Simone Kreth

Simone Kreth

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Simone Kreth

Simone Kreth

Publications by authors named "Simone Kreth"

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The IL-1 Antagonist Anakinra Attenuates Glioblastoma Aggressiveness by Dampening Tumor-Associated Inflammation.

Cancers (Basel) 2020 Feb 13;12(2). Epub 2020 Feb 13.

Department of Anesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany.

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http://dx.doi.org/10.3390/cancers12020433DOI Listing
February 2020

Identification of suitable controls for miRNA quantification in T-cells and whole blood cells in sepsis.

Sci Rep 2019 Oct 31;9(1):15735. Epub 2019 Oct 31.

Department of Anaesthesiology and Intensive Care Medicine, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany.

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http://dx.doi.org/10.1038/s41598-019-51782-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823537PMC
October 2019

Myeloid-Derived Suppressor Cells Mediate Immunosuppression After Cardiopulmonary Bypass.

Crit Care Med 2019 Aug;47(8):e700-e709

Department of Anesthesiology, University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1097/CCM.0000000000003820DOI Listing
August 2019

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis.

EBioMedicine 2019 Apr 21;42:120-132. Epub 2019 Mar 21.

Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig-Maximilians-University, Marchioninistr 27, München 81377, Germany; Biomedical Center, Ludwig-Maximilians-University, Großhaderner Str. 9, Planegg 82152, Germany; Hospital Pharmacy, University Hospital, Ludwig-Maximilians-University, Marchioninistraße 15, München 81377, Germany; DZHK (German Center for Cardiovascular Research) partner site Munich Heart Alliance, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193017
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http://dx.doi.org/10.1016/j.ebiom.2019.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491420PMC
April 2019

Identification and Validation of Potential Differential miRNA Regulation via Alternative Polyadenylation.

Methods Mol Biol 2018 ;1733:87-92

Department of Anaesthesiology, Clinic of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7601-0_7DOI Listing
December 2018

Intronic miR-744 Inhibits Glioblastoma Migration by Functionally Antagonizing Its Host Gene MAP2K4.

Cancers (Basel) 2018 Oct 25;10(11). Epub 2018 Oct 25.

Department of Anesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany.

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http://dx.doi.org/10.3390/cancers10110400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266622PMC
October 2018

MiRNAs: dynamic regulators of immune cell functions in inflammation and cancer.

Cancer Lett 2018 09 22;431:11-21. Epub 2018 May 22.

Department of Anesthesiology, University Hospital, LMU Munich, Germany; Walter-Brendel-Center of Experimental Medicine, LMU Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.05.020DOI Listing
September 2018

MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine.

Anesth Analg 2018 02;126(2):670-681

From the Department of Anesthesiology.

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http://dx.doi.org/10.1213/ANE.0000000000002444DOI Listing
February 2018

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.

Nat Commun 2018 02 26;9(1):816. Epub 2018 Feb 26.

Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.

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http://www.nature.com/articles/s41467-018-03105-2
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http://dx.doi.org/10.1038/s41467-018-03105-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827027PMC
February 2018

Intronic miRNA-641 controls its host Gene's pathway PI3K/AKT and this relationship is dysfunctional in glioblastoma multiforme.

Biochem Biophys Res Commun 2017 08 30;489(4):477-483. Epub 2017 May 30.

Department of Anesthesiology, University Hospital of the Ludwig-Maximilians-University Munich, Marchioninistraße 15, D-81377 Munich, Germany; Walter-Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Marchioninistraße 15, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.05.175DOI Listing
August 2017

Outcome in unresectable glioblastoma: MGMT promoter methylation makes the difference.

J Neurol 2017 Feb 5;264(2):350-358. Epub 2016 Dec 5.

Department of Neurosurgery, University of Munich LMU, Campus Grosshadern, Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00415-016-8355-1DOI Listing
February 2017

miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain.

J Neuroinflammation 2016 09 20;13(1):248. Epub 2016 Sep 20.

Department of Anesthesiology, Ludwig-Maximilians University Munich, Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-016-0712-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029065PMC
September 2016

Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain.

J Neuroinflammation 2016 May 4;13(1):100. Epub 2016 May 4.

Department of Anesthesiology and Pain Medicine, LMU-Munich, Marchioninistrasse 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-016-0565-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857287PMC
May 2016

Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing.

Anesthesiology 2016 Apr;124(4):908-22

From the Department of Anesthesiology, University of Munich Ludwig Maximilian University, Munich, Germany.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/ALN.0000000000001031DOI Listing
April 2016

Disrupted TH17/Treg balance in patients with chronic low back pain.

PLoS One 2014 14;9(8):e104883. Epub 2014 Aug 14.

Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133258PMC
March 2016

Emerging Roles for MicroRNAs in Perioperative Medicine.

Anesthesiology 2016 Feb;124(2):489-506

From the Department of Anesthesiology, Clinic of the University of Munich, Munich, Germany (V.N., S.K.); and Organ Protection Program, Department of Anesthesiology (V.N., K.S.B., A.A.G., H.K.E.) and Department of Emergency Medicine (A.A.G.), University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1097/ALN.0000000000000969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820395PMC
February 2016

miRIAD-integrating microRNA inter- and intragenic data.

Database (Oxford) 2014 6;2014. Epub 2014 Oct 6.

