Si-Yi Chen

Si-Yi Chen

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Si-Yi Chen

Si-Yi Chen

Publications by authors named "Si-Yi Chen"

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An ultrasensitive T-cell receptor detection method for TCR-Seq and RNA-Seq data.

Bioinformatics 2020 May 12. Epub 2020 May 12.

Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology; Wuhan, 430074, China.

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http://dx.doi.org/10.1093/bioinformatics/btaa432DOI Listing
May 2020

An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses.

Nat Commun 2020 Mar 13;11(1):1395. Epub 2020 Mar 13.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 90033, CA, USA.

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http://dx.doi.org/10.1038/s41467-020-15229-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070065PMC
March 2020

A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention.

Cancers (Basel) 2019 Dec 1;11(12). Epub 2019 Dec 1.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1450 Biggy St, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3390/cancers11121909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966557PMC
December 2019

Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation.

Int J Nanomedicine 2019 3;14:4767-4780. Epub 2019 Jul 3.

Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Guishan, Taoyuan City 33302, Taiwan, ROC.

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http://dx.doi.org/10.2147/IJN.S204844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613455PMC
September 2019

Transcriptome and Regulatory Network Analyses of CD19-CAR-T Immunotherapy for B-ALL.

Genomics Proteomics Bioinformatics 2019 04 13;17(2):190-200. Epub 2019 Jun 13.

Hubei Bioinformatics and Molecular Imaging Key Laboratory, Department of Bioinformatics and Systems Biology, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620363PMC
April 2019

A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy.

Front Immunol 2019 18;10:491. Epub 2019 Mar 18.

Department of Radiation Medicine and Applied Sciences, San Diego Moores Cancer Center, University of California, San Diego, San Diego, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431643PMC
March 2019

A novel frame-shift mutation c.703_704delTA in a Chinese pedigree with neurofibromatosis type 1.

Int J Ophthalmol 2018 18;11(9):1562-1565. Epub 2018 Sep 18.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

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http://dx.doi.org/10.18240/ijo.2018.09.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133898PMC
September 2018

Circulating tumor DNA detectable in early- and late-stage colorectal cancer patients.

Biosci Rep 2018 08 31;38(4). Epub 2018 Jul 31.

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive Diseases, Beijing 100050, China

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http://dx.doi.org/10.1042/BSR20180322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066652PMC
August 2018

MYSM1 Is Essential for Maintaining Hematopoietic Stem Cell (HSC) Quiescence and Survival.

Med Sci Monit 2018 Apr 25;24:2541-2549. Epub 2018 Apr 25.

State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939948PMC
http://dx.doi.org/10.12659/msm.906876DOI Listing
April 2018

A Metal-Polyphenol Network Coated Nanotheranostic System for Metastatic Tumor Treatments.

Small 2017 12 10;13(48). Epub 2017 Nov 10.

Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.

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http://dx.doi.org/10.1002/smll.201702714DOI Listing
December 2017

TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing.

Cancer Genomics Proteomics 2016 May-Jun;13(3):231-8

Norris Comprehensive Cancer Center, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A.

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January 2017

Circulating tumor DNA detection in lung cancer patients before and after surgery.

Sci Rep 2016 09 19;6:33519. Epub 2016 Sep 19.

Department of Thoracic Surgery, The General Hospital of People's Liberation Army, Beijing, China.

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http://dx.doi.org/10.1038/srep33519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027588PMC
September 2016

IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.

Cell Rep 2016 07 23;16(2):405-418. Epub 2016 Jun 23.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293007PMC
July 2016

Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation.

Sci Rep 2016 Feb 26;6:22211. Epub 2016 Feb 26.

Department of Stomatology, Chinese PLA General Hospital, 28Fuxing Road, HaidianDistrict, Beijing 100850, P.R. China.

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http://dx.doi.org/10.1038/srep22211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768166PMC
February 2016

Circulating tumor DNA identified by targeted sequencing in advanced-stage non-small cell lung cancer patients.

