Publications by authors named "Shuqiao Yao"

150 Publications

Psychometric Properties of the Chinese Version of the 10-Item Ruminative Response Scale Among Undergraduates and Depressive Patients.

Front Psychiatry 2021 26;12:626859. Epub 2021 May 26.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

Rumination is considered as a key process in the mechanism of depression. Assessing rumination is important for both research and clinical practice. The Ruminative Response Scale (RRS) is a widely-used instrument to measure rumination. This study aimed to examine the psychometric properties of the Chinese 10-item Ruminative Response Scale (RRS-10) in a large sample of Chinese undergraduates and depressive patients. A total of 1,773 university students and 286 clinical patients with major depressive disorder finished the Chinese version of the RRS10, State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). A confirmatory factor analysis (CFA) was performed to examine the two-factor structure (reflection and brooding) of the RRS-10. The correlations among RRS-10, STAI, and BDI were explored in two samples. In addition, the measurement invariance of the RRS-10 across gender, time, and groups with and without depressive symptoms were further investigated. The internal consistency and test-retest reliability were also evaluated. Confirmatory Factor Analysis revealed that the two-factor structure of RRS-10 fitted reasonably both in undergraduates (CFI = 0.933, TLI = 0.905, RMSEA = 0.071, SRMR = 0.035) and depressive patients (CFI = 0.941, TLI = 0.910, RMSEA = 0.077, SRMR = 0.057). The results of the multi-group confirmatory factor analysis supported the full strict invariance across genders and across groups (undergraduates and depressive patients). The full strong invariance over time was also supported by MGCFA. Besides, the RRS-10 showed acceptable internal consistency and good stability. The RRS-10 has good reliability and validity in different samples and over time, which demonstrated that RRS-10 is a valid measurement instrument to assess rumination.
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http://dx.doi.org/10.3389/fpsyt.2021.626859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187760PMC
May 2021

Psychometric Properties of the Chinese Version of the 10-Item Ruminative Response Scale Among Undergraduates and Depressive Patients.

Front Psychiatry 2021 26;12:626859. Epub 2021 May 26.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

Rumination is considered as a key process in the mechanism of depression. Assessing rumination is important for both research and clinical practice. The Ruminative Response Scale (RRS) is a widely-used instrument to measure rumination. This study aimed to examine the psychometric properties of the Chinese 10-item Ruminative Response Scale (RRS-10) in a large sample of Chinese undergraduates and depressive patients. A total of 1,773 university students and 286 clinical patients with major depressive disorder finished the Chinese version of the RRS10, State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). A confirmatory factor analysis (CFA) was performed to examine the two-factor structure (reflection and brooding) of the RRS-10. The correlations among RRS-10, STAI, and BDI were explored in two samples. In addition, the measurement invariance of the RRS-10 across gender, time, and groups with and without depressive symptoms were further investigated. The internal consistency and test-retest reliability were also evaluated. Confirmatory Factor Analysis revealed that the two-factor structure of RRS-10 fitted reasonably both in undergraduates (CFI = 0.933, TLI = 0.905, RMSEA = 0.071, SRMR = 0.035) and depressive patients (CFI = 0.941, TLI = 0.910, RMSEA = 0.077, SRMR = 0.057). The results of the multi-group confirmatory factor analysis supported the full strict invariance across genders and across groups (undergraduates and depressive patients). The full strong invariance over time was also supported by MGCFA. Besides, the RRS-10 showed acceptable internal consistency and good stability. The RRS-10 has good reliability and validity in different samples and over time, which demonstrated that RRS-10 is a valid measurement instrument to assess rumination.
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http://dx.doi.org/10.3389/fpsyt.2021.626859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187760PMC
May 2021

Impaired global efficiency in boys with conduct disorder and high callous unemotional traits.

