Sidney H Kennedy

Sidney H Kennedy

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Sidney H Kennedy

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Clinical staging for youth at-risk for serious mental illness.

Early Interv Psychiatry 2019 12 22;13(6):1416-1423. Epub 2019 Jan 22.

Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

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http://doi.wiley.com/10.1111/eip.12786
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http://dx.doi.org/10.1111/eip.12786DOI Listing
December 2019

Association between side effects and blood microRNA expression levels and their targeted pathways in patients with major depressive disorder treated by a selective serotonin reuptake inhibitor, escitalopram: a CAN-BIND-1 report.

Int J Neuropsychopharmacol 2019 Dec 10. Epub 2019 Dec 10.

McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/ijnp/pyz066DOI Listing
December 2019

Sleep disturbances in youth at-risk for serious mental illness.

Early Interv Psychiatry 2019 Nov 13. Epub 2019 Nov 13.

Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/eip.12898DOI Listing
November 2019

Collaborating with individuals with lived experience to adapt CANMAT clinical depression guidelines into a patient treatment guide: The CHOICE-D co-design process.

J Eval Clin Pract 2019 Nov 14. Epub 2019 Nov 14.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jep.13308DOI Listing
November 2019

Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI Emotional conflict task: A CAN-BIND-1 study.

J Affect Disord 2019 Nov 13. Epub 2019 Nov 13.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.11.068DOI Listing
November 2019

Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

J Affect Disord 2019 Oct 6;257:765-773. Epub 2019 Jul 6.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.07.037DOI Listing
October 2019

Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

J Affect Disord 2019 Oct 6;257:765-773. Epub 2019 Jul 6.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.07.037DOI Listing
October 2019

White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Oct 12;4(10):913-924. Epub 2019 Jun 12.

Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada; Imaging Research Center, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2019.05.016DOI Listing
October 2019

The Potential Procognitive Effects of Modafinil in Major Depressive Disorder: A Systematic Review.

J Clin Psychiatry 2019 Oct 8;80(6). Epub 2019 Oct 8.

ASR Suicide & Depression Studies Program, St Michael's Hospital, 193 Yonge St 6-013, Toronto, ON M5B 1M4, Canada.

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http://dx.doi.org/10.4088/JCP.19r12767DOI Listing
October 2019

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.

Brain Stimul 2019 Oct 31. Epub 2019 Oct 31.

Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Psychiatry, University Health Network, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.brs.2019.10.020DOI Listing
October 2019

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial.

Brain Stimul 2019 Oct 31. Epub 2019 Oct 31.

Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Psychiatry, University Health Network, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.brs.2019.10.020DOI Listing
October 2019

Integrating digital phenotyping in clinical characterization of individuals with mood disorders.

Neurosci Biobehav Rev 2019 09 19;104:223-230. Epub 2019 Jul 19.

Department of Psychiatry, Providence Care Hospital, Queen's University School of Medicine, Kingston ON, Canada; Canadian Biomarker Integration Network in Depression (CAN-BIND) at Queen's University and Providence Care Hospital, Kingston, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2019.07.009DOI Listing
September 2019

Social and role functioning in youth at risk of serious mental illness.

Early Interv Psychiatry 2019 Sep 10. Epub 2019 Sep 10.

Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/eip.12872DOI Listing
September 2019

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

J Psychiatry Neurosci 2019 Sep 17;44(6):1-10. Epub 2019 Sep 17.

From the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).

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http://dx.doi.org/10.1503/jpn.180207DOI Listing
September 2019

Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report.

Psychol Med 2019 Jul 17;49(10):1629-1638. Epub 2018 Sep 17.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health,Toronto, ON,Canada.

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http://dx.doi.org/10.1017/S0033291718002441DOI Listing
July 2019

