Simon Melov

Simon Melov

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From discoveries in ageing research to therapeutics for healthy ageing.

Nature 2019 07 10;571(7764):183-192. Epub 2019 Jul 10.

Buck Institute for Research on Aging, Novato, CA, USA.

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http://dx.doi.org/10.1038/s41586-019-1365-2DOI Listing
July 2019

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Cell Stem Cell 2017 Dec;21(6):806-818.e5

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945-1400, USA; Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena 07745, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823264PMC
December 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Unmasking Transcriptional Heterogeneity in Senescent Cells.

Curr Biol 2017 Sep 30;27(17):2652-2660.e4. Epub 2017 Aug 30.

European Research Institute for the Biology of Aging, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788810PMC
September 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.

Circ Res 2017 Mar 20;120(7):1103-1115. Epub 2017 Feb 20.

From the Department of Medicine, VA Medical Center, San Francisco, CA (B.-E.M., P.M.C., P.M.S., M.D.M., K.T., D.N., R.G., D.X.D., C.H., A.J.B., P.C.S.); Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco (B.-E.M., P.M.C., M.D.M., D.X.D., C.H., A.J.B., P.C.S.); and Buck Institute for Research on Aging, Novato, CA (J.M.F., S.M.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31052
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http://dx.doi.org/10.1161/CIRCRESAHA.117.310520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376223PMC
March 2017

Expression patterns of cardiac aging in Drosophila.

Aging Cell 2017 Feb;16(1):82-92

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/acel.12559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242310PMC
February 2017

Uncovering the Dark Energy of Aging.

Authors:
Simon Melov

Cell Syst 2016 10;3(4):328-330

Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.10.001DOI Listing
October 2016

Geroscience approaches to increase healthspan and slow aging.

Authors:
Simon Melov

F1000Res 2016 29;5. Epub 2016 Apr 29.

Buck Institute for Research on Aging, Novato, CA, USA.

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http://dx.doi.org/10.12688/f1000research.7583.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856109PMC
May 2016

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10407-12. Epub 2015 Aug 3.

Buck Institute for Research on Aging, Novato, CA 94945 Lawrence Berkeley National Laboratory, Berkeley, CA 94720

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http://dx.doi.org/10.1073/pnas.1505675112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547253PMC
August 2015

Translational geroscience: emphasizing function to achieve optimal longevity.

Aging (Albany NY) 2014 Sep;6(9):718-30

Buck Institute for Research on Aging, Novato, CA 94945, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221919PMC
http://dx.doi.org/10.18632/aging.100694DOI Listing
September 2014

Medical research: treat ageing.

Nature 2014 Jul;511(7510):405-7

Buck Institute for Research on Aging in Novato, California, USA.

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http://dx.doi.org/10.1038/511405aDOI Listing
July 2014

SOD2 in mitochondrial dysfunction and neurodegeneration.

Free Radic Biol Med 2013 Sep 29;62:4-12. Epub 2013 May 29.

Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811078PMC
September 2013

Age-related micro-RNA abundance in individual C. elegans.

Aging (Albany NY) 2013 Jun;5(6):394-411

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824409PMC
http://dx.doi.org/10.18632/aging.100564DOI Listing
June 2013

Single cell gene expression profiling of cortical osteoblast lineage cells.

Bone 2013 Mar 10;53(1):174-81. Epub 2012 Dec 10.

Buck Institute for Research on Aging, 8001 Redwood Blvd. Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.bone.2012.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589579PMC
March 2013

Proteogenomics of synaptosomal mitochondrial oxidative stress.

Free Radic Biol Med 2012 Sep 13;53(5):1048-60. Epub 2012 Jul 13.

Buck Institute for Research on Aging, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436120PMC
September 2012

Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

Cell Stem Cell 2012 Aug 28;11(2):253-63. Epub 2012 Jun 28.

The Buck Institute for Research on Aging, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.stem.2012.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608272PMC
August 2012

Premature expression of a muscle fibrosis axis in chronic HIV infection.

Skelet Muscle 2012 Jun 7;2(1):10. Epub 2012 Jun 7.

Boston University School of Medicine, 650 Albany St, EBRC 646, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1186/2044-5040-2-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407733PMC
June 2012

Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.

PLoS One 2011 9;6(12):e28530. Epub 2011 Dec 9.

College of Pharmacy, Touro University - California, Vallejo, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235131PMC
April 2012

cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad.

Aging (Albany NY) 2012 Apr;4(4):256-69

Buck Institute for Research on Aging, Novato, CA 94945, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378273PMC
http://dx.doi.org/10.18632/aging.100448DOI Listing
April 2012

Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage.

Sci Transl Med 2012 Feb;4(119):119ra13

Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3002882DOI Listing
February 2012

Cellular senescence: a link between cancer and age-related degenerative disease?

Semin Cancer Biol 2011 Dec 10;21(6):354-9. Epub 2011 Sep 10.

Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94545, USA.

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http://dx.doi.org/10.1016/j.semcancer.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230665PMC
December 2011

Single cell transcriptional profiling of adult mouse cardiomyocytes.

J Vis Exp 2011 Dec 28(58):e3302. Epub 2011 Dec 28.

Buck Institute for Research on Aging.

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http://dx.doi.org/10.3791/3302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369660PMC
December 2011

On the programmed/non-programmed nature of ageing within the life history.

Curr Biol 2011 Sep;21(18):R701-7

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.cub.2011.07.020DOI Listing
September 2011

Loss of intestinal nuclei and intestinal integrity in aging C. elegans.

