (R.J.); Edinger-Intsitute, Goethe-University Medical School, Frankfurt am Main, Germany (P.N.H.); Department of Pathology, Haukeland University Hospital, Bergen, Norway (J.A.H., H.M.); Department of Clinical Neurosciences, University of Cambridge, UK (S.G.P., C.W.); Statistics and Computational Biology Laboratory, University of Cambridge, UK (I.S.); Neuro Clinic, Haukeland University Hospital, Bergen, Norway; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany (P.E.); Department of Systems Medicine, University of Rome «Tor Vergata», Rome, Italy (G.G.); INSERM U1029 - University of Bordeaux, Allée Geoffroy St. Hilaire, Pessac, France (T.D.); Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway (M.L.-J., P. Ø.E.).

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http://dx.doi.org/10.1093/neuonc/now113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791772PMC
December 2016

Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.

Authors:
Stephanie Du Four Sarah K Maenhout Simone P Niclou Kris Thielemans Bart Neyns Joeri L Aerts

Am J Cancer Res 2016 1;6(11):2514-2531. Epub 2016 Nov 1.

Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel Laarbeeklaan 103E, 1090, Brussels, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126270PMC
November 2016

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma.

Authors:
Sébastien Bougnaud Anna Golebiewska Anaïs Oudin Olivier Keunen Patrick N Harter Lisa Mäder Francisco Azuaje Sabrina Fritah Daniel Stieber Tony Kaoma Laurent Vallar Nicolaas H C Brons Thomas Daubon Hrvoje Miletic Terje Sundstrøm Christel Herold-Mende Michel Mittelbronn Rolf Bjerkvig Simone P Niclou

Oncotarget 2016 May;7(22):31955-71

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (L.I.H.) Luxembourg, Luxembourg.

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http://dx.doi.org/10.18632/oncotarget.7454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077988PMC
May 2016

Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

Authors:
Sophie Rodius Ganna Androsova Lou Götz Robin Liechti Isaac Crespo Susanne Merz Petr V Nazarov Niek de Klein Céline Jeanty Juan M González-Rosa Arnaud Muller Francois Bernardin Simone P Niclou Laurent Vallar Nadia Mercader Mark Ibberson Ioannis Xenarios Francisco Azuaje

Sci Rep 2016 05 31;6:26822. Epub 2016 May 31.

NorLux Neuro-Oncology Laboratory, Oncology Department, Luxembourg Institute of Health (LIH), Luxembourg, L-1526, Luxembourg.

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http://dx.doi.org/10.1038/srep26822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886216PMC
May 2016

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma.

Authors:
Morgane Sanzey Siti Aminah Abdul Rahim Anais Oudin Anne Dirkse Tony Kaoma Laurent Vallar Christel Herold-Mende Rolf Bjerkvig Anna Golebiewska Simone P Niclou

PLoS One 2015 1;10(5):e0123544. Epub 2015 May 1.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (L.I.H.), Luxembourg, Luxembourg; KG Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Bergen, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416792PMC
February 2016

Targeted Proteomics to Assess the Response to Anti-Angiogenic Treatment in Human Glioblastoma (GBM).

Authors:
Kevin Demeure Fred Fack Elodie Duriez Katja Tiemann Amandine Bernard Anna Golebiewska Sébastien Bougnaud Rolf Bjerkvig Bruno Domon Simone P Niclou

Mol Cell Proteomics 2016 Feb 4;15(2):481-92. Epub 2015 Aug 4.

From the ‡NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg; ¶KG Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Bergen, Norway

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http://dx.doi.org/10.1074/mcp.M115.052423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739668PMC
February 2016

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Authors:
Saverio Tardito Anaïs Oudin Shafiq U Ahmed Fred Fack Olivier Keunen Liang Zheng Hrvoje Miletic Per Øystein Sakariassen Adam Weinstock Allon Wagner Susan L Lindsay Andreas K Hock Susan C Barnett Eytan Ruppin Svein Harald Mørkve Morten Lund-Johansen Anthony J Chalmers Rolf Bjerkvig Simone P Niclou Eyal Gottlieb

Nat Cell Biol 2015 Dec 23;17(12):1556-68. Epub 2015 Nov 23.