Cancer Lett 2016 Jan 12;370(2):324-31. Epub 2015 Nov 12.

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.005DOI Listing
January 2016

Genetic mutations in human rectal cancers detected by targeted sequencing.

J Hum Genet 2015 Oct 2;60(10):589-96. Epub 2015 Jul 2.

Central Laboratory, People's Hospital of Shaan Xi Province, Xi'an, China.

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http://dx.doi.org/10.1038/jhg.2015.71DOI Listing
October 2015

Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1.

Sci Rep 2015 Sep 8;5:13755. Epub 2015 Sep 8.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1038/srep13755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562257PMC
September 2015

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.

J Immunol 2015 Aug 8;195(4):1459-69. Epub 2015 Jul 8.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;

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http://dx.doi.org/10.4049/jimmunol.1500574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530047PMC
August 2015

Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1.

Blood 2014 Oct 12;124(17):2647-56. Epub 2014 Sep 12.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1182/blood-2013-10-534313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208280PMC
October 2014

Differential requirement of GRP94 and GRP78 in mammary gland development.

Sci Rep 2014 Jun 23;4:5390. Epub 2014 Jun 23.

Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

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http://www.nature.com/articles/srep05390
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http://dx.doi.org/10.1038/srep05390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066247PMC
June 2014

c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma.

Hepatology 2014 May 27;59(5):1850-63. Epub 2014 Mar 27.

State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China; Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1002/hep.26720DOI Listing
May 2014

The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation.

Blood 2013 Oct 6;122(16):2812-22. Epub 2013 Sep 6.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA; and.

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http://dx.doi.org/10.1182/blood-2013-03-489641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798996PMC
October 2013

Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):E3927-36. Epub 2013 Sep 23.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.

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http://dx.doi.org/10.1073/pnas.1308888110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799335PMC
October 2013

A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response.

PLoS One 2012 7;7(11):e48930. Epub 2012 Nov 7.

Norris Comprehensive Cancer Center, Department of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048930PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492139PMC
July 2013

A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity.

PLoS One 2012 7;7(11):e48614. Epub 2012 Nov 7.

Norris Comprehensive Cancer Center, Department of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048614PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492467PMC
April 2013

Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging.

Int J Nanomedicine 2012 11;7:2817-27. Epub 2012 Jun 11.

Department of Physiology and Pharmacology, Healthy Aging Research Center, Chang Gung University, Kuei-Shan, Tao-Yuan, Taiwan, ROC.

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http://www.dovepress.com/manipulation-of-magnetic-nanopartic
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http://dx.doi.org/10.2147/IJN.S31730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383323PMC
January 2013

Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C.

PLoS One 2012 19;7(7):e40639. Epub 2012 Jul 19.

State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400674PMC
December 2012

Ectopically expressed perforin-1 is proapoptotic in tumor cell lines by increasing caspase-3 activity and the nuclear translocation of cytochrome C.

PLoS One 2012 19;7(7):e40639. Epub 2012 Jul 19.

State Key Laboratory of Cancer Biology, Departments of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400674PMC
December 2012

SOCS1 silencing can break high-dose dendritic cell immunotherapy-induced immune tolerance.

Mol Med Rep 2008 Jan-Feb;1(1):61-70

Shanghai Jiao Tong University Medical School, Shanghai Institute of Immunology, Shanghai 200025, P.R. China.

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October 2012

HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells.

Gastroenterology 2011 Dec 16;141(6):2076-2087.e6. Epub 2011 Sep 16.

State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085110124
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http://dx.doi.org/10.1053/j.gastro.2011.08.050DOI Listing
December 2011

Control of B cell development by the histone H2A deubiquitinase MYSM1.

Immunity 2011 Dec 8;35(6):883-96. Epub 2011 Dec 8.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098839PMC
December 2011

The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells.

Biomaterials 2011 Oct 20;32(30):7641-50. Epub 2011 Jul 20.

State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

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http://dx.doi.org/10.1016/j.biomaterials.2011.06.071DOI Listing
October 2011

The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.

