Silvia Chaves

Silvia Chaves

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Silvia Chaves

Silvia Chaves

Publications by authors named "Silvia Chaves"

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New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.

Molecules 2019 Feb 7;24(3). Epub 2019 Feb 7.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.3390/molecules24030587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385087PMC
February 2019

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1212-1224

a Centro de Química Estrutural, Instituto Superior Técnico , Universidade de Lisboa , Lisbon , Portugal.

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http://dx.doi.org/10.1080/14756366.2018.1491564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127844PMC
December 2018

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug.

Metallomics 2018 10 5;10(10):1460-1475. Epub 2018 Sep 5.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal.

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http://dx.doi.org/10.1039/c8mt00143jDOI Listing
October 2018

Pure optic ataxia and visual hemiagnosia - extending the dual visual hypothesis.

J Neuropsychol 2018 Jun 4;12(2):271-290. Epub 2017 Mar 4.

Department of Neurology, Inselspital, University Hospital Bern, Switzerland.

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http://dx.doi.org/10.1111/jnp.12119DOI Listing
June 2018

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.

Eur J Med Chem 2018 Mar 12;148:255-267. Epub 2018 Feb 12.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.02.023DOI Listing
March 2018

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update.

Curr Med Chem 2018 ;25(1):97-112

Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa. Portugal.

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http://dx.doi.org/10.2174/0929867324666170330092304DOI Listing
February 2018

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.

J Inorg Biochem 2018 02 21;179:82-96. Epub 2017 Nov 21.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2017.11.015DOI Listing
February 2018

Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.

Future Med Chem 2016 Nov 24;8(17):2113-2142. Epub 2016 Oct 24.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.4155/fmc-2016-0103DOI Listing
November 2016

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity.

J Inorg Biochem 2016 10 13;163:266-277. Epub 2016 May 13.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2016.05.005DOI Listing
October 2016

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.

Chem Biol Drug Des 2016 Jan 29;87(1):101-11. Epub 2015 Sep 29.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal.

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http://dx.doi.org/10.1111/cbdd.12633DOI Listing
January 2016

3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.

Future Med Chem 2015 ;7(3):383-410

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.

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http://dx.doi.org/10.4155/fmc.14.162DOI Listing
December 2015

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles.

J Inorg Biochem 2015 Oct 10;151:58-66. Epub 2015 Jun 10.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jinorgbio.2015.06.008DOI Listing
October 2015

In your eyes only: deficits in executive functioning after frontal TMS reflect in eye movements.

Front Behav Neurosci 2014 27;8. Epub 2014 Jan 27.

Perception and Eye Movement Laboratory, Department of Neurology and Clinical Research, University Hospital Bern Inselspital Bern, Switzerland ; Center for Cognition, Learning, and Memory, University of Bern Bern, Switzerland.

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http://dx.doi.org/10.3389/fnbeh.2014.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902210PMC
January 2014

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.

J Inorg Biochem 2013 Oct 16;127:188-202. Epub 2013 Mar 16.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jinorgbio.2013.03.003DOI Listing
October 2013

Progression of liver fibrosis in monoinfected patients by hepatitis C virus and coinfected by HCV and human immunodeficiency virus.

Arq Gastroenterol 2013 Jan-Mar;50(1):19-22

Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil.

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September 2013

A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies.

Dalton Trans 2013 May 6;42(17):6033-45. Epub 2012 Dec 6.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1039/c2dt32361cDOI Listing
May 2013

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties.

Dalton Trans 2013 May 7;42(17):6046-57. Epub 2013 Jan 7.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1039/c2dt32237dDOI Listing
May 2013

Multifunctional iron-chelators with protective roles against neurodegenerative diseases.

Dalton Trans 2013 May 13;42(17):6058-73. Epub 2013 Mar 13.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1039/c3dt50406aDOI Listing
May 2013

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: physico-chemical properties and anti-oxidant activity.

J Inorg Biochem 2012 Sep 4;114:38-46. Epub 2012 May 4.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jinorgbio.2012.04.019DOI Listing
September 2012

New tris(hydroxypyridinones) as iron and aluminium sequestering agents: synthesis, complexation and in vivo studies.

