Silvia N J Moreno

Silvia N J Moreno

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Silvia N J Moreno

Publications by authors named "Silvia N J Moreno"

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The Toxoplasma Vacuolar H-ATPase Regulates Intracellular pH and Impacts the Maturation of Essential Secretory Proteins.

Cell Rep 2019 May;27(7):2132-2146.e7

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602-7400, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602-7400, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.038DOI Listing
May 2019

Characterization of Two EF-hand Domain-containing Proteins from Toxoplasma gondii.

J Eukaryot Microbiol 2019 Mar 16;66(2):343-353. Epub 2018 Aug 16.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, 30602.

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http://dx.doi.org/10.1111/jeu.12675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355381PMC
March 2019

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.

Biochim Biophys Acta Mol Cell Res 2018 11 10;1865(11 Pt B):1846-1856. Epub 2018 Aug 10.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183025
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http://dx.doi.org/10.1016/j.bbamcr.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477927PMC
November 2018

Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes.

J Eukaryot Microbiol 2018 07 30;65(5):722-728. Epub 2018 Mar 30.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, 30602.

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http://dx.doi.org/10.1111/jeu.12517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120783PMC
July 2018

Tagging of Weakly Expressed Toxoplasma gondii Calcium-Related Genes with High-Affinity Tags.

J Eukaryot Microbiol 2018 07 11;65(5):709-721. Epub 2018 May 11.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, 30602.

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http://dx.doi.org/10.1111/jeu.12626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175649PMC
July 2018

Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation.

Bioorg Med Chem 2017 12 16;25(24):6435-6449. Epub 2017 Oct 16.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.10.016DOI Listing
December 2017

A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii.

Cell Microbiol 2017 09 17;19(9). Epub 2017 May 17.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1111/cmi.12749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787377PMC
September 2017

Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis.

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA

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http://dx.doi.org/10.1128/AAC.02628-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527628PMC
August 2017

In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites.

Antimicrob Agents Chemother 2017 02 24;61(2). Epub 2017 Jan 24.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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http://dx.doi.org/10.1128/AAC.01590-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278718PMC
February 2017

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.

Molecules 2017 Jan 4;22(1). Epub 2017 Jan 4.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.3390/molecules22010082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155738PMC
January 2017

Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.

ChemMedChem 2016 12 25;11(24):2690-2702. Epub 2016 Nov 25.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina.

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http://dx.doi.org/10.1002/cmdc.201600505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5200956PMC
December 2016

Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS.

J Biol Chem 2015 Nov 15;290(45):26914-26. Epub 2015 Sep 15.

From the Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia 30602

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http://dx.doi.org/10.1074/jbc.M115.652511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646405PMC
November 2015

Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.

ChemMedChem 2015 Jun 27;10(6):1094-108. Epub 2015 Apr 27.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina).

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http://dx.doi.org/10.1002/cmdc.201500100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447534PMC
June 2015

Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C.

Eukaryot Cell 2015 May 13;14(5):486-94. Epub 2015 Mar 13.

Center for Tropical and Emerging Global Disease, University of Georgia, Athens, Georgia, USA Department of Cellular Biology, University of Georgia, Athens, Georgia, USA

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http://dx.doi.org/10.1128/EC.00019-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421009PMC
May 2015

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp.

Cell Calcium 2015 Mar 31;57(3):186-93. Epub 2014 Dec 31.

Center for Tropical and Emerging Global Diseases, Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428288PMC
March 2015

Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells.

PLoS Pathog 2014 Dec 11;10(12):e1004555. Epub 2014 Dec 11.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263762PMC
December 2014

Intracellular calcium channels in protozoa.

Eur J Pharmacol 2014 Sep 28;739:4-18. Epub 2013 Nov 28.

Department of Biology, University of Konstanz, P.O. Box M625, Konstanz 78457, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2013.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037393PMC
September 2014

Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii.

Mol Biol Cell 2014 Sep 2;25(17):2579-91. Epub 2014 Jul 2.

Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405

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http://dx.doi.org/10.1091/mbc.E13-11-0648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148248PMC
September 2014

A vacuolar-H(+) -pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of Toxoplasma gondii.

Mol Microbiol 2014 Aug 16;93(4):698-712. Epub 2014 Jul 16.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, GA, 30602-7400, USA; College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.

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http://dx.doi.org/10.1111/mmi.12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159726PMC
August 2014

Calcium entry in Toxoplasma gondii and its enhancing effect of invasion-linked traits.

J Biol Chem 2014 Jul 27;289(28):19637-47. Epub 2014 May 27.

From the Center for Tropical and Emerging Global Diseases and the Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 and

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http://dx.doi.org/10.1074/jbc.M114.565390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094074PMC
July 2014

Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin.

