Publications by authors named "Si-Yeon Park"

5 Publications

  • Page 1 of 1

Comparison of time and cost between conventional surgical planning and virtual surgical planning in orthognathic surgery in Korea.

Maxillofac Plast Reconstr Surg 2021 Jun 21;43(1):18. Epub 2021 Jun 21.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Busandaehak-ro, Mulgeum-eup, Yangsan, 50612, Republic of Korea.

Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost.

Material And Method: This is a retrospective study of the patients who underwent orthognathic surgery at the OOOOO University Dental Hospital from December 2017 to August 2018. All the patients were analyzed through both CSP and VSP, and all the surgical stents were fabricated through manual and 3-dimensional (3D) printing. The predictor variables were the planning method (CSP vs. VSP) and the surgery type (group I: Le Fort I osteotomy+bilateral sagittal split osteotomy [LFI+BSSO] or group II: only bilateral sagittal split osteotomy [BSSO]), and the outcomes were the time and cost. The results were analyzed using paired t test.

Results: Thirty patients (12 females, 18 males) met the inclusion criteria, and 17 patients were excluded from the study due to missing or incomplete data. There were 20 group I patients (LFI+BSSO regardless of genioplasty) and 10 group II patients (BSSO regardless of genioplasty). The average time of CSP for group I was 385±7.8 min, and that for group II was 195±8.33 min. The time reduction rate of VSP compared with CSP was 62.8% in group I and 41.5% in group II. On the other hand, there was no statistically significant cost reduction.

Conclusions: The time investment in VSP in this study was significantly smaller than that in CSP, and the difference was greater in group I than in group II.
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http://dx.doi.org/10.1186/s40902-021-00305-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217346PMC
June 2021

Complications associated with specific characteristics of supernumerary teeth.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Aug 5;130(2):150-155. Epub 2020 May 5.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Yangsan, Korea; Dental and Life Science Institute & Dental Research Institute, School of Dentistry, Pusan National University, Busan, Yangsan, Korea. Electronic address:

Objectives: The purpose of this study was to identify the characteristics of supernumerary teeth, analyze the associated complications, and to present new clinical knowledge on surgical interventions for supernumerary teeth.

Study Design: This retrospective cohort study was based on the medical records and radiographic records of patients who underwent surgical extraction of supernumerary teeth. The relationships among the patient's age, gender, anatomic features of supernumerary teeth, and presence and type of complications (i.e., spacing, rotation, delayed eruption of the adjacent tooth, cyst formation.) were investigated. The groups were compared by using the Mann-Whitney U test, the Kolmogorov-Smirnov test, and multiple logistic regression analysis (P < .05).

Results: The study population consisted of 705 participants who underwent extraction for 1036 supernumerary teeth. The mean age of the participants was 11.5 years, and 73.5% of the participants were males. The complication rate was 55.6%. Variables associated with an increased risk of complications were the patient's age, dentition, tuberculate shape, and horizontal direction of eruption (P < .05).

Conclusions: An increase in the patient's age or abnormalities in the shape and direction of eruption of supernumerary teeth was associated with complications. These parameters should be considered while formulating the treatment plan.
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http://dx.doi.org/10.1016/j.oooo.2020.03.002DOI Listing
August 2020

FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.

Food Chem Toxicol 2020 Mar 27;137:111163. Epub 2020 Jan 27.

