Shyam Biswal

Shyam Biswal

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Shyam Biswal

Shyam Biswal

Publications by authors named "Shyam Biswal"

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100Publications

995Reads

Chronic Obstructive Pulmonary Disease: Abandoning the "Streetlight Effect".

Am J Respir Crit Care Med 2018 Sep;198(6):697-698

1 Johns Hopkins University Baltimore, Maryland.

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September 2018

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation.

Free Radic Biol Med 2018 May 9;120:407-413. Epub 2018 Apr 9.

Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, 1550 East Orleans Street, Baltimore, MD 21231, United States. Electronic address:

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May 2018

Correction to: electronic cigarette use behaviors and motivations among smokers and non-smokers.

BMC Public Health 2018 01 24;18(1):175. Epub 2018 Jan 24.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, USA.

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January 2018

A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics.

J Allergy Clin Immunol Pract 2016 Sep-Oct;4(5):932-40. Epub 2016 Apr 27.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:

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October 2017

Electronic cigarette use behaviors and motivations among smokers and non-smokers.

BMC Public Health 2017 09 8;17(1):686. Epub 2017 Sep 8.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, USA.

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September 2017

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD.

Muscle Nerve 2017 08 13;56(2):282-291. Epub 2017 Feb 13.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, Maryland, 21201, USA.

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August 2017

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.

Mol Cell Biol 2017 08 14;37(15). Epub 2017 Jul 14.

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

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August 2017

Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice.

Am J Respir Cell Mol Biol 2017 07;57(1):59-65

2 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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July 2017

Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

Am J Physiol Lung Cell Mol Physiol 2017 07 13;313(1):L138-L153. Epub 2017 Apr 13.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts;

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July 2017

Selective Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice.

Hypertension 2017 06 1;69(6):1198-1206. Epub 2017 May 1.

From the Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha (L.G., M.C.Z., I.H.Z.); and Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (S.B.).

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June 2017

Individual and Joint Effects of Early-Life Ambient Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity.

Environ Health Perspect 2017 06 14;125(6):067005. Epub 2017 Jun 14.

Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA

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June 2017

Nuclear erythroid 2-related factor 2 activation inhibits house dust mite-induced sinonasal epithelial cell barrier dysfunction.

Int Forum Allergy Rhinol 2017 05 2;7(5):536-541. Epub 2017 Feb 2.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

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May 2017

Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity.

Sci Rep 2017 01 10;7:40194. Epub 2017 Jan 10.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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January 2017

Air pollutant-mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway.

J Allergy Clin Immunol 2016 12 27;138(6):1736-1738.e4. Epub 2016 Jul 27.

Johns Hopkins Department of Otolaryngology-Head and Neck Surgery, Baltimore, Md. Electronic address:

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December 2016

Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation.

Int Forum Allergy Rhinol 2016 11 31;6(11):1145-1150. Epub 2016 Aug 31.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

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November 2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.

J Allergy Clin Immunol 2016 07 28;138(1):294-297.e4. Epub 2016 Feb 28.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, Fla. Electronic address:

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July 2016

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.

Mol Cell Biol 2016 06 16;36(11):1655-72. Epub 2016 May 16.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan

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June 2016

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6927-36. Epub 2015 Nov 30.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287;

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December 2015

Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model.

PLoS One 2015 4;10(2):e0116861. Epub 2015 Feb 4.

Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

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October 2015

Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy.

Bioorg Med Chem 2015 Sep 29;23(17):5352-9. Epub 2015 Jul 29.

Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA, USA. Electronic address:

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September 2015

Nrf2 is required for normal postnatal bone acquisition in mice.

Bone Res 2014 11;2:14033. Epub 2014 Nov 11.

Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, USA.

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August 2015

Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.

Mol Cell Endocrinol 2015 Jul 25;409:113-20. Epub 2015 Mar 25.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.

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July 2015

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function.

Am J Physiol Lung Cell Mol Physiol 2015 Jul 8;309(1):L27-36. Epub 2015 May 8.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; and.

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July 2015

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

J Neurochem 2015 Apr 4;133(2):233-41. Epub 2015 Mar 4.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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April 2015

Field testing of alternative cookstove performance in a rural setting of western India.