Cancer Metabolism Research Unit, Cancer Research UK, Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb3272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663685PMC
December 2015

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes.

Authors:
Anne Burtey Marek Wagner Erlend Hodneland Kai Ove Skaftnesmo Julia Schoelermann Ivan Rios Mondragon Heidi Espedal Anna Golebiewska Simone P Niclou Rolf Bjerkvig Tanja Kögel Hans-Hermann Gerdes

FASEB J 2015 Nov 28;29(11):4695-712. Epub 2015 Jul 28.

*Department of Biomedicine, Biomaterials, Department of Clinical Dentistry, and K. G. Jebsen Brain Tumour Research Center, University of Bergen, Bergen, Norway; Department of Pathology and Department of Clinical Medicine, Haukeland University Hospital, Bergen, Norway; and NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

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http://dx.doi.org/10.1096/fj.14-268615DOI Listing
November 2015

Gauging heterogeneity in primary versus recurrent glioblastoma.

Authors:
Simone P Niclou

Neuro Oncol 2015 Jul 12;17(7):907-9. Epub 2015 May 12.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg and K.G. Jebsen Brain Tumor Research Center, Department of Biomedicine, University of Bergen, Norway.

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http://dx.doi.org/10.1093/neuonc/nov078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762011PMC
July 2015

Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.

Authors:
Stephanie Du Four Sarah K Maenhout Kari De Pierre Dries Renmans Simone P Niclou Kris Thielemans Bart Neyns Joeri L Aerts

Oncoimmunology 2015 Apr 22;4(4):e998107. Epub 2015 Jan 22.

Laboratory of Molecular and Cellular Therapy; Department of Immunology-Physiology; Vrije Universiteit Brussel , Brussels, Belgium.

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http://dx.doi.org/10.1080/2162402X.2014.998107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485747PMC
April 2015

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.

Authors:
Francisco Azuaje Katja Tiemann Simone P Niclou

Cell Commun Signal 2015 Mar 31;13:23. Epub 2015 Mar 31.

Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.

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http://dx.doi.org/10.1186/s12964-015-0098-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391485PMC
March 2015

Whole genomes redefine the mutational landscape of pancreatic cancer.

Authors:
Nicola Waddell Marina Pajic Ann-Marie Patch David K Chang Karin S Kassahn Peter Bailey Amber L Johns David Miller Katia Nones Kelly Quek Michael C J Quinn Alan J Robertson Muhammad Z H Fadlullah Tim J C Bruxner Angelika N Christ Ivon Harliwong Senel Idrisoglu Suzanne Manning Craig Nourse Ehsan Nourbakhsh Shivangi Wani Peter J Wilson Emma Markham Nicole Cloonan Matthew J Anderson J Lynn Fink Oliver Holmes Stephen H Kazakoff Conrad Leonard Felicity Newell Barsha Poudel Sarah Song Darrin Taylor Nick Waddell Scott Wood Qinying Xu Jianmin Wu Mark Pinese Mark J Cowley Hong C Lee Marc D Jones Adnan M Nagrial Jeremy Humphris Lorraine A Chantrill Venessa Chin Angela M Steinmann Amanda Mawson Emily S Humphrey Emily K Colvin Angela Chou Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Pettitt Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nigel B Jamieson Janet S Graham Simone P Niclou Rolf Bjerkvig Robert Grützmann Daniela Aust Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Massimo Falconi Giuseppe Zamboni Giampaolo Tortora Margaret A Tempero Anthony J Gill James R Eshleman Christian Pilarsky Aldo Scarpa Elizabeth A Musgrove John V Pearson Andrew V Biankin Sean M Grimmond

Nature 2015 Feb;518(7540):495-501

1] Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia [2] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523082PMC
February 2015

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.

Authors:
Fred Fack Heidi Espedal Olivier Keunen Anna Golebiewska Nina Obad Patrick N Harter Michel Mittelbronn Oliver Bähr Astrid Weyerbrock Linda Stuhr Hrvoje Miletic Per Ø Sakariassen Daniel Stieber Cecilie B Rygh Morten Lund-Johansen Liang Zheng Eyal Gottlieb Simone P Niclou Rolf Bjerkvig

Acta Neuropathol 2015 Jan 17;129(1):115-31. Epub 2014 Oct 17.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé, Strassen, Luxembourg.