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

J Psychiatry Neurosci 2019 07;44(4):223-236

From the Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alta., Canada (MacQueen, Hassel, Addington, Sharma); the Rotman Research Institute, Baycrest, and Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada (Arnott, Zamyadi, Strother); the Department of Psychology, Queen’s University, Kingston, Ont., Canada (Bowie, Harkness, Milev); the Department of Radiology, University of Calgary, Calgary, Alta., Canada (Bray, Lebel); the Alberta Children’s Hospital Research Institute, Calgary, Alta., Canada (Bray, Lebel); the Child and Adolescent Imaging Research (CAIR) Program, Calgary, Alta., Canada (Bray, Lebel); the Department of Psychology, Neuroscience and Behaviour, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Hall); the Krembil Research Institute and Centre for Mental Health, University Health Network, Toronto, Ont., Canada (Downar); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar, Müller, Rizvi, Rotzinger, Kennedy); the Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ont., Canada (Foster, Rotzinger, Kennedy); the Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Foster, Frey); the Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, Ont., Canada (Goldstein); the Departments of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Goldstein); the Department of Computer Science, University of Alberta, Edmonton, Alta., Canada (Harris); the University of British Columbia and Vancouver Coastal Health Authority, Vancouver, B.C., Canada (Lam, Vila-Rodriguez); the Department of Psychiatry, Queen’s University and Providence Care Hospital, Kingston, Ont., Canada (Milev, Soares); the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Müller); the Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA (Parikh); the Arthur Sommer Rotenberg Suicide and Depression Studies Program, Li Ka Shing Knowledge Institute and St. Michael’s Hospital, Toronto, Ont., Canada (Rizvi); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Rizvi); the Department of Psychiatry, St. Michael’s Hospital, University of Toronto, Toronto, Ont., Canada (Rotzinger, Soares, Yu); McGill University, Montréal, Que., Canada (Turecki); the Douglas Mental Health University Institute, Frank B. Common, Montréal, Que., Canada (Turecki); and the Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ont., Canada (Kennedy).

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http://dx.doi.org/10.1503/jpn.180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606427PMC
July 2019

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.

Am J Psychiatry 2019 May 15;176(5):367-375. Epub 2019 Feb 15.

The Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto (Kaster, Knyahnytska, Daskalakis, Blumberger); the Department of Psychiatry (Kaster, Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), the Institute of Medical Science (Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), and the Dalla Lana School of Public Health (Thorpe), University of Toronto, Toronto; the MRI-Guided rTMS Clinic, Toronto Western Hospital, Toronto (Downar); the Krembil Research Institute, University Health Network, Toronto (Downar, Kennedy); the Department of Psychiatry, University of British Columbia, Vancouver (Vila-Rodriguez, Lam); the Non-Invasive Neurostimulation Therapies Laboratory, University of British Columbia, Vancouver (Vila-Rodriguez); the Shalvata Mental Health Center, Hod-Hasharon, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv (Feffer); the Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo (Noda); the Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto (Giacobbe); and the Li Ka Shing Knowledge Institute, Saint Michael's Hospital, Toronto (Kennedy).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
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http://dx.doi.org/10.1176/appi.ajp.2018.18091096DOI Listing
May 2019

The impact of comorbid pain and depression in the United States: results from a nationally representative survey.

Scand J Pain 2019 04;19(2):319-325

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1515/sjpain-2018-0323DOI Listing
April 2019

Treatment History of Youth At-Risk for Serious Mental Illness.

Can J Psychiatry 2019 02 2;64(2):145-154. Epub 2018 Aug 2.

1 Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1177/0706743718792195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405799PMC
February 2019

Spanish adaptation of the Dimensional Anhedonia Rating Scale (DARS).

J Affect Disord 2019 02 6;245:702-707. Epub 2018 Nov 6.

Department of Psychiatry, IIS-Jimenez Diaz Foundation. Madrid, Spain; Department of Psychiatry, University Hospital Rey Juan Carlos, Móstoles, Spain; Department of Psychiatry, General Hospital of Villalba, Madrid, Spain; Department of Psychiatry, University Hospital Infanta Elena, Valdemoro, Spain; CIBERSAM (Centro de Investigació n en Salud Mental), Carlos III Institute of Health, Madrid, Spain; Universidad Católica del Maule, Talca, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.11.040DOI Listing
February 2019

Cortical thickness in major depressive disorder: A systematic review and meta-analysis.

Prog Neuropsychopharmacol Biol Psychiatry 2019 01 15;88:287-302. Epub 2018 Aug 15.

MiNDS Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2018.08.008DOI Listing
January 2019

Neurocognitive deficits in a transdiagnostic clinical staging model.

Psychiatry Res 2018 12 17;270:1137-1142. Epub 2018 Oct 17.

Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183024
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http://dx.doi.org/10.1016/j.psychres.2018.10.030DOI Listing
December 2018

Family functioning in youth at-risk for serious mental illness.

