Silvia Parolini

Silvia Parolini

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Silvia Parolini

Silvia Parolini

Publications by authors named "Silvia Parolini"

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The RAC2-PI3K axis regulates human NK cell maturation and function.

Clin Immunol 2019 Sep 3;208:108257. Epub 2019 Sep 3.

Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili di Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.108257DOI Listing
September 2019

A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency.

J Allergy Clin Immunol 2019 Apr 14;143(4):1649-1653.e3. Epub 2019 Jan 14.

Pediatrics Clinic and Institute of Molecular Medicine "A. Nocivelli", Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1016/j.jaci.2019.01.001DOI Listing
April 2019

Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

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http://dx.doi.org/10.3390/ijms20040890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412350PMC
February 2019

CTLA-4 regulates human Natural Killer cell effector functions.

Clin Immunol 2018 09 30;194:43-45. Epub 2018 Jun 30.

Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, Italy.

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http://dx.doi.org/10.1016/j.clim.2018.06.010DOI Listing
September 2018

Response to the Letter to the Editor Regarding "Functional evaluation of natural killer cell cytotoxic activity in NFKB-2 mutated patients".

Immunol Lett 2018 08 30;200:16-17. Epub 2018 May 30.

Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili of Brescia, Italy.

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http://dx.doi.org/10.1016/j.imlet.2018.05.004DOI Listing
August 2018

In vitro treatment with concentrated growth factors (CGF) and sodium orthosilicate positively affects cell renewal in three different human cell lines.

Cell Biol Int 2018 Mar 20;42(3):353-364. Epub 2017 Nov 20.

Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, V.le Europa 11, Brescia, 25123, Italy.

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http://dx.doi.org/10.1002/cbin.10908DOI Listing
March 2018

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 10;8:1244. Epub 2017 Oct 10.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641412PMC
October 2017

Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations.

J Allergy Clin Immunol 2017 Aug 6;140(2):553-564.e4. Epub 2017 Jan 6.

Institute of Molecular Medicine "Angelo Nocivelli," University of Brescia, Brescia, Italy; Department of Experimental and Clinical Sciences, University of Brescia, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.10.051DOI Listing
August 2017

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56 NKG2A Cells, and Yet Display Increased Degranulation and Higher Perforin Content.

Front Immunol 2017 17;8:798. Epub 2017 Jul 17.

Laboratory of Host Defenses, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511964PMC
July 2017

NFKB1 regulates human NK cell maturation and effector functions.

Clin Immunol 2017 02 3;175:99-108. Epub 2016 Dec 3.

Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy.

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http://dx.doi.org/10.1016/j.clim.2016.11.012DOI Listing
February 2017

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization.

J Allergy Clin Immunol 2017 01 27;139(1):335-346.e3. Epub 2016 May 27.

Department of Experimental Medicine, University of Genoa, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jaci.2016.04.025DOI Listing
January 2017

p85α is an intrinsic regulator of human natural killer cell effector functions.

J Allergy Clin Immunol 2016 08 23;138(2):605-608.e3. Epub 2016 Mar 23.

Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia, Spedali Civili di Brescia, Brescia, Italy.

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http://dx.doi.org/10.1016/j.jaci.2016.01.026DOI Listing
August 2016

Defective natural killer-cell cytotoxic activity in NFKB2-mutated CVID-like disease.

J Allergy Clin Immunol 2015 Jun 17;135(6):1641-3. Epub 2015 Jan 17.

Pediatrics Clinic and Institute for Molecular Medicine "Angelo Nocivelli," Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Brescia, Italy.

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http://dx.doi.org/10.1016/j.jaci.2014.11.038DOI Listing
June 2015