PLoS One 2011 24;6(5):e20364. Epub 2011 May 24.

Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020364PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101259PMC
September 2011

Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells.

J Clin Invest 2011 Feb 4;121(2):739-51. Epub 2011 Jan 4.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1172/JCI42656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026719PMC
February 2011

A Th1-inducing adenoviral vaccine for boosting adoptively transferred T cells.

Mol Ther 2011 Jan 19;19(1):211-7. Epub 2010 Oct 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, The Methodist Hospital, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/mt.2010.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017450PMC
January 2011

IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity.

J Immunol 2010 Oct 3;185(7):4223-32. Epub 2010 Sep 3.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.0903507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153346PMC
October 2010

HER2-mediated upregulation of MMP-1 is involved in gastric cancer cell invasion.

Arch Biochem Biophys 2010 Jul 10;499(1-2):49-55. Epub 2010 May 10.

State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an 710032, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00039861100017
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http://dx.doi.org/10.1016/j.abb.2010.05.009DOI Listing
July 2010

Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence.

Clin Cancer Res 2010 Apr 6;16(8):2284-94. Epub 2010 Apr 6.

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2367DOI Listing
April 2010

Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.

Gut 2010 Mar 30;59(3):292-9. Epub 2009 Nov 30.

State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, the Fourth Military Medical University, 15 West Chang-Le Road, Xi'an 710032, PR China.

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http://gut.bmj.com/content/59/3/292.full.pdf
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http://gut.bmj.com/cgi/doi/10.1136/gut.2008.155226
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http://dx.doi.org/10.1136/gut.2008.155226DOI Listing
March 2010

A Mage3/Heat Shock Protein70 DNA vaccine induces both innate and adaptive immune responses for the antitumor activity.

Vaccine 2009 Dec 14;28(2):561-70. Epub 2009 Oct 14.

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States.

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http://dx.doi.org/10.1016/j.vaccine.2009.09.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789186PMC
December 2009

Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2.

Cloning Stem Cells 2009 Dec;11(4):523-33

Department of Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1089/clo.2009.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883497PMC
December 2009

Human suppressor of cytokine signaling 1 controls immunostimulatory activity of monocyte-derived dendritic cells.

Cancer Res 2009 Oct 29;69(20):8076-84. Epub 2009 Sep 29.

Departments of Molecular and Human Genetics, Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763040PMC
October 2009

Attraction and activation of dendritic cells at the site of tumor elicits potent antitumor immunity.

Mol Ther 2009 Sep 16;17(9):1626-36. Epub 2009 Jun 16.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1038/mt.2009.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835257PMC
September 2009

Embryonic stem cells and mammary luminal progenitors directly sense and respond to microbial products.

Stem Cells 2009 Jul;27(7):1604-15

Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/stem.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157827PMC
July 2009

Targeting the intratumoral dendritic cells by the oncolytic adenoviral vaccine expressing RANTES elicits potent antitumor immunity.

J Immunother 2009 Feb-Mar;32(2):145-56

Center for Cell and Gene Therapy, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1097/CJI.0b013e318193d31eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146345PMC
April 2009

Twist-2 controls myeloid lineage development and function.

PLoS Biol 2008 Dec;6(12):e316

Department of Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1371/journal.pbio.0060316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602725PMC
December 2008

HER2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells.

Cancer Biol Ther 2008 Aug 10;7(8):1226-31. Epub 2008 Aug 10.

State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.4161/cbt.7.8.6261DOI Listing
August 2008

Cloning of apoB intrabodies: specific knockdown of apoB in HepG2 cells.

Biochem Biophys Res Commun 2008 Aug 17;373(2):235-40. Epub 2008 Jun 17.

Department of Medicine and Molecular & Cellular Biology, Baylor College of Medicine, St. Luke's Episcopal Hospital, Houston, TX, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0801147
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http://dx.doi.org/10.1016/j.bbrc.2008.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496960PMC
August 2008

Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumor growth.

Mol Cancer Ther 2008 Jul;7(7):1890-9

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Xi'an, People's Republic of China.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-2235DOI Listing
July 2008

A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting.

