Publications by authors named "Simon C Watkins"

100Publications

Michael J. Cullen 1994 - 2020.

Authors:
Simon C Watkins

Neuromuscul Disord 2020 Nov 26. Epub 2020 Nov 26.

Distinguished Professor, Cell Biology, Vice Chairman Cell Biology and Physiology, Professor Immunology, Director, CBI, University of Pittsburgh. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2020.10.011DOI Listing
November 2020

Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype.

Chest 2020 Nov 17. Epub 2020 Nov 17.

Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States;. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2020.10.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671922PMC
November 2020

Endothelial cell polarization and orientation to flow in a novel microfluidic multimodal shear stress generator.

Lab Chip 2020 Nov;20(23):4373-4390

Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1039/d0lc00738bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686155PMC
November 2020

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo.

Redox Biol 2020 Aug 22;37:101695. Epub 2020 Aug 22.

Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2020.101695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486459PMC
August 2020

Fluorogenic Probe Using a Mislow-Evans Rearrangement for Real-Time Imaging of Hydrogen Peroxide.

Angew Chem Int Ed Engl 2020 Jun 25. Epub 2020 Jun 25.

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, 15260, USA.

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http://dx.doi.org/10.1002/anie.202007104DOI Listing
June 2020

Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles.

JCI Insight 2020 Jul 23;5(14). Epub 2020 Jul 23.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.139437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453902PMC
July 2020

Transendothelial Perforations and the Sphere of Influence of Single-Site Sonoporation.

Ultrasound Med Biol 2020 Jul 10;46(7):1686-1697. Epub 2020 May 10.

Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Heart and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293920PMC
July 2020

Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport.

Autophagy 2020 May 25:1-17. Epub 2020 May 25.

Departments of Pathology, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute , Pittsburgh, PA, USA.

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http://dx.doi.org/10.1080/15548627.2020.1761742DOI Listing
May 2020

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca Flux in T-Cell-Receptor-Activated T Cells.

Cell Rep 2020 03;30(10):3448-3465.e8

Department of Immunology, University of Pittsburgh, School of Medicine Pittsburgh, PA, USA; Department of Dermatology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA; The McGowan Center for Regenerative Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169378PMC
March 2020

Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome.

J Cell Physiol 2020 Oct 27;235(10):6767-6778. Epub 2020 Jan 27.

Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.29571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382974PMC
October 2020

P-selectin-deficient mice to study pathophysiology of sickle cell disease.

Blood Adv 2020 01;4(2):266-273

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1182/bloodadvances.2019000603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988409PMC
January 2020

Reciprocal immune enhancement of dengue and Zika virus infection in human skin.

JCI Insight 2020 02 13;5(3). Epub 2020 Feb 13.

Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.133653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098780PMC
February 2020

The role of lipocalin-2 in age-related macular degeneration (AMD).

Cell Mol Life Sci 2020 Mar 4;77(5):835-851. Epub 2020 Jan 4.

Department of Ophthalmology, Children's Hospital of University of Pittsburgh School of Medicine, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.

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http://dx.doi.org/10.1007/s00018-019-03423-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079812PMC
March 2020

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction.

Proc Natl Acad Sci U S A 2019 09 26;116(37):18435-18444. Epub 2019 Aug 26.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1910574116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744920PMC
September 2019

Antigen-dependent interactions between regulatory B cells and T cells at the T:B border inhibit subsequent T cell interactions with DCs.

Am J Transplant 2020 01 30;20(1):52-63. Epub 2019 Aug 30.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1111/ajt.15546DOI Listing
January 2020

Damage sensor role of UV-DDB during base excision repair.

Nat Struct Mol Biol 2019 08 22;26(8):695-703. Epub 2019 Jul 22.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/s41594-019-0261-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684372PMC
August 2019

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication.

Proc Natl Acad Sci U S A 2019 07 17;116(27):13374-13383. Epub 2019 Jun 17.

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1903418116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613105PMC
July 2019

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.

Mol Cell 2019 07 14;75(1):117-130.e6. Epub 2019 May 14.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, and UPMC Hillman Cancer Center, Pittsburgh, PA, USA; Center for Nucleic Acids Science and Technology, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625854PMC
July 2019

Massive volumetric imaging of cleared tissue: The necessary tools to be successful.

Int J Biochem Cell Biol 2019 07 11;112:76-78. Epub 2019 May 11.