Int J Environ Res Public Health 2015 Feb 3;12(2):1773-87. Epub 2015 Feb 3.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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February 2015

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells.

Free Radic Biol Med 2014 May 17;70:155-66. Epub 2014 Jan 17.

Wilmer Eye Institute, Johns Hopkins School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

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May 2014

Source of biomass cooking fuel determines pulmonary response to household air pollution.

Am J Respir Cell Mol Biol 2014 Mar;50(3):538-48

1 Center for Global Clean Air, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland.

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March 2014

Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle.

Front Physiol 2014 19;5:57. Epub 2014 Feb 19.

Department of Organizational Systems and Adult Health, University of Maryland School of Nursing Baltimore, MD, USA.

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March 2014

Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.

Cell Rep 2014 Mar 13;6(6):1026-1036. Epub 2014 Mar 13.

Molecular Basis of Viral Pathogenicity, Centre International de Recherche en Infectologie (CIRI), INSERMU1111-CNRSUMR5308, Université de Lyon, Université Claude Bernard Lyon1, Ecole Normale Supérieure de Lyon, Lyon 69007, France. Electronic address:

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March 2014

Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling.

Mol Cell Biol 2014 Feb 2;34(4):653-63. Epub 2013 Dec 2.

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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February 2014

Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status.

Cytokine 2014 Jan 17;65(1):4-9. Epub 2013 Oct 17.

Department of Pediatrics, Division of Pediatric Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

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January 2014

NRF2 plays a protective role in diabetic retinopathy in mice.

Diabetologia 2014 Jan 3;57(1):204-13. Epub 2013 Nov 3.

Department of Ophthalmology, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD, 21287, USA.

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January 2014

Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway.

Eur J Neurosci 2013 Dec 23;38(11):3659-68. Epub 2013 Sep 23.

Department of Anesthesiology, University of Florida, College of Medicine, 1275 Center Drive, Gainesville, FL, 32610, USA.

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December 2013

The twist box domain is required for Twist1-induced prostate cancer metastasis.

Mol Cancer Res 2013 Nov 27;11(11):1387-400. Epub 2013 Aug 27.

Department of Radiation Oncology & Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1550 Orleans Street, CRB2 Rm 406, Baltimore, MD 21231.

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November 2013

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):E3910-8. Epub 2013 Sep 23.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.

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October 2013

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.

Sci Rep 2013 ;3:1540

Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma & Lung disease, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi-110007, India.

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September 2013

Linoleic acid metabolite drives severe asthma by causing airway epithelial injury.

Sci Rep 2013 ;3:1349

Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma and Lung Disease, CSIR-Institute of Genomics and Integrative Biology, India.

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August 2013

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.

J Clin Invest 2013 Jul 10;123(7):2921-34. Epub 2013 Jun 10.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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July 2013

Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.

PLoS Comput Biol 2012 19;8(7):e1002597. Epub 2012 Jul 19.

Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, United States of America.

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January 2013

A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model.

Int Immunopharmacol 2013 Jan 5;15(1):150-9. Epub 2012 Nov 5.

Molecular Immunogenetics Laboratory, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, India.

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January 2013

Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors.

Eur J Pharmacol 2013 Jan 20;700(1-3):32-41. Epub 2012 Dec 20.

Molecular Immunogenetics Laboratory, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.

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January 2013

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus.

Nanotoxicology 2012 Sep 29;6(6):614-22. Epub 2011 Jul 29.

Department of Environmental Health Sciences, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231, USA.

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September 2012

The transcription factor encyclopedia.