Chemistry 2010 Sep;16(34):10535-45

Centro de Química Estrutural, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1002/chem.201001335DOI Listing
September 2010

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity.

Metallomics 2010 Mar 9;2(3):220-7. Epub 2009 Nov 9.

Centro de Química Estrutural, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1039/b914169cDOI Listing
March 2010

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: solution and biodistribution studies.

J Inorg Biochem 2009 Nov 15;103(11):1521-9. Epub 2009 Aug 15.

Centro de Química Estrutural, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.

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http://linkinghub.elsevier.com/retrieve/pii/S016201340900176
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http://dx.doi.org/10.1016/j.jinorgbio.2009.07.026DOI Listing
November 2009

A bis(3-hydroxy-4-pyridinone)-EDTA derivative as a strong chelator for M3+ hard metal ions: complexation ability and selectivity.

Dalton Trans 2009 Aug 9(31):6141-50. Epub 2009 Jun 9.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.

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http://xlink.rsc.org/?DOI=b904950a
Publisher Site
http://dx.doi.org/10.1039/b904950aDOI Listing
August 2009

Linking physiology with behaviour: Functional specialisation of the visual field is reflected in gaze patterns during visual search.

Vision Res 2009 Jan 10;49(2):237-48. Epub 2008 Dec 10.

Perception & Eye Movement Laboratory, Departments of Neurology and Clinical Research, University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.visres.2008.10.021DOI Listing
January 2009

New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs.

Front Biosci 2008 May 1;13:6763-74. Epub 2008 May 1.

Centro de Neurociencias e Biologia Celular, Universidade de Coimbra, 3030 Coimbra, Portugal.

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May 2008

Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition.

Dalton Trans 2008 Apr 20(13):1773-82. Epub 2008 Feb 20.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001, Lisboa, Portugal.

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http://xlink.rsc.org/?DOI=b717172b
Publisher Site
http://dx.doi.org/10.1039/b717172bDOI Listing
April 2008

Neglect-like visual exploration behaviour after theta burst transcranial magnetic stimulation of the right posterior parietal cortex.

Eur J Neurosci 2008 Apr 26;27(7):1809-13. Epub 2008 Mar 26.

Perception and Eye Movement Laboratory, Department of Neurology, Department of Clinical Research, Inselspital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.

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http://doi.wiley.com/10.1111/j.1460-9568.2008.06154.x
Publisher Site
http://dx.doi.org/10.1111/j.1460-9568.2008.06154.xDOI Listing
April 2008

New silica-immobilized hydroxypyrimidinone as sorbent of hard metal ions from aqueous fluids.

J Inorg Biochem 2005 Sep;99(9):1762-8

INETI, Departamento de Tecnologia de Indústrias Químicas, Estrada do Paço do Lumiar, 1649-038 Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jinorgbio.2005.06.012DOI Listing
September 2005

Bifunctional 3-hydroxy-4-pyridinone derivatives as potential pharmaceuticals: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation with 67Ga.

J Biol Inorg Chem 2005 Aug 23;10(5):564-80. Epub 2005 Sep 23.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1007/s00775-005-0003-7DOI Listing
August 2005

N-Arylamine derivatives of 3-hydroxy-4-pyridinones: solution studies and bioevaluation in view of Al-detoxification roles.

Anal Bioanal Chem 2005 Jan 29;381(2):413-9. Epub 2004 Sep 29.

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

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http://dx.doi.org/10.1007/s00216-004-2823-7DOI Listing
January 2005

Iminodiacetyl-hydroxamate derivatives as metalloproteinase inhibitors: equilibrium complexation studies with Cu(II), Zn(II) and Ni(II).

J Inorg Biochem 2003 Dec;97(4):345-53

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001, Lisboa, Portugal.

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December 2003

Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application.

J Inorg Biochem 2003 Sep;97(1):161-72

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.

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September 2003

N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation.

J Inorg Biochem 2002 Sep;92(1):43-54

Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Av. Rovisco Pais, Lisbon, Portugal.

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September 2002