J Psychiatr Res 2021 Jun 29;138:560-568. Epub 2021 Apr 29.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Psychiatry and Psychology, Changsha, China; Medical Psychological Institute of Central South University, Changsha, China; National Clinical Research Center for Mental Disorders, Changsha, China. Electronic address:

Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. In this study, 43 CD boys with high and low CU trait (CD-HCU, CD-LCU), and 46 healthy controls (HCs) were subjected to resting-state functional magnetic resonance imaging to investigate how CU trait level and conduct problems may be reflected in topological organization. Brain functional networks were constructed and network/nodal properties, including small-world properties and network/nodal efficiency, were calculated. Topological analysis revealed that, compared with HCs, CD-HCU group were characterized by decreased small-worldness (σ), decreased global efficiency, and increased path length (λ). These variables were similar between the CD-LCU and HC groups. Self-reported CU traits in CD patients correlated negatively with global efficiency and positively with λ. Regional analysis revealed diminished nodal efficiency in the right amygdala in the CD-HCU group compared with HCs. The present results suggest that disrupted global efficiency, together with a regional abnormality affecting the amygdala, may contribute to abnormal information processing and integration in adolescents with CD and high CU traits.
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http://dx.doi.org/10.1016/j.jpsychires.2021.04.041DOI Listing
June 2021

Personality Inventory for DSM-5 in China: Evaluation of DSM-5 and ICD-11 Trait Structure and Continuity With Personality Disorder Types.

Front Psychiatry 2021 26;12:635214. Epub 2021 Mar 26.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

The Personality Inventory for the DSM-5 (PID-5) is an established tool for assessing personality disorder (PD) traits that was developed based on section III of the DSM-5. It is composed of 220 items, organized into 25 facets, which are distributed among five domains. The psychometric properties of the Chinese version of the PID-5 remain to be demonstrated. Two samples were embodied in this study that included 3,550 undergraduates and 406 clinical patients. To probe the structure of the PID-5, parallel analyses were conducted to explore the unidimensionality of its 25 facets and a series of confirmatory factor analyses (CFAs) were carried out to confirm the 25 lower-order facets and their distribution among five higher-order domains. Then, the PID-5 was employed to measure the DSM-5 and ICD-11 trait models and to explore the relationship of DSM-IV categorical PDs with DSM-5 and ICD-11 personality traits. Correlation and regression analyses were conducted to probe how well DSM-IV categorical PDs correspond with maladaptive personality traits specified in the DSM-5 and five ICD-11 domains. The respective average internal reliability coefficients of the 25 facets obtained for undergraduate and clinical patient samples were 0.76 and 0.81, those obtained for the five DSM-5 domains were 0.89 and 0.91, and those obtained for the five ICD-11 domains were 0.87 and 0.89. Serial CFAs confirmed the rationality of the PID-5's lower-order 25-facet structure and higher-order five-domain structure in both samples. Correlation and regression analyses showed that DSM-5 specified traits explain the variance in PD presentation with a manifold stronger correlation ( = 0.24-0.44) than non-specified traits ( = 0.04-0.12). Overall, the PID-5 was shown to be a reliable, stable, and structurally valid assessment tool that captures pathological personality traits related to DSM-5 and ICD-11 PDs.
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http://dx.doi.org/10.3389/fpsyt.2021.635214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033014PMC
March 2021

Personality inventory for DSM-5 brief form(PID-5-BF) in Chinese students and patients: evaluating the five-factor model and a culturally informed six-factor model.

BMC Psychiatry 2021 02 17;21(1):107. Epub 2021 Feb 17.

Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Background: The Personality Inventory for DSM-5 Brief Form (PID-5-BF) is a 25-item measuring tool evaluating maladaptive personality traits for the diagnosis of personality disorders(PDs). As a promising scale, its impressive psychometric properties have been verified in some countries, however, there have been no studies about the utility of the PID-5-BF in Chinese settings. The current study aimed to explore the maladaptive personality factor model which was culturally adapted to China and to examine psychometric properties of the PID-5-BF among Chinese undergraduate students and clinical patients.

Methods: Seven thousand one hundred fifty-five undergraduate students and 451 clinical patients completed the Chinese version of the PID-5-BF. Two hundered twenty-eight students were chosen randomly for test-retest reliability at a 4-week interval. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to discover the most suitable factor structure in China, measurement invariance(MI), internal consistency, and external validity were also calculated.