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

N Engl J Med 2015 Jun;372(25):2409-22

From the Division of Immunology (K.D., J.C., S.K., M.J.M., K.C., K.F., T.A.C., R.S.G., L.D.N.) and Manton Center for Orphan Disease Research (L.D.N.), Boston Children's Hospital, and Department of Molecular Biology, Massachusetts General Hospital (T.K.O.), Boston, Harvard Stem Cell Institute, Harvard University, Cambridge (L.D.N.), and Department of Pediatrics, University of Massachusetts Medical School, Worcester (A.M.C.) - all in Massachusetts; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (C.D.C., I.B., N.K.S., M.S., C.B., K.B.), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna (K.B.), and CeRUD Vienna Center for Rare and Undiagnosed Diseases (K.B.) - all in Vienna; St. Giles Laboratory of Human Genetics of Infectious Disease, Rockefeller Branch, Rockefeller University (S.-Y.Z., M.A., S.O., B.B., Y.I., L.A., J.-L.C.), and Institute for Genomic Medicine, Columbia University (S. Petrovski, D.B.G.) - both in New York; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (S.-Y.Z., V.P., L.A., J.-L.C.), Paris Descartes University, Sorbonne Paris Cité, Imagine Institute (S.-Y.Z., F.R., P.L., L.A., J.-L.C.), and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children (J.-L.C.) - all in Paris; Howard Hughes Medical Institute, Chevy Chase, MD (J.-L.C.); Department of Molecular and Translational Medicine, University of Brescia, Brescia (S. Parolini, O.P., G.T.), and Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa (A.M.) - both in Italy; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology (E.H.), Institute for Molecular Medicine Finland (J.S.), Children's Hospital (M.K.), Research Programs Unit, Diabetes and Obesity Research Program (M.K.), and Folkhälsan Research Center (M.K.), University of Helsinki and Helsinki University Central Hospital, Helsinki, Tampere Center

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http://dx.doi.org/10.1056/NEJMoa1413462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480434PMC
June 2015

B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape.

Oncoimmunology 2015 Apr 22;4(4):e1001224. Epub 2015 Jan 22.

Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche; Università degli Studi di Genova ; Genova, Italy ; Service d'Immunologie; Assistance Publique-Hôpitaux de Marseille; Hôpital de la Conception ; Marseille, France.

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http://dx.doi.org/10.1080/2162402X.2014.1001224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485754PMC
April 2015

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

J Allergy Clin Immunol 2014 Dec 27;134(6):1381-1387.e7. Epub 2014 Jun 27.

Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jaci.2014.04.043DOI Listing
December 2014

XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

Eur J Immunol 2014 May 27;44(5):1526-34. Epub 2014 Feb 27.

Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1002/eji.201344312DOI Listing
May 2014

Activin A as a mediator of NK-dendritic cell functional interactions.

J Immunol 2014 Feb 6;192(3):1241-8. Epub 2014 Jan 6.

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy;

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http://dx.doi.org/10.4049/jimmunol.1301487DOI Listing
February 2014

Effects of opioid therapy on human natural killer cells.

Int Immunopharmacol 2014 Jan 25;18(1):169-74. Epub 2013 Nov 25.

Department of Molecular and Translational Medicine, Division of Experimental Oncology and Immunology, University of Brescia, Brescia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15675769130046
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http://dx.doi.org/10.1016/j.intimp.2013.11.015DOI Listing
January 2014

Primitive neuroectodermal tumor in an ovarian cystic teratoma: natural killer and neuroblastoma cell analysis.

Case Rep Oncol 2014 Jan 24;7(1):70-8. Epub 2014 Jan 24.

Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, Genoa, Italy.

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http://dx.doi.org/10.1159/000357802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934805PMC
January 2014

Clinical, laboratory and molecular signs of immunodeficiency in patients with partial oculo-cutaneous albinism.

Orphanet J Rare Dis 2013 Oct 17;8:168. Epub 2013 Oct 17.

Department of Experimental and Clinical Sciences, Institute of Molecular Medicine "Angelo Nocivelli", University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1186/1750-1172-8-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856608PMC
October 2013

NK cells and their receptors during viral infections.

Immunotherapy 2011 Sep;3(9):1075-86

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via LB Alberti 2, 16132, Italy.

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http://dx.doi.org/10.2217/imt.11.99DOI Listing
September 2011

Novel insights from adaptor protein 3 complex deficiency.

J Allergy Clin Immunol 2007 Oct;120(4):735-41; quiz 742-3

Istituto di Medicina Molecolare Angelo Nocivelli and Clinica Pediatrica and Dipartimento di Scienze Biomediche e Biotecnologie, University of Brescia, Brescia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749070163
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http://dx.doi.org/10.1016/j.jaci.2007.08.039DOI Listing
October 2007

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency.

Blood 2007 Jun 1;109(11):4873-81. Epub 2007 Feb 1.

Dipartimento di Medicina Sperimentale, Istituto Giannina Gaslini, University of Genoa, Largo G. Gaslini 5, 16147 Genoa, Italy.

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http://dx.doi.org/10.1182/blood-2006-08-038760DOI Listing
June 2007

IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors.

J Immunol 2005 Apr;174(7):3992-8

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.4049/jimmunol.174.7.3992DOI Listing
April 2005