Department of Pharmacology, College of Medicine, Hanyang University, Sungdong-Gu, Haengdang-Dong 17, 133-79, Seoul, Republic of Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Sungdong-Gu, Haengdang-Dong 17, 133-79, Seoul, Republic of Korea; Hanyang Biomedical Research Institute, Sungdong-Gu, Haengdang-Dong 17, 133-79, Seoul, Republic of Korea. Electronic address:

Upon mitochondrial stress, PINK1 and Parkin cooperatively mediate a response that removes damaged mitochondria. In addition to the PINK1/Parkin pathway, the FUNDC1, mitophagy receptor regulates mitochondrial clearance. It is not clear whether these systems coordinate to mediate mitophagy in response to stress. Rotenone caused an increase in LC3II expression, and FUNDC1-knocked down cells showed remarkably reduced LC3 expression compared to control cells. In addition, treatment of cells with autophagy flux inhibitor, chloroquine, induced further accumulation of LC3-II, suggesting that mitophagy induced by rotenone is due to involvement of mitochondrial FUNDC1. Rotenone treatment resulted in PINK1 stabilization on the outer mitochondrial membrane and a subsequent increase in recruitment of Parkin from the cytosol to the abnormal mitochondria, as well as physical interaction of PINK1 with Parkin in the mitochondria of rotenone-treated cells. Interestingly, knockdown of FUNDC1 did not alter PINK1/Parkin expression in the mitochondrial fraction of rotenone-treated cells. Our findings indicate that FUNDC1 involves in receptor-mediated mitophagy separately from PINK1/Parkin-dependent mitophagy. Furthermore, inhibiting mitophagy by FUNDC1 or PINK1 knockdown accelerated rotenone-induced cytotoxicity. Taken together, our findings suggest that rotenone can be induced both receptor-mediated and PINK1/Parkin-dependent mitophagy for mitochondrial clearance, and that mitophagy by removing damaged mitochondria, has cytoprotective effects.
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http://dx.doi.org/10.1016/j.fct.2020.111163DOI Listing
March 2020

Comparison of time and cost between conventional surgical planning and virtual surgical planning in orthognathic surgery in Korea.

Maxillofac Plast Reconstr Surg 2019 Dec 12;41(1):35. Epub 2019 Sep 12.

1Department of Oral and Maxillofacial surgery School of dentistry, Pusan National University, Busandaehak-ro, Mulgeum-eup, Yangsan, 50612 Republic of Korea.

Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost.

Material And Method: This is a retrospective study of the patients who underwent orthognathic surgery at the Pusan National University Dental Hospital from December 2017 to August 2018. All the patients were analyzed through both CSP and VSP, and all the surgical stents were fabricated through manual and three-dimensional (3D) printing. The predictor variables were the planning method (CSP vs. VSP) and the surgery type (group I: Le Fort I osteotomy + bilateral sagittal split osteotomy [LFI+BSSO] or group II: only bilateral sagittal split osteotomy [BSSO]), and the outcomes were the time and cost. The results were analyzed using the paired test.

Results: Thirty patients (12 females, 18 males) met the inclusion criteria, and 17 patients were excluded from the study due to missing or incomplete data. There were 20 group I patients (LFI+BSSO regardless of genioplasty) and 10 group II patients (BSSO regardless of genioplasty). The average time of CSP for group I was 385 ± 7.8 min, and that for group II was 195 ± 8.33 min. The time reduction rate of VSP compared with CSP was 62.8% in group I and 41.5% in group II. On the other hand, there was no statistically significant cost reduction.

Conclusions: The time investment in VSP in this study was significantly smaller than that in CSP, and the difference was greater in group I than in group II.
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http://dx.doi.org/10.1186/s40902-019-0220-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739435PMC
December 2019

Fatal vocal cord granuloma after orthognathic surgery.

J Dent Anesth Pain Med 2018 Dec 28;18(6):375-378. Epub 2018 Dec 28.

Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan, Republic of Korea.

Endotracheal intubation is commonly associated with laryngeal injury that often resolves spontaneously without any complication. However, stenosis or granulomatous lesions are generally found on the tracheal wall or vocal process at the tube cuff level, caused by excessive cuff pressure. We present a case of fatal vocal cord granuloma leading to dyspnea following orthognathic surgery and sustained intubation for 14 hours.
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http://dx.doi.org/10.17245/jdapm.2018.18.6.375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323036PMC
December 2018
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