PLoS Pathog 2013 17;9(10):e1003665. Epub 2013 Oct 17.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798403PMC
May 2014

New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.

Bioorg Med Chem 2014 Jan 13;22(1):398-405. Epub 2013 Nov 13.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902031PMC
January 2014

Polyphosphate and its diverse functions in host cells and pathogens.

PLoS Pathog 2013 2;9(5):e1003230. Epub 2013 May 2.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.

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http://dx.doi.org/10.1371/journal.ppat.1003230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642070PMC
December 2013

Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents.

Eur J Med Chem 2013 Nov 18;69:480-9. Epub 2013 Sep 18.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.ejmech.2013.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831659PMC
November 2013

Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Bioorg Med Chem Lett 2013 Apr 30;23(7):2158-61. Epub 2013 Jan 30.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.01.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602143PMC
April 2013

Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.

Eur J Med Chem 2013 Feb 20;60:431-40. Epub 2012 Dec 20.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582829PMC
February 2013

Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.

Proc Natl Acad Sci U S A 2013 Jan 14;110(5):1887-92. Epub 2013 Jan 14.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1073/pnas.1216955110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562765PMC
January 2013

The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.

Biochemistry 2012 Sep 12;51(38):7533-40. Epub 2012 Sep 12.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1021/bi3005335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618988PMC
September 2012

Calcium storage and function in apicomplexan parasites.

Essays Biochem 2011 ;51:97-110

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1042/bse0510097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488345PMC
June 2012

1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase.

Org Biomol Chem 2012 Feb 3;10(7):1424-33. Epub 2012 Jan 3.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina.

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http://dx.doi.org/10.1039/c1ob06602aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458512PMC
February 2012

The role of acidocalcisomes in the stress response of Trypanosoma cruzi.

Adv Parasitol 2011 ;75:307-24

Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, GA, USA

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http://dx.doi.org/10.1016/B978-0-12-385863-4.00014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427654PMC
December 2011

Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii.

Biochem J 2011 Dec;440(2):229-40

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1042/BJ20110641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874478PMC
December 2011

Acidocalcisomes.

Cell Calcium 2011 Aug 12;50(2):113-9. Epub 2011 Jul 12.

Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens 30602, USA.

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http://dx.doi.org/10.1016/j.ceca.2011.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156361PMC
August 2011

A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion.

Exp Cell Res 2011 Jun 9;317(10):1382-96. Epub 2011 Apr 9.

Department of Biological Sciences, University of Idaho, Life Sciences South Room 142, Moscow, ID 83844, USA.

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http://dx.doi.org/10.1016/j.yexcr.2011.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096714PMC
June 2011

TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii.

Mol Biochem Parasitol 2011 Apr 30;176(2):121-6. Epub 2010 Dec 30.

Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Microbial Sciences Building Room 3345, 1550 Linden Drive, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2010.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042031PMC
April 2011

Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

Bioorg Med Chem 2011 Apr;19(7):2211-7

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.bmc.2011.02.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071284PMC
April 2011

Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii.

PLoS One 2011 Apr 25;6(4):e18390. Epub 2011 Apr 25.

Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018390PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081817PMC
April 2011

Identification of contractile vacuole proteins in Trypanosoma cruzi.

PLoS One 2011 Mar 18;6(3):e18013. Epub 2011 Mar 18.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018013PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060929PMC
March 2011

Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis.

Infect Immun 2010 Oct 19;78(10):4206-12. Epub 2010 Jul 19.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602-2607, USA.

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http://dx.doi.org/10.1128/IAI.00473-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950344PMC
October 2010

Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.

J Biol Chem 2010 Oct 20;285(40):30906-17. Epub 2010 Jul 20.

Department of Cellular Biology, University of Georgia, Center for Tropical and Emerging Global Diseases, Athens, Georgia 30602, USA.

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http://dx.doi.org/10.1074/jbc.M110.142190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945582PMC
October 2010

Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes.

Philos Trans R Soc Lond B Biol Sci 2010 Mar;365(1541):775-84

Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1098/rstb.2009.0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817225PMC
March 2010

The role of acidocalcisomes in parasitic protists.

J Eukaryot Microbiol 2009 May-Jun;56(3):208-13

Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, 30602, USA.

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http://doi.wiley.com/10.1111/j.1550-7408.2009.00404.x
Publisher Site
http://dx.doi.org/10.1111/j.1550-7408.2009.00404.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802266PMC
August 2009

The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites.

Curr Pharm Des 2008 ;14(9):882-8

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664259PMC
June 2008

Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

Bioorg Med Chem 2008 Mar 10;16(6):3283-90. Epub 2007 Dec 10.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.bmc.2007.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330165PMC
March 2008

Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii.

