Shyam K Sharan

Shyam K Sharan

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Shyam K Sharan

Shyam K Sharan

Publications by authors named "Shyam K Sharan"

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48Publications

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The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib.

Clin Cancer Res 2019 Aug 13. Epub 2019 Aug 13.

Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0419DOI Listing
August 2019

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.

Nat Commun 2018 02 7;9(1):537. Epub 2018 Feb 7.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1038/s41467-018-03020-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803202PMC
February 2018

Survival of BRCA2-Deficient Cells Is Promoted by , a Novel Genetic Interactor of .

Genetics 2017 12 11;207(4):1335-1345. Epub 2017 Oct 11.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702

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http://dx.doi.org/10.1534/genetics.117.300357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714451PMC
December 2017

Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect.

Proc Natl Acad Sci U S A 2017 10 9;114(43):11440-11445. Epub 2017 Oct 9.

Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India;

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http://dx.doi.org/10.1073/pnas.1708447114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664520PMC
October 2017

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Mol Cell 2017 Aug 20;67(3):374-386.e5. Epub 2017 Jul 20.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548441PMC
August 2017

Synthetic lethality synthetic viability due to and loss.

Transl Cancer Res 2017 Mar;6(Suppl 2):S441-S442

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.

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http://dx.doi.org/10.21037/tcr.2017.03.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329468PMC
March 2017

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.

PLoS Genet 2016 08 4;12(8):e1006236. Epub 2016 Aug 4.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973925PMC
August 2016

Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration.

Oncotarget 2016 Mar;7(10):11094-112

Department of Biomedical Sciences, Department of Physiology, University of Ulsan School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.18632/oncotarget.7150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905460PMC
March 2016

MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.

Oncogene 2014 Nov 25;33(48):5511-5522. Epub 2013 Nov 25.

Texas Children's Cancer Center, Department of Pediatric Hematology/Oncology, Houston, TX 77030.

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http://dx.doi.org/10.1038/onc.2013.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032816PMC
November 2014

The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression.

Transcription 2013 Jan-Feb;4(1):24-8. Epub 2012 Nov 6.

Dept. of Medicine, Graduate School, University of Ulsan College of Medicine, Asan Institute for Life Science, Songpa-gu, Seoul, Republic of Korea.

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http://www.tandfonline.com/doi/abs/10.4161/trns.22600
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644038PMC
http://dx.doi.org/10.4161/trns.22600DOI Listing
July 2013

Manipulating the Mouse Genome Using Recombineering.

Adv Genet Eng 2013 27;2(2). Epub 2013 Jun 27.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702.

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http://dx.doi.org/10.4172/2169-0111.1000108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688634PMC
June 2013

BRCA1 and microRNAs: emerging networks and potential therapeutic targets.

Mol Cells 2012 Nov 24;34(5):425-32. Epub 2012 Jul 24.

Mouse Cancer Genetics Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1007/s10059-012-0118-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887789PMC
November 2012

Using recombineering to generate point mutations: the oligonucleotide-based "hit and fix" method.

Methods Mol Biol 2012 ;852:111-20

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.

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http://link.springer.com/10.1007/978-1-61779-564-0_9
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http://dx.doi.org/10.1007/978-1-61779-564-0_9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668621PMC
May 2012

Using recombineering to generate point mutations:galK-based positive-negative selection method.

Methods Mol Biol 2012 ;852:121-31

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-61779-564-0_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668620PMC
May 2012

Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay.

Methods Mol Biol 2010 ;653:259-80

Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-60761-759-4_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669890PMC
December 2010

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.

J Clin Invest 2009 Oct 21;119(10):3160-71. Epub 2009 Sep 21.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1172/JCI39836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752086PMC
October 2009

Recombineering: a homologous recombination-based method of genetic engineering.

Nat Protoc 2009 ;4(2):206-23

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

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http://www.nature.com/articles/nprot.2008.227
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http://dx.doi.org/10.1038/nprot.2008.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790811PMC
April 2009

Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.

Cancer Res 2009 Feb 20;69(3):863-72. Epub 2009 Jan 20.

Mouse Cancer Genetics Program, Center for Cancer Research, Science Applications International Corporation-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-3057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754281PMC
February 2009

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

Cancer Res 2008 Dec;68(23):9973-81

Mouse Cancer Genetics Program, Center for Cancer Research, and Pathology Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729200PMC
December 2008

A handcuff model for the cohesin complex.

J Cell Biol 2008 Dec;183(6):1019-31

Department of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1083/jcb.200801157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600748PMC
December 2008

Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2.

Nat Med 2008 Aug 6;14(8):875-81. Epub 2008 Jul 6.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640324PMC
http://dx.doi.org/10.1038/nm.1719DOI Listing
August 2008

Resolving RAD51C function in late stages of homologous recombination.

Cell Div 2007 Jun 4;2:15. Epub 2007 Jun 4.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1186/1747-1028-2-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892012PMC
June 2007

Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.

J Neurosci 2006 Nov;26(46):11903-14

Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3020-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674879PMC
November 2006

Bacterial artificial chromosome engineering.

Methods Mol Biol 2004 ;256:89-106

Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

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http://dx.doi.org/10.1385/1-59259-753-X:089DOI Listing
May 2004

BAC rescue: a tool for functional analysis of the mouse genome.

Methods Mol Biol 2004 ;256:183-98

Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

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http://dx.doi.org/10.1385/1-59259-753-X:183DOI Listing
May 2004

BRCA2 deficiency in mice leads to meiotic impairment and infertility.

Development 2004 Jan 3;131(1):131-42. Epub 2003 Dec 3.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1242/dev.00888DOI Listing
January 2004

Mini-lambda: a tractable system for chromosome and BAC engineering.

Gene 2003 Oct;315:63-9

Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, NCI/FCRDC, National Cancer Institute at Frederick, Building 539/Room 243, P.O. Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/s0378-1119(03)00728-5DOI Listing
October 2003

Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model.

Hum Mol Genet 2003 Sep 8;12(17):2121-31. Epub 2003 Jul 8.

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/hmg/ddg222DOI Listing
September 2003

A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments.

Nucleic Acids Res 2003 Aug;31(15):e80

Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169966PMC
http://dx.doi.org/10.1093/nar/gng080DOI Listing
August 2003