Simona Daniele

Simona Daniele

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Simona Daniele

Simona Daniele

Publications by authors named "Simona Daniele"

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Synthesis of New GABA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold.

Int J Mol Sci 2019 Mar 21;20(6). Epub 2019 Mar 21.

Dipartimento Neurofarba, sezione Farmaceutica e Nutraceutica, Università di Firenze, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Firenze, Italy.

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http://dx.doi.org/10.3390/ijms20061438DOI Listing
March 2019

Brain ageing and neurodegenerative disease: The role of cellular waste management.

Biochem Pharmacol 2018 Dec 28;158:207-216. Epub 2018 Oct 28.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.10.030DOI Listing
December 2018

An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds.

Biomed Pharmacother 2018 May 22;101:805-819. Epub 2018 Mar 22.

Department of Clinical and Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.1016/j.biopha.2018.03.006DOI Listing
May 2018

A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABA) receptor subtype ligand: synthesis and pharmacological evaluation.

Bioorg Med Chem 2018 05 4;26(9):2475-2487. Epub 2018 Apr 4.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmc.2018.04.011DOI Listing
May 2018

Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity.

J Med Chem 2017 12 22;60(23):9691-9702. Epub 2017 Nov 22.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze , Via Ugo Schiff 6, Sesto Fiorentino, Firenze 50019, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01151DOI Listing
December 2017

Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases.

Biochem Pharmacol 2017 05 31;131:1-15. Epub 2017 Jan 31.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952173004
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http://dx.doi.org/10.1016/j.bcp.2017.01.017DOI Listing
May 2017

Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABA-R ligands.

Bioorg Med Chem 2017 03 11;25(6):1901-1906. Epub 2017 Feb 11.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università di Firenze, Via Ugo Schiff, 6 - 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmc.2017.02.013DOI Listing
March 2017

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.

Eur J Med Chem 2016 Aug 20;118:47-63. Epub 2016 Apr 20.

Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.003DOI Listing
August 2016

Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.

ACS Chem Neurosci 2016 07 31;7(7):952-63. Epub 2016 May 31.

Department of Pharmacy, University of Pisa , Pisa 56126, Italy.

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http://dx.doi.org/10.1021/acschemneuro.6b00078DOI Listing
July 2016

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights.

Cell Signal 2016 Jun 10;28(6):631-42. Epub 2016 Mar 10.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy; Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano, Via Gian Battista Grassi 74, 20157 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.03.001DOI Listing
June 2016

An Effective Virtual Screening Protocol To Identify Promising p53-MDM2 Inhibitors.

J Chem Inf Model 2016 06 7;56(6):1216-27. Epub 2016 Jun 7.

Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti , Via dei Vestini 31, 66100 Chieti, Italy.

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http://dx.doi.org/10.1021/acs.jcim.5b00747DOI Listing
June 2016

New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line.

Int J Biochem Cell Biol 2016 May 3;74:95-108. Epub 2016 Mar 3.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy; Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, via del Borghetto 80, 56124 Pisa, Italy.

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http://dx.doi.org/10.1016/j.biocel.2016.02.019DOI Listing
May 2016

Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

Nucl Med Biol 2016 05 27;43(5):309-17. Epub 2016 Feb 27.

Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124 Pisa, Italy; Fondazione Toscana G. Monasterio, Via Moruzzi, 1, I-56124, Pisa, Italy.

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http://dx.doi.org/10.1016/j.nucmedbio.2016.02.005DOI Listing
May 2016

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes.

J Neuroinflammation 2015 Dec 1;12:225. Epub 2015 Dec 1.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, Pisa, 56126, PI, Italy.

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http://dx.doi.org/10.1186/s12974-015-0446-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666178PMC
December 2015

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.

Cell Signal 2015 Aug 21;27(8):1609-29. Epub 2015 Apr 21.

Department of Pharmacy, University of Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.04.006DOI Listing
August 2015

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Eur J Med Chem 2015 Jan 12;89:32-41. Epub 2014 Oct 12.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2014.10.020DOI Listing
January 2015

Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation.

Cell Signal 2014 Dec 22;26(12):2614-20. Epub 2014 Aug 22.

Laboratorio di Biochimica e Biofisica Computazionale, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2014.08.003DOI Listing
December 2014

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.

Biochim Biophys Acta 2014 Dec 18;1843(12):2957-66. Epub 2014 Sep 18.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.09.013DOI Listing
December 2014

Allosteric modulators of human A2B adenosine receptor.

Biochim Biophys Acta 2014 Mar 19;1840(3):1194-203. Epub 2013 Dec 19.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2013.12.021DOI Listing
March 2014

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle.

Pulm Pharmacol Ther 2013 Dec 27;26(6):693-9. Epub 2013 Jun 27.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2013.06.006DOI Listing
December 2013

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor.

Bioorg Med Chem 2013 Apr 26;21(8):2186-2198. Epub 2013 Feb 26.

Centro di Cristallografia, Università degli Studi di Firenze, Via della Lastruccia, 3, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130016
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http://dx.doi.org/10.1016/j.bmc.2013.02.027DOI Listing
April 2013

The GABAA-BZR complex as target for the development of anxiolytic drugs.

Curr Top Med Chem 2012 ;12(4):254-69

Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology. Via Bonanno, 6. 56126 Pisa, Italy.

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June 2012

Platelet uptake of GABA and glutamate in patients with bipolar disorder.

Bipolar Disord 2012 May;14(3):301-8

Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1111/j.1399-5618.2012.01005.xDOI Listing
May 2012

Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.

Bioorg Med Chem 2011 Dec 21;19(24):7441-52. Epub 2011 Oct 21.

Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente attivi (HeteroBioLab) Università degli Studi di Firenze, Via U. Schiff, 6, 50019 Polo Scientifico, Sesto Fiorentino, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.10.047DOI Listing
December 2011

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases.

J Comput Aided Mol Des 2011 Aug 9;25(8):743-52. Epub 2011 Jul 9.

Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, Italy.

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http://dx.doi.org/10.1007/s10822-011-9455-8DOI Listing
August 2011

A(2A) adenosine receptor binding parameters in platelets from patients affected by pathological gambling.

Neuropsychobiology 2011 13;63(3):154-9. Epub 2011 Jan 13.

Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy.

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https://www.karger.com/Article/FullText/321592
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http://dx.doi.org/10.1159/000321592DOI Listing
June 2011

New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor.

Bioorg Med Chem 2011 May 12;19(10):3074-85. Epub 2011 Apr 12.

Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente attivi Università degli Studi di Firenze, Sesto Fiorentino-Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.04.009DOI Listing
May 2011

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.

J Med Chem 2011 Apr 14;54(7):2102-13. Epub 2011 Mar 14.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Firenze, Polo Scientifico, Via U. Schiff, 6-50019 Sesto Fiorentino (Firenze), Italy.

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http://dx.doi.org/10.1021/jm101328nDOI Listing
April 2011

New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABA(A)) receptor. Design, synthesis, biological, and molecular modeling investigation.

J Med Chem 2010 Nov;53(21):7532-48

Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi HeteroBioLab, Università degli Studi di Firenze, Via U Schiff 6, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1021/jm1001887DOI Listing
November 2010

Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17.

Cell Signal 2010 Apr 6;22(4):697-706. Epub 2010 Jan 6.

Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2009.12.006DOI Listing
April 2010