Silvia Deaglio

Silvia Deaglio

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Silvia Deaglio

Publications by authors named "Silvia Deaglio"

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NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation.

Front Oncol 2020 19;10:358. Epub 2020 Mar 19.

Laboratory of Tumor Immunogenetics, Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.3389/fonc.2020.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096376PMC
March 2020

Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT).

Semin Cell Dev Biol 2020 02 14;98:192-201. Epub 2019 May 14.

Department of Medical Sciences, University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, Turin, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.05.001DOI Listing
February 2020

HLA typing in lung transplantation: does high resolution fit all?

Ann Transl Med 2020 Feb;8(3):45

AOU Città della Salute e della Scienza University Hospital, Turin, Italy.

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http://dx.doi.org/10.21037/atm.2020.01.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036624PMC
February 2020

Ectonucleotidases in Blood Malignancies: A Tale of Surface Markers and Therapeutic Targets.

Front Immunol 2019 4;10:2301. Epub 2019 Oct 4.

Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.3389/fimmu.2019.02301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788384PMC
October 2019

Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.

Handb Exp Pharmacol 2018;249:203-229

Human Genetics Foundation, via Nizza 52, Turin, 10126, Italy.

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http://dx.doi.org/10.1007/164_2017_12DOI Listing
June 2019

Genomic Mismatch at Locus and Kidney Allograft Rejection.

N Engl J Med 2019 05;380(20):1918-1928

From the Department of Medicine, Division of Nephrology (N.J.S., Y.L., J.A.D., C.F., L.L., K.X., Y.-J.N., Y.D.N., J.Y.Z., R.S., O.B., D.B., N.O., F.O., S.G., K.M., J.W., S.M., J.R., D.J.C., J.B., A.G.G., K.K.), the Department of Surgery (L.E.R.), and the Department of Pathology and Cell Biology (E.-R.M.V., G.V., V.D.), Vagelos College of Physicians and Surgeons, and the Departments of Epidemiology (S.M.) and Biostatistics (I.I.-L.), Mailman School of Public Health, Columbia University, New York; Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, and Medical Genetics, Department of Medical Sciences, University of Turin, Turin (Z.D., S.D., A.A.), and the Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia (F.S.) - all in Italy; the Department of Pathology, M.D. Anderson Cancer Center, Houston (F.Z.J.); the Division of Genetics and Genomics, Boston Children's Hospital, and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (M.R.); the Department of Pediatrics, Division of Pediatric Nephrology, University of Michigan School of Medicine, Ann Arbor (C.E.G., M.G.S.); the Department of Medicine, Renal, Electrolyte, and Hypertension Division, University of Pennsylvania, Philadelphia (Y.-A.K., K.S.); the Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey (Y.C.); the Nephrology Research Group, Queen's University of Belfast, Belfast, United Kingdom (A.E.C., A.P.M., A.J.M.); and the Department of Internal Medicine, Division of Nephrology (S.J.L.B., M.H.B.), and the Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics (H.S.), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1056/NEJMoa1803731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589355PMC
May 2019

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies.

Front Oncol 2018 26;8:550. Epub 2018 Nov 26.

Italian Institute for Genomic Medicine, Turin, Italy.

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http://dx.doi.org/10.3389/fonc.2018.00550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275466PMC
November 2018

Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?

Int J Mol Sci 2018 Apr 12;19(4). Epub 2018 Apr 12.

Department of Medical Sciences, University of Turin School of Medicine & Italian Institute for Genomic Medicine (IIGM), via Nizza, 52, 10126 Torino, Italy.

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http://dx.doi.org/10.3390/ijms19041167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979564PMC
April 2018

Linking SLAMF1 to autophagy and sensitivity to therapy in chronic lymphocytic leukemia.

Mol Cell Oncol 2018 10;5(3):e1143077. Epub 2018 Apr 10.

Department of Medical Sciences, University of Torino, Italy.

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http://dx.doi.org/10.1080/23723556.2016.1143077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149729PMC
April 2018

miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer.

Cancer Res 2016 09 21;76(17):5151-62. Epub 2016 Jun 21.

Molecular Biotechnology Center (MBC), University of Torino, Torino, Italy. Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1322DOI Listing
September 2016

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells.

J Vis Exp 2016 07 20(113). Epub 2016 Jul 20.

Department of Medical Sciences, Human Genetics Foundation (HuGeF), University of Turin;

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http://www.jove.com/video/54124/hplc-based-assay-to-monitor-
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http://dx.doi.org/10.3791/54124DOI Listing
July 2016

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts.

