Simon P Mooijaart

Simon P Mooijaart

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Simon P Mooijaart

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Geriatric assessment and 1-year mortality in older patients with cancer in the head and neck region: A cohort study.

Head Neck 2019 Aug 28;41(8):2477-2483. Epub 2019 Feb 28.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/hed.25714DOI Listing
August 2019

Geriatric emergency medicine: time for a new approach on a European level.

Eur J Emerg Med 2019 04;26(2):75-76

Department of Emergency Medicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/MEJ.0000000000000594DOI Listing
April 2019

Systematic review: components of a comprehensive geriatric assessment in inflammatory bowel disease - a potentially promising but often neglected risk stratification.

J Crohns Colitis 2019 Apr 19. Epub 2019 Apr 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ecco-jcc/jjz082DOI Listing
April 2019

Spatial QRS-T Angle and Cognitive Decline in Older Subjects.

J Alzheimers Dis 2019 ;67(1):279-289

Department of Internal Medicine, Gerontology and Geriatrics Section, Leiden University Medical Center, Leiden, The Netherlands.

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/JAD-180633DOI Listing
January 2019

Acute care assessment of older adults living with frailty.

BMJ 2019 Jan 31;364:l13. Epub 2019 Jan 31.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1136/bmj.l13DOI Listing
January 2019

The association between intravenous fluid resuscitation and mortality in older emergency department patients with suspected infection.

Int J Emerg Med 2019 Jan 5;12(1). Epub 2019 Jan 5.

Department of Emergency Medicine, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/s12245-018-0219-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326108PMC
January 2019

Functional and cognitive impairment, social functioning, frailty and adverse health outcomes in older patients with esophageal cancer, a systematic review.

J Geriatr Oncol 2018 Nov 19;9(6):560-568. Epub 2018 Apr 19.

Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands; Institute for Evidence-based Medicine in Old Age (IEMO), Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jgo.2018.03.019DOI Listing
November 2018

Clinical aspects of thyroid function during ageing.

Lancet Diabetes Endocrinol 2018 09 17;6(9):733-742. Epub 2018 Jul 17.

Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(18)30028-7DOI Listing
September 2018

The Six-Item Cognitive Impairment Test Is Associated with Adverse Outcomes in Acutely Hospitalized Older Patients: A Prospective Cohort Study.

Dement Geriatr Cogn Dis Extra 2018 May-Aug;8(2):259-267. Epub 2018 Jul 12.

Section of Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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https://www.karger.com/Article/FullText/490240
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http://dx.doi.org/10.1159/000490240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103363PMC
July 2018

Regression discontinuity was a valid design for dichotomous outcomes in three randomized trials.

J Clin Epidemiol 2018 Jun 24;98:70-79. Epub 2018 Feb 24.

Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands; Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jclinepi.2018.02.015DOI Listing
June 2018

Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history.

J Hypertens 2018 04;36(4):773-778

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden.

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http://dx.doi.org/10.1097/HJH.0000000000001625DOI Listing
April 2018

Predictors and Outcomes of Revisits in Older Adults Discharged from the Emergency Department.

J Am Geriatr Soc 2018 04 28;66(4):735-741. Epub 2018 Feb 28.

Institute of Evidence-Based Medicine in Old Age, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/jgs.15301DOI Listing
April 2018

Early prediction of hospital admission for emergency department patients: a comparison between patients younger or older than 70 years.

Emerg Med J 2018 Jan 16;35(1):18-27. Epub 2017 Aug 16.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/emermed-2016-205846DOI Listing
January 2018

The Cognitive decline in Older Patients with End stage renal disease (COPE) study - rationale and design.

Curr Med Res Opin 2017 11 11;33(11):2057-2064. Epub 2017 Jul 11.

a Department of Nephrology , Leiden University Medical Center , Leiden , The Netherlands.

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http://dx.doi.org/10.1080/03007995.2017.1341404DOI Listing
November 2017

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study.

Stat Med 2017 06 16;36(14):2288-2301. Epub 2017 Mar 16.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/sim.7281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485037PMC
June 2017

Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.

