Publications by authors named "Silvia Buonamici"

52Publications

Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer.

Nat Commun 2020 04 29;11(1):2089. Epub 2020 Apr 29.

Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York, 14263, USA.

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http://dx.doi.org/10.1038/s41467-020-15815-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190674PMC
April 2020

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

EBioMedicine 2019 Jan 20;39:215-225. Epub 2018 Dec 20.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Italy; CNR-Nano, Institute of Nanoscience and Nanotechnology, Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183060
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http://dx.doi.org/10.1016/j.ebiom.2018.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355829PMC
January 2019

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Cancer Cell 2018 08;34(2):225-241.e8

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, Zuckerman 701, 408 East 69(th) Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373472PMC
August 2018

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

Mol Cell 2018 04 12;70(2):265-273.e8. Epub 2018 Apr 12.

Research Group Macromolecular Crystallography, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183021
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http://dx.doi.org/10.1016/j.molcel.2018.03.011DOI Listing
April 2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Cancer Cell 2018 03 22;33(3):386-400.e5. Epub 2018 Feb 22.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849534PMC
March 2018

Targeting splicing abnormalities in cancer.

Curr Opin Genet Dev 2018 02 12;48:67-74. Epub 2017 Nov 12.

H3 Biomedicine, Inc., Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.10.010DOI Listing
February 2018

Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival.

Mol Cancer Ther 2017 Dec 6;16(12):2849-2861. Epub 2017 Sep 6.

Division of Computational Biomedicine, Department of Surgery, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997774PMC
December 2017

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia.

Cancer Cell 2016 Nov 3;30(5):750-763. Epub 2016 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 540, 44 Binney Street, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127278PMC
November 2016

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Nat Med 2013 Nov 29;19(11):1518-23. Epub 2013 Sep 29.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [4] Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/nm.3328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923315PMC
November 2013

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.

J Exp Med 2008 Jun 12;205(6):1395-408. Epub 2008 May 12.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1084/jem.20080277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413036PMC
June 2008

Molecular pathogenesis of T-cell leukaemia and lymphoma.

Nat Rev Immunol 2008 May;8(5):380-90

Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nri2304DOI Listing
May 2008

Notches, NFkappaBs and the making of T cell leukemia.

Cell Cycle 2007 Feb 17;6(4):403-6. Epub 2007 Feb 17.

Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.4161/cc.6.4.3858DOI Listing
February 2007

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

Nat Med 2007 Jan 17;13(1):70-7. Epub 2006 Dec 17.

Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nm1524DOI Listing
January 2007

EVI1 abrogates interferon-alpha response by selectively blocking PML induction.

J Biol Chem 2005 Jan 1;280(1):428-36. Epub 2004 Nov 1.

Department of Pathology and Cancer Center, University of Illinois, Chicago, Illinois 60607, USA.

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http://dx.doi.org/10.1074/jbc.M410836200DOI Listing
January 2005

EVI1 induces myelodysplastic syndrome in mice.

J Clin Invest 2004 Sep;114(5):713-9

Department of Pathology and Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1172/JCI21716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514587PMC
September 2004

Targeted therapies in myelodysplastic syndromes: ASH 2003 review.

Semin Hematol 2004 Apr;41(2 Suppl 4):13-20

Section of Myeloids Diseases and MDS Center, Rush University, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1053/j.seminhematol.2004.02.003DOI Listing
April 2004

The role of EVI1 in normal and leukemic cells.

Blood Cells Mol Dis 2003 Sep-Oct;31(2):206-12

Department of Pathology and Cancer Center, University of Illinois at Chicago, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1016/s1079-9796(03)00159-1DOI Listing
May 2004

P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.

Biochem Biophys Res Commun 2003 Aug;307(4):980-6

Department of Pathology, Molecular Biology Research Building, M/C 737, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)01288-9DOI Listing
August 2003