Results: The theoretical five-factor model was acceptable, but the exploratory six-factor model was more applicable in both samples (Undergraduate sample: CFI = 0.905, TLI = 0.888, RMSEA = 0.044, SRMR = 0.039; Clinical sample: CFI = 0.904, TLI = 0.886, RMSEA = 0.047, SRMR = 0.060). In the Chinese six-factor model, the Negative Affect domain was divided into two factors and the new factor was named "Interpersonal Relationships", which was in line with the Big-Six Personality model in Chinese. Measurement invariance across non-clinical and clinical sample was established (configural, weak, strong MI, and partial strict MI). Aside from acceptable internal consistency (Undergraduate sample: alpha = 0.84, MIC = 0.21; Clinical sample: alpha = 0.86, MIC = 0.19) and test-retest reliability(0.73), the correlation between the 25-item PID-5-BF and the 220-item PID-5 was significant(p < 0.01). The six PDs measured by Personality diagnostic questionnaire-4+ (PDQ-4+) were associated with and predicted by expected domains of PID-5-BF.

Conclusions: Both the theoretical five-factor model and the exploratory six-factor model of the PID-5-BF were acceptable to the Chinese population. The five-factor model could allow for comparison and integration with other work on the original theoretical model. However, the Chinese six-factor structure may be more culturally informed in East Asian settings. In sum, the PID-5-BF is a convenient and useful screening tool for personality disorders.
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http://dx.doi.org/10.1186/s12888-021-03080-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890813PMC
February 2021

Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment.

Eur Child Adolesc Psychiatry 2021 Jan 4. Epub 2021 Jan 4.

Medical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Childhood maltreatment (CM) poses a serious risk to the physical, emotional and psychological well-being of children, and can advance the development of maladaptive behaviors, including conduct disorder (CD). CD involves repetitive, persistent violations of others' basic rights and societal norms. Little is known about whether and how CM influences the neural mechanisms underlying CD, and CD-characteristic neuroanatomical changes have not yet been defined in a structural magnetic resonance imaging (sMRI) study. Here, we used voxel-based morphometry (VBM) and surface-based morphometry (SBM) to investigate the influence of the CD diagnosis and CM on the brain in 96 boys diagnosed with CD (62 with CM) and 86 typically developing (TD) boys (46 with CM). The participants were 12-17 years of age. Compared to the CM- CD group, the CM+ CD group had structural gray matter (GM) alterations in the fronto-limbic regions, including the left amygdala, right posterior cingulate cortex (PCC), right putamen, right dorsolateral prefrontal cortex (dlPFC) and right anterior cingulate cortex (ACC). We also found boys with CD exhibited increased GM volume in bilateral dorsomedial prefrontal cortex (dmPFC), as well as decreased GM volume and decreased gyrification in the left superior temporal gyrus (STG) relative to TD boys. Regional GM volume correlated with aggression and conduct problem severity in the CD group, suggesting that the GM changes may contribute to increased aggression and conduct problems in boys with CD who have suffered CM. In conclusion, these results demonstrate previously unreported CM-associated distinct brain structural changes among CD-diagnosed boys.
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http://dx.doi.org/10.1007/s00787-020-01697-zDOI Listing
January 2021

Factor Structure and Measurement Invariance of the Chinese version of the Snaith-Hamilton Pleasure Scale (SHAPS) in Non-clinical and Clinical populations.

J Affect Disord 2021 02 13;281:759-766. Epub 2020 Nov 13.

Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address:

Background: Anhedonia, a key symptom of depression and schizophrenia, has emerged as a potential endophenotype. The aim of this study was to evaluate the psychometric properties of a Chinese version of the Snaith-Hamilton Pleasure Scale(SHAPS), a self-report anhedonia scale, in a non-clinical sample and clinical sample inclusive of major depressive disorder (MDD), schizophrenia, or a personality disorder.

Methods: A total of 4,722 undergraduate students and 352 clinical patients participated in this study. Internal consistency was assessed by calculating Cronbach's α and mean inter-item correlation (MIC) values. Test-retest reliability and convergent validity were assessed with Pearson r coefficients. The best fitting of six potential factor-structure models was determined by confirmatory factor analysis (CFA). Measurement invariance across genders and samples was determined by multi-group CFA.