N Engl J Med 2017 06 3;376(26):2534-2544. Epub 2017 Apr 3.

From the Academic Section of Geriatric Medicine, Institute of Cardiovascular and Medical Sciences (D.J.S., K.H., P.L., M. McDade, T.J.Q.), the Robertson Centre for Biostatistics, Institute of Health and Wellbeing (I.F., S.K., A.M., M. Messow, R.W.), and the Institute of Cardiovascular and Medical Sciences (N.S.), University of Glasgow, Glasgow, and Care of the Elderly-Rehabilitation, Monklands Hospital, NHS Lanarkshire, Airdrie (G.E.) - all in the United Kingdom; the Department of General Internal Medicine, Inselspital, Bern University Hospital (N.R., C.E.A., D.A., C.B., M.R.B., M.F., C.F., D.K., H.A.V.D.), and the Institute of Primary Health Care (N.R., M.F.), University of Bern, Bern, and the Service of Endocrinology, Diabetes, and Metabolism, University Hospital of Lausanne, Lausanne (T.-H.C.) - all in Switzerland; the Department of Epidemiology and Public Health (P.M.K., J.P.B., C.H., G.M., A.O., D.O., C.S., K.A.W., E.K.W.), the Pharmaceutical Care Research Group, School of Pharmacy (S.B., M.K., K.A.W.), the School of Nursing and Midwifery (V.M.), and the Department of General Practice (A.R., E.K.W.), University College Cork, and the Health Research Board Clinical Research Facility, Mercy University Hospital (M.K.) - all in Cork, Ireland; the Department of Public Health and Center for Healthy Aging, University of Copenhagen (R.G.J.W.), and the Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet (T.W.), Copenhagen, and the Department of Internal Medicine, Copenhagen University Hospital Herlev, Herlev (T.W.) - all in Denmark; the Departments of Gerontology and Geriatrics (S.P.M.), Internal Medicine (O.M.D.), Clinical Epidemiology (O.M.D.), Clinical Chemistry and Laboratory Medicine (W.P.J.E.), Public Health and Primary Care (R.S.D.P., R.K.E.P., J.G.), and Cardiology (J.W.J.), Leiden University Medical Center, and the Institute for Evidence-based Medicine in Old Age (S.P.M.), Leiden, and Radboud University Medical Center, Nijmegen (J.W.A.S.) - all in the Netherlands; and the Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco (D.C.B.).

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http://dx.doi.org/10.1056/NEJMoa1603825DOI Listing
June 2017

Complement receptor 1 gene polymorphisms are associated with cardiovascular risk.

Atherosclerosis 2017 02 20;257:16-21. Epub 2016 Dec 20.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.12.017DOI Listing
February 2017

Functional and cognitive impairment, social environment, frailty and adverse health outcomes in older patients with head and neck cancer, a systematic review.

Oral Oncol 2017 01 1;64:27-36. Epub 2016 Dec 1.

Department of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands; Institute for Evidence-based Medicine in Old Age (IEMO), Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.oraloncology.2016.11.013DOI Listing
January 2017

Subclinical Thyroid Dysfunction and the Risk of Cognitive Decline: a Meta-Analysis of Prospective Cohort Studies.

J Clin Endocrinol Metab 2016 12 30;101(12):4945-4954. Epub 2016 Sep 30.

Department of General Internal Medicine (C.R., D.S., C.E.A., C.B., D.A., N.R.), Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland; Institute of Primary Health Care (BIHAM), Faculty of Medicine (B.R.d.C., N.R.), University of Bern, 3012 Bern, Switzerland; Service of Endocrinology, Diabetes and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; University of Cambridge Metabolic Research Laboratories (T.-H.C.), Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Epidemiology (L.C., R.P.P.), Rotterdam Thyroid Center, 3015 GE Rotterdam, The Netherlands; School of Psychiatry and Clinical Neurosciences (O.P.A.), University of Western Australia, Perth 6009, Australia; School of Sport, Exercise and Health Sciences (E.H.), Loughborough University, Loughborough LE11 3TU, United Kingdom; Department of Cardiology (S.T.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Kuakini Medical Center and the Department of Geriatric Medicine (K.M.), John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96817; Department of Gerontology and Geriatrics (S.P.M.), Leiden University Medical Center, Leiden and Institute for Evidence-based Medicine in Old Age (IEMO), 2333 ZA Leiden, The Netherlands; Department of Public Health and Primary Care (J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; and Department of Medicine (D.C.B.), University of California-San Francisco, San Francisco California 94143.