Immunol Rev 2008 Apr;222:316-27

Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00605.xDOI Listing
April 2008

A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression.

Nat Med 2008 Mar 2;14(3):258-65. Epub 2008 Mar 2.

Center for Cell and Gene Therapy, Baylor College of Medicine (BCM), One Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nm1721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684168PMC
March 2008

SOCS1 downregulation in dendritic cells promotes memory T-cell responses.

Vaccine 2008 Feb 7;26(8):1128-35. Epub 2007 Dec 7.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.vaccine.2007.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750824PMC
February 2008

Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells.

Cancer Res 2007 Dec;67(24):11830-9

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1160DOI Listing
December 2007

Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency.

World J Gastroenterol 2007 Nov;13(44):5911-7

Department of Surgery, Shanghai Institute of Digestive Surgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 227 Chongqing Nan Road, Shanghai 200025, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205437PMC
http://dx.doi.org/10.3748/wjg.v13.i44.5911DOI Listing
November 2007

Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery.

Hepatology 2007 Jul;46(1):84-94

State Key Laboratory of Cancer Biology, Department of Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1002/hep.21663DOI Listing
July 2007

Suppressor of cytokine signaling 1 inhibition strategy to enhance anti-HIV vaccination.

Expert Rev Vaccines 2006 Aug;5(4):495-503

Baylor College of Medicine, Center for Cell and Gene Therapy, Department of Molecular and Human Genetics, Houston, TX 77030, USA.

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http://dx.doi.org/10.1586/14760584.5.4.495DOI Listing
August 2006

Stable knockdown of estrogen receptor alpha by vector-based RNA interference suppresses proliferation and enhances apoptosis in breast cancer cells.

Cancer Biol Ther 2006 Jul 21;5(7):842-7. Epub 2006 Jul 21.

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.4161/cbt.5.7.2840DOI Listing
July 2006

Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervical cancers.

Cancer Biol Ther 2006 Jul 9;5(7):860-6. Epub 2006 Jul 9.

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.4161/cbt.5.7.2893DOI Listing
July 2006

Dendritic cell-based tumor vaccines and antigen presentation attenuators.

Mol Ther 2006 May 30;13(5):850-8. Epub 2006 Mar 30.

Center for Cell and Gene Therapy, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ymthe.2006.02.009DOI Listing
May 2006

Inhibition of antigen-presentation attenuators to augment vaccines.

Curr Opin Mol Ther 2006 Feb;8(1):24-30

Baylor College of Medicine, Center for Cell and Gene Therapy, 1 Baylor Plaza, Houston, TX 77030, USA.

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February 2006

SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling.

J Clin Invest 2006 Jan 15;116(1):90-100. Epub 2005 Dec 15.

Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1172/JCI26169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312019PMC
January 2006

Anti-tumor immune responses following neoadjuvant immunotherapy with a recombinant adenovirus expressing HSP72 to rodent tumors.

Cancer Immunol Immunother 2005 Oct 12;54(10):988-98. Epub 2005 May 12.

Center for Anatomic Studies, Saint Louis University, USA.

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http://link.springer.com/10.1007/s00262-005-0683-4
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http://dx.doi.org/10.1007/s00262-005-0683-4DOI Listing
October 2005

CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo.

Cancer Gene Ther 2005 Jan;12(1):84-9

Department of Molecular and Human Genetics, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700770DOI Listing
January 2005

Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity.

Nat Biotechnol 2004 Dec 21;22(12):1546-53. Epub 2004 Nov 21.

Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nbt1035DOI Listing
December 2004

Enhanced intracellular stability of sFv-Fc fusion intrabodies.

Methods 2004 Oct;34(2):179-83

Department of Cancer Biology, Wake Forest University Graduate School of Arts and Sciences, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.ymeth.2004.04.003DOI Listing
October 2004

CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo.

Cancer Gene Ther 2005 Jan;12(1):84-9

Department of Molecular and Human Genetics, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700770DOI Listing
January 2005

A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors.