Centro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, SP 01308-060, Brazil

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http://dx.doi.org/10.1093/database/bau099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186326PMC
February 2015

MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCε.

Eur J Immunol 2015 Jan 27;45(1):260-72. Epub 2014 Nov 27.

Research Group Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Munich, Germany.

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http://dx.doi.org/10.1002/eji.201444667DOI Listing
January 2015

Anti-inflammatory T-cell shift in neuropathic pain.

J Neuroinflammation 2015 Jan 21;12:12. Epub 2015 Jan 21.

Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich, Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-014-0225-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308022PMC
January 2015

MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure.

Biochem Biophys Res Commun 2014 Sep 9;451(4):516-21. Epub 2014 Aug 9.

Research Group Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140141
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http://dx.doi.org/10.1016/j.bbrc.2014.08.008DOI Listing
September 2014

MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure.

J Heart Lung Transplant 2014 Mar 12;33(3):252-60. Epub 2013 Oct 12.

Department of Cardiac Surgery, Goethe University Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.healun.2013.10.014DOI Listing
March 2014

Epigenetics in human gliomas.

Cancer Lett 2014 Jan 21;342(2):185-92. Epub 2012 Apr 21.

Research Group of Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030438351200256
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http://dx.doi.org/10.1016/j.canlet.2012.04.008DOI Listing
January 2014

Personalized treatment strategies in glioblastoma: MGMT promoter methylation status.

Onco Targets Ther 2013 Sep 27;6:1363-72. Epub 2013 Sep 27.

Department of Neurosurgery, Hospital of the University of Munich, Campus Grosshadern, Munich, Germany.

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http://www.dovepress.com/personalized-treatment-strategies-i
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http://dx.doi.org/10.2147/OTT.S50208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792931PMC
September 2013

Setting up an intronic miRNA database.

Methods Mol Biol 2013 ;936:69-76

Department of Anaesthesiology, Clinic of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-62703-083-0_5DOI Listing
June 2013

Experimental miRNA target validation.

Methods Mol Biol 2013 ;936:83-90

Clinic of Anesthesiology, Clinic of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-62703-083-0_7DOI Listing
June 2013

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.

Acta Neuropathol 2013 May 23;125(5):671-81. Epub 2013 Jan 23.

Research Group Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Marchioninistrasse 15, 81337, Munich, Germany.

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http://link.springer.com/10.1007/s00401-013-1081-1
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http://dx.doi.org/10.1007/s00401-013-1081-1DOI Listing
May 2013

MicroRNAs as potential therapeutic agents in the treatment of myocardial infarction.

Curr Vasc Pharmacol 2011 Nov;9(6):733-40

Department of Anaesthesiology, Ludwig-Maximilians Universität München, Marchioninistrasse 15, D-81377 Munich, Germany.

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http://dx.doi.org/10.2174/157016111797484143DOI Listing
November 2011

Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils.

BMC Res Notes 2011 Oct 20;4:427. Epub 2011 Oct 20.

Department of Anesthesiology, Ludwig-Maximilians-University Munich, Germany.

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http://dx.doi.org/10.1186/1756-0500-4-427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229292PMC
October 2011

Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide.

J Neurol Neurosurg Psychiatry 2011 Apr 22;82(4):441-6. Epub 2010 Sep 22.

Department of Neurosurgery, University Hospital Großhadern, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://jnnp.bmj.com/content/82/4/441.full.pdf
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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.2010.214593
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http://dx.doi.org/10.1136/jnnp.2010.214593DOI Listing
April 2011

Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function.

Recent Pat Endocr Metab Immune Drug Discov 2011 Jan;5(1):1-6

Department of Anesthesiology, Ludwig-Maximilian-University of Munich, Germany.

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http://dx.doi.org/10.2174/187221411794351897DOI Listing
January 2011

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure.

Peptides 2010 Dec 8;31(12):2222-8. Epub 2010 Sep 8.

Department of Cardiac Surgery, Ludwig-Maximilian-University of Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01969781100035
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http://dx.doi.org/10.1016/j.peptides.2010.08.019DOI Listing
December 2010

Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways.

Shock 2010 Jul;34(1):10-6

Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1097/SHK.0b013e3181cdc3e2DOI Listing
July 2010

Identification of valid endogenous control genes for determining gene expression in human glioma.

Neuro Oncol 2010 Jun 5;12(6):570-9. Epub 2010 Feb 5.

Department of Neurosurgery, Ludwig Maximilians University Munich, Marchioninistr. 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1093/neuonc/nop072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940642PMC
June 2010

Huge intracardiac thrombosis in a patient on veno-arterial extracorporeal membrane oxygenation support.

Interact Cardiovasc Thorac Surg 2009 Feb 13;8(2):247-9. Epub 2008 Nov 13.

Department of Anesthesiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1510/icvts.2008.193391DOI Listing
February 2009

Differential expression of 5'-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation.

FASEB J 2008 Sep 9;22(9):3276-86. Epub 2008 Jun 9.

Department of Anaesthesiology, Ludwig Maximilians University of Munich, Germany.

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http://dx.doi.org/10.1096/fj.07-101097DOI Listing
September 2008

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.

PLoS One 2007 Sep 5;2(9):e853. Epub 2007 Sep 5.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000853PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959117PMC
September 2007