Sieghart Sopper

Sieghart Sopper

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Sieghart Sopper

Publications by authors named "Sieghart Sopper"

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Ovarian Cancer Stem Cell Heterogeneity.

Adv Exp Med Biol 2019 ;1139:201-221

Department of Gynecology and Obstetrics, Medical University of Innsbruck, Innsbruck, Austria.

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http://link.springer.com/10.1007/978-3-030-14366-4_12
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http://dx.doi.org/10.1007/978-3-030-14366-4_12DOI Listing
August 2019

Fibroblasts in cancer: Defining target structures for therapeutic intervention.

Biochim Biophys Acta Rev Cancer 2019 08 29;1872(1):111-121. Epub 2019 Jun 29.

Lung Center, Cantonal Hospital St. Gallen, Rorschacherstrasse 95, 9007 St. Gallen, Switzerland.

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http://dx.doi.org/10.1016/j.bbcan.2019.06.003DOI Listing
August 2019

Correction: Molecular response prediction in CML: novel ideas?

Oncotarget 2018 11 9;9(88):35871. Epub 2018 Nov 9.

Department of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.18632/oncotarget.26360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254682PMC
November 2018

Evaluation of Vav3.1 as prognostic marker in endometrial cancer.

J Cancer Res Clin Oncol 2018 Oct 6;144(10):2067-2076. Epub 2018 Aug 6.

Oncotyrol, Center for Personalized Cancer Medicine GmbH, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00432-018-2725-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153599PMC
October 2018

Flow Cytometry: To Dump or Not To Dump.

J Immunol 2018 10;201(7):1813-1815

Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria;

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http://dx.doi.org/10.4049/jimmunol.1801037DOI Listing
October 2018

(Iso-)form Matters: Differential Implication of Vav3 Variants in Ovarian Cancer.

Oncologist 2018 07 19;23(7):757-759. Epub 2018 Apr 19.

Department of Gynecology and Obstetrics, Medical University of Innsbruck, Innsbruck, Austria

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http://dx.doi.org/10.1634/theoncologist.2017-0683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058338PMC
July 2018

Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response.

Int J Cancer 2018 04 14;142(8):1640-1651. Epub 2017 Dec 14.

Department of Obstetrics and Gynecology, Medical University Innsbruck, 6020, Innsbruck, Austria.

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http://doi.wiley.com/10.1002/ijc.31186
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http://dx.doi.org/10.1002/ijc.31186DOI Listing
April 2018

Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling.

Stem Cells Int 2018 8;2018:5284963. Epub 2018 Feb 8.

Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1155/2018/5284963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822806PMC
February 2018

Molecular response prediction in CML: novel ideas?

Oncotarget 2017 Oct 19;8(46):80105-80106. Epub 2017 Sep 19.

Department of Hematology, Oncology and Rheumatology, Center of Integrated Oncology Cologne Bonn, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.18632/oncotarget.21049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655181PMC
October 2017

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples.

J Vis Exp 2017 05 10(123). Epub 2017 May 10.

Internal Medicine V, Medical University of Innsbruck; Tyrolean Cancer Research Institute (TKFI).

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http://dx.doi.org/10.3791/55634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607907PMC
May 2017

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.

J Clin Oncol 2017 Jan 7;35(2):175-184. Epub 2016 Nov 7.

Sieghart Sopper, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, and Dominik Wolf, Medical University Innsbruck; Sieghart Sopper and Dominik Wolf, Tyrolean Cancer Research Institute; Matthias Baldauf, Oncotyrol, Innsbruck; Peter Valent, Medical University of Vienna, Vienna, Austria; Satu Mustjoki and Kimmo Porkka, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Deborah White and Timothy Hughes, South Australian Health and Medical Research Institute and University of Adelaide School of Medicine, Adelaide, South Australia, Australia; Andreas Burchert, Universitätsklinikum Gießen und Marburg and Philipps Universität Marburg, Marburg; Andreas Hochhaus, Thomas Ernst, and Thomas Schenk, Universitätsklinikum Jena, Jena; Dominik Wolf, University Hospital of Bonn, Bonn, Germany; Bjørn T. Gjertsen, University of Bergen, Bergen, Norway; Frank Giles, Northwestern University, Chicago, IL; and Jeroen J.W.M. Janssen and Gert J. Ossenkoppele, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2016.67.0893DOI Listing
January 2017

Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem Cell Niche.

Biochim Biophys Acta 2016 12 15;1866(2):276-289. Epub 2016 Oct 15.

