Publications by authors named "Silvia Soddu"

70Publications

The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division.

Proc Natl Acad Sci U S A 2020 Nov 16. Epub 2020 Nov 16.

Unit of Molecular Genetics of Aging, Department of Ecology and Biology, University of Tuscia, 01100 Viterbo, Italy;

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http://dx.doi.org/10.1073/pnas.2006543117DOI Listing
November 2020

Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.

Life Sci Alliance 2020 12 26;3(12). Epub 2020 Oct 26.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University, Rome, Italy

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http://dx.doi.org/10.26508/lsa.202000799DOI Listing
December 2020

HIPK2 Is Required for Midbody Remnant Removal Through Autophagy-Mediated Degradation.

Front Cell Dev Biol 2020 15;8:572094. Epub 2020 Sep 15.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.3389/fcell.2020.572094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525647PMC
September 2020

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers.

J Exp Clin Cancer Res 2020 Mar 4;39(1):46. Epub 2020 Mar 4.

Cellular Networks and Molecular Therapeutic Targets Unit, Department of Research and Advanced Technologies, IRCCS-Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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http://dx.doi.org/10.1186/s13046-020-01554-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055088PMC
March 2020

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis.

Cells 2020 02 20;9(2). Epub 2020 Feb 20.

Unit of Cellular Networks and Molecular Therapeutic Targets; IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.

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http://dx.doi.org/10.3390/cells9020484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072727PMC
February 2020

Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division.

Cells 2019 11 5;8(11). Epub 2019 Nov 5.

Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy.

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http://dx.doi.org/10.3390/cells8111391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912571PMC
November 2019

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission.

Cells 2019 07 5;8(7). Epub 2019 Jul 5.

Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), c/o Sapienza University, 00185 Rome, Italy.

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http://dx.doi.org/10.3390/cells8070684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678495PMC
July 2019

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

Oncogene 2018 06 22;37(26):3562-3574. Epub 2018 Mar 22.

Unit of Cellular Networks and Molecular Therapeutic Targets, Regina Elena National Cancer Institute-IRCCS, Rome, 00144, Italy.

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http://dx.doi.org/10.1038/s41388-018-0191-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021368PMC
June 2018

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Protein Sci 2018 03 28;27(3):725-737. Epub 2017 Dec 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, P.le A. Moro 5, 00185, Italy, Rome.

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http://doi.wiley.com/10.1002/pro.3367
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http://dx.doi.org/10.1002/pro.3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818748PMC
March 2018

HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation.

Oncotarget 2017 Mar;8(10):16744-16754

Unit of Cellular Networks and Molecular Therapeutic Targets, Department of Research, Advanced Diagnostics, and Technological Innovation, Regina Elena National Cancer Institute - IRCCS, Rome, Italy.

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http://dx.doi.org/10.18632/oncotarget.14421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369998PMC
March 2017

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

J Exp Clin Cancer Res 2016 Feb 2;35:24. Epub 2016 Feb 2.

Department of Ecological and Biological Sciences (DEB), La Tuscia University, Largo dell'Università, 01100, Viterbo, Italy.

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http://dx.doi.org/10.1186/s13046-016-0302-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736710PMC
February 2016

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

Oncotarget 2016 Jan;7(2):1675-86

Department of Research, Advanced Diagnostics, and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.18632/oncotarget.6423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811489PMC
January 2016

Prognostic role of serum p53 antibodies in lung cancer.

BMC Cancer 2015 Mar 18;15:148. Epub 2015 Mar 18.

Laboratory of Medical Physic and Expert System, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144, Rome, Italy.

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http://dx.doi.org/10.1186/s12885-015-1174-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374590PMC
March 2015

Abscopal effect of radiation therapy: interplay between radiation dose and p53 status.

Int J Radiat Biol 2015 Mar 4;91(3):294. Epub 2015 Feb 4.

Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.3109/09553002.2014.997514DOI Listing
March 2015

Mutant cohesin drives chromosomal instability in early colorectal adenomas.

Hum Mol Genet 2014 Dec 30;23(25):6773-8. Epub 2014 Jul 30.

Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Pisa, Italy Istituto Toscano Tumori, Firenze, Italy

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http://dx.doi.org/10.1093/hmg/ddu394DOI Listing
December 2014

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status.

Int J Radiat Biol 2014 Mar 6;90(3):248-55. Epub 2014 Feb 6.

Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute , Rome.

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http://www.tandfonline.com/doi/full/10.3109/09553002.2014.87
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http://dx.doi.org/10.3109/09553002.2014.874608DOI Listing
March 2014

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.

J Exp Clin Cancer Res 2013 Nov 19;32:95. Epub 2013 Nov 19.

Experimental Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi, 53-00144 Rome, Italy.

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http://dx.doi.org/10.1186/1756-9966-32-95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176289PMC
November 2013

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

Biochim Biophys Acta 2013 Jun 26;1833(6):1443-53. Epub 2013 Feb 26.

Dipartimento di Oncologia Sperimentale, Istituto Nazionale Tumori Regina Elena, Roma, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2013.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787740PMC
June 2013

p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.

