Publications by authors named "Simon L Goodman"

47Publications

The 3rd Antibody Validation meeting: Bath UK 20-21 September 2018.

Authors:
Simon L Goodman

F1000Res 2018 31;7:1989. Epub 2018 Dec 31.

Independent Freelance Writer, Darmstadt, Hessen, Germany.

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http://dx.doi.org/10.12688/f1000research.17645.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317493PMC
September 2019

The path to VICTORy - a beginner's guide to success using commercial research antibodies.

Authors:
Simon L Goodman

J Cell Sci 2018 05 15;131(10). Epub 2018 May 15.

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http://dx.doi.org/10.1242/jcs.216416DOI Listing
May 2018

The antibody horror show: an introductory guide for the perplexed.

Authors:
Simon L Goodman

N Biotechnol 2018 Oct 3;45:9-13. Epub 2018 Feb 3.

Translational Biomarkers Research, Translational Innovation Platform - Oncology, Merck KGaA, Frankfurterstr. 250, 64293, Darmstadt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbt.2018.01.006DOI Listing
October 2018

Integrins as Therapeutic Targets: Successes and Cancers.

Cancers (Basel) 2017 Aug 23;9(9). Epub 2017 Aug 23.

Translational and Biomarkers Research, Translational Innovation Platform Oncology, Merck KGaA, 64293 Darmstadt, Germany.

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http://dx.doi.org/10.3390/cancers9090110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615325PMC
August 2017

Integrins αvβ3 and αvβ5 as prognostic, diagnostic, and therapeutic targets in gastric cancer.

Gastric Cancer 2015 Oct 15;18(4):784-95. Epub 2014 Oct 15.

Department of Pathology, Christian Albrechts University, Arnold-Heller-Str. 3, Haus 14, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s10120-014-0435-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572058PMC
October 2015

Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.

J Biol Chem 2014 May 1;289(20):13801-9. Epub 2014 Apr 1.

From the Structural Biology Program and the Leukocyte Biology and Inflammation Program, Departments of Medicine and Developmental & Regenerative Biology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129,

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http://dx.doi.org/10.1074/jbc.M113.546929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022854PMC
May 2014

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin.

Nat Struct Mol Biol 2014 Apr 23;21(4):383-8. Epub 2014 Mar 23.

1] Structural Biology Program, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [2] Leukocyte Biology and Inflammation Program, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://www.nature.com/articles/nsmb.2797
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http://dx.doi.org/10.1038/nsmb.2797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012256PMC
April 2014

Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors.

Int J Clin Exp Pathol 2013 15;6(12):2719-32. Epub 2013 Nov 15.

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen Tübingen 72076, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843253PMC
August 2014

Integrins and their ligands are expressed in non-small cell lung cancer but not correlated with parameters of disease progression.

Virchows Arch 2014 Jan 26;464(1):69-78. Epub 2013 Nov 26.

Department of Pathology, Christian-Albrechts-University, Arnold-Heller-Str. 3, Haus 14, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s00428-013-1506-1DOI Listing
January 2014

Invasion patterns in brain metastases of solid cancers.

Neuro Oncol 2013 Dec 30;15(12):1664-72. Epub 2013 Sep 30.

Corresponding Author: Matthias Preusser, MD, Department of Medicine I and Comprehensive Cancer Center, Central Nervous System Tumours Unit (CCC-CNS), Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1093/neuonc/not112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829586PMC
December 2013

αv-Integrin isoform expression in primary human tumors and brain metastases.

Int J Cancer 2013 Nov 10;133(10):2362-71. Epub 2013 Jun 10.

Department of Pathology, Institute for Surgical Pathology, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1002/ijc.28267DOI Listing
November 2013

Validation and comparison of anti-αvβ3 and anti-αvβ5 rabbit monoclonal versus murine monoclonal antibodies in four different tumor entities.

Appl Immunohistochem Mol Morphol 2013 Dec;21(6):553-60

Departments of *Pathology †Experimental Cancer Research, Christian-Albrechts-University, Kiel ‡Department of Biochemistry and Cellular Pharmacology, Oncology Platform, Merck KGaA, Darmstadt, Germany.

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http://dx.doi.org/10.1097/PAI.0b013e318284a03aDOI Listing
December 2013

Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor.

J Neuropathol Exp Neurol 2013 Mar;72(3):194-210

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3182851019DOI Listing
March 2013

Integrin control of the transforming growth factor-β pathway in glioblastoma.

Brain 2013 Feb 31;136(Pt 2):564-76. Epub 2013 Jan 31.

Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1093/brain/aws351DOI Listing
February 2013

The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model.

Int J Cancer 2013 Jun 5;132(11):2694-704. Epub 2012 Dec 5.