Authors:
Dimas Yusuf Stefanie L Butland Magdalena I Swanson Eugene Bolotin Amy Ticoll Warren A Cheung Xiao Yu Cindy Zhang Christopher T D Dickman Debra L Fulton Jonathan S Lim Jake M Schnabl Oscar H P Ramos Mireille Vasseur-Cognet Charles N de Leeuw Elizabeth M Simpson Gerhart U Ryffel Eric W-F Lam Ralf Kist Miranda S C Wilson Raquel Marco-Ferreres Jan J Brosens Leonardo L Beccari Paola Bovolenta Bérénice A Benayoun Lara J Monteiro Helma D C Schwenen Lars Grontved Elizabeth Wederell Susanne Mandrup Reiner A Veitia Harini Chakravarthy Pamela A Hoodless M Michela Mancarelli Bruce E Torbett Alison H Banham Sekhar P Reddy Rebecca L Cullum Michaela Liedtke Mario P Tschan Michelle Vaz Angie Rizzino Mariastella Zannini Seth Frietze Peggy J Farnham Astrid Eijkelenboom Philip J Brown David Laperrière Dominique Leprince Tiziana de Cristofaro Kelly L Prince Marrit Putker Luis del Peso Gieri Camenisch Roland H Wenger Michal Mikula Marieke Rozendaal Sylvie Mader Jerzy Ostrowski Simon J Rhodes Capucine Van Rechem Gaylor Boulay Sam W Z Olechnowicz Mary B Breslin Michael S Lan Kyster K Nanan Michael Wegner Juan Hou Rachel D Mullen Stephanie C Colvin Peter John Noy Carol F Webb Matthew E Witek Scott Ferrell Juliet M Daniel Jason Park Scott A Waldman Daniel J Peet Michael Taggart Padma-Sheela Jayaraman Julien J Karrich Bianca Blom Farhad Vesuna Henriette O'Geen Yunfu Sun Richard M Gronostajski Mark W Woodcroft Margaret R Hough Edwin Chen G Nicholas Europe-Finner Magdalena Karolczak-Bayatti Jarrod Bailey Oliver Hankinson Venu Raman David P LeBrun Shyam Biswal Christopher J Harvey Jason P DeBruyne John B Hogenesch Robert F Hevner Christophe Héligon Xin M Luo Marissa Cathleen Blank Kathleen Joyce Millen David S Sharlin Douglas Forrest Karin Dahlman-Wright Chunyan Zhao Yuriko Mishima Satrajit Sinha Rumela Chakrabarti Elodie Portales-Casamar Frances M Sladek Philip H Bradley Wyeth W Wasserman

Genome Biol 2012 ;13(3):R24

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.

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September 2012

Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.

Biochem Biophys Res Commun 2012 Sep 22;426(2):253-9. Epub 2012 Aug 22.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

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September 2012

Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA.

ISRN Oncol 2012 21;2012:641246. Epub 2012 May 21.

Department of Chemistry Geology & Physics, Elizabeth City State University, Elizabeth City, NC 27909, USA.

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August 2012

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease.

Physiol Genomics 2012 Aug 12;44(15):754-63. Epub 2012 Jun 12.

UBC James Hogg Research Centre, Providence Heart + Lung Institute, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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August 2012

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.

J Carcinog 2012 13;11. Epub 2012 Jul 13.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland.

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August 2012

Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.

Proc Am Thorac Soc 2012 May;9(2):47-51

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

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May 2012

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

Cancer Prev Res (Phila) 2012 Apr 31;5(4):544-52. Epub 2012 Mar 31.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore Maryland 21201, USA.

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April 2012

Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry.

PLoS One 2011 17;6(8):e22988. Epub 2011 Aug 17.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

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February 2012

Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation.

Am J Pathol 2012 Feb;180(2):562-74

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

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February 2012

Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation.

Am J Respir Cell Mol Biol 2011 Dec 9;45(6):1161-8. Epub 2011 Jun 9.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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December 2011

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels.

Blood 2011 Dec 28;118(25):6572-9. Epub 2011 Oct 28.

Division of Hematology, Department of Medicine, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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December 2011

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

J Clin Invest 2011 Nov 17;121(11):4289-302. Epub 2011 Oct 17.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

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November 2011

Telomere length is a determinant of emphysema susceptibility.

Am J Respir Crit Care Med 2011 Oct 14;184(8):904-12. Epub 2011 Jul 14.

Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21287, USA.

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October 2011

Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.

Am J Respir Crit Care Med 2011 Oct 28;184(8):928-38. Epub 2011 Jul 28.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

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October 2011

Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice.