Aging Cell 2011 Aug 25;10(4):699-710. Epub 2011 May 25.

Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2011.00713.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135675PMC
August 2011

The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.

Exp Gerontol 2011 Jun 2;46(6):441-52. Epub 2011 Feb 2.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.exger.2011.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104016PMC
June 2011

Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice.

Free Radic Biol Med 2011 Apr 6;50(7):866-73. Epub 2011 Jan 6.

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061438PMC
April 2011

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.

Free Radic Biol Med 2009 Feb 30;46(3):387-96. Epub 2008 Oct 30.

The Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665299PMC
February 2009

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.

Physiol Genomics 2008 Jan 23;32(2):219-28. Epub 2007 Oct 23.

Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00157.2007DOI Listing
January 2008

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.

J Biol Chem 2008 Jan 24;283(1):350-7. Epub 2007 Oct 24.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1074/jbc.M705028200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739662PMC
January 2008

Resistance exercise reverses aging in human skeletal muscle.

PLoS One 2007 May 23;2(5):e465. Epub 2007 May 23.

Buck Institute for Age Research, Novato, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866181PMC
May 2007

Gene expression changes associated with aging in C. elegans.

WormBook 2007 Feb 12:1-12. Epub 2007 Feb 12.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1895/wormbook.1.127.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781587PMC
February 2007

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.

J Biol Chem 2006 Feb 2;281(6):3354-9. Epub 2005 Dec 2.

Buck Institute for Age Research, Novato, California 94945, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M509261200
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http://dx.doi.org/10.1074/jbc.M509261200DOI Listing
February 2006

Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice.

PLoS Genet 2006 Jan 27;2(1):e10. Epub 2006 Jan 27.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358942PMC
January 2006

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.

J Clin Invest 2005 Sep 25;115(9):2556-63. Epub 2005 Aug 25.

Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI23610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190368PMC
September 2005

Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase.

Breast 2005 Aug 19;14(4):256-63. Epub 2005 Apr 19.

Department of Anatomy, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.breast.2005.02.004DOI Listing
August 2005

Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy.

Free Radic Biol Med 2005 Jul 30;39(2):152-63. Epub 2005 Mar 30.

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.03.002DOI Listing
July 2005

Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment.

Free Radic Biol Med 2005 Jan;38(2):258-61

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.10.023DOI Listing
January 2005

Proteomic analysis of mitochondrial proteins.

Int Rev Neurobiol 2004 ;61:31-48

PerkinElmer Life and Analytical Sciences, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1016/S0074-7742(04)61002-6DOI Listing
December 2004

Modeling mitochondrial function in aging neurons.

Authors:
Simon Melov

Trends Neurosci 2004 Oct;27(10):601-6

Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/j.tins.2004.08.004DOI Listing
October 2004

Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future.

Sci Aging Knowledge Environ 2004 Oct 20;2004(42):re7. Epub 2004 Oct 20.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1126/sageke.2004.42.re7DOI Listing
October 2004

Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR.

Mitochondrion 2004 Sep 30;4(5-6):453-70. Epub 2004 Sep 30.

Gorilla Genomics Inc., 851 Midway, Suite 201, Alameda, CA 94501, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156772490400137
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http://dx.doi.org/10.1016/j.mito.2004.07.029DOI Listing
September 2004

Microarray analysis of gene expression with age in individual nematodes.

Aging Cell 2004 Jun;3(3):111-24

The Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1111/j.1474-9728.2004.00095.xDOI Listing
June 2004

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts.

Nat Cell Biol 2003 Aug;5(8):741-7

Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1038/ncb1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940195PMC
August 2003

Microarray workshop on aging.

Mech Ageing Dev 2003 Jan;124(1):133-8

Department of Physiology and South Texas Centers for Biology in Medicine, University of Texas Health Science Center in San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA.

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http://dx.doi.org/10.1016/s0047-6374(02)00176-8DOI Listing
January 2003

Oxidative stress and aging: beyond correlation.

Aging Cell 2002 Dec;1(2):117-23

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1046/j.1474-9728.2002.00015.xDOI Listing
December 2002

Animal models of oxidative stress, aging, and therapeutic antioxidant interventions.

Authors:
Simon Melov

Int J Biochem Cell Biol 2002 Nov;34(11):1395-400

Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/s1357-2725(02)00086-9DOI Listing
November 2002

Spotlight on nematode mitochondria in RNAi mega-screen.

Authors:
Simon Melov

Sci Aging Knowledge Environ 2002 Nov 27;2002(47):pe18. Epub 2002 Nov 27.

Buck Institute for Age Research, Novato, CA 94945, USA.

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http://dx.doi.org/10.1126/sageke.2002.47.pe18DOI Listing
November 2002

Therapeutics against mitochondrial oxidative stress in animal models of aging.

Authors:
Simon Melov

Ann N Y Acad Sci 2002 Apr;959:330-40

Buck Institute for Age Research, Novato, California 94945, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb02104.xDOI Listing
April 2002

'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease.

Authors:
Simon Melov

Trends Neurosci 2002 Mar;25(3):121-3; discussion 123-4

Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.

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http://dx.doi.org/10.1016/s0166-2236(00)02086-5DOI Listing
March 2002

Applied proteomics: mitochondrial proteins and effect on function.

Circ Res 2002 Mar;90(4):380-9

Proteome Systems, Woburn, MA 01801, USA.

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http://dx.doi.org/10.1161/hh0402.105757DOI Listing
March 2002