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http://dx.doi.org/10.1007/s00401-014-1352-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282692PMC
January 2015

Databases for lncRNAs: a comparative evaluation of emerging tools.

Authors:
Sabrina Fritah Simone P Niclou Francisco Azuaje

RNA 2014 Nov;20(11):1655-65

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg L-1526, Luxembourg

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http://dx.doi.org/10.1261/rna.044040.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201818PMC
November 2014

A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells.

Authors:
Swapnil V Bhujbal Bart de Haan Simone P Niclou Paul de Vos

Sci Rep 2014 Oct 31;4:6856. Epub 2014 Oct 31.

Department of Pathology and Medical Biology; Immunoendocrinology, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1038/srep06856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215319PMC
October 2014

Tumor versus stromal cells in culture--survival of the fittest?

Authors:
Krishna M Talasila Narve Brekka Kjersti Mangseth Daniel Stieber Lasse Evensen Gro V Rosland Anja Torsvik Marek Wagner Simone P Niclou Rupavathana Mahesparan Olav K Vintermyr Rolf Bjerkvig Janice M Nigro Hrvoje Miletic

PLoS One 2013 2;8(12):e81183. Epub 2013 Dec 2.

Department of Biomedicine, University of Bergen, Bergen, Norway ; Department of Pathology, Haukeland University Hospital, Bergen, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857854PMC
September 2014

Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells.

Authors:
Swapnil V Bhujbal Genaro A Paredes-Juarez Simone P Niclou Paul de Vos

J Mech Behav Biomed Mater 2014 Sep 2;37:196-208. Epub 2014 Jun 2.

Department of Pathology and Medical Biology; Immunoendocrinology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

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September 2014

Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.

Authors:
Olivier Keunen Torfinn Taxt Renate Grüner Morten Lund-Johansen Joerg-Christian Tonn Tina Pavlin Rolf Bjerkvig Simone P Niclou Frits Thorsen

Adv Drug Deliv Rev 2014 Sep 28;76:98-115. Epub 2014 Jul 28.

Translational Cancer Research, Department of Biomedicine, University of Bergen, Norway; Molecular Imaging Center, Department of Biomedicine, University of Bergen, Norway; The Kristian Gerhard Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Norway.

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http://dx.doi.org/10.1016/j.addr.2014.07.010DOI Listing
September 2014

PeptideManager: a peptide selection tool for targeted proteomic studies involving mixed samples from different species.

Authors:
Kevin Demeure Elodie Duriez Bruno Domon Simone P Niclou

Front Genet 2014 2;5:305. Epub 2014 Sep 2.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé Luxembourg, Luxembourg.

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http://dx.doi.org/10.3389/fgene.2014.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151198PMC
September 2014

Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?

Authors:
Sanne A M van Lith Anna C Navis Kiek Verrijp Simone P Niclou Rolf Bjerkvig Pieter Wesseling Bastiaan Tops Remco Molenaar Cornelis J F van Noorden William P J Leenders

Biochim Biophys Acta 2014 Aug 18;1846(1):66-74. Epub 2014 Apr 18.

Radboud University Medical Centre, Department of Pathology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.04.004DOI Listing
August 2014

U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells.

Authors:
Anja Torsvik Daniel Stieber Per Øyvind Enger Anna Golebiewska Anders Molven Agnete Svendsen Bengt Westermark Simone P Niclou Thale Kristin Olsen Martha Chekenya Enger Rolf Bjerkvig

Cancer Med 2014 Aug 8;3(4):812-24. Epub 2014 May 8.

Department of Biomedicine, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1002/cam4.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303149PMC
August 2014

Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture.

Authors:
Uros Rajcevic Jaco C Knol Sander Piersma Sébastien Bougnaud Fred Fack Eirik Sundlisaeter Karl Søndenaa Reidar Myklebust Thang V Pham Simone P Niclou Connie R Jiménez

Proteome Sci 2014 11;12:39. Epub 2014 Jul 11.

OncoProteomics Laboratory, Department of Medical Oncology, VUmc-Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/1477-5956-12-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114130PMC
July 2014

Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment?