The Department of Cell Biology and The Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.biocel.2019.05.007DOI Listing
July 2019

Learn to segment single cells with deep distance estimator and deep cell detector.

Comput Biol Med 2019 05 8;108:133-141. Epub 2019 Apr 8.

Department of Computational and System Biology, University of Pittsburgh, Pittsburgh, PA, 15260, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, 15232, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781873PMC
May 2019

Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration.

Cancer Res 2019 06 5;79(11):2962-2977. Epub 2019 Apr 5.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548579PMC
June 2019

Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission.

J Cell Sci 2019 04 3;132(7). Epub 2019 Apr 3.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA

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http://dx.doi.org/10.1242/jcs.224568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467486PMC
April 2019

CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes.

J Virol 2019 05 17;93(9). Epub 2019 Apr 17.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00214-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475785PMC
May 2019

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.

PLoS Genet 2019 02 14;15(2):e1007720. Epub 2019 Feb 14.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375579PMC
February 2019

Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level.

Angew Chem Int Ed Engl 2019 03 14;58(10):3156-3161. Epub 2019 Feb 14.

Department of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.

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http://dx.doi.org/10.1002/anie.201814256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622167PMC
March 2019

Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells.

Mol Biol Cell 2019 02 26;30(4):506-523. Epub 2018 Dec 26.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-08-0512
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http://dx.doi.org/10.1091/mbc.E18-08-0512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594441PMC
February 2019

The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression.

Biol Psychiatry 2019 03 9;85(6):517-526. Epub 2018 Oct 9.

Campbell Family Mental Health Research Institute of CAMH, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380918PMC
March 2019

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

ACS Chem Biol 2018 10 14;13(10):2868-2879. Epub 2018 Sep 14.

Department of Critical Care Medicine, Safar Center for Resuscitation Research , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania 15260 , United States.

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http://dx.doi.org/10.1021/acschembio.8b00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402482PMC
October 2018

Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality.

Nat Commun 2018 08 23;9(1):3381. Epub 2018 Aug 23.

Department of Developmental Biology, University of Pittsburgh, 3501 5th Avenue, Pittsburgh, PA, 5213, USA.

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http://dx.doi.org/10.1038/s41467-018-05866-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107537PMC
August 2018

Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.

Gastroenterology 2018 10 30;155(4):1218-1232.e24. Epub 2018 Jun 30.

Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.06.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174089PMC
October 2018

High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes.

Invest Ophthalmol Vis Sci 2018 05;59(6):2371-2380

Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1167/iovs.17-23075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939687PMC
May 2018

Light sheet imaging comes of age.

J Cell Biol 2018 05 13;217(5):1567-1569. Epub 2018 Apr 13.

Department of Cell Biology, University of Pittsburgh, Pittsburgh PA

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http://www.jcb.org/lookup/doi/10.1083/jcb.201804016
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http://dx.doi.org/10.1083/jcb.201804016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940317PMC
May 2018

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid.

J Virol 2018 07 13;92(13). Epub 2018 Jun 13.

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00368-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002704PMC
July 2018

Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter.

Elife 2018 04 9;7. Epub 2018 Apr 9.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.

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http://dx.doi.org/10.7554/eLife.32293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896956PMC
April 2018

EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.

Elife 2017 12 21;6. Epub 2017 Dec 21.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.

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http://dx.doi.org/10.7554/eLife.31993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741375PMC
December 2017

14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in T2 and CD8 lymphocytes from patients with scleroderma.

J Allergy Clin Immunol 2018 07 15;142(1):109-119.e6. Epub 2017 Nov 15.

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pa; Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953767PMC
July 2018

Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin.

J Invest Dermatol 2018 03 26;138(3):618-626. Epub 2017 Oct 26.

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.10.018DOI Listing
March 2018

Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response.

Acta Biomater 2018 Jan 31;65:259-271. Epub 2017 Oct 31.

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2017.10.043DOI Listing
January 2018

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Cell 2017 Oct;171(3):628-641.e26

Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173113
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http://dx.doi.org/10.1016/j.cell.2017.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683852PMC
October 2017

Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans.

Hum Mol Genet 2017 12;26(24):4916-4928

Graduate Program in Cell Biology and Molecular Physiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1093/hmg/ddx372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886095PMC
December 2017

A versatile optical tool for studying synaptic GABA receptor trafficking.