Results: Internal consistency of the Chinese version of the SHAPS was acceptable in non-clinical (Cronbach's α = 0.90) and clinical (Cronbach's α = 0.91) samples. Four-week interval test-retest reliability was 0.60. Moreover, the Spanish four-factor structure had the best fit indexes in both samples. Scalar invariance was established across genders as well as across non-clinical sample and clinical sample. SHAPS was significantly related with the Temporal Experience of Pleasure Scale (TEPS) and Beck Depression Inventory (BDI).

Limitations: There was a restricted scope of convergent validity and the size of clinical sample is relatively small, psychometric properties in elderly sample is also required.

Conclusion: The Chinese version of the SHAPS is a reliable, effective, simple and convenient tool for assessing and screening for anhedonia.
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http://dx.doi.org/10.1016/j.jad.2020.11.068DOI Listing
February 2021

A novel construct of anhedonia revealed in a Chinese sample via the Revised Physical and Social Anhedonia Scales.

BMC Psychiatry 2020 11 9;20(1):529. Epub 2020 Nov 9.

Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Background: Anhedonia is a core clinical symptom of mental disorders. The Revised Physical Anhedonia Scale (RPAS) and the Revised Social Anhedonia Scale (RSAS) have been applied in clinical and non-clinical samples since 1980s. However, the construct of a unified RPAS&RSAS for comprehensive measurement of anhedonia has never been explored. Therefore, the purpose of our study was to examine the factor structure of the unified RPAS&RSAS among undergraduates and clinical patients.

Methods: A total of 3435 undergraduates from two universities and 294 clinical patients with mental disorders had completed the Chinese version of the RPAS and the RSAS. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were each conducted to reveal the constructs of the RPAS and the RSAS. CFA was used to evaluate first- and second-order models for the unified RPAS&RSAS in undergraduates and clinical patients. The internal consistency and test-retest reliability of the RPAS and the RSAS were also evaluated.

Results: EFA and CFA indicated 2-factor structures for RPAS and RSAS, with the factors being defined as anticipatory anhedonia and consummatory anhedonia. The second-order model of the unified RPAS&RSAS in the undergraduates and clinical patients both had satisfactory fit index values (Undergraduate sample: CFI = 0.901, TLI = 0.899, RMSEA = 0.055, SRMR = 0.086; Clinical sample: CFI = 0.922, TLI = 0.911, RMSEA = 0.052, SRMR = 0.078). The psychometric robustness of the RPAS&RSAS were confirmed by high internal consistency and test-retest reliability values.

Conclusions: The unified RPAS&RSAS with a second-order structure was confirmed in both undergraduates and clinical samples in Chinese. The construct of anhedonia was refreshed as covering physical and social domains, and each of them includes both anticipatory and consummatory components.
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http://dx.doi.org/10.1186/s12888-020-02900-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650163PMC
November 2020

PSYCHOMETRIC properties of the Chinese version of the THINC-it tool for cognitive symptoms in patients with major depressive disorder.

J Affect Disord 2020 08 26;273:586-591. Epub 2020 May 26.

Peking University Sixth Hospital, Beijing, 100191, China; Peking University Institute of Mental Health, Beijing, 100191, China; NHC Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, 100191, China; The National Clinical Research Center for Mental Health Disorders (Peking University Sixth Hospital), Beijing, 100191, China. Electronic address:

Background: To validate the reliability and validity of the Chinese version of the THINC-it tool in adults with major depressive disorder (MDD).

Methods: Subjects aged 18 to 65 years (n=117) with MDD were evaluated and compared to age- and sex-matched healthy controls (n=124). Subjects completed the THINC-it, four criteria-related objective cognitive subtests, and the paper version of Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).

Results: There were significant differences in Spotter [Mean difference (MD) Standard errors (SE)=-0.40 (0.17), P=0.018; 95% Confidence intervals (CI) (-0.73 to -0.07)]; Codebreaker [MD (SE)=-0.39 (0.14), P=0.006; 95% CI(-0.67 to -0.11)]; and the overall performance of four objective tests (including variants of IDN, OBK, DSST, and TMT-B) [MD (SE)=-0.30 (0.12), P=0.013; 95% CI (-0.53 to -0.06]) between the two groups. In the HC group, PDQ-5-D retest reliability was good (ICC = 0.841), and the test-retest reliability of the objective cognitive test was relatively low (ICC ranging from 0.123 to 0.545). In the MDD group: Cronbach's α of PDQ-5-D=0.704; all the THINC-it subtests had good concurrent validity (r ranging from 0.343 to 0.835, all P<0.01).

