Dr Simone Brogi, PhD, MSc - University of Siena - research fellow

Dr Simone Brogi

PhD, MSc

University of Siena

research fellow

Italy

ORCID logohttps://orcid.org/0000-0001-9375-6242

Dr Simone Brogi, PhD, MSc - University of Siena - research fellow

Dr Simone Brogi

PhD, MSc

Introduction

Primary Affiliation: University of Siena - Italy


View Dr Simone Brogi’s Resume / CV

Education

Jan 2007 - Jan 2010
Università degli Studi di Siena
PhD in pharmaceutical sciences
pharmaceutical and applied chemistry
Jan 2007 - Jan 2007
Università degli Studi di Siena
MSc in Drug Design and Synthesis
pharmaceutical and applied chemistry
Jan 2005
Università degli Studi di Siena
Dr in Biological Sciences

Experience

Jan 2011
Università degli Studi di Siena
Research Fellow
Biotechnology, Chemistry and Pharmacy

Publications

46Publications

428Reads

300Profile Views

141PubMed Central Citations

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Eur J Med Chem 2019 Jan 3;162:290-320. Epub 2018 Nov 3.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, via Aldo Moro 2, I-53100, Siena, Italy; Istituto Toscano Tumori, University of Siena, via Aldo Moro 2, I-53100, Siena, Italy; Department of Pharmacy, University of Napoli Federico II, DoE Department of Excellence 2018-2022, Via D. Montesano 49, 80131, Napoli, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183095
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http://dx.doi.org/10.1016/j.ejmech.2018.11.004DOI Listing
January 2019
16 Reads
3.450 Impact Factor

Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.

ChemMedChem 2018 Oct 30;13(19):2090-2103. Epub 2018 Aug 30.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy (DoE 2018-2020), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.201800397DOI Listing
October 2018
2.970 Impact Factor

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.

Eur J Med Chem 2018 Sep 31;157:127-138. Epub 2018 Jul 31.

European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.07.069DOI Listing
September 2018
18 Reads
3.450 Impact Factor

Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase.

Chem Biol Drug Des 2018 Sep 14. Epub 2018 Sep 14.

Universidade Anhembi Morumbi, São Paulo, Brazil.

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http://dx.doi.org/10.1111/cbdd.13391DOI Listing
September 2018
2.485 Impact Factor

Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues.

Eur J Med Chem 2018 Apr 10;150:698-718. Epub 2018 Mar 10.

Department of Biotechnology, Chemistry and Pharmacy, Dipartimento di Eccellenza 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902032PMC
April 2018
6 Reads
3.450 Impact Factor

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages.

ChemMedChem 2018 03 14;13(5):422-430. Epub 2018 Feb 14.

European Research Centre for Drug Discovery and Development - NatSynDrugs - and Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, via Aldo Moro 1, 53100, Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.201700759DOI Listing
March 2018
11 Reads
1 Citation
2.970 Impact Factor

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.

Prog Neurobiol 2017 04 18;151:4-34. Epub 2016 Jan 18.

Laboratory of Medicinal Chemistry (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2015.12.003DOI Listing
April 2017
56 Reads
6 Citations
9.992 Impact Factor

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.

J Enzyme Inhib Med Chem 2016 28;31(sup1):98-109. Epub 2016 Apr 28.

a European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena , Siena , Italy.

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http://dx.doi.org/10.3109/14756366.2016.1172575DOI Listing
February 2017
16 Reads
1 Citation
2.383 Impact Factor

Identification of novel fluorescent probes preventing PrP replication in prion diseases.

Eur J Med Chem 2017 Feb 1;127:859-873. Epub 2016 Nov 1.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2016.10.064DOI Listing
February 2017
2 Reads
3 Citations
3.450 Impact Factor

Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents.

Eur J Med Chem 2017 Jan 27;126:614-630. Epub 2016 Nov 27.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Via A. Moro, 53100 Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.11.053DOI Listing
January 2017
8 Reads
2 Citations
3.450 Impact Factor

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.

Eur J Med Chem 2016 Oct 9;121:864-879. Epub 2015 Oct 9.

Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.10.001DOI Listing
October 2016
2 Reads
7 Citations
3.450 Impact Factor

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.

Front Neurosci 2016 5;10:451. Epub 2016 Oct 5.

European Research Centre for Drug Discovery and Development and Department of Biotechnology, Chemistry and Pharmacy, University of Siena Siena, Italy.

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http://dx.doi.org/10.3389/fnins.2016.00451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050208PMC
October 2016
3 Reads
6 Citations

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.

Future Med Chem 2016 09 24;8(13):1573-87. Epub 2016 Aug 24.

European Research Centre for Drug Discovery & Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.4155/fmc-2016-0068DOI Listing
September 2016
14 Reads
1 Citation
4.000 Impact Factor

Development of novel cyclic peptides as pro-apoptotic agents.

Eur J Med Chem 2016 Jul 5;117:301-20. Epub 2016 Apr 5.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Siena University, via Aldo Moro 2, I-53100 Siena, Italy; Istituto Toscano Tumori, Siena University, via Aldo Moro 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2016.04.001DOI Listing
July 2016
16 Reads
2 Citations
3.450 Impact Factor

Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.

J Nat Prod 2016 05 20;79(5):1459-63. Epub 2016 Apr 20.

Department of Veterinary Medicine, Universidade de São Paulo , Avenida Duque de Caxias Norte, 225, 13635-900 Pirassununga, SP, Brazil.

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http://dx.doi.org/10.1021/acs.jnatprod.5b00875DOI Listing
May 2016
1 Read
1 Citation
3.800 Impact Factor

Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.

PLoS One 2015 1;10(4):e0121027. Epub 2015 Apr 1.

