Publications by authors named "Silvana Zanlungo"

57Publications

Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage.

Int J Mol Sci 2020 Mar 20;21(6). Epub 2020 Mar 20.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

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http://dx.doi.org/10.3390/ijms21062127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139721PMC
March 2020

Lysosome motility and distribution: Relevance in health and disease.

Biochim Biophys Acta Mol Basis Dis 2019 06 21;1865(6):1076-1087. Epub 2019 Mar 21.

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.03.009DOI Listing
June 2019

Gadolinium Chloride Rescues Niemann⁻Pick Type C Liver Damage.

Int J Mol Sci 2018 Nov 14;19(11). Epub 2018 Nov 14.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

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http://dx.doi.org/10.3390/ijms19113599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274821PMC
November 2018

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease.

Front Physiol 2017 30;8:982. Epub 2017 Nov 30.

Department of Cell Death and Proliferation, Intituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.

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http://dx.doi.org/10.3389/fphys.2017.00982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714892PMC
November 2017

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content.

Redox Biol 2017 08 2;12:274-284. Epub 2017 Mar 2.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344325PMC
August 2017

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.

Redox Biol 2017 04 20;11:60-72. Epub 2016 Nov 20.

Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), CSIC, Barcelona, Spain; Liver Unit, Hospital Clinic I Provincial de Barcelona, IDIBAPS and CIBERehd, Barcelona, Spain; Research Center for ALPD, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123076PMC
April 2017

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.

Biochem Biophys Res Commun 2016 Oct 20;479(3):496-501. Epub 2016 Sep 20.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Center of Genome Regulation (Fondap 15090007), Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.096DOI Listing
October 2016

Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

J Alzheimers Dis 2016 10;54(3):1193-1205

Cell Signaling Laboratory, Cell and Molecular Biology Department, Biological Sciences Faculty, Pontificia Universidad Católica de Chile, Chile.

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http://dx.doi.org/10.3233/JAD-151087DOI Listing
October 2016

Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.

Biochim Biophys Acta 2016 Feb 19;1859(2):269-79. Epub 2015 Nov 19.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; FONDAP Center for Genome Regulation (CGR), Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2015.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014229PMC
February 2016

Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice.

J Hepatol 2016 Feb 10;64(2):361-369. Epub 2015 Dec 10.

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; FONDAP "Center for Genome Regulation" (CGR), Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.10.002DOI Listing
February 2016

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease.

Biochim Biophys Acta 2015 Sep 29;1852(9):1765-78. Epub 2015 May 29.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; FONDAP Center for Genome Regulation (CGR), Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.05.015DOI Listing
September 2015

The unique case of the Niemann-Pick type C cholesterol storage disorder.

Pediatr Endocrinol Rev 2014 Sep;12 Suppl 1:166-75

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September 2014

c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease.

Mol Cell 2014 Oct 11;56(1):163-73. Epub 2014 Sep 11.

Department of Cell & Molecular Biology, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.08.013DOI Listing
October 2014

Hepatic metabolic response to restricted copper intake in a Niemann-Pick C murine model.

Metallomics 2014 Aug;6(8):1527-39

INTA, Laboratorio de Bioinformática y Expresión Génica, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile.

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http://dx.doi.org/10.1039/c4mt00056kDOI Listing
August 2014

Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability.

Reprod Fertil Dev 2014 ;26(4):609-21

Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica. Avda. Bernardo O'Higgins 340. 8331150 Santiago, Chile.

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http://dx.doi.org/10.1071/RD12059DOI Listing
December 2014

Oxidative stress: a pathogenic mechanism for Niemann-Pick type C disease.

Oxid Med Cell Longev 2012 5;2012:205713. Epub 2012 Jun 5.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta no. 364, Casilla 114-D, 8330024 Santiago, Chile.

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http://dx.doi.org/10.1155/2012/205713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374944PMC
October 2012

Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease.

Biometals 2012 Aug 17;25(4):777-86. Epub 2012 Apr 17.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://link.springer.com/content/pdf/10.1007/s10534-012-9546
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http://link.springer.com/10.1007/s10534-012-9546-6
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http://dx.doi.org/10.1007/s10534-012-9546-6DOI Listing
August 2012

Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.

Mol Neurodegener 2012 Mar 29;7:11. Epub 2012 Mar 29.

Physiology Department, Millennium Nucleus in Regenerative Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1186/1750-1326-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395862PMC
March 2012

Molecular Mechanisms Underlying the Link between Nuclear Receptor Function and Cholesterol Gallstone Formation.

J Lipids 2012 1;2012:547643. Epub 2011 Nov 1.

Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica, Marcoleta No. 367, 8330024 Santiago, Chile.

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http://dx.doi.org/10.1155/2012/547643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206498PMC
August 2012

Lysosomal vitamin E accumulation in Niemann-Pick type C disease.

Biochim Biophys Acta 2012 Feb 15;1822(2):150-60. Epub 2011 Nov 15.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbadis.2011.11.009DOI Listing
February 2012

Niemann-Pick C2 protein expression regulates lithogenic diet-induced gallstone formation and dietary cholesterol metabolism in mice.

Lipids 2012 Jan 30;47(1):13-25. Epub 2011 Oct 30.

Departmento de Gastroenterología, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Casilla 114-D, Santiago, Chile.

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http://dx.doi.org/10.1007/s11745-011-3625-2DOI Listing
January 2012

Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology.

Biochem Biophys Res Commun 2011 Sep 2;413(3):400-6. Epub 2011 Sep 2.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbrc.2011.08.096DOI Listing
September 2011

[The metabolic syndrome: from an aggravating condition to a pathogenic risk factor for chronic diseases].