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http://dx.doi.org/10.1210/jc.2016-2129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287525PMC
December 2016

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk.

Eur J Prev Cardiol 2016 09 16;23(13):1383-92. Epub 2016 Feb 16.

Department of Gerontology and Geriatrics, Leiden University Medical Center, the Netherlands Institute for Evidence-Based Medicine in Old Age, the Netherlands.

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http://dx.doi.org/10.1177/2047487316632364DOI Listing
September 2016

Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review.

Clin J Am Soc Nephrol 2016 09 24;11(9):1624-39. Epub 2016 Jun 24.

Gerontology and Geriatrics, and Institute for Evidence-Based Medicine in Old Age, Leiden, The Netherlands.

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http://dx.doi.org/10.2215/CJN.13611215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012494PMC
September 2016

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity.

Exp Gerontol 2016 09 29;82:166-74. Epub 2016 Jun 29.

Department of Molecular Epidemiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2016.06.013DOI Listing
September 2016

Regression Discontinuity Design: Simulation and Application in Two Cardiovascular Trials with Continuous Outcomes.

Epidemiology 2016 07;27(4):503-11

From the aCentre for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands; bDepartment of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands; cInstitute for Evidence-Based Medicine in Old Age, Leiden, The Netherlands; dDepartment of Neurology, Academic Medical Center, Amsterdam, The Netherlands; and eDepartment of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/EDE.0000000000000486DOI Listing
July 2016

Predicting mortality in acutely hospitalized older patients: a retrospective cohort study.

Intern Emerg Med 2016 Jun 29;11(4):587-94. Epub 2016 Jan 29.

Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11739-015-1381-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853459PMC
June 2016

Evaluation of the Use of Home Blood Pressure Measurement Using Mobile Phone-Assisted Technology: The iVitality Proof-of-Principle Study.

JMIR Mhealth Uhealth 2016 Jun 13;4(2):e67. Epub 2016 Jun 13.

Leiden University Medical Center, Department of Gerontology & Geriatrics, Leiden, Netherlands.

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http://dx.doi.org/10.2196/mhealth.5485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923587PMC
June 2016

Characteristics of randomized controlled trials designed for elderly: a systematic review.

PLoS One 2015 15;10(5):e0126709. Epub 2015 May 15.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands; Institute for Evidence-Based Medicine in Old Age, IEMO, Leiden, Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433127PMC
April 2016

Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age.

Am J Hypertens 2016 Mar 8;29(3):311-8. Epub 2015 Jul 8.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Institute for Evidence-Based Medicine in Old age, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ajh/hpv101DOI Listing
March 2016

Physician's Prescribing Preference as an Instrumental Variable: Exploring Assumptions Using Survey Data.

Epidemiology 2016 Mar;27(2):276-83

From the aDepartment of Clinical Epidemiology, bDepartment of Medical Statistics and Bioinformatics, cDepartment of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands; dDepartment of Clinical Epidemiology, Aarhus Medical Centre, Aarhus, Denmark; eBern Institute of General Practice, University of Bern, Bern, Switzerland; fDepartment of Epidemiology and Public Health, University College Cork, Cork, Ireland; gDepartment of General Practice and Primary Health Care, University of Auckland, Auckland, New Zealand; hArthritis Research UK Primary Care Centre, Keele University, Keele, Staffordshire, United Kingdom; iInstitute for Evidence-based Medicine in Old age (IEMO), Leiden, The Netherlands; jDepartment of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands; kInstitute of General Practice, Johann Wolfgang Goethe University, Frankfurt, Germany; lDepartment of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland; mInstitute of General Practice and Health Services Research, University of Zürich, Zürich, Switzerland; nDepartment of Primary and Community Care, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands; oDepartment of Internal Medicine, University Hospital of Zürich, Zürich, Switzerland; pDepartment of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands; and qResearch department of Primary Care and Population health, University College London, United Kingdom.

