Simon Gravel

Simon Gravel

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Simon Gravel

Simon Gravel

Publications by authors named "Simon Gravel"

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UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts.

PLoS Genet 2019 Nov 1;15(11):e1008432. Epub 2019 Nov 1.

McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1008432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853336PMC
November 2019

Unbiased estimation of linkage disequilibrium from unphased data.

Mol Biol Evol 2019 Nov 7. Epub 2019 Nov 7.

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/molbev/msz265DOI Listing
November 2019

Legacy Data Confounds Genomics Studies.

Mol Biol Evol 2019 Aug 30. Epub 2019 Aug 30.

Department of Human Genetics, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1093/molbev/msz201DOI Listing
August 2019

A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect.

Hum Mol Genet 2019 06;28(12):2093-2106

Anesthesia and the Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1093/hmg/ddz018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548228PMC
June 2019

Models of archaic admixture and recent history from two-locus statistics.

PLoS Genet 2019 06 10;15(6):e1008204. Epub 2019 Jun 10.

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1008204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586359PMC
June 2019

Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.

Am J Hum Genet 2019 05 25;104(5):815-834. Epub 2019 Apr 25.

CHU-Sainte Justine Research Centre, University of Montreal, Montreal, QC H3T 1C5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507050PMC
May 2019

Genomic inference using diffusion models and the allele frequency spectrum.

Curr Opin Genet Dev 2018 12 23;53:140-147. Epub 2018 Oct 23.

Department of Human Genetics, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2018.10.001DOI Listing
December 2018

On the decidability of population size histories from finite allele frequency spectra.

Theor Popul Biol 2018 03 3;120:42-51. Epub 2018 Jan 3.

Department of Human Genetics, McGill University, Montreal, QC, Canada; McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tpb.2017.12.008DOI Listing
March 2018

Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation.

Genetics 2017 07 11;206(3):1549-1567. Epub 2017 May 11.

Department of Human Genetics and Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A 0G1, Canada

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http://dx.doi.org/10.1534/genetics.117.200493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500150PMC
July 2017

Intratumor Heterogeneity and Circulating Tumor Cell Clusters.

Mol Biol Evol 2017 Jun 12. Epub 2017 Jun 12.

Department of Human Genetics, McGill University, Montréeal, QC, Canada.

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http://dx.doi.org/10.1093/molbev/msy115DOI Listing
June 2017

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Am J Hum Genet 2017 Apr 30;100(4):635-649. Epub 2017 Mar 30.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center of Statistical Genetics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384097PMC
April 2017

When Is Selection Effective?

Authors:
Simon Gravel

Genetics 2016 05 23;203(1):451-62. Epub 2016 Mar 23.

Department of Human Genetics, McGill University, and Genome Quebec Innovation Centre, Montreal, Québec, Canada, H3A 1A4

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http://dx.doi.org/10.1534/genetics.115.184630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858791PMC
May 2016

Computationally Efficient Composite Likelihood Statistics for Demographic Inference.

Mol Biol Evol 2016 Feb 5;33(2):591-3. Epub 2015 Nov 5.

Department of Molecular and Cellular Biology, University of Arizona

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http://dx.doi.org/10.1093/molbev/msv255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854098PMC
February 2016

Estimating the mutation load in human genomes.

Nat Rev Genet 2015 Jun 12;16(6):333-43. Epub 2015 May 12.

McGill University, Department of Human Genetics and Genome Quebec Innovation Centre, 740 Dr Penfield Avenue, Montreal, Quebec H3A 0G1, Canada.

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http://dx.doi.org/10.1038/nrg3931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959039PMC
June 2015

The existence and abundance of ghost ancestors in biparental populations.

Theor Popul Biol 2015 May 19;101:47-53. Epub 2015 Feb 19.

Biomathematics Research Centre, University of Canterbury, New Zealand.

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http://dx.doi.org/10.1016/j.tpb.2015.02.002DOI Listing
May 2015

Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.

Proc Natl Acad Sci U S A 2014 09 18;111(35):E3596-603. Epub 2014 Aug 18.

Sainte-Justine Hospital Research Centre, Montreal, QC, Canada H3T 1C5; Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland;

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http://dx.doi.org/10.1073/pnas.1402875111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156716PMC
September 2014

Predicting discovery rates of genomic features.

Authors:
Simon Gravel

Genetics 2014 Jun 17;197(2):601-10. Epub 2014 Mar 17.

Department of Human Genetics and Génome Québec Innovation Centre, McGill University, Montréal, Quebec H3A 0G1, Canada and

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http://dx.doi.org/10.1534/genetics.114.162149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063918PMC
June 2014

RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference.

Am J Hum Genet 2013 Aug 1;93(2):278-88. Epub 2013 Aug 1.

Department of Genetics, Stanford University, Stanford, CA 94305, USA; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738819PMC
August 2013

Gene flow from North Africa contributes to differential human genetic diversity in southern Europe.

Proc Natl Acad Sci U S A 2013 Jul 3;110(29):11791-6. Epub 2013 Jun 3.

Institut de Biologia Evolutiva, Consejo Superior de Investigaciones Científicas-Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1073/pnas.1306223110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718088PMC
July 2013

Population genetics models of local ancestry.

Authors:
Simon Gravel

Genetics 2012 Jun 4;191(2):607-19. Epub 2012 Apr 4.

Genetics Department, Stanford University, Stanford, California 94305-5120, USA.

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http://dx.doi.org/10.1534/genetics.112.139808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374321PMC
June 2012

Demographic history and rare allele sharing among human populations.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11983-8. Epub 2011 Jul 5.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.

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http://dx.doi.org/10.1073/pnas.1019276108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142009PMC
July 2011

Method for dense packing discovery.

Phys Rev E Stat Nonlin Soft Matter Phys 2010 Nov 8;82(5 Pt 2):056707. Epub 2010 Nov 8.

Laboratory of Atomic and Solid-State Physics, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1103/PhysRevE.82.056707DOI Listing
November 2010

Fine-scale population structure and the era of next-generation sequencing.

Hum Mol Genet 2010 Oct 28;19(R2):R221-6. Epub 2010 Sep 28.

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1093/hmg/ddq403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953744PMC
October 2010

Divide and concur: a general approach to constraint satisfaction.

Phys Rev E Stat Nonlin Soft Matter Phys 2008 Sep 22;78(3 Pt 2):036706. Epub 2008 Sep 22.

Laboratory of Atomic and Solid-State Physics, Cornell University, Ithaca, New York 14853-2501, USA.

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http://dx.doi.org/10.1103/PhysRevE.78.036706DOI Listing
September 2008