Biotechnology and Cell Signaling Laboratory (UMR 7242), CNRS-University of Strasbourg, Illkirch, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121027PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382091PMC
April 2016
6 Reads
5 Citations
3.234 Impact Factor

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors.

J Mol Graph Model 2016 Mar 19;64:121-130. Epub 2016 Jan 19.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.jmgm.2016.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276822PMC
March 2016
2 Citations
1.722 Impact Factor

Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents.

Bioorg Med Chem Lett 2015 Nov 5;25(22):5412-8. Epub 2015 Sep 5.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, via Aldo Moro 2, 53100 Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2015.09.007DOI Listing
November 2015
3 Reads
2 Citations
2.420 Impact Factor

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Sci Rep 2015 May 7;5:9705. Epub 2015 May 7.

1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena [2] Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1038/srep09705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423475PMC
May 2015
8 Reads
2 Citations
5.080 Impact Factor

HCV-targeted antivirals: current status and future challenges.

Curr Pharm Des 2014 ;20(21):3445-64

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università di Siena, via Aldo Moro 2, 53100, Siena (Italy).

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March 2015
1 Read
4 Citations
3.452 Impact Factor

Discovery of GPCR ligands for probing signal transduction pathways.

Front Pharmacol 2014 28;5:255. Epub 2014 Nov 28.

Receptor Signaling and Therapeutic Innovations, GPCR and Cardiovascular and Metabolic Regulations, Biotechnology and Cell Signaling Laboratory, UMR 7242, CNRS/University of Strasbourg - LabEx Medalis Illkirch, France.

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http://dx.doi.org/10.3389/fphar.2014.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246677PMC
December 2014
4 Reads
11 Citations

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.

J Med Chem 2014 Nov 7;57(22):9578-97. Epub 2014 Nov 7.

European Research Centre for Drug Discovery and Development, and ‡Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm501119jDOI Listing
November 2014
21 Reads
8 Citations
5.450 Impact Factor

A stereoselective approach to peptidomimetic BACE1 inhibitors.

Eur J Med Chem 2013 6;70:233-47. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.09.056DOI Listing
September 2014
7 Reads
3 Citations
3.450 Impact Factor

Rational design of the first difluorostatone-based PfSUB1 inhibitors.

Bioorg Med Chem Lett 2014 Aug 23;24(15):3582-6. Epub 2014 May 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2014.05.044DOI Listing
August 2014
5 Citations
2.420 Impact Factor

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

CNS Neurosci Ther 2014 Jul;20(7):624-32

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/cns.12290DOI Listing
July 2014
2 Reads
4 Citations
3.931 Impact Factor

The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.

Curr Top Med Chem 2013 ;13(15):1787-807

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034716PMC
March 2014
1 Read
4 Citations
3.402 Impact Factor

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.

ACS Med Chem Lett 2013 Dec 6;4(12):1178-82. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy ; European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/ml4002908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027481PMC
December 2013
17 Reads
3 Citations
3.120 Impact Factor

3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors.

Eur J Med Chem 2013 Sep 1;67:344-51. Epub 2013 Jul 1.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, I-53100 Siena, Italy; European Research Centre for Drug Discovery and Development (NatSynDrugs), I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.06.048DOI Listing
September 2013
4 Citations
3.450 Impact Factor

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Eur J Med Chem 2013 May 8;63:85-94. Epub 2013 Feb 8.

Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.01.044DOI Listing
May 2013
5 Reads
6 Citations
3.450 Impact Factor

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Bioorg Med Chem Lett 2012 Aug 23;22(16):5317-21. Epub 2012 Jun 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.023DOI Listing
August 2012
7 Reads
6 Citations
2.420 Impact Factor

Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA(B) receptor.

J Pharmacol Exp Ther 2012 Mar 30;340(3):529-38. Epub 2011 Nov 30.

Department of Neuroscience Bernard B. Brodie, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1124/jpet.111.186460DOI Listing
March 2012
11 Reads
9 Citations
3.972 Impact Factor

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.

J Med Chem 2011 Aug 29;54(16):5949-53. Epub 2011 Jul 29.

European Research Centre for Drug Discovery and Development (NatSynDrugs), 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm200686dDOI Listing
August 2011
8 Reads
5.450 Impact Factor

Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Eur J Med Chem 2011 Feb 27;46(2):547-55. Epub 2010 Nov 27.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2010.11.034DOI Listing
February 2011
14 Reads
6 Citations
3.450 Impact Factor

Pharmacophore modeling for qualitative prediction of antiestrogenic activity.

J Chem Inf Model 2009 Nov;49(11):2489-97

Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.

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http://dx.doi.org/10.1021/ci900254bDOI Listing
November 2009
1 Read
3 Citations
3.740 Impact Factor

Tetrahydrofuran acetogenins from Laurencia glandulifera.

J Nat Prod 2009 Feb;72(2):190-3

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.

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http://dx.doi.org/10.1021/np800481wDOI Listing
February 2009
1 Read
1 Citation
3.800 Impact Factor

Top co-authors

Giuseppe Campiani
Giuseppe Campiani

Trinity College

33
Stefania Butini
Stefania Butini

University of Siena

32
Sandra Gemma
Sandra Gemma

University of Siena

31
Margherita Brindisi
Margherita Brindisi

University of Siena

28
Ettore Novellino
Ettore Novellino

University of Naples Federico II

20
Stefania Lamponi
Stefania Lamponi

University of Siena

10
Samuele Maramai
Samuele Maramai

University of Siena

9
Andrea Tafi
Andrea Tafi

Università di Siena

8
Andrea Cappelli
Andrea Cappelli

Università degli Studi di Siena

6
Giulia Chemi
Giulia Chemi

Università degli Studi di Siena

6