Limitation: The test-retest sample size was relatively small, the educational level and IQ of the control and MDD groups were not completely matched.

Conclusion: The Chinese version of the THINC-it tool exhibits good reliability and validity in adults with MDD. There is a need to incorporate cognitive assessment of adults with MDD broadly. The THINC-it tool is the first tool validated to assess cognition of MDD in a Chinese population.
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http://dx.doi.org/10.1016/j.jad.2020.03.146DOI Listing
August 2020

The MAOA Gene Influences the Neural Response to Psychosocial Stress in the Human Brain.

Front Behav Neurosci 2020 15;14:65. Epub 2020 May 15.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

The stress response is regulated by many mechanisms. Monoamine oxidase A (MAOA) has been related to many mental illnesses. However, few studies have explored the relationship between MAOA and acute laboratory-induced psychosocial stress with functional magnetic resonance imaging (fMRI). In the current study, the Montreal Imaging Stress Task (MIST) and fMRI were used to investigate how MAOA influences the stress response. Increased cortisol concentrations were observed after the task; functional connectivity between the bilateral anterior hippocampus and other brain regions was reduced during stress. MAOA-H allele carriers showed greater deactivation of the right anterior hippocampus and greater cortisol response after stress than did MAOH-L allele carriers. Hippocampal deactivation may lead to disinhibition of the hypothalamic-pituitary-adrenal (HPA) axis and the initiation of stress hormone release under stress. Our results suggest that the MAOA gene regulates the stress response by influencing the right anterior hippocampus.
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http://dx.doi.org/10.3389/fnbeh.2020.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243356PMC
May 2020

Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder.

Front Psychol 2020 6;11:843. Epub 2020 May 6.

Medical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, China.

Conduct disorder is one of the most common developmental psychiatric disorders which is characterized by persistent aggressive and antisocial behaviors during childhood or adolescence. Previous neuroimaging studies have investigated the neural correlates underlying CD and demonstrated several constructive findings. However, Individuals with CD are at high risk for comorbidities, which might give rise to the inconsistencies of existed findings. It remains unclear which neuroanatomical abnormalities are specifically related to CD without comorbidities. Using structural magnetic resonance imaging (sMRI) data of 69 CD and 69 typically developing (TD) male youths (aged 14-17 years), the present study aims at investigating gray matter volume alterations of non-comorbid CD (i.e., not comorbid with attention deficit hyperactivity disorder, substance abuse disorder, anxiety or depression). We also examined how regional gray matter volumes were related to callous-unemotional (CU) traits and conduct problems in the CD group. The whole-brain analysis revealed decreased gray matter volumes in the right pre-postcentral cortex, supramarginal gyrus and right putamen in CD youths compared with TD youths. The region-of-interest analyses showed increased gray matter volumes in the superior temporal gyrus (STG) and right orbitofrontal cortex (OFC) in CD youths. Correlation analysis found that gray matter volume in the left amygdala was negatively correlated with CU traits in CD participants. These results demonstrated that gray matter volume in the orbitofrontal-paralimbic cortex, including OFC, STG and amygdala, might characterize the male youths with non-comorbid CD and might contribute to different severe forms and trajectories of CD.
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http://dx.doi.org/10.3389/fpsyg.2020.00843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218112PMC
May 2020

Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder.

Front Psychol 2020 6;11:843. Epub 2020 May 6.

Medical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, China.

