Simon Hohenester

Simon Hohenester

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Simon Hohenester

Simon Hohenester

Publications by authors named "Simon Hohenester"

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Predictors of ribociclib-mediated antitumour effects in native and sorafenib-resistant human hepatocellular carcinoma cells.

Cell Oncol (Dordr) 2019 Oct 27;42(5):705-715. Epub 2019 Jun 27.

Department of Medicine II, Liver Center Munich, University Hospital, LMU Munich, Marchioninistr. 15, D-81377, Munich, Germany.

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http://dx.doi.org/10.1007/s13402-019-00458-8DOI Listing
October 2019

Fatigue in Primary Biliary Cholangitis: no Place for Rituximab.

Hepatology 2019 Aug 23. Epub 2019 Aug 23.

Department of Medicine II, University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1002/hep.30906DOI Listing
August 2019

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.

Cell Mol Gastroenterol Hepatol 2019 23;7(3):571-596. Epub 2018 Dec 23.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407159PMC
June 2019

Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective.

PLoS One 2019 26;14(3):e0214436. Epub 2019 Mar 26.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435145PMC
March 2019

Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation, and fibrosis.

Am J Physiol Gastrointest Liver Physiol 2018 09 7;315(3):G329-G338. Epub 2018 Jun 7.

Center for Clinical Nutrition and Preventive Medicine, Hospital Barmherzige Brüder , Munich , Germany.

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http://dx.doi.org/10.1152/ajpgi.00044.2018DOI Listing
September 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Mitochondrial adaptation in steatotic mice.

Mitochondrion 2018 05 19;40:1-12. Epub 2017 Sep 19.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University of Munich, 80802 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.08.015DOI Listing
May 2018

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

JCI Insight 2018 03 8;3(5). Epub 2018 Mar 8.

Division of Gastroenterology, Endocrinology, Infectiology and Metabolism, University Hospital Giessen and Marburg, Campus Marburg, Philipps University Marburg, Marburg, Germany.

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https://insight.jci.org/articles/view/96322
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http://dx.doi.org/10.1172/jci.insight.96322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922280PMC
March 2018

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.

Hepatology 2017 08 19;66(2):542-554. Epub 2017 Jun 19.

Department of Gastroenterology & Hepatology and Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/hep.29029
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http://dx.doi.org/10.1002/hep.29029DOI Listing
August 2017

CD14 is associated with biliary stricture formation.

Hepatology 2016 09 20;64(3):843-52. Epub 2016 Apr 20.

Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/hep.28543DOI Listing
September 2016

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

N Engl J Med 2016 Aug;375(7):631-43

From University Hospitals KU Leuven, Leuven, Belgium (F.N.); University of Bologna, Bologna (P.A., G.M.), Program for Autoimmune Liver Disease, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan (P.I.), Humanitas Clinical and Research Center, Rozzano (P.I.), and University of Padua, Padua (A.F.) - all in Italy; Royal Prince Alfred Hospital, Camperdown, NSW, Australia (S.I.S.); University of California Davis Medical Center, Sacramento (C.B.), Scripps Clinic, La Jolla (P.J.P.), and Intercept Pharmaceuticals, San Diego (R.H.-R., T.M., S.S., R.P., L.M., M.P., D.S.) - all in California; Radboud University Nijmegen Medical Center, Nijmegen (J.P.H.D.), University of Amsterdam, Amsterdam (U.B.), University Medical Center Utrecht, Utrecht (K.J.E.), and University Medical Center Rotterdam, Rotterdam (B.H.) - all in the Netherlands; Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland (J.R.); Medical University of Vienna, Vienna (M.T.); Newcastle University Medical School, Newcastle upon Tyne (D.E.J.), and the Centre for Liver Research, NIHR Biomedical Research Unit, University of Birmingham, Birmingham (G.M.H.) - both in the United Kingdom; Liver Center Munich, Department of Medicine II, University of Munich, Munich, Germany (S.H.); Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond (V.L.), and the Liver Institute of Virginia, Newport News (M.S.) - all in Virginia; the Liver Unit, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas del Instituto de Salud Carlos III, Barcelona (V.V.); Centre Hospitalier de l'Université de Montréal-St. Luc, Montreal (C.V.); University Health Network Toronto Western Hospital, Toronto (H.S.); Arizona State University, Tempe (K.D.L.); Sahlgrenska Academy, University of Gothenburg,

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http://dx.doi.org/10.1056/NEJMoa1509840DOI Listing
August 2016

The Cholangiocyte Glycocalyx Stabilizes the 'Biliary HCO3 Umbrella': An Integrated Line of Defense against Toxic Bile Acids.