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http://dx.doi.org/10.1097/EDE.0000000000000425DOI Listing
March 2016

Resting heart rate, heart rate variability and functional decline in old age.

CMAJ 2015 Oct 31;187(15):E442-E449. Epub 2015 Aug 31.

Department of Gerontology and Geriatrics (Ogliari, Mahinrad, Mooijaart, Westendorp, de Craen, Sabayan), Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Sciences and Community Health (Ogliari), University of Milan, Milan, Italy; Academic Section of Geriatric Medicine (Stott), Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Cardiology (Jukema), Leiden University Medical Center, Leiden, the Netherlands; Institute for Evidence-Based Medicine in Old Age (Mooijaart), Leiden, the Netherlands; Institute of Cardiovascular and Medical Sciences (Macfarlane, Clark), University of Glasgow, Glasgow, United Kingdom; Department of Epidemiology and Public Health (Kearney), University College Cork, Cork, Ireland; Department of Public Health (Westendorp), University of Copenhagen, Copenhagen, Denmark; Department of Radiology (Sabayan), Leiden University Medical Center, Leiden, the Netherlands

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http://dx.doi.org/10.1503/cmaj.150462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610849PMC
October 2015

Executive function, but not memory, associates with incident coronary heart disease and stroke.

Neurology 2015 Sep 5;85(9):783-9. Epub 2015 Aug 5.

From the Departments of Radiology (S.R., M.A.v.B., B.S.), Gerontology and Geriatrics (S.R., R.G.J.W., S.P.M., B.S., A.J.M.d.C.), and Cardiology (J.W.J.), Leiden University Medical Center, the Netherlands; and the Department of Public Health (R.G.J.W.), Copenhagen University, Denmark.

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http://dx.doi.org/10.1212/WNL.0000000000001895DOI Listing
September 2015

Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease.

Am J Hypertens 2015 Apr 8;28(4):469-79. Epub 2014 Oct 8.

Academic Section of Geriatric Medicine, University of Glasgow-Faculty of Medicine, Glasgow Royal Infirmary, Glasgow, UK.

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http://dx.doi.org/10.1093/ajh/hpu181DOI Listing
April 2015

New genetic loci link adipose and insulin biology to body fat distribution.