Internal Medicine V, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute (TKFI), Innrain 66, 6020 Innsbruck, Austria; Medical Clinic III, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818142PMC
December 2016

Ionophore Antibiotics as Cancer Stem Cell-Selective Drugs: Open Questions.

Oncologist 2016 Nov 2;21(11):1291-1293. Epub 2016 Aug 2.

Medical Clinic III, University Clinic Bonn, Bonn, Germany.

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http://dx.doi.org/10.1634/theoncologist.2016-0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189623PMC
November 2016

Successful management of mixed chimerism after bone marrow transplant in beta-thalassemia major.

Am J Hematol 2016 Sep 4;91(9):E357-8. Epub 2016 Jul 4.

Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ajh.24436DOI Listing
September 2016

Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy.

Clin Cancer Res 2016 Aug 22;22(16):4030-8. Epub 2016 Mar 22.

Hematology Research Unit Helsinki, University of Helsinki and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland. Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2791DOI Listing
August 2016

High prevalence of side population in human cancer cell lines.

Oncoscience 2016 10;3(3-4):85-87. Epub 2016 Apr 10.

Medical Clinic III, University Clinic Bonn (UKB), 53127 Bonn, Germany.

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http://dx.doi.org/10.18632/oncoscience.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872646PMC
May 2016

Opiate receptor blockade on human granulosa cells inhibits VEGF release.

Reprod Biomed Online 2016 Mar 6;32(3):316-22. Epub 2016 Jan 6.

Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.rbmo.2015.12.006DOI Listing
March 2016

Optimized Stem Cell Detection Using the DyeCycle-Triggered Side Population Phenotype.

Stem Cells Int 2016 20;2016:1652389. Epub 2015 Dec 20.

Internal Medicine V, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1155/2016/1652389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699066PMC
January 2016

Treg(s) in Cancer: Friends or Foe?

J Cell Physiol 2015 Nov;230(11):2598-605

Medical Clinic 3, Oncology, Hematology and Rheumatology, University Hospital Bonn (UKB), Bonn, Germany.

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http://dx.doi.org/10.1002/jcp.25016DOI Listing
November 2015

Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys.

Retrovirology 2015 Nov 10;12:92. Epub 2015 Nov 10.

Department of Hematology and Oncology, Medical University Innsbruck, ZVG 7G5 009A, Anichstr. 35, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1186/s12977-015-0219-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641394PMC
November 2015

OMIP-026: Phenotypic analysis of B and plasma cells in rhesus macaques.

Cytometry A 2015 Sep 26;87(9):800-2. Epub 2015 Jun 26.

Unit of Infection Models, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.

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http://doi.wiley.com/10.1002/cyto.a.22712
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http://dx.doi.org/10.1002/cyto.a.22712DOI Listing
September 2015

Drug Transporter-Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics.

Stem Cells Transl Med 2015 Sep 1;4(9):1028-32. Epub 2015 Jul 1.

Tyrolean Cancer Research Institute, Innsbruck, Austria; Internal Medicine V and Medical Clinic III, Oncology, Hematology and Rheumatology, University Clinic Bonn, Bonn, Germany.

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http://dx.doi.org/10.5966/sctm.2015-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542876PMC
September 2015

Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.

Front Oncol 2015 11;5:58. Epub 2015 Mar 11.

Department of Hematology and Oncology, Medical University Innsbruck , Innsbruck , Austria ; Tumor Immunology Laboratory, Tyrolean Cancer Research Institute , Innsbruck , Austria.

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http://dx.doi.org/10.3389/fonc.2015.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356231PMC
March 2015

Characterization of B and plasma cells in blood, bone marrow, and secondary lymphoid organs of rhesus macaques by multicolor flow cytometry.

J Leukoc Biol 2015 Jan 23;97(1):19-30. Epub 2014 Oct 23.

Unit of Infection Models, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany;

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http://dx.doi.org/10.1189/jlb.1HI0514-243RDOI Listing
January 2015

Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus.

J Gen Virol 2014 Oct 13;95(Pt 10):2273-84. Epub 2014 Jun 13.

Unit of Infection Models, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Goettingen, Germany

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.066563-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165933PMC
October 2014

Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line.

Virol J 2014 Aug 27;11:152. Epub 2014 Aug 27.

Epigenetic Regulation Mechanisms, Helmholtz Centre for Infection Research (HZI), Inhoffenstr, 7, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1186/1743-422X-11-152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163169PMC
August 2014

The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics.

Oncotarget 2014 Aug;5(16):7027-39

Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria. Tyrolean Cancer Research Institute, Innsbruck, Austria. These authors contributed equally to this work.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196181PMC
http://dx.doi.org/10.18632/oncotarget.2053DOI Listing
August 2014

DyeCycle Violet used for side population detection is a substrate of P-glycoprotein.