Department of Surgery, Section Surgical Oncology, Laboratory Experimental Surgical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/ijc.27940
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http://dx.doi.org/10.1002/ijc.27940DOI Listing
June 2013

Integrins as therapeutic targets.

Trends Pharmacol Sci 2012 Jul 25;33(7):405-12. Epub 2012 May 25.

Department of Cellular Pharmacology - Oncology Platform, Merck KGaA, Frankfurterstrasse 250, 64271 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.tips.2012.04.002DOI Listing
July 2012

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency.

Int J Cancer 2009 Jun;124(11):2719-27

Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA.

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http://dx.doi.org/10.1002/ijc.24240DOI Listing
June 2009

Circulating and imaging markers for angiogenesis.

Angiogenesis 2008 17;11(4):321-35. Epub 2008 Oct 17.

JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://link.springer.com/content/pdf/10.1007/s10456-008-9119
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http://link.springer.com/10.1007/s10456-008-9119-z
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http://dx.doi.org/10.1007/s10456-008-9119-zDOI Listing
April 2009

Structure and mechanics of integrin-based cell adhesion.

Curr Opin Cell Biol 2007 Oct 24;19(5):495-507. Epub 2007 Oct 24.

Nephrology Division, Leukocyte Biology & Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, United States.

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http://dx.doi.org/10.1016/j.ceb.2007.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443699PMC
October 2007

Purification, analysis, and crystal structure of integrins.

Methods Enzymol 2007 ;426:307-36

Structural Biology Program, Leukocyte Biology and Inflammation Program, Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)26014-8DOI Listing
October 2007

Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate cell migration and activation in vitro.

J Hepatol 2007 May 12;46(5):878-87. Epub 2006 Dec 12.

Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2006.11.011DOI Listing
May 2007

Piltdown wasn't cricket but does the hobbit ring true?

Authors:
Simon L Goodman

Nature 2006 Sep;443(7110):394

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http://dx.doi.org/10.1038/443394dDOI Listing
September 2006

Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides.

Chembiochem 2005 Nov;6(11):2034-40

Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universität München, Garching, Germany.

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http://dx.doi.org/10.1002/cbic.200500031DOI Listing
November 2005

Improving implant materials by coating with nonpeptidic, highly specific integrin ligands.

Angew Chem Int Ed Engl 2004 Dec;43(48):6649-52

Department Chemie, Lehrstuhl Organische Chemie II, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.

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http://dx.doi.org/10.1002/anie.200460770DOI Listing
December 2004

A novel adaptation of the integrin PSI domain revealed from its crystal structure.

J Biol Chem 2004 Sep 6;279(39):40252-4. Epub 2004 Aug 6.

Structural Biology Program, Leukocyte Biology and Inflammation Program, Renal Unit.

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http://dx.doi.org/10.1074/jbc.C400362200DOI Listing
September 2004

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation.

Chemistry 2003 Jun;9(12):2717-25

Institut für Organische Chemie und Biochemie, Technische Universität Munich, Lichtenbergstrasse 4, 85747 Garching, Germany.

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http://dx.doi.org/10.1002/chem.200204304DOI Listing
June 2003

New insights into the structural basis of integrin activation.

Blood 2003 Aug 24;102(4):1155-9. Epub 2003 Apr 24.

Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1182/blood-2003-01-0334DOI Listing
August 2003

Coming to grips with integrin binding to ligands.

Curr Opin Cell Biol 2002 Oct;14(5):641-51

Renal Unit, Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09550674020037
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http://dx.doi.org/10.1016/s0955-0674(02)00371-xDOI Listing
October 2002

Divalent cations and the relationship between alphaA and betaA domains in integrins.

Biochem Pharmacol 2002 Sep;64(5-6):805-12

Department of Bio- and Chemoinformatics, Merck KGaA, Frankfurterstr. 250, Darmstadt, Germany.

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http://dx.doi.org/10.1016/s0006-2952(02)01142-5DOI Listing
September 2002

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.

Science 2002 Apr 7;296(5565):151-5. Epub 2002 Mar 7.

Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.1069040DOI Listing
April 2002

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.

J Med Chem 2002 Feb;45(5):1045-51

Department of Preclinical Oncology and Medicinal Chemistry, Merck KGaA, Frankfurterstr. 250, 64271 Darmstadt, Germany.

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http://dx.doi.org/10.1021/jm0102598DOI Listing
February 2002

Nonpeptidic α β Integrin Antagonist Libraries: On-Bead Screening and Mass Spectrometric Identification without Tagging.

Angew Chem Int Ed Engl 2001 Jan;40(1):165-169

Institut für Organische Chemie und Biochemie Technische Universität München Lichtenbergstrasse 4, 85747 Garching, Germany, Fax: (+49) 89-289-13210.

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http://dx.doi.org/10.1002/1521-3773(20010105)40:1<165::AID-ANIE165>3.0.CO;2-8DOI Listing
January 2001