Authors:
Dmitry Shungin Thomas W Winkler Damien C Croteau-Chonka Teresa Ferreira Adam E Locke Reedik Mägi Rona J Strawbridge Tune H Pers Krista Fischer Anne E Justice Tsegaselassie Workalemahu Joseph M W Wu Martin L Buchkovich Nancy L Heard-Costa Tamara S Roman Alexander W Drong Ci Song Stefan Gustafsson Felix R Day Tonu Esko Tove Fall Zoltán Kutalik Jian'an Luan Joshua C Randall André Scherag Sailaja Vedantam Andrew R Wood Jin Chen Rudolf Fehrmann Juha Karjalainen Bratati Kahali Ching-Ti Liu Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Georg B Ehret Mary F Feitosa Anuj Goel Anne U Jackson Toby Johnson Marcus E Kleber Kati Kristiansson Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Alena Stančáková Yun Ju Sung Toshiko Tanaka Alexander Teumer Jana V Van Vliet-Ostaptchouk Loïc Yengo Weihua Zhang Eva Albrecht Johan Ärnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Stefan Böhringer Fabrice Bonnet Yvonne Böttcher Marcel Bruinenberg Delia B Carba Ida H Caspersen Robert Clarke E Warwick Daw Joris Deelen Ewa Deelman Graciela Delgado Alex Sf Doney Niina Eklund Michael R Erdos Karol Estrada Elodie Eury Nele Friedrich Melissa E Garcia Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Harald Grallert Tanja B Grammer Jürgen Gräßler Jagvir Grewal Christopher J Groves Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Kauko Heikkilä Karl-Heinz Herzig Quinta Helmer Hans L Hillege Oddgeir Holmen Steven C Hunt Aaron Isaacs Till Ittermann Alan L James Ingegerd Johansson Thorhildur Juliusdottir Ioanna-Panagiota Kalafati Leena Kinnunen Wolfgang Koenig Ishminder K Kooner Wolfgang Kratzer Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon François Mach Patrik Ke Magnusson Anubha Mahajan Wendy L McArdle Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Rebecca Mills Alireza Moayyeri Keri L Monda Simon P Mooijaart Thomas W Mühleisen Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Ramaiah Nagaraja Michael A Nalls Narisu Narisu Nicola Glorioso Ilja M Nolte Matthias Olden Nigel W Rayner Frida Renstrom Janina S Ried Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Bengt Sennblad Thomas Seufferlein Colleen M Sitlani Albert Vernon Smith Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Andreas Tomaschitz Chiara Troffa Floor Va van Oort Niek Verweij Judith M Vonk Lindsay L Waite Roman Wennauer Tom Wilsgaard Mary K Wojczynski Andrew Wong Qunyuan Zhang Jing Hua Zhao Eoin P Brennan Murim Choi Per Eriksson Lasse Folkersen Anders Franco-Cereceda Ali G Gharavi Åsa K Hedman Marie-France Hivert Jinyan Huang Stavroula Kanoni Fredrik Karpe Sarah Keildson Krzysztof Kiryluk Liming Liang Richard P Lifton Baoshan Ma Amy J McKnight Ruth McPherson Andres Metspalu Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Christian Olsson John Rb Perry Eva Reinmaa Rany M Salem Niina Sandholm Eric E Schadt Robert A Scott Lisette Stolk Edgar E Vallejo Harm-Jan Westra Krina T Zondervan Philippe Amouyel Dominique Arveiler Stephan Jl Bakker John Beilby Richard N Bergman John Blangero Morris J Brown Michel Burnier Harry Campbell Aravinda Chakravarti Peter S Chines Simone Claudi-Boehm Francis S Collins Dana C Crawford John Danesh Ulf de Faire Eco Jc de Geus Marcus Dörr Raimund Erbel Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Christian Gieger Vilmundur Gudnason Christopher A Haiman Tamara B Harris Andrew T Hattersley Markku Heliövaara Andrew A Hicks Aroon D Hingorani Wolfgang Hoffmann Albert Hofman Georg Homuth Steve E Humphries Elina Hyppönen Thomas Illig Marjo-Riitta Jarvelin Berit Johansen Pekka Jousilahti Antti M Jula Jaakko Kaprio Frank Kee Sirkka M Keinanen-Kiukaanniemi Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Kari Kuulasmaa Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Arthur W Musk Stefan Möhlenkamp Andrew D Morris Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Lyle J Palmer Brenda W Penninx Annette Peters Peter P Pramstaller Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter Eh Schwarz Alan R Shuldiner Jan A Staessen Valgerdur Steinthorsdottir Ronald P Stolk Konstantin Strauch Anke Tönjes Angelo Tremblay Elena Tremoli Marie-Claude Vohl Uwe Völker Peter Vollenweider James F Wilson Jacqueline C Witteman Linda S Adair Murielle Bochud Bernhard O Boehm Stefan R Bornstein Claude Bouchard Stéphane Cauchi Mark J Caulfield John C Chambers Daniel I Chasman Richard S Cooper George Dedoussis Luigi Ferrucci Philippe Froguel Hans-Jörgen Grabe Anders Hamsten Jennie Hui Kristian Hveem Karl-Heinz Jöckel Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Winfried März Patricia B Munroe Inger Njølstad Ben A Oostra Colin Na Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Juha Sinisalo P Eline Slagboom Harold Snieder Tim D Spector Kari Stefansson Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Giovanni Veronesi Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann Goncalo R Abecasis Themistocles L Assimes Sonja I Berndt Michael Boehnke Ingrid B Borecki Panos Deloukas Lude Franke Timothy M Frayling Leif C Groop David J Hunter Robert C Kaplan Jeffrey R O'Connell Lu Qi David Schlessinger David P Strachan Unnur Thorsteinsdottir Cornelia M van Duijn Cristen J Willer Peter M Visscher Jian Yang Joel N Hirschhorn M Carola Zillikens Mark I McCarthy Elizabeth K Speliotes Kari E North Caroline S Fox Inês Barroso Paul W Franks Erik Ingelsson Iris M Heid Ruth Jf Loos L Adrienne Cupples Andrew P Morris Cecilia M Lindgren Karen L Mohlke