J Cell Sci 2017 Nov 12;130(22):3933-3945. Epub 2017 Oct 12.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA

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http://dx.doi.org/10.1242/jcs.205286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702044PMC
November 2017

Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles.

Ultrasound Med Biol 2017 11 25;43(11):2678-2689. Epub 2017 Aug 25.

Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ultrasmedbio.2017.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644032PMC
November 2017

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.

PLoS One 2017 7;12(7):e0180486. Epub 2017 Jul 7.

Center for Biologic Imaging and the Department of Cellular Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501561PMC
October 2017

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells.

Nat Commun 2017 05 31;8:15648. Epub 2017 May 31.

Department of Immunology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1038/ncomms15648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460028PMC
May 2017

Tumor-Derived α-Fetoprotein Directly Drives Human Natural Killer-Cell Activation and Subsequent Cell Death.

Cancer Immunol Res 2017 06 3;5(6):493-502. Epub 2017 May 3.

University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0216DOI Listing
June 2017

Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective.

Curr Protoc Cytom 2017 Apr 3;80:12.45.1-12.45.15. Epub 2017 Apr 3.

Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/cpcy.18DOI Listing
April 2017

Inducible turnover of optineurin regulates T cell activation.

Mol Immunol 2017 05 11;85:9-17. Epub 2017 Feb 11.

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385146PMC
May 2017

Affibody-targeted fluorogen activating protein for in vivo tumor imaging.

Chem Commun (Camb) 2017 Feb;53(12):2001-2004

The Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA. and The Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA and The Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1039/c6cc09137gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340305PMC
February 2017

Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca in putative nociceptive glabrous skin neurons from the rat.

Cell Calcium 2017 03 16;62:16-28. Epub 2017 Jan 16.

Center for Neuroscience University of Pittsburgh, United States; Departments of Neurobiology, University of Pittsburgh School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365154PMC
March 2017

Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.

Mol Cell 2016 10 6;64(2):376-387. Epub 2016 Oct 6.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123691PMC
October 2016

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage.

Cell Rep 2016 09;17(1):221-232

Departments of Pathology and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087334PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.080DOI Listing
September 2016

Biophysical insight into mechanisms of sonoporation.

Proc Natl Acad Sci U S A 2016 09 22;113(36):9983-8. Epub 2016 Aug 22.

Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA 15213; Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1606915113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018802PMC
September 2016

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Immunity 2016 08 2;45(2):374-88. Epub 2016 Aug 2.

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207350PMC
August 2016

Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.

Neurobiol Dis 2016 Nov 22;95:238-49. Epub 2016 Jul 22.

Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010936PMC
November 2016

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.

J Virol 2016 09 26;90(18):8059-73. Epub 2016 Aug 26.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00553-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008097PMC
September 2016

Transient Fcho1/2⋅Eps15/R⋅AP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding.

Dev Cell 2016 06 26;37(5):428-43. Epub 2016 May 26.

Department of Cell Biology, University of Pittsburgh School of Medicine, 3500 Terrace Street, S312 BST, Pittsburgh, PA 15261, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921775PMC
June 2016

Impact of the Sensory Neurons on Melanoma Growth In Vivo.

PLoS One 2016 26;11(5):e0156095. Epub 2016 May 26.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania,United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156095PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882065PMC
July 2017

Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.

Cell Rep 2016 05 12;15(8):1700-14. Epub 2016 May 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI 49008, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880515PMC
May 2016

Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathy.

J Thorac Cardiovasc Surg 2016 Jun 13;151(6):1718-1728.e5. Epub 2016 Feb 13.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2016.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875874PMC
June 2016

Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2122-7. Epub 2016 Feb 8.

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

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http://dx.doi.org/10.1073/pnas.1520301113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776482PMC
February 2016

A genetically targetable near-infrared photosensitizer.

Nat Methods 2016 Mar 25;13(3):263-8. Epub 2016 Jan 25.

Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nmeth.3735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916159PMC
March 2016

Necrostatin-1 rescues mice from lethal irradiation.

Biochim Biophys Acta 2016 04 20;1862(4):850-856. Epub 2016 Jan 20.

Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, United States; Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh, United States; Children's Hospital of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788560PMC
April 2016

Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters.

Med Eng Phys 2016 Feb 6;38(2):121-30. Epub 2015 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Thoracic Aortic Disease, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/j.medengphy.2015.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755864PMC
February 2016