Compr Psychiatry 2018 11 25;87:17-24. Epub 2018 Aug 25.

Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0010440X183014
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http://dx.doi.org/10.1016/j.comppsych.2018.08.010DOI Listing
November 2018

Effect of agomelatine 25-50 mg on functional outcomes in patients with major depressive disorder.

J Affect Disord 2018 10 29;238:122-128. Epub 2018 May 29.

Institut de Recherches Internationales Servier (IRIS), 50 rue Carnot, Suresnes Cedex 92284, France.

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http://dx.doi.org/10.1016/j.jad.2018.05.060DOI Listing
October 2018

Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement.

World J Biol Psychiatry 2018 08 6;19(5):330-348. Epub 2017 Oct 6.

a School of Medicine, Barwon Health , Deakin University, IMPACT SRC (Innovation in Mental and Physical Health and Clinical Treatment - Strategic Research Centre) , Geelong , Australia.

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http://dx.doi.org/10.1080/15622975.2017.1379609DOI Listing
August 2018

Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression.

Brain Stimul 2018 Jan - Feb;11(1):181-189. Epub 2017 Oct 19.

MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2017.10.010DOI Listing
July 2018

Anhedonia in depression and schizophrenia: A transdiagnostic challenge.

CNS Neurosci Ther 2018 07 23;24(7):615-623. Epub 2018 Apr 23.

Arthur Sommer Rotenberg Suicide and Depression Studies Program, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/cns.12854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489811PMC
July 2018

Youth at-risk for serious mental illness: methods of the PROCAN study.

BMC Psychiatry 2018 07 5;18(1):219. Epub 2018 Jul 5.

Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Mathison Centre, 3280 Hospital Dr NW, Calgary, AB, Calgary, AB, T2N 4Z6, Canada.

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https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12888-018-1801-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034268PMC
July 2018

Neuroimaging biomarkers as predictors of treatment outcome in Major Depressive Disorder.

J Affect Disord 2018 06 31;233:21-35. Epub 2017 Oct 31.

Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.10.049DOI Listing
June 2018

Vagus Nerve Stimulation: A Treatment in Evolution.

Cogn Behav Neurol 2018 06;31(2):99-100

Arthur Sommer Rotenberg Depression and Suicide Studies Program St. Michael's Hospital.

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http://dx.doi.org/10.1097/WNN.0000000000000155DOI Listing
June 2018

Unpacking Major Depressive Disorder: From Classification to Treatment Selection.

Can J Psychiatry 2018 05 26;63(5):308-313. Epub 2017 Dec 26.

1 Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario.

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http://journals.sagepub.com/doi/10.1177/0706743717748883
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http://dx.doi.org/10.1177/0706743717748883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912302PMC
May 2018

More data, more answers: picking the optimal antidepressant.

Lancet 2018 04 21;391(10128):1333-1334. Epub 2018 Feb 21.

Department of Psychiatry, Faculty of Medicine, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S0140-6736(18)30421-5DOI Listing
April 2018

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 04 27;3(4):337-347. Epub 2017 Dec 27.

Krembil Research Institute, University Health Network, Toronto, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2017.12.003DOI Listing
April 2018

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Lancet 2018 04 26;391(10131):1683-1692. Epub 2018 Apr 26.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183029
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http://dx.doi.org/10.1016/S0140-6736(18)30295-2DOI Listing
April 2018

Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis.

J Affect Disord 2018 01 1;225:54-63. Epub 2017 Aug 1.

Mood Disorders Program, St. Joseph's Healthcare Hamilton, ON, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.07.047DOI Listing
January 2018

Efficacy and tolerability of lisdexamfetamine as an antidepressant augmentation strategy: A meta-analysis of randomized controlled trials.

J Affect Disord 2018 01 3;226:294-300. Epub 2017 Oct 3.

Centre for Mental Health, University Health Network, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jad.2017.09.041DOI Listing
January 2018

Editorial: mood and anxiety disorders.

Curr Opin Psychiatry 2018 01;31(1):1-2

Clinical Psychology and Psychotherapy, MPCB.

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http://dx.doi.org/10.1097/YCO.0000000000000386DOI Listing
January 2018

Relative short-term efficacy and acceptability of agomelatine versus vortioxetine in adult patients suffering from major depressive disorder.

