Shyamala Maheswaran

Shyamala Maheswaran

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Shyamala Maheswaran

Shyamala Maheswaran

Publications by authors named "Shyamala Maheswaran"

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Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring.

Recent Results Cancer Res 2020 ;215:77-88

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/978-3-030-26439-0_4DOI Listing
January 2020

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Cell 2019 Jun 25;177(7):1903-1914.e14. Epub 2019 Apr 25.

Molecular Pathology Unit, Massachusetts General Hospital Research Institute, Charlestown, MA 02129, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570580PMC
June 2019

Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics.

J Mol Diagn 2019 May 9;21(3):390-407. Epub 2019 Mar 9.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504678PMC
May 2019

Ultra-fast vitrification of patient-derived circulating tumor cell lines.

PLoS One 2018 23;13(2):e0192734. Epub 2018 Feb 23.

BioMEMS Resource Center, Center for Engineering in Medicine & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192734PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825040PMC
April 2018

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.

Cold Spring Harb Symp Quant Biol 2016 7;81:269-274. Epub 2017 Apr 7.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1101/sqb.2016.81.031120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501288PMC
February 2018

On the trail of invasive cells in breast cancer.

Nature 2018 02;554(7692):308-309

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http://dx.doi.org/10.1038/d41586-018-01634-wDOI Listing
February 2018

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells.

Sci Rep 2017 09 7;7(1):10936. Epub 2017 Sep 7.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-11119-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589885PMC
September 2017

A conduit to metastasis: circulating tumor cell biology.

Genes Dev 2017 09;31(18):1827-1840

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, 02129, USA.

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http://dx.doi.org/10.1101/gad.305805.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695084PMC
September 2017

Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.

Curr Opin Biomed Eng 2017 Sep 10;3:13-19. Epub 2017 Aug 10.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1016/j.cobme.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720146PMC
September 2017

Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells.

Mol Oncol 2017 07 9;11(7):770-780. Epub 2017 Jun 9.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1002/1878-0261.12081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496489PMC
July 2017

Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.

Sci Rep 2017 07 18;7(1):5658. Epub 2017 Jul 18.

BioMEMS Resource Center, Center for Engineering in Medicine, & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-05978-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515929PMC
July 2017

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry.

Sci Rep 2017 05 26;7(1):2433. Epub 2017 May 26.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-01150-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446400PMC
May 2017

SETD1A induced miRNA network suppresses the p53 gene expression module.

Cell Cycle 2016 11;15(4):487-8. Epub 2016 Feb 11.

a Department of Surgery , Massachusetts General Hospital Cancer Center, Harvard Medical School , Charlestown , MA , USA.

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http://dx.doi.org/10.1080/15384101.2015.1130572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056611PMC
December 2016

Deformability-based cell selection with downstream immunofluorescence analysis.

Integr Biol (Camb) 2016 05 21;8(5):654-64. Epub 2016 Mar 21.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1039/c5ib00284bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868639PMC
May 2016

Clusters of circulating tumor cells traverse capillary-sized vessels.

Proc Natl Acad Sci U S A 2016 May 18;113(18):4947-52. Epub 2016 Apr 18.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Shriners Hospital for Children, Boston, MA 02114

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http://dx.doi.org/10.1073/pnas.1524448113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983862PMC
May 2016

The Role of Physical Stabilization in Whole Blood Preservation.

Sci Rep 2016 Feb 15;6:21023. Epub 2016 Feb 15.

BioMEMS Resource Center, Center for Engineering in Medicine, &Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep21023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753451PMC
February 2016

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.

Proc Natl Acad Sci U S A 2015 Dec 2;112(49):15148-53. Epub 2015 Nov 2.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129; Howard Hughes Medical Institute, Chevy Chase, MD 20815; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1518008112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679016PMC
December 2015

Deformability of Tumor Cells versus Blood Cells.

Sci Rep 2015 Dec 18;5:18542. Epub 2015 Dec 18.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1038/srep18542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683468PMC
December 2015

Cell fate: Transition loses its invasive edge.

Nature 2015 Nov 11;527(7579):452-3. Epub 2015 Nov 11.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature16313DOI Listing
November 2015

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition.

Trends Cancer 2015 Sep 28;1(1):44-52. Epub 2015 Sep 28.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.07.006DOI Listing
September 2015

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Science 2015 Sep;349(6254):1351-6

Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.aab0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872391PMC
September 2015

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Nat Methods 2015 Jul 18;12(7):685-91. Epub 2015 May 18.

1] Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490017PMC
July 2015

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

J Biol Chem 2015 Jun 16;290(23):14381-90. Epub 2015 Apr 16.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129 and From the Departments of Medicine and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815

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http://dx.doi.org/10.1074/jbc.M114.631945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505506PMC
June 2015

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy.

Cancer Res 2015 Jun 21;75(12):2411-5. Epub 2015 May 21.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470788PMC
June 2015

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Mol Cancer Res 2015 May 12;13(5):934-43. Epub 2015 Feb 12.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433453PMC
May 2015

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Adv Mater 2015 Mar 15;27(9):1593-9. Epub 2015 Jan 15.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201404677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492283PMC
March 2015

Brain tumor cells in circulation are enriched for mesenchymal gene expression.

Cancer Discov 2014 Nov 19;4(11):1299-309. Epub 2014 Aug 19.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221467PMC
November 2014

Isolation and molecular characterization of circulating melanoma cells.

Cell Rep 2014 May 18;7(3):645-53. Epub 2014 Apr 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00217-4.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400217
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http://dx.doi.org/10.1016/j.celrep.2014.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079008PMC
May 2014

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.

Cell Rep 2013 Dec 19;5(6):1679-89. Epub 2013 Dec 19.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034764PMC
December 2013

Biopolymer system for cell recovery from microfluidic cell capture devices.

Anal Chem 2012 Apr 3;84(8):3682-8. Epub 2012 Apr 3.

Harvard-MIT Division of Health Sciences and Technology, Massachussets Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ac300190jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328665PMC
April 2012

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.

Proc Natl Acad Sci U S A 2012 Feb 19;109(8):2760-5. Epub 2011 Sep 19.

Department of Surgery, Pathology and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1018867108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286905PMC
February 2012

Circulating tumor cells: approaches to isolation and characterization.

J Cell Biol 2011 Feb;192(3):373-82

Howard Hughes Medical Institute, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1083/jcb.201010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101098PMC
February 2011

Circulating tumor cells: a window into cancer biology and metastasis.

Curr Opin Genet Dev 2010 Feb 12;20(1):96-9. Epub 2010 Jan 12.

Howard Hughes Medical Institute, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, United States.

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http://dx.doi.org/10.1016/j.gde.2009.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846729PMC
February 2010

Isolation of rare circulating tumour cells in cancer patients by microchip technology.

Nature 2007 Dec;450(7173):1235-9

Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature06385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090667PMC
December 2007

Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism.

Cancer Res 2007 Mar;67(6):2747-56

Department of Surgical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2312DOI Listing
March 2007

Mullerian inhibiting substance regulates androgen-induced gene expression and growth in prostate cancer cells through a nuclear factor-kappaB-dependent Smad-independent mechanism.

Mol Endocrinol 2006 Oct 1;20(10):2382-91. Epub 2006 Jun 1.

Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/me.2005-0480DOI Listing
October 2006

Expression of the NF-kappaB-responsive gene BTG2 is aberrantly regulated in breast cancer.

Oncogene 2004 Oct;23(50):8310-9

Department of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/sj.onc.1208008DOI Listing
October 2004

Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth.

Mol Endocrinol 2004 Mar 18;18(3):696-707. Epub 2003 Dec 18.

Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/me.2003-0360DOI Listing
March 2004

Mullerian inhibiting substance promotes interferon gamma-induced gene expression and apoptosis in breast cancer cells.

J Biol Chem 2003 Dec 7;278(51):51703-12. Epub 2003 Oct 7.

Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M307626200DOI Listing
December 2003

Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications.

Mol Cell Endocrinol 2003 Dec;211(1-2):37-42

Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Warren 11, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.mce.2003.09.009DOI Listing
December 2003

Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells.

Mol Cell Endocrinol 2003 Dec;211(1-2):43-9

Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.mce.2003.09.010DOI Listing
December 2003

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

Proc Natl Acad Sci U S A 2003 Dec 11;100(26):15601-6. Epub 2003 Dec 11.

Pediatric Surgical Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.2636900100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307614PMC
December 2003

Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo.

Proc Natl Acad Sci U S A 2002 Jan 2;99(1):239-44. Epub 2002 Jan 2.

Pediatric Surgical Research Laboratories, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.221599298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117545PMC
January 2002