Nature 2015 Feb;518(7538):187-196

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://kooperberg.fhcrc.org/papers/2015shungin.pdf
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http://www.nature.com/doifinder/10.1038/nature14132
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http://dx.doi.org/10.1038/nature14132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338562PMC
February 2015

Low thyroid function and anemia in old age: the Leiden 85-plus study.

J Am Geriatr Soc 2015 Feb;63(2):407-9

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/jgs.13282DOI Listing
February 2015

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity.

PLoS One 2014 14;9(3):e91085. Epub 2014 Mar 14.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091085PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954617PMC
December 2014

NT-proBNP, blood pressure, and cognitive decline in the oldest old: The Leiden 85-plus Study.

Neurology 2014 Sep 20;83(13):1192-9. Epub 2014 Aug 20.

From the Departments of Gerontology and Geriatrics (P.v.V., B.S., L.W.W., S.P.M., A.J.M.d.C., R.G.J.W.), Neurology (P.v.V.), Radiology (B.S.), and Public Health and Primary Care (R.K.E.P., W.d.R., J.G.), Leiden University Medical Center; and Netherlands Consortium of Healthy Ageing (L.W.W., A.J.M.d.C., R.G.J.W.), Leiden, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000000820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176025PMC
September 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk.

Ann Neurol 2014 Aug 9;76(2):213-22. Epub 2014 Jul 9.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.

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http://doi.wiley.com/10.1002/ana.24203
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http://dx.doi.org/10.1002/ana.24203DOI Listing
August 2014

Letter regarding the Paper by Pearce et al. Entitled '2013 ETA Guideline: Management of Subclinical Hypothyroidism'.

Eur Thyroid J 2014 Jun 9;3(2):141-2. Epub 2014 May 9.

Institute for Evidence-Based Medicine in Old Age/IEMO, Leiden, The Netherlands ; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1159/000362089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109500PMC
June 2014

Renal function in familial longevity: the Leiden Longevity Study.

Exp Gerontol 2014 Mar 2;51:65-70. Epub 2014 Jan 2.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2013.12.012DOI Listing
March 2014

Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study.

Eur J Heart Fail 2013 May 17;15(5):528-33. Epub 2012 Dec 17.

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfs203DOI Listing
May 2013

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals.

Aging Cell 2013 Apr 6;12(2):207-13. Epub 2013 Feb 6.

Department of Gerontology and Geriatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/acel.12042DOI Listing
April 2013

High serum glucose levels are associated with a higher perceived age.

Age (Dordr) 2013 Feb 20;35(1):189-95. Epub 2011 Nov 20.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11357-011-9339-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543736PMC
February 2013

Blood pressure trends and mortality: the Leiden 85-plus Study.

J Hypertens 2013 Jan;31(1):63-70

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0b013e32835aa351DOI Listing
January 2013

[Should subclinical hypothyroidism in older persons be treated?].

Ned Tijdschr Geneeskd 2012 ;156(49):A5094

Leids Universitair Medisch Centrum, afd. Public Health en Eerstelijnsgeneeskunde, Leiden, the Netherlands.

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January 2013

Genetic variation in galectin-3 gene associates with cognitive function at old age.