Authors:
Pakzad Fathpour Nina Obad Heidi Espedal Daniel Stieber Olivier Keunen Per Ø Sakariassen Simone P Niclou Rolf Bjerkvig

Neuro Oncol 2014 May;16(5):754-6

Department of Biomedicine, University of Bergen, Norway (P.F., N.O., H.E.,P.Ø.S., R.B); Centre de Recherche Public de la Santé, Luxembourg (D.S., O.K., S.P.N.).

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http://dx.doi.org/10.1093/neuonc/nou013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984560PMC
May 2014

Drug and cell encapsulation: alternative delivery options for the treatment of malignant brain tumors.

Authors:
Swapnil V Bhujbal Paul de Vos Simone P Niclou

Adv Drug Deliv Rev 2014 Apr 31;67-68:142-53. Epub 2014 Jan 31.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), 84, Val Fleuri, L-1586 Luxembourg, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.01.010DOI Listing
April 2014

Gene set based integrated data analysis reveals phenotypic differences in a brain cancer model.

Authors:
Kjell Petersen Uros Rajcevic Siti Aminah Abdul Rahim Inge Jonassen Karl-Henning Kalland Connie R Jimenez Rolf Bjerkvig Simone P Niclou

PLoS One 2013 9;8(7):e68288. Epub 2013 Jul 9.

Computational Biology Unit, Uni Computing, Uni Research AS, Bergen, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068288PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706599PMC
February 2014

Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes.

Authors:
Daniel Stieber Anna Golebiewska Lisa Evers Elizabeth Lenkiewicz Nicolaas H C Brons Nathalie Nicot Anaïs Oudin Sébastien Bougnaud Frank Hertel Rolf Bjerkvig Laurent Vallar Michael T Barrett Simone P Niclou

Acta Neuropathol 2014 Feb 24;127(2):203-19. Epub 2013 Oct 24.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), 84, Val Fleuri, 1526, Luxembourg, Luxembourg.

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http://link.springer.com/10.1007/s00401-013-1196-4
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895194PMC
February 2014

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.

Authors:
Joanna Baginska Elodie Viry Guy Berchem Aurélie Poli Muhammad Zaeem Noman Kris van Moer Sandrine Medves Jacques Zimmer Anaïs Oudin Simone P Niclou R Chris Bleackley Ing Swie Goping Salem Chouaib Bassam Janji

Proc Natl Acad Sci U S A 2013 Oct 7;110(43):17450-5. Epub 2013 Oct 7.

Laboratory of Experimental Hemato-Oncology, Department of Oncology, and Laboratory of Immunogenetics and Allergology, Public Research Center for Health, L-1526 Luxembourg City, Luxembourg.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1304790110
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http://dx.doi.org/10.1073/pnas.1304790110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808626PMC
October 2013

A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.

Authors:
Barbara Klink Hrvoje Miletic Daniel Stieber Peter C Huszthy Jaime Alberto Campos Valenzuela Jaime Alberto Campos Valenzuela Jörg Balss Jian Wang Manja Schubert Per Øystein Sakariassen Terje Sundstrøm Anja Torsvik Mads Aarhus Rupavathana Mahesparan Andreas von Deimling Lars Kaderali Simone P Niclou Evelin Schröck Rolf Bjerkvig Janice M Nigro

PLoS One 2013 19;8(3):e59773. Epub 2013 Mar 19.

Institut für Klinische Genetik, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602110PMC
September 2013

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status.

Authors:
Mikael Johansson Anaïs Oudin Katja Tiemann Amandine Bernard Anna Golebiewska Olivier Keunen Fred Fack Daniel Stieber Baofeng Wang Håkan Hedman Simone P Niclou

Neuro Oncol 2013 Sep 30;15(9):1200-11. Epub 2013 May 30.

NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg, Sweden.

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http://dx.doi.org/10.1093/neuonc/not054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748912PMC
September 2013

In vivo animal models for studying brain metastasis: value and limitations.

Authors:
Inderjit Daphu Terje Sundstrøm Sindre Horn Peter C Huszthy Simone P Niclou Per Ø Sakariassen Heike Immervoll Hrvoje Miletic Rolf Bjerkvig Frits Thorsen

Clin Exp Metastasis 2013 Jun 16;30(5):695-710. Epub 2013 Jan 16.

