Simona Polo

Simona Polo

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Simona Polo

Simona Polo

Publications by authors named "Simona Polo"

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Detection of ubiquitinated targets in mammalian and Drosophila models.

Methods Enzymol 2019 11;619:293-318. Epub 2019 Feb 11.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy; Dipartimento di oncologia ed emato-oncologia, Universita' degli Studi di Milano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.12.030DOI Listing
February 2020

Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading.

mBio 2020 01 21;11(1). Epub 2020 Jan 21.

Department of Biological Sciences, Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia, Canada

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http://dx.doi.org/10.1128/mBio.02857-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974566PMC
January 2020

When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.

Semin Cell Dev Biol 2019 09 20;93:136-144. Epub 2018 Dec 20.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan 20139, Italy; Dipartimento di oncologia ed emato-oncologia, Universita' degli Studi di Milano, Via Santa Sofia 9/1, Milan 20122, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2018.12.005DOI Listing
September 2019

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Cell Rep 2019 07;28(1):11-20.e9

Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.005DOI Listing
July 2019

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Cell Rep 2019 06;27(10):3049-3061.e6

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy; Istituto Europeo di Oncologia IRCCS, Via Ripamonti 435, 20141 Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-oncologia, Via Santa Sofia 9/1, 20122 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581797PMC
June 2019

HECT E3 Ligases: A Tale With Multiple Facets.

Front Physiol 2019 3;10:370. Epub 2019 Apr 3.

Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.

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http://dx.doi.org/10.3389/fphys.2019.00370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457168PMC
April 2019

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

J Cell Biol 2018 09 29;217(9):3219-3235. Epub 2018 Jun 29.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

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http://dx.doi.org/10.1083/jcb.201710161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123000PMC
September 2018

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

J Mol Biol 2018 09 28;430(18 Pt B):3218-3233. Epub 2018 Jun 28.

Max Planck Institute for Developmental Biology, Max-Planck-Ring 5, 72076 Tübingen, Germany; Institute of Biophysics and Physical Biochemistry, University of Regensburg, Universitätsstr. 31, 93040 Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.06.044DOI Listing
September 2018

Strategies to Detect Endogenous Ubiquitination of a Target Mammalian Protein.

Methods Mol Biol 2016 ;1449:143-51

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan, 20139, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3756-1_6DOI Listing
January 2018

In Vitro Ubiquitination: Self-Ubiquitination, Chain Formation, and Substrate Ubiquitination Assays.

Methods Mol Biol 2016 ;1449:153-60

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan, 20139, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3756-1_7DOI Listing
January 2018

Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.

FEBS Lett 2017 09 20;591(17):2636-2647. Epub 2017 Aug 20.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.

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http://dx.doi.org/10.1002/1873-3468.12775DOI Listing
September 2017

Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.

Cell Rep 2016 Mar 10;14(11):2683-94. Epub 2016 Mar 10.

Protein Processing Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805485PMC
March 2016

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Curr Biol 2016 Jan 31;26(2):173-183. Epub 2015 Dec 31.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy; DIPO, Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di Milano, Via di Rudinì 8, 20122 Milan, Italy. Electronic address:

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http://www.cell.com/current-biology/pdf/S0960-9822(15)01489-
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http://linkinghub.elsevier.com/retrieve/pii/S096098221501489
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http://dx.doi.org/10.1016/j.cub.2015.11.050DOI Listing
January 2016

Keeping EGFR signaling in check: ubiquitin is the guardian.

Cell Cycle 2014 21;13(5):681-2. Epub 2014 Jan 21.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare; Milan, Italy.

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http://dx.doi.org/10.4161/cc.27855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979896PMC
May 2015

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Structure 2014 Nov 30;22(11):1639-49. Epub 2014 Oct 30.

Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.09.006DOI Listing
November 2014

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Sci Signal 2014 Oct 7;7(346):ra95. Epub 2014 Oct 7.

Cell Biology Program, The Hospital for Sick Children, and Biochemistry Department, University of Toronto, 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1126/scisignal.2005290DOI Listing
October 2014

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.

J Lipid Res 2013 Aug 3;54(8):2174-84. Epub 2013 Jun 3.

Department of Medical Biochemistry, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M037713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708367PMC
August 2013

Ubiquitination dynamics in the early-branching eukaryote Giardia intestinalis.

Microbiologyopen 2013 Jun 23;2(3):525-39. Epub 2013 Apr 23.

Laboratorio de Investigaciones Básicas en Bioquímica - LIBBIQ, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.

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http://doi.wiley.com/10.1002/mbo3.88
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http://dx.doi.org/10.1002/mbo3.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684764PMC
June 2013

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

Nat Struct Mol Biol 2013 Jun 5;20(6):696-701. Epub 2013 May 5.

Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.

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http://dx.doi.org/10.1038/nsmb.2566DOI Listing
June 2013

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase.

Cell Cycle 2012 Jul 1;11(13):2538-44. Epub 2012 Jul 1.

Department of Pharmaceutical Sciences, University of Piemonte Orientale "A. Avogadro", Novara, Italy.

