Publications by authors named "Siavosh Mahboobi"

35Publications

Enantioselective synthesis and biological investigation of tetrahydro-β-carboline-based HDAC6 inhibitors with improved solubility.

Arch Pharm (Weinheim) 2019 Jun 6;352(6):e1900026. Epub 2019 May 6.

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1002/ardp.201900026DOI Listing
June 2019

Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.

Eur J Med Chem 2018 May 26;152:329-357. Epub 2018 Apr 26.

Institute of Pharmacy, Department of Pharmaceutical/Medicinal Chemistry I, University of Regensburg, 93040, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.04.046DOI Listing
May 2018

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.

Cell Signal 2017 11 21;39:9-17. Epub 2017 Jul 21.

Department of Toxicology, University Medical Center, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.07.014DOI Listing
November 2017

Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.

Cell Signal 2017 01 9;29:218-225. Epub 2016 Nov 9.

Department of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.11.002DOI Listing
January 2017

Generation and Assessment of Fusions Between HDACi and TKi.

Methods Mol Biol 2017 ;1510:405-412

Faculty of Chemistry and Pharmacy, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, Regensburg, D-93040, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_31DOI Listing
January 2018

How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot.

Methods Mol Biol 2017 ;1510:355-364

Institute of Toxicology, University Medical Center Mainz, Mainz, 55131, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_26DOI Listing
January 2018

Concepts to Target MYC in Pancreatic Cancer.

Mol Cancer Ther 2016 08 12;15(8):1792-8. Epub 2016 Jul 12.

II. Medizinische Klinik, Technische Universität München, München, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0050DOI Listing
August 2016

Drugging the HDAC6-HSP90 interplay in malignant cells.

Trends Pharmacol Sci 2014 Oct 16;35(10):501-9. Epub 2014 Sep 16.

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.tips.2014.08.001DOI Listing
October 2014

Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents.

Anticancer Drugs 2010 Sep;21(8):759-65

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Friedrich-Schiller-University Jena, Germany.

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http://dx.doi.org/10.1097/CAD.0b013e32833ccf25DOI Listing
September 2010

Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model.

Vascul Pharmacol 2010 Jan-Feb;52(1-2):55-62. Epub 2009 Nov 29.

Clinic for Internal Medicine III, Friedrich-Schiller-University Jena, Erlanger Alle 101, D-07747 Jena, Germany.

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http://dx.doi.org/10.1016/j.vph.2009.11.001DOI Listing
September 2010

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.

Eur J Med Chem 2008 Jul 2;43(7):1444-53. Epub 2007 Oct 2.

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.ejmech.2007.09.021DOI Listing
July 2008

2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.

J Med Chem 2007 Sep 11;50(18):4405-18. Epub 2007 Aug 11.

Department of Pharmaceutical Chemistry I, University of Regensburg, D-93040 Regensburg, Germany.

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http://dx.doi.org/10.1021/jm0703136DOI Listing
September 2007

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study.

Eur J Med Chem 2008 Mar 3;43(3):633-56. Epub 2007 Jun 3.

Department of Pharmaceutical Chemistry I, University of Regensburg, D-93040 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.ejmech.2007.05.009DOI Listing
March 2008

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.

Bioorg Med Chem 2007 Mar 12;15(5):2187-97. Epub 2006 Dec 12.

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, D-93040 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bmc.2006.12.011DOI Listing
March 2007

3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances.

Eur J Med Chem 2006 Feb 10;41(2):176-91. Epub 2006 Jan 10.

Department of Pharmaceutical Chemistry I, University of Regensburg, D-93040 Regensburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234050027
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http://dx.doi.org/10.1016/j.ejmech.2005.10.006DOI Listing
February 2006

Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.

Eur J Med Chem 2005 Jan;40(1):85-92

Department of Pharmaceutical Chemistry I, University of Regensburg, 93040 Regensburg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234040023
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http://dx.doi.org/10.1016/j.ejmech.2004.10.007DOI Listing
January 2005

A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571.

J Biol Chem 2003 Feb 14;278(7):5148-55. Epub 2002 Nov 14.

Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, D-07747 Jena, Germany.

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http://dx.doi.org/10.1074/jbc.M209861200DOI Listing
February 2003

Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues.

J Org Chem 1999 Oct;64(22):8130-8137

Faculty of Chemistry and Pharmacy, University Regensburg, D-93040 Regensburg, Germany.

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http://dx.doi.org/10.1021/jo981926gDOI Listing
October 1999

Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction.

J Org Chem 1999 Jun;64(13):4697-4704

Institute of Organic Chemistry, University of Mainz, D-55099 Mainz, Germany.

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http://dx.doi.org/10.1021/jo9825106DOI Listing
June 1999