Hum Psychopharmacol 2018 01 12;33(1). Epub 2018 Jan 12.

Biostatistics Department and Neuropsychiatry Center for Therapeutic Innovation, Institut de Recherches Internationales Servier (IRIS), Suresnes, France.

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http://dx.doi.org/10.1002/hup.2646DOI Listing
January 2018

Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management.

CNS Drugs 2018 01;32(1):65-74

Centre for Mental Health, University Health Network, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s40263-018-0490-z
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http://dx.doi.org/10.1007/s40263-018-0490-zDOI Listing
January 2018

Oral Ketamine in Treatment-Resistant Depression: A Clinical Effectiveness Case Series.

J Clin Psychopharmacol 2017 Aug;37(4):464-467

From the *Department of Psychiatry, University Health Network; †Department of Psychiatry, ‡Institute of Medical Science, Faculty of Medicine, University of Toronto; §Krembil Research Institute, Toronto Western Hospital; ∥Li Ka Shing Knowledge Institute, St. Michael's Hospital; ¶Ontario Brain Institute; and #MRI-Guided repetitive transcranial magnetic stimulation Clinic, Centre for Mental Health, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491240PMC
August 2017

Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response.

Int J Neuropsychopharmacol 2017 08;20(8):619-623

McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada (Drs Fiori, Lopez, Richard-Devantoy, Berlim, Chachamovich, Jollant, and Turecki); Department of Psychiatry, University Health Network, University of Toronto, Toronto, Ontario, Canada (Drs Foster, Rotzinger, and Kennedy).

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http://dx.doi.org/10.1093/ijnp/pyx034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570004PMC
August 2017

The Efficacy of Psychostimulants in Major Depressive Episodes: A Systematic Review and Meta-Analysis.

J Clin Psychopharmacol 2017 Aug;37(4):412-418

From the *Mood Disorder Psychopharmacology Unit, University Health Network; †Brain and Cognition Discovery Foundation, ‡Department of Psychiatry, §Department of Pharmacology, and ∥Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ¶Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada; #Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; and **Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, SC.

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http://dx.doi.org/10.1097/JCP.0000000000000723DOI Listing
August 2017

Neuroimaging tests for clinical psychiatry: Are we there yet?

J Psychiatry Neurosci 2017 06;42(4):219-221

From the Department of Psychiatry and Psychology, McGill University, Montreal, Que., Canada (Leyton); the Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Que., Canada (Leyton); the Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Que., Canada (Leyton); the Research Unit on Children's Psychosocial Maladjustment, Université de Montréal, Montreal, Que., Canada (Leyton); the Canadian Biomarker Integration Network for Depression, St. Michael's Hospital, University Health Network, Toronto, Ont., Canada (Kennedy); and the Department of Psychiatry, University of Toronto, Toronto, Ont., Canada (Kennedy).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487268PMC
http://dx.doi.org/10.1503/jpn.170109DOI Listing
June 2017

Recognition and management of antidepressant discontinuation syndrome.

J Psychiatry Neurosci 2017 06;42(4):E7-E8

From the Department of Psychiatry, St. Michael's Hospital and University of Toronto, Toronto, Ont., Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487275PMC
http://dx.doi.org/10.1503/jpn.170022DOI Listing
June 2017

Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation.

Front Hum Neurosci 2017 24;11:74. Epub 2017 Feb 24.

Department of Psychiatry, University Health NetworkToronto, ON, Canada; Faculty of Medicine, University of TorontoToronto, ON, Canada; Department of Psychiatry, St. Michael's HospitalToronto, ON, Canada; Arthur Sommer Rotenberg Suicide and Depression Studies Program, St. Michael's HospitalToronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's HospitalToronto, ON, Canada; Krembil Research Institute, University Health NetworkToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnhum.2017.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323405PMC
February 2017

Effect of antipsychotic pharmacotherapy on clinical outcomes of intermittent theta-burst stimulation for refractory depression.

J Psychopharmacol 2017 03 11;31(3):312-319. Epub 2016 Nov 11.

1 MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Canada.

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http://dx.doi.org/10.1177/0269881116675516DOI Listing
March 2017

A randomized, double-blind, placebo-controlled, crossover trial evaluating the effect of intranasal insulin on cognition and mood in individuals with treatment-resistant major depressive disorder.

