Siddharthan Chandran

Siddharthan Chandran

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Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS.

J Neurol Neurosurg Psychiatry 2019 Sep 12. Epub 2019 Sep 12.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/jnnp-2019-320807DOI Listing
September 2019

In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells.

Methods Mol Biol 2019 ;1936:65-77

Centre For Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-4939-9072-6_4DOI Listing
July 2019

The brief Dimensional Apathy Scale: A short clinical assessment of apathy.

Clin Neuropsychol 2019 Jun 3:1-13. Epub 2019 Jun 3.

a Human Cognitive Neuroscience, School of Philosophy, Psychology and Language Science , University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.1080/13854046.2019.1621382DOI Listing
June 2019

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

Front Mol Neurosci 2019 21;12:124. Epub 2019 May 21.

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fnmol.2019.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536688PMC
May 2019

Changing epidemiology of motor neurone disease in Scotland.

J Neurol 2019 Apr 25;266(4):817-825. Epub 2019 Feb 25.

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building 49 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.1007/s00415-019-09190-7DOI Listing
April 2019

Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies.

Acta Neuropathol 2019 Mar 27;137(3):363-377. Epub 2018 Nov 27.

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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http://link.springer.com/10.1007/s00401-018-1941-9
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http://dx.doi.org/10.1007/s00401-018-1941-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514076PMC
March 2019

ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS.

Neurology 2018 10 12;91(15):e1370-e1380. Epub 2018 Sep 12.

From Human Cognitive Neuroscience (C.C., J.N., T.B., R.R., S.A.), Psychology, Philosophy, Psychology and Language Sciences, Euan MacDonald Centre for Motor Neurone Disease Research (C.C., S.A.), and Alzheimer Scotland Dementia Research Centre (R.R.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (J.N., S.C., S.P., R.R., L.S., R.S., S.A.), Royal Infirmary of Edinburgh, UK; Academic Unit of Neurology (K.L., M.H., I.M., M.P.-G., A.V., O.H.), Trinity College Dublin; Departments of Psychology (K.L., I.M., N.P., M.P.-G.) and Neurology (O.H.), Beaumont Hospital, Dublin, Ireland; and Maurice Wohl Clinical Neuroscience Institute (T.C., C.E.S., A.A.-C.), Department of Basic and Clinical Neuroscience, King's College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000006317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177274PMC
October 2018

Elucidating Pro-Inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model.

J Neurotrauma 2018 01 3;35(2):341-352. Epub 2017 Nov 3.

1 Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Cambridge, United Kingdom .

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http://dx.doi.org/10.1089/neu.2017.5155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784793PMC
January 2018

Human stem cell-derived astrocytes replicate human prions in a genotype-dependent manner.

J Exp Med 2017 Dec 15;214(12):3481-3495. Epub 2017 Nov 15.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, UK

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http://dx.doi.org/10.1084/jem.20161547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716027PMC
December 2017

Multidimensional apathy and executive dysfunction in amyotrophic lateral sclerosis.

Cortex 2017 09 13;94:142-151. Epub 2017 Jul 13.

Human Cognitive Neuroscience Unit - School of Philosophy, Psychology & Language Sciences, University of Edinburgh, Edinburgh, UK; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.cortex.2017.06.023DOI Listing
September 2017

Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.

Prog Retin Eye Res 2017 07 28;59:131-157. Epub 2017 Apr 28.

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK; Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2017.04.003DOI Listing
July 2017

Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.

Brain Pathol 2017 07;27(4):518-524

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH16 4UU, UK.

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http://dx.doi.org/10.1111/bpa.12520DOI Listing
July 2017

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.

Neurobiol Aging 2017 03 21;51:178.e11-178.e20. Epub 2016 Dec 21.

The Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302213PMC
March 2017

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 31;18(1-2):1-9. Epub 2016 Aug 31.

a Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.1080/21678421.2016.1221433DOI Listing
February 2017

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

J Physiol 2016 11 30;594(22):6573-6582. Epub 2015 Dec 30.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.

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http://dx.doi.org/10.1113/JP270660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108911PMC
November 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions.

Mol Cell Probes 2016 08 7;30(4):218-224. Epub 2016 Jun 7.

South East Scotland Genetics Service, Western General Hospital, Edinburgh, EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1016/j.mcp.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978699PMC
August 2016

Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale.

J Neurol Neurosurg Psychiatry 2016 Jun 22;87(6):663-9. Epub 2015 Jul 22.

Department of Psychology, School of Philosophy, Psychology & Language Sciences, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/jnnp-2015-310772DOI Listing
June 2016

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.

EBioMedicine 2016 Jan 12;3:141-154. Epub 2015 Dec 12.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Midlothian EH16 4UU, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; The Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964153024
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http://dx.doi.org/10.1016/j.ebiom.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739435PMC
January 2016

High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.

Stem Cell Reports 2013 31;1(5):437-50. Epub 2013 Oct 31.