J Immunol 2004 Jul;173(1):61-7

Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 17 Changle West Road, 710-032 Xi'an, China.

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http://dx.doi.org/10.4049/jimmunol.173.1.61DOI Listing
July 2004

Identification of a MHC class-II restricted epitope in carcinoembryonic antigen.

Cancer Immunol Immunother 2004 May 18;53(5):391-403. Epub 2003 Nov 18.

Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Alkek Bldg. N1004, Houston, TX 77030, USA.

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http://link.springer.com/content/pdf/10.1007/s00262-003-0455
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http://link.springer.com/10.1007/s00262-003-0455-y
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http://dx.doi.org/10.1007/s00262-003-0455-yDOI Listing
May 2004

Secreted antibody/granzyme B fusion protein stimulates selective killing of HER2-overexpressing tumor cells.

J Biol Chem 2004 May 5;279(20):21343-8. Epub 2004 Mar 5.

Departments of Biochemistry and Molecular Biology and Immunology, the Fourth Military Medical University, Xi'an 710032, China.

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http://dx.doi.org/10.1074/jbc.M312648200DOI Listing
May 2004

Destruction of nonimmunogenic mammary tumor cells by a fusogenic oncolytic herpes simplex virus induces potent antitumor immunity.

Mol Ther 2004 May;9(5):658-65

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ymthe.2004.02.019DOI Listing
May 2004

Lentiviral transduction of human dendritic cells.

Methods Mol Biol 2004 ;246:451-9

Department of Internal Medicine, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1385/1-59259-650-9:451DOI Listing
March 2004

Identification of a naturally processed HLA-DR-restricted T-helper epitope in Epstein-Barr virus nuclear antigen type 1.

J Immunother 2003 May-Jun;26(3):212-21

Center for Cell and Gene Therapy, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

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http://pdfs.journals.lww.com/immunotherapy-journal/2003/0500
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http://dx.doi.org/10.1097/00002371-200305000-00005DOI Listing
January 2004

Augmentation of DNA vaccine potency through secretory heat shock protein-mediated antigen targeting.

Methods 2003 Nov;31(3):225-31

Institute of Immunology, University of Vienna, and Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria.

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http://dx.doi.org/10.1016/s1046-2023(03)00136-1DOI Listing
November 2003

A broadly applicable, personalized heat shock protein-mediated oncolytic tumor vaccine.

Cancer Res 2003 Nov;63(21):7321-9

Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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November 2003

Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.

Clin Cancer Res 2003 Oct;9(13):4743-55

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

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October 2003

Intrabody and intrakine strategies for molecular therapy.

Mol Ther 2003 Sep;8(3):355-66

Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, 27157, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1016/s1525-0016(03)00183-7DOI Listing
September 2003

Intrabody-based strategies for inhibition of vascular endothelial growth factor receptor-2: effects on apoptosis, cell growth, and angiogenesis.

FASEB J 2003 Sep 3;17(12):1733-5. Epub 2003 Jul 3.

Section of Cardiology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1045, USA.

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http://dx.doi.org/10.1096/fj.02-0942fjeDOI Listing
September 2003

Identification of MHC class II-restricted T-cell epitopes in prostate-specific membrane antigen.

Clin Cancer Res 2003 Aug;9(9):3260-71

Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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August 2003

Specific tumoricidal activity of a secreted proapoptotic protein consisting of HER2 antibody and constitutively active caspase-3.

Cancer Res 2003 Jun;63(12):3257-62

Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an 710032, China.

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June 2003

Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells.

Cancer Res 2002 May;62(9):2600-5

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

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May 2002

Characterization of anti-cyclin E single-chain Fv antibodies and intrabodies in breast cancer cells: enhanced intracellular stability of novel sFv-F(c) intrabodies.

J Immunol Methods 2002 May;263(1-2):149-67

Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27109, USA.

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http://dx.doi.org/10.1016/s0022-1759(02)00035-2DOI Listing
May 2002

Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.

Cancer Res 2002 Feb;62(4):1123-8

Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.

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February 2002