J Affect Disord 2017 Mar 18;210:57-65. Epub 2016 Dec 18.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.12.006DOI Listing
March 2017

The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis.

Brain Connect 2017 02 9;7(1):25-33. Epub 2017 Jan 9.

1 Center for Neuroscience Studies, Queen's University , Kingston, Canada .

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http://dx.doi.org/10.1089/brain.2016.0438DOI Listing
February 2017

Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation.

Front Hum Neurosci 2017 24;11:74. Epub 2017 Feb 24.

Department of Psychiatry, University Health NetworkToronto, ON, Canada; Faculty of Medicine, University of TorontoToronto, ON, Canada; Department of Psychiatry, St. Michael's HospitalToronto, ON, Canada; Arthur Sommer Rotenberg Suicide and Depression Studies Program, St. Michael's HospitalToronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's HospitalToronto, ON, Canada; Krembil Research Institute, University Health NetworkToronto, ON, Canada.

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http://dx.doi.org/10.3389/fnhum.2017.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323405PMC
February 2017

Sirukumab: A Potential Treatment for Mood Disorders?

Adv Ther 2017 01 2;34(1):78-90. Epub 2016 Dec 2.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12325-016-0455-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216059PMC
January 2017

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder.

Innov Clin Neurosci 2016 Sep-Oct;13(9-10):20-31. Epub 2016 Oct 1.

Dr. Vaccarino is with Indoc Research, Toronto, Ontario, Canada; Dr. Evans is with Indoc Research, Toronto, Ontario, Canada, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada; Dr. Kalali is with Quintiles Inc, San Diego, California, USA, and Department of Psychiatry, University of California, San Diego, California, USA; Drs. Kennedy and Placenza are with University Health Network, Toronto, Ontario, Canada; Dr. Engelhardt is with Cronos Clinical Consulting Services, Lambertville, New Jersey, USA; Dr. Frey is with Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Dr. Greist is with Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Dr. Kobak is with Center for Telepsychology, Madison, Wisconsin, USA; Dr. Lam is with Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada; Dr. MacQueen is with Mathison Centre for Mental Health Research and Education, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Dr. Milev is with Department of Psychiatry, Queen's University, Kingston, Ontario, Canada; Dr. Ravindran is with Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dr. Sheehan is with Department of Psychiatry and Behavioral Health, University of South Florida College of Medicine, Tampa, Florida, USA; Dr. Sills was with OCBN, Toronto, Ontario, Canada; Dr. Williams is with Columbia University, New York, New York, USA, and Medavante Inc., Trenton, New Jersey, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141593PMC
October 2016

Admixture analysis of age at onset in first episode bipolar disorder.

J Affect Disord 2016 Sep 27;201:88-94. Epub 2016 Apr 27.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.04.006DOI Listing
September 2016

Deep Brain Stimulation Modulates Gamma Oscillations and Theta-Gamma Coupling in Treatment Resistant Depression.

Brain Stimul 2015 Nov-Dec;8(6):1033-42. Epub 2015 Jun 26.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, 1001 Queen Street West, Unit 4-1, Toronto, Ontario M6J 1H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2015.06.010DOI Listing
June 2016

Assessing anhedonia in depression: Potentials and pitfalls.

Neurosci Biobehav Rev 2016 Jun 6;65:21-35. Epub 2016 Mar 6.

ASR Chair in Suicide and Depression Studies Program, Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.neubiorev.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856554PMC
June 2016

Divergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression.

Am J Psychiatry 2016 May 12;173(5):481-90. Epub 2016 Feb 12.

From the Department of Psychology, Truman State University, Kirksville, Mo.; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Clinical Psychology and the EMGO Institute for Health and Care Research, VU University Amsterdam, the Netherlands; the Department of Psychology, Vanderbilt University, Nashville, Tenn.; the Department of Clinical Psychology and Psychotherapy, Babes-Bolyai University, Cluj, Romania; the Department of Psychology, University of Pennsylvania, Philadelphia; the Department of Psychology and Neuroscience, University of Colorado, Boulder; the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Fatemeh Zahra Infertility and Reproductive Health Research Center and the Department of Psychiatry, Babol University of Medical Sciences, Babol, Iran; the Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; the Department of Psychiatry, Faculty of Medicine, University of Toronto; the Department of Psychology, University of Toronto-Scarborough; the Health Services Research Center, Neuropsychiatric Institute, University of California, Los Angeles; the Department of Preventive Medicine and the Center for Behavioral Intervention Technologies, Feinberg School of Medicine, Northwestern University, Chicago; the Duke-National University of Singapore Graduate Medical School, Singapore; and the Department of Psychology, University of Notre Dame, Notre Dame, Ind.