Am J Respir Cell Mol Biol 2011 Sep 14;45(3):610-6. Epub 2011 Jan 14.

Department of Pediatrics, Division of Pediatric Pulmonary, Suite 3029, 200 N. Wolfe St. Baltimore, MD 21287-2533, USA.

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September 2011

Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia.

Stroke 2011 Sep 18;42(9):2605-10. Epub 2011 Aug 18.

Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Dr, Biomed Sci J493, PO 100159, Gainesville, FL 32610, USA.

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September 2011

Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice.

Exp Lung Res 2011 Aug 7;37(6):354-63. Epub 2011 Jun 7.

Division of Pediatric Pulmonary, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287-2533, USA.

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August 2011

Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system.

Respir Res 2011 Jul 13;12:92. Epub 2011 Jul 13.

Health Effects Assessment Laboratory, Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.

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July 2011

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

J Med Chem 2011 Jun 19;54(12):4147-59. Epub 2011 May 19.

Laboratory of Synthetic Chemistry, SAIC Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, United States.

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June 2011

Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.

Eur J Pharm Sci 2011 May 21;43(1-2):16-24. Epub 2011 Mar 21.

Institute of Nano-science and Engineering Technology, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA.

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May 2011

KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma.

J Hum Genet 2011 Mar 20;56(3):230-4. Epub 2011 Jan 20.

Department of Pathology, The Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

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March 2011

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.

Biochem Biophys Res Commun 2011 Mar 12;406(2):292-8. Epub 2011 Feb 12.

Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.

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March 2011

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.

J Cereb Blood Flow Metab 2010 Dec 5;30(12):1951-61. Epub 2010 May 5.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

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December 2010

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance.

Antioxid Redox Signal 2010 Dec 13;13(11):1627-37. Epub 2010 Jul 13.

Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, USA.

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December 2010

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract.

Am J Respir Cell Mol Biol 2010 Sep 5;43(3):276-85. Epub 2009 Oct 5.

Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.

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September 2010

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.

Nucleic Acids Res 2010 Sep 11;38(17):5718-34. Epub 2010 May 11.

Department of Environmental Health Sciences Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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September 2010

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.

Mol Cancer Ther 2010 Aug 3;9(8):2365-76. Epub 2010 Aug 3.

Johns Hopkins University, of Environmental Health Sciences, Bloomberg School of Public Health, E7624, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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August 2010

NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.

J Immunol 2010 Jul 28;185(1):569-77. Epub 2010 May 28.

Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA.

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July 2010

Regulation of notch1 signaling by nrf2: implications for tissue regeneration.

Sci Signal 2010 Jul 13;3(130):ra52. Epub 2010 Jul 13.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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July 2010

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Am J Respir Cell Mol Biol 2010 May 11;42(5):524-36. Epub 2009 Jun 11.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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May 2010

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration.

Vision Res 2010 Mar 22;50(7):652-64. Epub 2009 Aug 22.

Wilmer Eye Institute, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

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March 2010

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

Mol Cancer Ther 2010 Feb 2;9(2):336-46. Epub 2010 Feb 2.

Division of Toxicology, Bloomberg School of Public Health, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.

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February 2010

Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.

Am J Respir Crit Care Med 2009 12 1;180(12):1196-207. Epub 2009 Oct 1.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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December 2009

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.

Am J Respir Crit Care Med 2009 Sep 11;180(5):396-406. Epub 2009 Jun 11.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.

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September 2009

Nrf2 is a critical modulator of the innate immune response in a model of uveitis.

Free Radic Biol Med 2009 Aug 3;47(3):300-6. Epub 2009 May 3.

Wilmer Eye Institute, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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August 2009

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression.

Am J Physiol Lung Cell Mol Physiol 2009 Jun 13;296(6):L888-900. Epub 2009 Mar 13.

Division of Pulmonary and Critical Care Medicine, Univ. of Rochester School of Medicine and Dentistry, Rochester, NY 14642-8692, USA.

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June 2009

Cell stiffness, contractile stress and the role of extracellular matrix.

Biochem Biophys Res Commun 2009 May 25;382(4):697-703. Epub 2009 Mar 25.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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May 2009