Dig Dis 2015 27;33(3):397-407. Epub 2015 May 27.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000371864DOI Listing
March 2016

Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model.

World J Hepatol 2016 Mar;8(8):401-10

Florian P Reiter, Ralf Wimmer, Lena Wottke, Renate Artmann, Jutta M Nagel, Alexander L Gerbes, Simon Hohenester, Gerald U Denk, Department of Medicine II, Liver Center Munich, University of Munich, D-81377 Munich, Germany.

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http://dx.doi.org/10.4254/wjh.v8.i8.401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794530PMC
March 2016

Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review.

Clin Rev Allergy Immunol 2015 Jun;48(2-3):182-91

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12016-014-8423-1DOI Listing
June 2015

1,25-(OH)₂-vitamin D₃ prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model.

Biochem Biophys Res Commun 2015 Apr 21;459(2):227-233. Epub 2015 Feb 21.

Department of Medicine II, Liver Center Munich, University of Munich, Marchioninistr. 15, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2015.02.074DOI Listing
April 2015

Soluble intracellular adhesion molecule, M30 and M65 as serum markers of disease activity and prognosis in cholestatic liver diseases.

Hepatol Res 2014 Dec 28;44(13):1286-98. Epub 2014 Feb 28.

Department of Medicine II - Grosshadern, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/hepr.12304DOI Listing
December 2014

Physiological hypoxia prevents bile salt-induced apoptosis in human and rat hepatocytes.

Liver Int 2014 Sep 20;34(8):1224-31. Epub 2013 Nov 20.

Department of Medicine II, University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/liv.12368DOI Listing
September 2014

Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity.

Hepatology 2013 Apr 18;57(4):1509-17. Epub 2013 Jan 18.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.26133DOI Listing
April 2013

A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.

Hepatology 2012 Jan;55(1):173-83

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.24691DOI Listing
January 2012

Phosphatidylcholines as regulators of glucose and lipid homeostasis: promises and potential risks.

Hepatology 2011 Dec;54(6):2265-7

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology & Hepatology, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.24697DOI Listing
December 2011

Biliary bicarbonate secretion constitutes a protective mechanism against bile acid-induced injury in man.

Dig Dis 2011 17;29(1):62-5. Epub 2011 Jun 17.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000324687DOI Listing
October 2011

The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.

Hepatology 2010 Oct;52(4):1489-96

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.23810DOI Listing
October 2010

PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line.

Am J Physiol Gastrointest Liver Physiol 2009 Dec 8;297(6):G1259-67. Epub 2009 Oct 8.

Dept. of Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, N. Grafton, MA 01536, USA.

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http://dx.doi.org/10.1152/ajpgi.00177.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850086PMC
December 2009

Primary biliary cirrhosis.

Semin Immunopathol 2009 Sep 15;31(3):283-307. Epub 2009 Jul 15.

Department of Gastroenterology & Hepatology/Liver Center, Academic Medical Center, G4-213, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00281-009-0164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758170PMC
September 2009

cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes.

Am J Physiol Gastrointest Liver Physiol 2009 Apr 5;296(4):G764-74. Epub 2009 Feb 5.

Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd., North Grafton, MA 01536, USA.

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http://dx.doi.org/10.1152/ajpgi.90622.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670669PMC
April 2009

Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver.

Hepatol Res 2008 Jul 4;38(7):717-26. Epub 2008 Mar 4.

Department of Medicine II-Grosshadern, Klinikum of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/j.1872-034X.2008.00321.xDOI Listing
July 2008