J Clin Invest 2013 Mar 1;123(3):1335-42. Epub 2013 Feb 1.

Department of Experimental Oncology, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1172/JCI67289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582149PMC
March 2013

Serum p53 antibody detection in patients with impaired lung function.

BMC Cancer 2013 Feb 6;13:62. Epub 2013 Feb 6.

Experimental Research Centre, Regina Elena National Cancer Institute, via delle Messi d'Oro 156, 00158, Rome, Italy.

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http://dx.doi.org/10.1186/1471-2407-13-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570357PMC
February 2013

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.

J Exp Clin Cancer Res 2012 Aug 13;31:63. Epub 2012 Aug 13.

Department of Medical, Oral, and Biotechnological Sciences, University "G, d'Annunzio", Chieti 66013, Italy.

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http://dx.doi.org/10.1186/1756-9966-31-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432601PMC
August 2012

Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.

J Biol Chem 2011 08 29;286(33):29005-13. Epub 2011 Jun 29.

Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M111.230854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190708PMC
August 2011

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Mol Cancer Res 2011 Jan 20;9(1):67-77. Epub 2010 Dec 20.

Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0227DOI Listing
January 2011

P53 detection by fluorescence lifetime on a hybrid fluorescein isothiocyanate gold nanosensor.

J Biomed Nanotechnol 2009 Dec;5(6):683-91

Physics Department, Università di Milano Bicocca, Milano 20126, Italy.

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http://dx.doi.org/10.1166/jbn.2009.1085DOI Listing
December 2009

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.

EMBO Rep 2009 Dec 9;10(12):1327-33. Epub 2009 Oct 9.

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy.

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http://dx.doi.org/10.1038/embor.2009.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799202PMC
December 2009

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

Cancer Res 2009 Aug 28;69(15):6241-8. Epub 2009 Jul 28.

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-0337DOI Listing
August 2009

Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

DNA Cell Biol 2009 Apr;28(4):161-7

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1089/dna.2008.0778DOI Listing
April 2009

HIPKs: Jack of all trades in basic nuclear activities.

Biochim Biophys Acta 2008 Nov 18;1783(11):2124-9. Epub 2008 Jun 18.

Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2008.06.006DOI Listing
November 2008

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

Biochem Cell Biol 2007 Aug;85(4):411-8

Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1139/O07-071DOI Listing
August 2007

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

Mol Cell 2007 Mar;25(5):739-50

Department of Experimental Oncology, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.molcel.2007.02.008DOI Listing
March 2007

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

J Clin Invest 2007 Mar 8;117(3):693-702. Epub 2007 Feb 8.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy.

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http://dx.doi.org/10.1172/JCI29852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784001PMC
March 2007

Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: a strategy to convert a radio-resistant phenotype into a radiosensitive one.

Cancer Lett 2006 Jan;231(1):102-12

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.canlet.2005.01.033DOI Listing
January 2006

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

Cell Cycle 2006 Jan 21;5(1):88-92. Epub 2006 Jan 21.

Institute of Biology and Molecular Pathology, National Research Council, Rome, Italy.

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http://dx.doi.org/10.4161/cc.5.1.2269DOI Listing
January 2006

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage.

Oncogene 2005 Aug;24(35):5431-42

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1038/sj.onc.1208717DOI Listing
August 2005

5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking.

FASEB J 2004 Nov 16;18(14):1740-2. Epub 2004 Sep 16.

Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy.

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http://dx.doi.org/10.1096/fj.04-2258fjeDOI Listing
November 2004

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function.

Oncogene 2004 Jul;23(30):5185-92

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy.

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http://dx.doi.org/10.1038/sj.onc.1207656DOI Listing
July 2004

Discrimination of single amino acid mutations of the p53 protein by means of deterministic singularities of recurrence quantification analysis.

Proteins 2004 May;55(3):743-55

Department of Experimental Oncology, Regina Elena Cancer Institute, Via delle Messi d'Oro, Rome, Italy.

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http://dx.doi.org/10.1002/prot.20075DOI Listing
May 2004

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.

Exp Cell Res 2004 Feb;293(2):311-20

Deparment of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1016/j.yexcr.2003.09.032DOI Listing
February 2004

Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy.

Oncogene 2004 Jan;23(2):418-25

Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, Rome 00158, Italy.

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http://dx.doi.org/10.1038/sj.onc.1207042DOI Listing
January 2004

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

J Biol Chem 2003 Sep 7;278(39):37722-9. Epub 2003 Jul 7.

Centre de Recherche INSERM, EMI 0116, 163 Avenue de Luminy, BP172, Parc Scientifique et Technologique de Luminy, 13009 Marseille, France.

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http://dx.doi.org/10.1074/jbc.M301979200DOI Listing
September 2003

Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.

Mol Endocrinol 2002 Jul;16(7):1577-89

Chair of Endocrinology, Second Faculty of Medicine, Università La Sapienza di Roma, Centro Ricerca Ospedale S. Pietro Fatebenefratelli, 00189 Roma, Italy.

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https://academic.oup.com/mend/article/16/7/1577/2741699
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http://dx.doi.org/10.1210/mend.16.7.0881DOI Listing
July 2002