NorLux Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway.

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http://link.springer.com/10.1007/s10585-013-9566-9
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June 2013

Combined effect of tissue stabilization and protein extraction methods on phosphoprotein analysis.

Authors:
Olga A Kofanova Fred Fack Simone P Niclou Fay Betsou

Biopreserv Biobank 2013 Jun 29;11(3):161-5. Epub 2013 May 29.

1 Integrated BioBank of Luxembourg (IBBL) , Luxembourg .

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http://dx.doi.org/10.1089/bio.2013.0008DOI Listing
June 2013

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells.

Authors:
Anna Golebiewska Sébastien Bougnaud Daniel Stieber Nicolaas H C Brons Laurent Vallar Frank Hertel Barbara Klink Evelin Schröck Rolf Bjerkvig Simone P Niclou

Brain 2013 May 4;136(Pt 5):1462-75. Epub 2013 Mar 4.

NorLux Neuro-Oncology Laboratory, Centre de Recherche Public de la Santé (CRP-Santé), Department of Oncology NorLux Neuro-Oncology Laboratory 84, Val Fleuri, L- 1526 Luxembourg.

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http://dx.doi.org/10.1093/brain/awt025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634193PMC
May 2013

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

Authors:
Anna C Navis Simone P Niclou Fred Fack Daniel Stieber Sanne van Lith Kiek Verrijp Alan Wright Jonathan Stauber Bastiaan Tops Irene Otte-Holler Ron A Wevers Arno van Rooij Stefan Pusch Andreas von Deimling Wikky Tigchelaar Cornelis J F van Noorden Pieter Wesseling William P J Leenders

Acta Neuropathol Commun 2013 May 29;1:18. Epub 2013 May 29.

Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1186/2051-5960-1-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893588PMC
May 2013

In vivo models of primary brain tumors: pitfalls and perspectives.

Authors:
Peter C Huszthy Inderjit Daphu Simone P Niclou Daniel Stieber Janice M Nigro Per Ø Sakariassen Hrvoje Miletic Frits Thorsen Rolf Bjerkvig

Neuro Oncol 2012 Aug 7;14(8):979-93. Epub 2012 Jun 7.

NorLux, Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway.

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nos135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408261PMC
August 2012

Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI.

Authors:
Thomas Viel Krishna M Talasila Parisa Monfared Jian Wang Jan F Jikeli Yannic Waerzeggers Bernd Neumaier Heiko Backes Narve Brekka Frits Thorsen Daniel Stieber Simone P Niclou Alexandra Winkeler Bertrand Tavitian Mathias Hoehn Rolf Bjerkvig Hrvoje Miletic Andreas H Jacobs

J Nucl Med 2012 Jul 11;53(7):1135-45. Epub 2012 Jun 11.

Westfälische Wilhelm-University Münster (WWU), European Institute for Molecular Imaging (EIMI), Münster, Germany.

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http://dx.doi.org/10.2967/jnumed.111.101659DOI Listing
July 2012

Novel ways to target brain tumour metabolism.

Authors:
Daniel Stieber Siti A Abdul Rahim Simone P Niclou

Expert Opin Ther Targets 2011 Oct 2;15(10):1227-39. Epub 2011 Jun 2.

Centre de Recherche Public de la Santé (CRP-Santé), Oncology Department , NorLux Neuro-Oncology Laboratory, Luxembourg.

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http://dx.doi.org/10.1517/14728222.2011.588211DOI Listing
October 2011

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.

Authors:
Olivier Keunen Mikael Johansson Anaïs Oudin Morgane Sanzey Siti A Abdul Rahim Fred Fack Frits Thorsen Torfinn Taxt Michal Bartos Radovan Jirik Hrvoje Miletic Jian Wang Daniel Stieber Linda Stuhr Ingrid Moen Cecilie Brekke Rygh Rolf Bjerkvig Simone P Niclou

Proc Natl Acad Sci U S A 2011 Mar 14;108(9):3749-54. Epub 2011 Feb 14.

NorLux Neuro-Oncology Laboratory, Oncology Department, Centre de Recherche Public de la Santé, 1526 Luxembourg, Luxembourg.

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http://dx.doi.org/10.1073/pnas.1014480108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048093PMC
March 2011

Critical appraisal of the side population assay in stem cell and cancer stem cell research.