Expert Opin Ther Targets 2008 Mar;12(3):253-63

University of Georgia, Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, 500 D. W. Brooks Dr, Athens, Georgia 30602, USA.

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http://dx.doi.org/10.1517/14728222.12.3.253DOI Listing
March 2008

Acidocalcisomes in Apicomplexan parasites.

Exp Parasitol 2008 Jan 3;118(1):2-9. Epub 2007 Aug 3.

Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, 350 Paul D. Coverdell Center, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1016/j.exppara.2007.07.009DOI Listing
January 2008

Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.

Antimicrob Agents Chemother 2007 Nov 13;51(11):3816-23. Epub 2007 Aug 13.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1128/AAC.00582-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151471PMC
November 2007

The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates.

J Biol Chem 2007 Oct 27;282(42):30804-16. Epub 2007 Aug 27.

Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1074/jbc.M703178200DOI Listing
October 2007

Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.

Bioorg Med Chem Lett 2007 Sep 13;17(18):5068-71. Epub 2007 Jul 13.

Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.bmcl.2007.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707766PMC
September 2007

Drugs Against Protozoan Parasites - a Keystone Symposium.

IDrugs 2007 Apr;10(4):240-2

University of Georgia, 500 DW Brooks Drive, Paul Coverdell Center, Athens, GA 30602, USA.

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April 2007

A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol.

Biochem J 2006 Mar;394(Pt 2):417-25

Department of Cellular Biology, and Center for Tropical and Emerging Global Diseases, The University of Georgia, Athens, GA 30602, USA.

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http://www.biochemj.org/content/ppbiochemj/394/2/417.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20051393
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http://dx.doi.org/10.1042/BJ20051393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408672PMC
March 2006

A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte.

J Biol Chem 2005 Nov 31;280(44):36841-7. Epub 2005 Aug 31.

Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

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http://dx.doi.org/10.1074/jbc.M507727200DOI Listing
November 2005

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.

J Med Chem 2005 May;48(9):3130-40

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61802, USA.

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http://dx.doi.org/10.1021/jm040132tDOI Listing
May 2005

A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi.

J Biol Chem 2005 Apr 14;280(16):16235-43. Epub 2005 Feb 14.

Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

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http://dx.doi.org/10.1074/jbc.M414535200DOI Listing
April 2005

Acidocalcisomes - conserved from bacteria to man.

Nat Rev Microbiol 2005 Mar;3(3):251-61

Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, Georgia 30602, USA.

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http://www.nature.com/doifinder/10.1038/nrmicro1097
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http://dx.doi.org/10.1038/nrmicro1097DOI Listing
March 2005

The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence.

Mol Microbiol 2005 Feb;55(4):1034-45

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2004.04464.xDOI Listing
February 2005

Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii.

J Cell Sci 2004 Nov 26;117(Pt 24):5739-48. Epub 2004 Oct 26.

Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jcs.01495DOI Listing
November 2004

Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum.

Microsc Microanal 2004 Oct;10(5):563-7

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

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http://dx.doi.org/10.1017/S1431927604040875DOI Listing
October 2004

Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ.

J Biol Chem 2004 Jan 15;279(1):385-93. Epub 2003 Oct 15.

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

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http://dx.doi.org/10.1074/jbc.M307264200DOI Listing
January 2004

Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes.

J Biol Chem 2003 Aug 3;278(32):29971-8. Epub 2003 Jun 3.

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

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http://dx.doi.org/10.1074/jbc.M304548200DOI Listing
August 2003

Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote.

Eukaryot Cell 2003 Aug;2(4):756-68

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61802, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC178363PMC
http://dx.doi.org/10.1128/ec.2.4.756-768.2003DOI Listing
August 2003

Calcium regulation in protozoan parasites.

Curr Opin Microbiol 2003 Aug;6(4):359-64

Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

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August 2003

Current chemotherapy of human African trypanosomiasis.

Parasitol Res 2003 Jun 23;90 Supp 1:S10-3. Epub 2002 Nov 23.

Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.

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http://dx.doi.org/10.1007/s00436-002-0752-yDOI Listing
June 2003

Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate.

J Biol Chem 2002 Dec 11;277(50):48650-6. Epub 2002 Oct 11.

Laboratory of Molecular Parasitology, Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, 61802, USA.

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http://dx.doi.org/10.1074/jbc.M208990200DOI Listing
December 2002

Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores.

J Biol Chem 2002 Jul 13;277(29):25870-6. Epub 2002 May 13.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M202553200
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July 2002

Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.

FEBS Lett 2002 Jul;523(1-3):207-12

Departments of Chemistry and Biophysics, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

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July 2002

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii.

Antimicrob Agents Chemother 2002 Mar;46(3):929-31

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127510PMC
http://dx.doi.org/10.1128/aac.46.3.929-931.2002DOI Listing
March 2002