Publications by authors named "Simone Hettmer"

47Publications

Case Report: Hepatic Adenoma in a Child With a Congenital Extrahepatic Portosystemic Shunt.

Front Pediatr 2020 25;8:501. Epub 2020 Aug 25.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.

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http://dx.doi.org/10.3389/fped.2020.00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477041PMC
August 2020

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells.

PLoS One 2020 8;15(9):e0238572. Epub 2020 Sep 8.

Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478754PMC
September 2020

Patterns of Prior and Subsequent Neoplasms in Children and Adolescents With Soft Tissue Sarcomas.

J Pediatr Hematol Oncol 2020 Jul;42(5):e265-e270

Department of Pediatric and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, University of Freiburg.

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http://dx.doi.org/10.1097/MPH.0000000000001837DOI Listing
July 2020

Dermatofibrosarcoma protuberans in children and adolescents: Primary and Relapsed disease-Experience of the Cooperative Weichteilsarkomstudiengruppe (CWS).

J Surg Oncol 2020 Aug 19;122(2):263-272. Epub 2020 May 19.

Klinikum Stuttgart-Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany.

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http://dx.doi.org/10.1002/jso.25943DOI Listing
August 2020

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Myxoid liposarcoma: it's a hippo's world.

EMBO Mol Med 2019 05;11(5)

Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.15252/emmm.201910470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505570PMC
May 2019

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.

Sci Rep 2018 10 23;8(1):15674. Epub 2018 Oct 23.

University of Aberdeen, School of Medicine, Medical Sciences and Nutrition, Foresterhill, Aberdeen, AB25 2ZD, Scotland.

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http://dx.doi.org/10.1038/s41598-018-33852-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199242PMC
October 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Second malignancy risk among pediatric, adolescent, and young adult survivors of fusion-positive and fusion-negative sarcomas: Results from the SEER database, 1992 through 2012.

Cancer 2016 Nov 2;122(22):3492-3500. Epub 2016 Aug 2.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/cncr.30222DOI Listing
November 2016

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity.

Exp Cell Res 2016 Jan 13;340(1):43-52. Epub 2015 Oct 13.

Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.yexcr.2015.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718790PMC
January 2016

An Increased Risk of Second Malignant Neoplasms After Rhabdomyosarcoma: Population-Based Evidence for a Cancer Predisposition Syndrome?

Pediatr Blood Cancer 2016 Feb 20;63(2):196-201. Epub 2015 Jul 20.

Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.25678DOI Listing
February 2016

Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.

Front Oncol 2015 24;5:50. Epub 2015 Feb 24.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.

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http://dx.doi.org/10.3389/fonc.2015.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338657PMC
March 2015

The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

Cancer Cell 2014 Aug 31;26(2):273-87. Epub 2014 Jul 31.

Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.05.029DOI Listing
August 2014

Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.

Cell Rep 2014 Jul 4;8(1):256-71. Epub 2014 Jul 4.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096327PMC
July 2014

Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle.

Stem Cell Reports 2014 Jan 14;2(1):92-106. Epub 2014 Jan 14.

Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA 02138, USA ; Joslin Diabetes Center and the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966115PMC
January 2014

Myogenic tumors in nevoid Basal cell carcinoma syndrome.

J Pediatr Hematol Oncol 2015 Mar;37(2):147-9

*Department of Pediatric Oncology, Dana-Farber Cancer Institute †Division of Pediatric Hematology/Oncology, Boston Children's Hospital ¶Department of Pathology, Boston Children's Hospital ‡Howard Hughes Medical Institute §Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University ∥Joslin Diabetes Center #Department of Pathology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1097/MPH.0000000000000115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127382PMC
March 2015

Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma.

PLoS Genet 2014 Jan 16;10(1):e1004107. Epub 2014 Jan 16.

Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894165PMC
January 2014

Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.

Cancer 2014 Apr 30;120(7):1068-75. Epub 2013 Dec 30.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Pediatric Hematology/ Oncology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, Massachusetts; Joslin Diabetes Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173134PMC
April 2014

Mutations in Hedgehog pathway genes in fetal rhabdomyomas.

J Pathol 2013 Sep;231(1):44-52

Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/path.4229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875333PMC
September 2013

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

Development 2013 Jun 24;140(11):2354-64. Epub 2013 Apr 24.

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.088427
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http://dx.doi.org/10.1242/dev.088427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653557PMC
June 2013

Induction of histiocytic sarcoma in mouse skeletal muscle.

PLoS One 2012 31;7(8):e44044. Epub 2012 Aug 31.

Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, and Joslin Diabetes Center, Cambridge, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044044PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432091PMC
February 2013

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.

Proc Natl Acad Sci U S A 2011 Dec 30;108(50):20002-7. Epub 2011 Nov 30.

The Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1111733108
Publisher Site
http://dx.doi.org/10.1073/pnas.1111733108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250188PMC
December 2011

Efficient generation of iPS cells from skeletal muscle stem cells.

PLoS One 2011 18;6(10):e26406. Epub 2011 Oct 18.

Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts, United Stated of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196574PMC
February 2012

Synovial sarcoma in children: imaging features and common benign mimics.

AJR Am J Roentgenol 2010 Oct;195(4):1026-32

Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2214/AJR.10.4348DOI Listing
October 2010

Muscling in: Uncovering the origins of rhabdomyosarcoma.

Nat Med 2010 Feb;16(2):171-3

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University and Joslin Diabetes Center, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm0210-171DOI Listing
February 2010

Cefepime-induced neutropenia in a teenager.

Pediatr Blood Cancer 2008 Nov;51(5):715-6

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http://dx.doi.org/10.1002/pbc.21664DOI Listing
November 2008

Low complex ganglioside expression characterizes human neuroblastoma cell lines.

Cancer Lett 2005 Jul 7;225(1):141-9. Epub 2005 Jan 7.

Glycobiology Program, Center for Cancer and Immunology Research, Children's National Medical Center, Children's Research Institute, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington DC 20010, USA.

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http://dx.doi.org/10.1016/j.canlet.2004.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866625PMC
July 2005

Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells.

Hum Immunol 2005 Feb;66(2):95-103

Department of Pediatric Hematology/Oncology and Section of Endocrinology, University Children's Hospital, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.humimm.2004.10.014DOI Listing
February 2005

Biological stratification of human neuroblastoma by complex "B" pathway ganglioside expression.

Cancer Res 2003 Nov;63(21):7270-6

Glycobiology Program, Center for Cancer Research, Children's Research Institute, 111 Michigan Avenue NW, Washington DC 20010, USA.

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November 2003

Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.

Cancer Res 2003 Jul;63(13):3654-8

Center for Cancer Research, Children's Research Institute, and Department of Pediatrics, George Washington University School of Medicine, Washington, DC 20010, USA.

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July 2003