Authors:
Anna Golebiewska Nicolaas H C Brons Rolf Bjerkvig Simone P Niclou

Cell Stem Cell 2011 Feb;8(2):136-47

NorLux Neuro-Oncology Laboratory, Oncology Department, Centre de Recherche Public de la Santé, 84 Val Fleuri, Luxembourg.

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http://dx.doi.org/10.1016/j.stem.2011.01.007DOI Listing
February 2011

Glioma proteomics: status and perspectives.

Authors:
Simone P Niclou Fred Fack Uros Rajcevic

J Proteomics 2010 Sep 20;73(10):1823-38. Epub 2010 Mar 20.

Norlux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg, Luxembourg.

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http://dx.doi.org/10.1016/j.jprot.2010.03.007DOI Listing
September 2010

Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease.

Authors:
Pierre Garcia Ihsen Youssef Jo K Utvik Sabrina Florent-Béchard Vanassa Barthélémy Catherine Malaplate-Armand Badreddine Kriem Christophe Stenger Violette Koziel Jean-Luc Olivier Marie-Christine Escanye Marine Hanse Ahmad Allouche Cédric Desbène Frances T Yen Rolf Bjerkvig Thierry Oster Simone P Niclou Thierry Pillot

J Neurosci 2010 Jun;30(22):7516-27

JE2482 Lipidomix, Nancy Université, Vandoeuvre, France.

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http://dx.doi.org/10.1523/JNEUROSCI.4182-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632372PMC
June 2010

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system.

Authors:
Erich M Ehlert Ruben Eggers Simone P Niclou Joost Verhaagen

BMC Neurosci 2010 Feb 18;11:20. Epub 2010 Feb 18.

Department of Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/1471-2202-11-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841193PMC
February 2010

iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype.

Authors:
Uros Rajcevic Kjell Petersen Jaco C Knol Maarten Loos Sébastien Bougnaud Oleg Klychnikov Ka Wan Li Thang V Pham Jian Wang Hrvoje Miletic Zhao Peng Rolf Bjerkvig Connie R Jimenez Simone P Niclou

Mol Cell Proteomics 2009 Nov 12;8(11):2595-612. Epub 2009 Aug 12.

Norlux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public Santé (CRP-Santé), 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.

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http://dx.doi.org/10.1074/mcp.M900124-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773724PMC
November 2009

Cancer stem cells and angiogenesis.

Authors:
Rolf Bjerkvig Mikael Johansson Hrvoje Miletic Simone P Niclou

Semin Cancer Biol 2009 Oct 7;19(5):279-84. Epub 2009 Oct 7.

NorLux Neuro-Oncology, Department of Biomedicine, University of Bergen, N-5009, Bergen, Norway.

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http://dx.doi.org/10.1016/j.semcancer.2009.09.001DOI Listing
October 2009

Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms.

Authors:
Hrvoje Miletic Simone P Niclou Mikael Johansson Rolf Bjerkvig

Expert Opin Ther Targets 2009 Apr;13(4):455-68

Department of Biomedicine, University of Bergen, NorLux Neuro-Oncology, Bergen, Norway.

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http://dx.doi.org/10.1517/14728220902806444DOI Listing
April 2009

Proteomics strategies for target identification and biomarker discovery in cancer.

Authors:
Uros Rajcevic Simone P Niclou Connie R Jimenez

Front Biosci (Landmark Ed) 2009 Jan 1;14:3292-303. Epub 2009 Jan 1.

Norlux Neuro-Oncology Laboratory, CRP-Sante, 84, Val Fleuri, L-1526 Luxembourg, Luxembourg. www.norlux.lu

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http://dx.doi.org/10.2741/3452DOI Listing
January 2009

A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions.

Authors:
Simone P Niclou Claude Danzeisen Hans P Eikesdal Helge Wiig Nicolaas H C Brons Aurélie M F Poli Agnete Svendsen Anja Torsvik Per Øyvind Enger Jorge A Terzis Rolf Bjerkvig

FASEB J 2008 Sep 21;22(9):3120-8. Epub 2008 May 21.

CRP-Santé, NorLux Neuro-Oncology Laboratory, 84, Val Fleuri, L-1526 Luxembourg.