Neurobiol Aging 2012 Sep 5;33(9):2232.e1-2232.e9. Epub 2012 Jun 5.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.05.001DOI Listing
September 2012

Responsiveness of the innate immune system and glucose concentrations in the oldest old.

Age (Dordr) 2012 Aug 11;34(4):983-6. Epub 2011 Aug 11.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11357-011-9292-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682070PMC
August 2012

Subclinical thyroid disorders.

Lancet 2012 Jul;380(9839):335; author reply 336-7

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http://linkinghub.elsevier.com/retrieve/pii/S014067361261241
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http://dx.doi.org/10.1016/S0140-6736(12)61241-0DOI Listing
July 2012

Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk.

J Clin Endocrinol Metab 2012 Mar 11;97(3):852-61. Epub 2012 Jan 11.

Leiden University Medical Center, Department of Gerontology and Geriatrics, Netherlands Consortium for Health Aging, Leiden, The Netherlands.

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http://dx.doi.org/10.1210/jc.2011-1978DOI Listing
March 2012

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Authors:
Daniel I Swerdlow Michael V Holmes Karoline B Kuchenbaecker Jorgen E L Engmann Tina Shah Reecha Sofat Yiran Guo Christina Chung Anne Peasey Roman Pfister Simon P Mooijaart Helen A Ireland Maarten Leusink Claudia Langenberg Ka Wah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos John Hardy Michael A Nalls Yun Rose Li Gordon Lowe Marlene Stewart Suzette J Bielinski Julian Peto Nicholas J Timpson John Gallacher Malcolm Dunlop Richard Houlston Ian Tomlinson Ioanna Tzoulaki Jian'an Luan Jolanda M A Boer Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Luigi Ferrucci Stefania Bandenelli Toshiko Tanaka James F Meschia Andrew Singleton Gerjan Navis Irene Mateo Leach Stephan J L Bakker Ron T Gansevoort Ian Ford Stephen E Epstein Mary Susan Burnett Joe M Devaney J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Yolanda van der Graaf Pim A de Jong Anke-Hilse Mailand-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Jeffrey W Stephens Charles B Eaton Jennifer G Robinson JoAnn E Manson F Gerry Fowkes Timonthy M Frayling Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Susan Redline Leslie A Lange Meena Kumari Nick J Wareham W M Monique Verschuren Emelia J Benjamin John C Whittaker Anders Hamsten Frank Dudbridge J A Chris Delaney Andrew Wong Diana Kuh Rebecca Hardy Berta Almoguera Castillo John J Connolly Pim van der Harst Eric J Brunner Michael G Marmot Christina L Wassel Steve E Humphries Philippa J Talmud Mika Kivimaki Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Hakon Hakonarson Alex P Reiner Brendan J Keating Naveed Sattar Aroon D Hingorani Juan Pablo Casas

Lancet 2012 Mar 14;379(9822):1214-24. Epub 2012 Mar 14.

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http://dx.doi.org/10.1016/S0140-6736(12)60110-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316968PMC
March 2012

C-reactive protein and glucose regulation in familial longevity.

Age (Dordr) 2011 Dec 19;33(4):623-30. Epub 2011 Jan 19.

Department of Gerontology and Geriatrics, Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1007/s11357-011-9206-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220397PMC
December 2011

Familial longevity is marked by enhanced insulin sensitivity.

Aging Cell 2011 Feb 7;10(1):114-21. Epub 2010 Dec 7.

Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00650.xDOI Listing
February 2011

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study.

J Gerontol A Biol Sci Med Sci 2010 Apr 16;65(4):365-8. Epub 2009 Dec 16.

Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/gerona/glp200DOI Listing
April 2010

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

J Am Geriatr Soc 2009 Sep 17;57(9):1634-7. Epub 2009 Jul 17.

Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1532-5415.2009.02381.xDOI Listing
September 2009

Human insulin/IGF-1 and familial longevity at middle age.

Aging (Albany NY) 2009 Jul 24;1(8):714-22. Epub 2009 Jul 24.

Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806046PMC
http://dx.doi.org/10.18632/aging.100071DOI Listing
July 2009