Rev Med Chil 2010 Aug 26;138(8):1012-9. Epub 2010 Nov 26.

Departamento de Neurología, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org//S0034-98872010000800012DOI Listing
August 2010

Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice.

Liver Int 2011 Feb 7;31(2):263-71. Epub 2010 Dec 7.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1478-3231.2010.02421.xDOI Listing
February 2011

Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice.

Liver Int 2011 Jan 29;31(1):52-64. Epub 2010 Oct 29.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1478-3231.2010.02361.xDOI Listing
January 2011

Lack of activation of the unfolded protein response in mouse and cellular models of Niemann-Pick type C disease.

Neurodegener Dis 2011 13;8(3):124-8. Epub 2010 Aug 13.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1159/000316540DOI Listing
July 2011

STARTing to understand MLN64 function in cholesterol transport.

J Lipid Res 2010 Aug 28;51(8):2015-7. Epub 2010 May 28.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1194/jlr.E008854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903795PMC
August 2010

Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice.

Liver Int 2010 Jul 8;30(6):887-97. Epub 2010 Apr 8.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1478-3231.2010.02230.xDOI Listing
July 2010

Determinants of transhepatic cholesterol flux and their relevance for gallstone formation.

Liver Int 2009 Mar;29(3):323-30

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1478-3231.2009.01972.xDOI Listing
March 2009

Insulin and cholesterol gallstones: new insights for a complex pathogenic relationship.

Hepatology 2008 Dec;48(6):2078-80

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/hep.22618DOI Listing
December 2008

A new twist in the cholesterol metabolism-based enterohepatic connection.

Gastroenterology 2008 Aug 9;135(2):705-6. Epub 2008 Jul 9.

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http://dx.doi.org/10.1053/j.gastro.2008.06.067DOI Listing
August 2008

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease.

FASEB J 2008 Oct 30;22(10):3617-27. Epub 2008 Jun 30.

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, casilla 114-D, Santiago, Chile.

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http://www.fasebj.org/doi/10.1096/fj.07-102715
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http://dx.doi.org/10.1096/fj.07-102715DOI Listing
October 2008

Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease.

Hepatology 2007 May;45(5):1261-6

Department of Gastroenterology, Pontificia Universidad Católica, Santiago, Chile, and Center for Metabolism and Endocrinology, Karolinska Institute at Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/hep.21616DOI Listing
May 2007

Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice.

Liver Int 2007 May;27(4):569-81

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile.

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http://dx.doi.org/10.1111/j.1478-3231.2007.01442.xDOI Listing
May 2007

Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse.

Biochim Biophys Acta 2007 Jun 1;1770(6):979-88. Epub 2007 Mar 1.

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Casilla 114-D, Santiago, Chile, and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bbagen.2007.02.010DOI Listing
June 2007

P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation.

J Lipid Res 2007 Apr 17;48(4):924-34. Epub 2007 Jan 17.

Centro de Regulación Celular y Patología and Millennium Institute for Fundamental and Applied Biology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile.

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http://dx.doi.org/10.1194/jlr.M700002-JLR200DOI Listing
April 2007

Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones.

Gastroenterology 2006 Dec 14;131(6):1870-8. Epub 2006 Aug 14.

Departamento de Gastroenterología, Facultad de Medicina Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1053/j.gastro.2006.08.029DOI Listing
December 2006

Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility.

Endocrinology 2006 Apr 12;147(4):1577-88. Epub 2006 Jan 12.

Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA.

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http://dx.doi.org/10.1210/en.2005-1286DOI Listing
April 2006

NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis.

Hepatology 2006 Jan;43(1):126-33

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1002/hep.20985DOI Listing
January 2006

The old enigma of diets, oils, and stones.

Nutrition 2005 Mar;21(3):419-21

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http://dx.doi.org/10.1016/j.nut.2004.11.002DOI Listing
March 2005

Diet as a risk factor for cholesterol gallstone disease.

J Am Coll Nutr 2004 Jun;23(3):187-96

Departmento de Nutrición, Diabetes, y Metabolismo, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1080/07315724.2004.10719360DOI Listing
June 2004

Hepatic cholesterol transport from plasma into bile: implications for gallstone disease.

Curr Opin Lipidol 2004 Jun;15(3):279-86

Department of Gastroenterology, Faculty of Medicine, Pontifical Catholic University of Chile, Marcoleta 367, Santiago, Chile.

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http://pdfs.journals.lww.com/co-lipidology/2004/06000/Hepati
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http://dx.doi.org/10.1097/00041433-200406000-00007DOI Listing
June 2004

Hepatic overexpression of caveolins increases bile salt secretion in mice.

Hepatology 2003 Dec;38(6):1477-88

Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.hep.2003.09.011DOI Listing
December 2003

The molecular and metabolic basis of biliary cholesterol secretion and gallstone disease.

Front Biosci 2003 Sep 1;8:s1166-74. Epub 2003 Sep 1.

Departamento de Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.2741/1193DOI Listing
September 2003

Biliary lipid secretion, bile acid metabolism, and gallstone formation are not impaired in hepatic lipase-deficient mice.

Hepatology 2003 Sep;38(3):726-34

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://doi.wiley.com/10.1053/jhep.2003.50379
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http://dx.doi.org/10.1053/jhep.2003.50379DOI Listing
September 2003

Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice.

Hepatology 2002 Oct;36(4 Pt 1):819-28

Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.

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http://dx.doi.org/10.1053/jhep.2002.35617DOI Listing
October 2002