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http://dx.doi.org/10.1176/appi.ajp.2015.15040492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934129PMC
May 2016

Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications.

Mol Neuropsychiatry 2016 May 8;2(1):1-14. Epub 2016 Jan 8.

Department of Psychiatry, University Health Network, University of Toronto, Toronto, Ont., Canada; Department of Psychiatry, St. Michael's Hospital, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000441521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996002PMC
May 2016

Ketamine: stimulating antidepressant treatment?

BJPsych Open 2016 May 11;2(3):e5-e9. Epub 2016 May 11.

, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM, USA.

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http://dx.doi.org/10.1192/bjpo.bp.116.002923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995167PMC
May 2016

Sustained efficacy of agomelatine 10 mg, 25 mg, and 25-50 mg on depressive symptoms and functional outcomes in patients with major depressive disorder. A placebo-controlled study over 6 months.

Eur Neuropsychopharmacol 2016 Feb 25;26(2):378-389. Epub 2015 Sep 25.

Institut de Recherches Internationales Servier (IRIS), 50 rue Carnot, 92284 Suresnes Cedex, France.

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.006DOI Listing
February 2016

Zebrafish models of major depressive disorders.

J Neurosci Res 2016 Jan 9;94(1):3-14. Epub 2015 Oct 9.

Department of Psychiatry, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jnr.23639DOI Listing
January 2016

Evidence to support peripheral and central IL-6 signaling targets to treat depression.

Expert Opin Investig Drugs 2015 16;24(7):991-2. Epub 2015 Jun 16.

University Health Network, University of Toronto, Department of Psychiatry , 200 Elizabeth Street, 8-EN-238, Toronto, ON, M5G 2C4 , Canada +416 340 3888 ; +416 340 4198 ;

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http://dx.doi.org/10.1517/13543784.2015.1057675DOI Listing
November 2015

Correlates of benzodiazepine use in major depressive disorder: The effect of anhedonia.

J Affect Disord 2015 Nov 21;187:101-5. Epub 2015 Aug 21.

Department of Psychiatry, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jad.2015.07.040DOI Listing
November 2015

Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder.

Pharmacogenomics 2015 Nov 10;16(17):1919-29. Epub 2015 Nov 10.

Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.2217/pgs.15.136DOI Listing
November 2015

Development and validation of the Dimensional Anhedonia Rating Scale (DARS) in a community sample and individuals with major depression.

Psychiatry Res 2015 Sep 26;229(1-2):109-19. Epub 2015 Jul 26.

Department of Psychiatry, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.psychres.2015.07.062DOI Listing
September 2015

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder.

J Vis Exp 2015 Aug 11(102):e53129. Epub 2015 Aug 11.

MRI-Guided rTMS Clinic, University Health Network; Department of Psychiatry, University Health Network; Toronto Western Research Institute, University Health Network; Department of Psychiatry, University of Toronto;

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http://www.jove.com/video/53129/mri-guided-dmpfc-rtms-as-tre
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http://dx.doi.org/10.3791/53129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692428PMC
August 2015

Canadian Network for Mood and Anxiety Treatments (CANMAT) consensus recommendations for functional outcomes in major depressive disorder.

Ann Clin Psychiatry 2015 May;27(2):142-9

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. E-mail:

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May 2015

STAR*D and Measurement-Based Care for Depression: Don't Toss Out the Baby!

Can J Psychiatry 2015 Jan;60(1):6-8

Professor, Department of Psychiatry, University of Toronto, Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314061PMC
http://dx.doi.org/10.1177/070674371506000103DOI Listing
January 2015

Depression and employment status in primary and tertiary care settings.

Can J Psychiatry 2015 Jan;60(1):14-22

Psychiatrist, Department of Psychiatry, University Health Network, Toronto, Ontario; Professor, Department of Psychiatry and Institute of Medical Sciences, University of Toronto, Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314052PMC
http://dx.doi.org/10.1177/070674371506000105DOI Listing
January 2015