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http://dx.doi.org/10.4161/cc.20919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404880PMC
July 2012

Signaling-mediated control of ubiquitin ligases in endocytosis.

Authors:
Simona Polo

BMC Biol 2012 Mar 15;10:25. Epub 2012 Mar 15.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1186/1741-7007-10-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305638PMC
March 2012

USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

Nat Cell Biol 2011 Sep 25;13(11):1368-75. Epub 2011 Sep 25.

Department of Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale G. Colombo 3, 35100 Padua, Italy.

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http://dx.doi.org/10.1038/ncb2346DOI Listing
September 2011

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation.

EMBO Rep 2011 Apr 11;12(4):342-9. Epub 2011 Mar 11.

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Istituto Europeo di Oncologia, Via Adamello 16, Milan 20139, Italy.

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http://dx.doi.org/10.1038/embor.2011.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077247PMC
April 2011

Ubiquitin in trafficking: the network at work.

Exp Cell Res 2009 May 28;315(9):1610-8. Epub 2008 Oct 28.

IFOM Foundation, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.yexcr.2008.10.014DOI Listing
May 2009

Finding the right partner: science or ART?

Cell 2008 Nov;135(4):590-2

IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy.

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http://dx.doi.org/10.1016/j.cell.2008.10.032DOI Listing
November 2008

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

Dev Cell 2008 Aug;15(2):209-19

IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.devcel.2008.06.012DOI Listing
August 2008

The ubiquitination code: a signalling problem.

Cell Div 2007 Mar 13;2:11. Epub 2007 Mar 13.

IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1186/1747-1028-2-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832185PMC
March 2007

Molecular mechanisms of coupled monoubiquitination.

Nat Cell Biol 2006 Nov 1;8(11):1246-54. Epub 2006 Oct 1.

IFOM, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.

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http://dx.doi.org/10.1038/ncb1484DOI Listing
November 2006

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.

Cell 2006 Mar 23;124(6):1183-95. Epub 2006 Feb 23.

IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1016/j.cell.2006.02.020DOI Listing
March 2006

Endocytosis conducts the cell signaling orchestra.

Cell 2006 Mar;124(5):897-900

IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134 Milan, Italy.

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http://dx.doi.org/10.1016/j.cell.2006.02.025DOI Listing
March 2006

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

Proc Natl Acad Sci U S A 2005 Sep 23;102(36):12700-5. Epub 2005 Aug 23.

Howard Hughes Medical Institute and Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.0506344102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188261PMC
September 2005

N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits.

J Cell Sci 2005 Jul 28;118(Pt 14):3103-15. Epub 2005 Jun 28.

Cytoskeleton Dynamics Group, German Research Centre for Biotechnology (GBF), Mascheroder Weg 1, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1242/jcs.02444DOI Listing
July 2005

Clathrin-independent endocytosis of ubiquitinated cargos.

Proc Natl Acad Sci U S A 2005 Feb 8;102(8):2760-5. Epub 2005 Feb 8.

Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.0409817102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549482PMC
February 2005

Endocytosis and cancer.

Curr Opin Cell Biol 2004 Apr;16(2):156-61

IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740400012
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http://dx.doi.org/10.1016/j.ceb.2004.02.003DOI Listing
April 2004

Rapid Ca2+-dependent decrease of protein ubiquitination at synapses.

Proc Natl Acad Sci U S A 2003 Dec 1;100(25):14908-13. Epub 2003 Dec 1.

Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.2136625100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299851PMC
December 2003

EH and UIM: endocytosis and more.

Sci STKE 2003 Dec 16;2003(213):re17. Epub 2003 Dec 16.

Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy.

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http://dx.doi.org/10.1126/stke.2132003re17DOI Listing
December 2003

When ubiquitin meets ubiquitin receptors: a signalling connection.

Nat Rev Mol Cell Biol 2003 Jun;4(6):491-7

Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy.

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http://dx.doi.org/10.1038/nrm1124DOI Listing
June 2003

Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity.

J Biol Chem 2003 May 3;278(22):19682-90. Epub 2003 Mar 3.

Laboratory of Leukocyte Biology, DIBIT and Universita' Vita-Salute San Raffaele, via Olgettina 58, 20132, Milan, Italy.

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http://dx.doi.org/10.1074/jbc.M212681200DOI Listing
May 2003

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation.

Nat Cell Biol 2003 May;5(5):461-6

Ludwig Institute for Cancer Research, Husargatan 3, SE-75 124 Uppsala, Sweden.

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http://dx.doi.org/10.1038/ncb983DOI Listing
May 2003

Differential nucleocytoplasmic trafficking between the related endocytic proteins Eps15 and Eps15R.

J Biol Chem 2002 Mar 2;277(11):8941-8. Epub 2002 Jan 2.

INSERM E9925, Faculté Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M108385200
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http://dx.doi.org/10.1074/jbc.M108385200DOI Listing
March 2002

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins.

Nature 2002 Mar;416(6879):451-5

Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy.

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http://dx.doi.org/10.1038/416451aDOI Listing
March 2002