Cytometry A 2012 Jun 7;81(6):517-22. Epub 2012 Mar 7.

Internal Medicine V, Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria.

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http://doi.wiley.com/10.1002/cyto.a.22038
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http://dx.doi.org/10.1002/cyto.a.22038DOI Listing
June 2012

Cytokine levels in CSF and neuropsychological performance in HIV patients.

J Neurovirol 2012 Jun 12;18(3):157-61. Epub 2012 Apr 12.

Department of Neurology, Medical School, Heinrich-Heine-University, Duesseldorf, Germany.

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http://dx.doi.org/10.1007/s13365-012-0091-4DOI Listing
June 2012

Stable multi-infection of splenocytes during SIV infection--the basis for continuous recombination.

Retrovirology 2012 Apr 23;9:31. Epub 2012 Apr 23.

Department of Virology, Saarland University, Homburg D-66421, Germany.

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http://dx.doi.org/10.1186/1742-4690-9-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395872PMC
April 2012

Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy.

Diabetes 2011 Nov 12;60(11):2954-62. Epub 2011 Sep 12.

Clinical Division of Nephrology, Department of Internal Medicine, Medical University Graz, Graz, Austria.

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http://dx.doi.org/10.2337/db11-0358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198056PMC
November 2011

Definition of leukocyte subsets in primate central nervous system by polychromatic flow cytometry.

Cytometry A 2011 Jun 18;79(6):436-45. Epub 2011 Mar 18.

Unit of Infection Biology, German Primate Center (DPZ), Goettingen, Germany.

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http://dx.doi.org/10.1002/cyto.a.21046DOI Listing
June 2011

Flow cytometric characterization of the lymphocyte composition in a variety of mucosal tissues in healthy rhesus macaques.

J Med Primatol 2011 Feb;40(1):41-51

Unit of Infection Models, German Primate Center, Leibniz Institute for Primate Research, Goettingen, Germany.

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http://dx.doi.org/10.1111/j.1600-0684.2010.00446.xDOI Listing
February 2011

Susceptibility to Simian immunodeficiency virus ex vivo predicts outcome of a prime-boost vaccine after SIVmac239 challenge.

J Acquir Immune Defic Syndr 2009 Oct;52(2):162-9

Department of Virology and Immunology, German Primate Centre, Kellnerweg, Goettingen, Germany.

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http://dx.doi.org/10.1097/QAI.0b013e3181b22f4aDOI Listing
October 2009

Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine.

Neuropsychopharmacology 2008 Aug 31;33(9):2228-36. Epub 2007 Oct 31.

Institute of Virology and Immunobiology, University of Wurzburg, Germany.

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http://www.nature.com/articles/1301615
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http://dx.doi.org/10.1038/sj.npp.1301615DOI Listing
August 2008

Caspase inhibition in apoptotic T cells triggers necrotic cell death depending on the cell type and the proapoptotic stimulus.

J Cell Biochem 2006 Apr;97(6):1350-61

Institute of Virology and Immunobiology, University of Würzburg, Versbacher Strasse 7, 97078 Würzburg, Germany.

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http://doi.wiley.com/10.1002/jcb.20670
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http://dx.doi.org/10.1002/jcb.20670DOI Listing
April 2006

HIV-infection of the central nervous system: the tightrope walk of innate immunity.

Mol Immunol 2005 Feb;42(2):213-28

Institute of Hygiene and Social Medicine, Medical University Innsbruck and Ludwig-Boltzmann-Institute for AIDS Research, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.molimm.2004.06.018DOI Listing
February 2005

Caspase inhibitors as a supplement in immune activation therapies to achieve eradication of HIV in its latent reservoirs.

Ann N Y Acad Sci 2003 Dec;1010:209-12

Institute for Virology and Immunobiology, Julius-Maximilians-Universität, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1196/annals.1299.036DOI Listing
December 2003

Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95.

J Biol Chem 2002 May 19;277(18):15459-64. Epub 2002 Feb 19.

Institute for Virology and Immunobiology, Julius-Maximilians-Universität, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M200763200DOI Listing
May 2002

The Role of the Envelope Glycoprotein in the Depletion of T Helper Cells in Human Immunodeficiency Virus Infection.

Pathol Oncol Res 1997 ;3(1):62-67

Julius-Maximilians University, Institute for Virology and Immunobiology, Würzburg, Germany.

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http://dx.doi.org/10.1007/bf02893356DOI Listing
January 1997