Blood 2016 Jan 13;127(2):221-32. Epub 2015 Oct 13.

Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy; Department of Pathology, New York University Cancer Center, New York University School of Medicine, New York, NY.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-614503DOI Listing
January 2016

Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases.

Mediterr J Hematol Infect Dis 2012 9;4(1):e2012053. Epub 2012 Aug 9.

Department of Onco-Hematology, IRCCS "Centro di Riferimento Oncologico della Basilicata", Rionero in Vulture, Italy.

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http://dx.doi.org/10.4084/MJHID.2012.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435126PMC
October 2015

Multiple metamorphoses of CD38 from prognostic marker to disease modifier to therapeutic target in chronic lymphocytic leukemia.

Curr Top Med Chem 2013 ;13(23):2955-64

Department of Medical Sciences, University of Turin School of Medicine & Human Genetics Foundation (HuGeF), via Nizza, 52, 10126 Torino, Italy.

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http://dx.doi.org/10.2174/15680266113136660210DOI Listing
August 2014

Anti-CD44 mAb for the treatment of B-cell chronic lymphocytic leukemia and other hematological malignancies: evaluation of WO2013063498.

Expert Opin Ther Pat 2014 Jul 6;24(7):821-8. Epub 2014 May 6.

IRCCS "Centro di Riferimento Oncologico della Basilicata", Hematology Oncology Department , 85028 Rionero in Vulture , Italy +39 0972 726521 ; +39 0972 726217 ;

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http://dx.doi.org/10.1517/13543776.2014.915942DOI Listing
July 2014

rs2072135, a low-penetrance variant for chronic lymphocytic leukaemia?

Br J Haematol 2013 Jul 14;162(2):221-8. Epub 2013 May 14.

Division of Genetics and Epidemiology, Molecular and Population Genetics, Institute of Cancer Research, Sutton, UK.

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http://dx.doi.org/10.1111/bjh.12366DOI Listing
July 2013

The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia.

Haematologica 2013 Jun 8;98(6):953-63. Epub 2013 Jan 8.

Human Genetics Foundation (HuGeF) and Department of Medical Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.3324/haematol.2012.077537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669453PMC
June 2013

Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.

J Mol Med (Berl) 2013 Feb 6;91(2):165-72. Epub 2013 Jan 6.

Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, Denmark Hill, SE5 9RS, London, UK.

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http://dx.doi.org/10.1007/s00109-012-0991-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266600PMC
February 2013

Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options.

Cancer Lett 2013 Jan 19;328(1):27-35. Epub 2012 Aug 19.

Department of Medical Sciences, University of Turin, School of Medicine, Turin, Italy; Human Genetics Foundation (HuGeF), Turin, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835120048
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http://dx.doi.org/10.1016/j.canlet.2012.08.012DOI Listing
January 2013

Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy.

Curr Pharm Des 2012 ;18(23):3323-34

Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, PN, Italy.

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http://dx.doi.org/10.2174/138161212801227078DOI Listing
December 2012

Chronic lymphocytic leukemia after chronic myeloid leukemia in the same patient: two different genomic events and a common treatment?

J Clin Oncol 2012 Nov 24;30(32):e327-30. Epub 2012 Sep 24.

Department of Onco-Hematology, Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Via Padre Pio n. 1, 85028 Rionero in Vulture (Pz), Italy.

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http://dx.doi.org/10.1200/JCO.2012.42.6767DOI Listing
November 2012

CD38 and chronic lymphocytic leukemia: a decade later.

Blood 2011 Sep 15;118(13):3470-8. Epub 2011 Jul 15.

Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Torino, Italy.

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http://www.bloodjournal.org/content/118/13/3470.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-06-27
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http://dx.doi.org/10.1182/blood-2011-06-275610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574275PMC
September 2011

Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.

Adv Pharmacol 2011 ;61:301-32

Department of Genetics, Biology, and Biochemistry, University of Turin & Human Genetics Foundation, Italy.

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http://dx.doi.org/10.1016/B978-0-12-385526-8.00010-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879773PMC
August 2011

A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine.

FEMS Immunol Med Microbiol 2011 Jul 28;62(2):215-24. Epub 2011 Apr 28.

Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1111/j.1574-695X.2011.00802.xDOI Listing
July 2011

NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model.

FEBS Lett 2011 Jun 19;585(11):1514-20. Epub 2011 Apr 19.

Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1016/j.febslet.2011.04.036DOI Listing
June 2011

Variable impact of CD39 in experimental murine colitis.