Department of Clinical Neurosciences, Cambridge University, Cambridge CB2 0PY, UK ; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Veterinary Medicine, Cambridge University, Cambridge CB3 0ES, UK.

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http://dx.doi.org/10.1016/j.stemcr.2013.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841262PMC
October 2015

Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders.

Amyotroph Lateral Scler Frontotemporal Degener 2015 Jun 12;16(3-4):172-9. Epub 2015 May 12.

Human Cognitive Neuroscience-PPLS, The University of Edinburgh , UK.

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http://dx.doi.org/10.3109/21678421.2015.1030430DOI Listing
June 2015

Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming.

EBioMedicine 2015 Jun 11;2(6):528-35. Epub 2015 Apr 11.

Centre for Clinical Brain Sciences, University of Edinburgh, Midlothian EH16 4SB, United Kingdom ; MRC Centre for Regenerative Medicine, University of Edinburgh, Midlothian EH16 4SB, United Kingdom ; The Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Midlothian EH16 4SB, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964150009
Publisher Site
http://dx.doi.org/10.1016/j.ebiom.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534756PMC
June 2015

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.

Nat Commun 2015 Jan 12;6:5999. Epub 2015 Jan 12.

1] School of Psychology and Neuroscience, University of St. Andrews, Westburn Lane, St. Andrews KY16 9JP, UK [2] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.1038/ncomms6999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338554PMC
January 2015

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

J Physiol 2014 Oct 28;592(19):4353-63. Epub 2014 Aug 28.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9XD, UK

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http://dx.doi.org/10.1113/jphysiol.2014.278994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215781PMC
October 2014

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.

PLoS One 2014 17;9(1):e85932. Epub 2014 Jan 17.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom ; Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085932PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895023PMC
September 2014

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

Nat Chem Biol 2014 Aug 29;10(8):677-85. Epub 2014 Jun 29.

1] Gladstone Institute of Neurologic Disease, San Francisco, California, USA. [2] Department of Neurology, University of California-San Francisco Medical Center, San Francisco, California, USA. [3] Biomedical Sciences Graduate Program, University of California-San Francisco, San Francisco, California, USA. [4] Keck Program in Brain Cell Engineering, Gladstone Institutes, San Francisco, California, USA. [5] Department of Physiology, University of California-San Francisco, San Francisco, California, USA. [6] Taube-Koret Center for Neurodegenerative Disease Research, San Francisco, California, USA. [7] Hellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA. [8] Roddenberry Stem Cell Program, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.1563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106236PMC
August 2014

Mesenchymal stromal cell transplantation modulates neuroinflammatory milieu in amyotrophic lateral sclerosis.

Cytotherapy 2014 Aug;16(8):1031-2

Centre for Clinical Brain Sciences, University of Edinburgh, Scotland; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Scotland.

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http://dx.doi.org/10.1016/j.jcyt.2014.06.001DOI Listing
August 2014

Can stem cells repair the brain.

Trans Med Soc Lond 2011-2012;128:69-74

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July 2014

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.

J Neurosci 2014 Mar;34(11):4070-5

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom; and Euan MacDonald Centre for MND Research, Centre for Clinical Brain Sciences, and MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

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http://www.jneurosci.org/content/34/11/4070.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5410-13.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.5410-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951701PMC
March 2014

Management of sialorrhoea in motor neuron disease: a survey of current UK practice.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 7;14(7-8):521-7. Epub 2013 May 7.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital , Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.3109/21678421.2013.790452DOI Listing
December 2013

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.

Acta Neuropathol Commun 2013 Dec 23;1:84. Epub 2013 Dec 23.

Centre for Clinical Brain Sciences, MS Centre, University of Edinburgh Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

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http://dx.doi.org/10.1186/2051-5960-1-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895761PMC
December 2013

Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time.

Cell Cycle 2013 Aug 11;12(15):2339-40. Epub 2013 Jul 11.

Euan MacDonald Centre for Motor Neurone Disease Research; Centre for Neuroregeneration and Medical Research Council Centre for Regenerative Medicine; University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.4161/cc.25705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841307PMC
August 2013

Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.

Pain 2013 May 14;154(5):632-42. Epub 2012 Dec 14.

Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.pain.2012.12.002DOI Listing
May 2013

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.

Neurosci Lett 2013 May 18;543:95-100. Epub 2013 Mar 18.

Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.

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http://dx.doi.org/10.1016/j.neulet.2013.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725411PMC
May 2013

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.

Br J Clin Pharmacol 2013 Apr;75(4):907-18

Anne McLaren Laboratory for Regenerative Medicine & Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.

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http://dx.doi.org/10.1111/bcp.12022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612708PMC
April 2013

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

Proc Natl Acad Sci U S A 2013 Mar 11;110(12):4697-702. Epub 2013 Feb 11.

Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Neuroregeneration, and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1300398110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607024PMC
March 2013

Patterns of cognitive dysfunction in progressive MS.

Behav Neurol 2013 Jan;27(3):259-65

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3233/BEN-120286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215559PMC
January 2013

Experimental and therapeutic opportunities for stem cells in multiple sclerosis.

Int J Mol Sci 2012 Nov 8;13(11):14470-91. Epub 2012 Nov 8.

Anne McLaren Laboratory for Regenerative Medicine, Stem Cell Institute, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK.

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http://dx.doi.org/10.3390/ijms131114470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509592PMC
November 2012

What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease.

Cortex 2012 Jul 31;48(7):936-44. Epub 2011 Aug 31.

Human Cognitive Neuroscience, Department of Psychology, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.cortex.2011.07.008DOI Listing
July 2012

Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases.

Brain Res 2012 Jun 5;1462:129-38. Epub 2012 Jan 5.

Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1016/j.brainres.2011.12.057DOI Listing
June 2012

Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency.

Am J Pathol 2012 May 15;180(5):1897-905. Epub 2012 Mar 15.

Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.ajpath.2012.01.018DOI Listing
May 2012

Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality?

J Anat 2012 Feb 2;220(2):122-30. Epub 2011 Dec 2.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1111/j.1469-7580.2011.01459.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275767PMC
February 2012

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.

Cell Res 2011 Sep 12;21(9):1332-42. Epub 2011 Jul 12.

Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1038/cr.2011.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193467PMC
September 2011

Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.

J Neurosci 2011 Apr;31(17):6289-95

Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0008-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116378PMC
April 2011

Human stem cell-derived neurons: a system to study human tau function and dysfunction.

PLoS One 2010 Nov 11;5(11):e13947. Epub 2010 Nov 11.

Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978712PMC
November 2010

Improving the translational hit of experimental treatments in multiple sclerosis.

Mult Scler 2010 Sep 4;16(9):1044-55. Epub 2010 Aug 4.

Centre for Clinical Brain Sciences, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK.

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http://dx.doi.org/10.1177/1352458510379612DOI Listing
September 2010

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.

Mol Neurobiol 2010 Aug 30;42(1):97-102. Epub 2010 Apr 30.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK.

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http://dx.doi.org/10.1007/s12035-010-8136-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948543PMC
August 2010

Origins of gliogenic stem cell populations within adult skin and bone marrow.

Stem Cells Dev 2010 Jul;19(7):1055-65

Anne Maclaren Laboratory for Regenerative Medicine, MRC Centre for Stem Cell Biology and Regenerative Medicine, Forvie Site, University of Cambridge , Cambridge, United Kingdom.

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http://dx.doi.org/10.1089/scd.2009.0371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136724PMC
July 2010

Cell-mediated neuroprotection in a mouse model of human tauopathy.

J Neurosci 2010 Jul;30(30):9973-83

Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.0834-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633376PMC
July 2010

Abnormal tau phosphorylation in primary progressive multiple sclerosis.

Acta Neuropathol 2010 May 21;119(5):591-600. Epub 2010 Mar 21.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://link.springer.com/10.1007/s00401-010-0671-4
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May 2010

Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia.

Am J Pathol 2009 Dec 22;175(6):2332-42. Epub 2009 Oct 22.

Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.2353/ajpath.2009.090051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789608PMC
December 2009

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.

PLoS One 2009 Oct 6;4(10):e7327. Epub 2009 Oct 6.

Anne McLaren Laboratory for Regenerative Medicine & Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752165PMC
October 2009

Multipotent skin-derived precursors: from biology to clinical translation.

Curr Opin Biotechnol 2009 Oct 5;20(5):522-30. Epub 2009 Nov 5.

Euan MacDonald Centre, Centre for Clinical Brain Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.

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http://dx.doi.org/10.1016/j.copbio.2009.10.004DOI Listing
October 2009

Tissue, cell and pathway engineering.

Curr Opin Biotechnol 2009 Oct 10;20(5):509-10. Epub 2009 Nov 10.

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http://dx.doi.org/10.1016/j.copbio.2009.10.014DOI Listing
October 2009

Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.

Acta Neuropathol 2009 May 14;117(5):583-9. Epub 2009 Mar 14.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1007/s00401-009-0515-2DOI Listing
May 2009

What are the prospects of stem cell therapy for neurology?

BMJ 2008 Nov 28;337:a1934. Epub 2008 Nov 28.

Anne McLaren Laboratory for Regenerative Medicine and Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0SZ.

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http://dx.doi.org/10.1136/bmj.a1934DOI Listing
November 2008

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.

J Neuroimmunol 2008 Sep 30;201-202:200-11. Epub 2008 Jul 30.

Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY. UK.

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September 2008

Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level.

PLoS One 2008 Aug 6;3(8):e2863. Epub 2008 Aug 6.

Department of Clinical Neurosciences and Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483937PMC
August 2008