Siddharth Balachandran

Siddharth Balachandran

UNVERIFIED PROFILE

Are you Siddharth Balachandran?   Register this Author

Register author
Siddharth Balachandran

Siddharth Balachandran

Publications by authors named "Siddharth Balachandran"

Are you Siddharth Balachandran?   Register this Author

59Publications

1066Reads

8Profile Views

The Benefits and Perils of Necroptosis in Influenza Infection.

J Virol 2020 Feb 12. Epub 2020 Feb 12.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01101-19DOI Listing
February 2020

ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis.

Curr Top Microbiol Immunol 2020 Jan 23. Epub 2020 Jan 23.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Room 224 Reimann Building, 333 Cottman Ave., 19111, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/82_2019_190DOI Listing
January 2020

Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice.

Front Immunol 2019 6;10:2101. Epub 2019 Sep 6.

Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742979PMC
September 2019

Bayonets over bombs: RIPK3 and MLKL restrict without triggering necroptosis.

J Cell Biol 2019 Jun 16;218(6):1773-1775. Epub 2019 May 16.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201905047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548124PMC
June 2019

Analysis of Cytokine- and Influenza A Virus-Driven RIPK3 Necrosome Formation.

Methods Mol Biol 2018 ;1857:93-99

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8754-2_9DOI Listing
May 2019

Interferon-γ in Salmonella pathogenesis: New tricks for an old dog.

Cytokine 2017 10 20;98:27-32. Epub 2016 Oct 20.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA 19111, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10434666163054
Publisher Site
http://dx.doi.org/10.1016/j.cyto.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398957PMC
October 2017

RIPK3-driven cell death during virus infections.

Immunol Rev 2017 05;277(1):90-101

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12539DOI Listing
May 2017

TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.

Mol Cell Biol 2017 01 19;37(1). Epub 2016 Dec 19.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00422-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192085PMC
January 2017

Phosphorylation of STAT2 on serine-734 negatively regulates the IFN-α-induced antiviral response.

J Cell Sci 2016 11 19;129(22):4190-4199. Epub 2016 Oct 19.

Dept. of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.185421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518330PMC
November 2016

Immune-Mediated Nephropathy and Systemic Autoimmunity in Mice Does Not Require Receptor Interacting Protein Kinase 3 (RIPK3).

PLoS One 2016;11(9):e0163611. Epub 2016 Sep 26.

Department of Medicine/Rheumatology Section, Lewis Katz School of Medicine, Temple University, 3500 N. Broad Street, Philadelphia, PA, 19140, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163611PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036882PMC
September 2016

StIKKing it to a death kinase: IKKs prevent TNF-α-induced cell death by phosphorylating RIPK1.

Cytokine 2016 Feb 28;78:47-50. Epub 2015 Nov 28.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2015.10.014DOI Listing
February 2016

Interferon gamma induces protective non-canonical signaling pathways in primary neurons.

J Neurochem 2015 Oct 31;135(2):309-22. Epub 2015 Aug 31.

Fox Chase Cancer Center, Program in Immune Cell Development and Host Defense, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809142PMC
October 2015

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways.

J Virol 2015 May 18;89(9):4880-93. Epub 2015 Feb 18.

Department of Cell Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.02493-14
Publisher Site
http://dx.doi.org/10.1128/JVI.02493-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403453PMC
May 2015

Meta-analysis identifies NF-κB as a therapeutic target in renal cancer.

PLoS One 2013 7;8(10):e76746. Epub 2013 Oct 7.

Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076746PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792024PMC
August 2014

The interferon-inducible antiviral protein Daxx is not essential for interferon-mediated protection against avian sarcoma virus.

Virol J 2014 May 28;11:100. Epub 2014 May 28.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Room 422 Reimann Building, 333 Cottman Ave,, 19111 Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1743-422X-11-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049388PMC
May 2014

Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.

PLoS One 2013 17;8(4):e61446. Epub 2013 Apr 17.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629199PMC
November 2013

NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.

Mol Cancer Ther 2013 Aug 8;12(8):1568-78. Epub 2013 May 8.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746800PMC
August 2013

Development of interferon γ-based immunocytokines targeting renal cancer.

Oncoimmunology 2013 Jul 16;2(7):e24964. Epub 2013 May 16.

Immune Cell Development and Host Defense Program; Fox Chase Cancer Center; Philadelphia, PA USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/onci.24964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782162PMC
July 2013

Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.

Cell Host Microbe 2013 Jun;13(6):701-10

Immune Cell Development and Host Defense Program, Research Institute of Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2013.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688842PMC
June 2013

NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells.

Mol Cancer Res 2013 Apr 29;11(4):360-9. Epub 2013 Jan 29.

The Wistar Institute, Fox Chase Cancer Center, Philadelphia, Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-12-0661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631279PMC
April 2013

Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective.

J Interferon Cytokine Res 2013 Apr;33(4):171-80

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center , Philadelphia, PA 19111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jir.2012.0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624769PMC
April 2013

STAT1-independent control of a neurotropic measles virus challenge in primary neurons and infected mice.

J Immunol 2012 Feb 13;188(4):1915-23. Epub 2012 Jan 13.

Program in Immune Cell Development and Host Defense, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1101356
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1101356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273675PMC
February 2012

Interferon impedes an early step of hepatitis delta virus infection.

PLoS One 2011 19;6(7):e22415. Epub 2011 Jul 19.

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139649PMC
December 2011

Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm.

PLoS Pathog 2011 Oct 13;7(10):e1002165. Epub 2011 Oct 13.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1002165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192840PMC
October 2011

NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.

Mol Cell Biol 2011 Jul 16;31(14):2934-46. Epub 2011 May 16.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.05445-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133390PMC
July 2011

Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses.

J Virol 2011 Mar 5;85(6):2599-610. Epub 2011 Jan 5.

Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Room 224, Reimann Building, 333 Cottman Ave., Philadelphia, PA 19111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02213-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067974PMC
March 2011

PKR in innate immunity, cancer, and viral oncolysis.

Methods Mol Biol 2007 ;383:277-301

University of Miami School of Medicine, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-335-6_18DOI Listing
April 2008

TBK1 protects vacuolar integrity during intracellular bacterial infection.

PLoS Pathog 2007 Mar;3(3):e29

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.0030029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808071PMC
March 2007

Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7.

J Immunol 2007 Feb;178(4):2429-39

Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.178.4.2429DOI Listing
February 2007

Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

Mol Ther 2005 May;11(5):717-23

Department of Thoracic and Cardiovascular Surgery, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 445, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2005.01.018DOI Listing
May 2005

A FADD-dependent innate immune mechanism in mammalian cells.

Nature 2004 Nov;432(7015):401-5

Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature03124DOI Listing
November 2004

Defective translational control facilitates vesicular stomatitis virus oncolysis.

Cancer Cell 2004 Jan;5(1):51-65

Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1535-6108(03)00330-1DOI Listing
January 2004

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

Cancer Res 2002 Apr;62(8):2239-43

Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
April 2002