Dig Dis Sci 2011 May 9;56(5):1393-403. Epub 2010 Oct 9.

Transplant Institute and Gastroenterology Division, Beth Israel Deaconess Medical Centre/Harvard Medical School, Harvard University, Boston, MA 02215, USA.

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http://dx.doi.org/10.1007/s10620-010-1425-9DOI Listing
May 2011

CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells.

Semin Cancer Biol 2010 Dec 9;20(6):416-23. Epub 2010 Sep 9.

Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Turin, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2010.08.003DOI Listing
December 2010

Chronic lymphocytic leukemia-associated immune thrombocytopenia treated with rituximab: a retrospective study of 21 patients.

Eur J Haematol 2010 Dec 8;85(6):502-7. Epub 2010 Nov 8.

Hematology and Stem Cell Transplantation Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.

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http://dx.doi.org/10.1111/j.1600-0609.2010.01527.xDOI Listing
December 2010

The hidden life of NAD+-consuming ectoenzymes in the endocrine system.

J Mol Endocrinol 2010 Oct 21;45(4):183-91. Epub 2010 Jul 21.

Laboratory of Immunogenetics and CeRMS, Department of Genetics, Biology and Biochemistry, University of Torino School of Medicine, Turin, Italy.

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https://jme.bioscientifica.com/view/journals/jme/45/4/183.xm
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http://dx.doi.org/10.1677/JME-10-0082DOI Listing
October 2010

TfR2 expression in human colon carcinomas.

Blood Cells Mol Dis 2009 Nov-Dec;43(3):243-9. Epub 2009 Sep 2.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2009.08.001DOI Listing
December 2009

CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus.

Mol Med 2009 Mar-Apr;15(3-4):76-84. Epub 2008 Nov 19.

Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy.

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http://dx.doi.org/10.2119/molmed.2008.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593003PMC
April 2009

Regulation of transferrin receptor 2 in human cancer cell lines.

Blood Cells Mol Dis 2009 Jan-Feb;42(1):5-13. Epub 2008 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2008.10.001DOI Listing
February 2009

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.

Physiol Rev 2008 Jul;88(3):841-86

Laboratory of Immunogenetics, Department of Genetics, Biology, and Biochemistry and Centro di Ricerca in Medicina Sperimentale, University of Torino Medical School, Torino, Italy.

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http://www.physiology.org/doi/10.1152/physrev.00035.2007
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http://dx.doi.org/10.1152/physrev.00035.2007DOI Listing
July 2008

CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?

Blood 2008 Jun 18;111(12):5646-53. Epub 2008 Apr 18.

Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy.

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http://dx.doi.org/10.1182/blood-2008-01-129726DOI Listing
June 2008

CD38 at the junction between prognostic marker and therapeutic target.

Trends Mol Med 2008 May 9;14(5):210-8. Epub 2008 Apr 9.

Department of Genetics, Laboratory of Immunogenetics, Biology and Biochemistry and CeRMS, Via Santena 19, 10126 Torino, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S147149140800081
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http://dx.doi.org/10.1016/j.molmed.2008.02.005DOI Listing
May 2008

Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.

Haematologica 2007 Oct;92(10):1359-66

Division of Investigative Sciences, Department of Haematology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.3324/haematol.11340DOI Listing
October 2007

Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia.

Am J Hematol 2007 Sep;82(9):787-91

Hematology Oncology Unit, National Cancer Institute, Fondazione G. Pascale, Via Mariano Semmola, Naples, Italy.

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http://dx.doi.org/10.1002/ajh.20936DOI Listing
September 2007

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.

J Exp Med 2007 Jun 14;204(6):1257-65. Epub 2007 May 14.

Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20062512
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http://dx.doi.org/10.1084/jem.20062512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118603PMC
June 2007

CD39 and control of cellular immune responses.

Purinergic Signal 2007 Mar 6;3(1-2):171-80. Epub 2007 Feb 6.

Immunology Research Centre, St. Vincent’s Health, Melbourne, Australia.

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http://link.springer.com/10.1007/s11302-006-9050-y
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http://dx.doi.org/10.1007/s11302-006-9050-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096766PMC
March 2007

The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes.

Purinergic Signal 2006 Jun 30;2(2):431-41. Epub 2006 May 30.

Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, and Research Center on Experimental Medicine, University of Torino Medical School, via Santena, 19, 10126, Torino, Italy.

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http://dx.doi.org/10.1007/s11302-006-9002-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096639PMC
June 2006