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http://www.fasebj.org/doi/10.1096/fj.08-109611
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http://dx.doi.org/10.1096/fj.08-109611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518261PMC
September 2008

Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization.

Authors:
Ulrika Johansson Ida Rasmusson Simone P Niclou Naomi Forslund Linda Gustavsson Bo Nilsson Olle Korsgren Peetra U Magnusson

Diabetes 2008 Sep 2;57(9):2393-401. Epub 2008 Jun 2.

Division of Clinical Immunology, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-09
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http://dx.doi.org/10.2337/db07-0981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518490PMC
September 2008

The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease.

Authors:
Fred De Winter Tam Vo Floor J Stam Liselijn A B Wisman Peter R Bär Simone P Niclou Freek L van Muiswinkel Joost Verhaagen

Mol Cell Neurosci 2006 May-Jun;32(1-2):102-17. Epub 2006 May 3.

Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/j.mcn.2006.03.002DOI Listing
September 2006

Cell therapies for glioblastoma.

Authors:
A Jorge A Terzis Simone P Niclou Uros Rajcevic Claude Danzeisen Rolf Bjerkvig

Expert Opin Biol Ther 2006 Aug;6(8):739-49

National Department of Neurosurgery, Hospital Center Luxembourg, 4 Rue Barblé, L-1210, Luxembourg.

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http://dx.doi.org/10.1517/14712598.6.8.739DOI Listing
August 2006

Chemorepellent axon guidance molecules in spinal cord injury.

Authors:
Simone P Niclou Erich M E Ehlert Joost Verhaagen

J Neurotrauma 2006 Mar-Apr;23(3-4):409-21

Netherlands Institute for Brain Research, Laboratory for Neuroregeneration, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1089/neu.2006.23.409DOI Listing
June 2006

A novel role for Sema3A in neuroprotection from injury mediated by activated microglia.

Authors:
Henry H Majed Siddharthan Chandran Simone P Niclou Richard S Nicholas Alastair Wilkins Mark G Wing Kate E Rhodes Maria Grazia Spillantini Alastair Compston

J Neurosci 2006 Feb;26(6):1730-8

Department of Clinical Neurosciences, Centre for Brain Repair, University of Cambridge, Forvie Site, Cambridge CB2 2PY, United Kingdom.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0702-05.2
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http://dx.doi.org/10.1523/JNEUROSCI.0702-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793642PMC
February 2006

Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration.

Authors:
Ying Hu Simone G Leaver Giles W Plant William T J Hendriks Simone P Niclou Joost Verhaagen Alan R Harvey Qi Cui

Mol Ther 2005 Jun;11(6):906-15

School of Anatomy and Human Biology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Australia.

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http://dx.doi.org/10.1016/j.ymthe.2005.01.016DOI Listing
June 2005

Prothrombin overexpressed in post-natal neurones requires blood factors for activation in the mouse brain.

Authors:
Michael Sinnreich Marita Meins Simone P Niclou Hana S Suidan Denis Monard

J Neurochem 2004 Mar;88(6):1380-8

Friedrich-Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1046/j.1471-4159.2003.02268.xDOI Listing
March 2004

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors.

Authors:
Bushra Y Ahmed Sridhara Chakravarthy Ruben Eggers Wim T J M C Hermens Jing Ying Zhang Simone P Niclou Christiaan Levelt Fred Sablitzky Patrick N Anderson A R Lieberman Joost Verhaagen

BMC Neurosci 2004 Jan 30;5. Epub 2004 Jan 30.

Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/1471-2202-5-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC343275PMC
January 2004

Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth.

Authors:
Simone P Niclou Elske H P Franssen Erich M E Ehlert Masahiko Taniguchi Joost Verhaagen

Mol Cell Neurosci 2003 Dec;24(4):902-12

Graduate School of Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s1044-7431(03)00243-4DOI Listing
December 2003

The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways.

Authors:
Morven C Shearer Simone P Niclou David Brown Richard A Asher Anthony J G D Holtmaat Joel M Levine Joost Verhaagen James W Fawcett

Mol Cell Neurosci 2003 Dec;24(4):913-25

Department of Physiology and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 3EG, England, UK.

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December 2003