Conduct disorder is one of the most common developmental psychiatric disorders which is characterized by persistent aggressive and antisocial behaviors during childhood or adolescence. Previous neuroimaging studies have investigated the neural correlates underlying CD and demonstrated several constructive findings. However, Individuals with CD are at high risk for comorbidities, which might give rise to the inconsistencies of existed findings. It remains unclear which neuroanatomical abnormalities are specifically related to CD without comorbidities. Using structural magnetic resonance imaging (sMRI) data of 69 CD and 69 typically developing (TD) male youths (aged 14-17 years), the present study aims at investigating gray matter volume alterations of non-comorbid CD (i.e., not comorbid with attention deficit hyperactivity disorder, substance abuse disorder, anxiety or depression). We also examined how regional gray matter volumes were related to callous-unemotional (CU) traits and conduct problems in the CD group. The whole-brain analysis revealed decreased gray matter volumes in the right pre-postcentral cortex, supramarginal gyrus and right putamen in CD youths compared with TD youths. The region-of-interest analyses showed increased gray matter volumes in the superior temporal gyrus (STG) and right orbitofrontal cortex (OFC) in CD youths. Correlation analysis found that gray matter volume in the left amygdala was negatively correlated with CU traits in CD participants. These results demonstrated that gray matter volume in the orbitofrontal-paralimbic cortex, including OFC, STG and amygdala, might characterize the male youths with non-comorbid CD and might contribute to different severe forms and trajectories of CD.
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http://dx.doi.org/10.3389/fpsyg.2020.00843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218112PMC
May 2020

Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus.

Physiol Behav 2020 06 16;220:112876. Epub 2020 Mar 16.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Medical Psychological Institute of Central South University, Changsha 410011, Hunan, China; National Clinical Research Center for Mental Disorders. Electronic address:

Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
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http://dx.doi.org/10.1016/j.physbeh.2020.112876DOI Listing
June 2020

Childhood Maltreatment Experience Influences Neural Response to Psychosocial Stress in Adults: An fMRI Study.

Front Psychol 2019 14;10:2961. Epub 2020 Jan 14.

Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Childhood maltreatment is a strong risk factor for the development of depression in later life. However, the neurobiological mechanisms underlying this vulnerability are not well understood. As depression has been associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and increased responsiveness to psychosocial stressors, we speculated that childhood maltreatment may lead to lasting alteration of the stress response system, thereby increasing the risk of depression. This study investigated the effects of childhood maltreatment on the stress response in healthy subjects while controlling for psychiatric condition.

Methods: Forty-eight healthy young adults (24 females) with childhood maltreatment experience and 48 healthy controls (33 females) without such experience were administered the Montreal Imaging Stress Task during functional magnetic resonance imaging. Childhood maltreatment experience was assessed using the 28-item Childhood Trauma Questionnaire (CTQ). Between-group differences in subjective stress levels, whole brain activations and cortisol levels were assessed.

Results: Relative to healthy control subjects, individuals exposed to childhood maltreatment exhibited higher subjective stress and cortisol levels. Neurofunctionally, participants with histories of childhood maltreatment displayed significantly increased activation in the dorsolateral prefrontal cortex (dlPFC), insula and precuneus, and decreased activation in ventromedial prefrontal cortex (vmPFC) relative to healthy controls during the psychosocial stress task. Activations in dlPFC and insula correlated with CTQ scores in the childhood maltreatment group.

Conclusion: The results of this study show that childhood maltreatment induces lasting changes in brain function and HPA-axis responsiveness to stress. The observed abnormal activation in the dlPFC, insula and vmPFC and enhanced cortisol response are similar to those seen in individuals with depression. This dysfunction might serve as a diathesis that embeds latent vulnerability to psychiatric disorders, and this mechanism provides evidence supporting the stress sensitization model.
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http://dx.doi.org/10.3389/fpsyg.2019.02961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971063PMC
January 2020

Altered resting-state dynamic functional brain networks in major depressive disorder: Findings from the REST-meta-MDD consortium.

Neuroimage Clin 2020 7;26:102163. Epub 2020 Jan 7.

Faculty of Psychology, Southwest University, Chongqing 400716, China.

Background: Major depressive disorder (MDD) is known to be characterized by altered brain functional connectivity (FC) patterns. However, whether and how the features of dynamic FC would change in patients with MDD are unclear. In this study, we aimed to characterize dynamic FC in MDD using a large multi-site sample and a novel dynamic network-based approach.

Methods: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from a total of 460 MDD patients and 473 healthy controls, as a part of the REST-meta-MDD consortium. Resting-state dynamic functional brain networks were constructed for each subject by a sliding-window approach. Multiple spatio-temporal features of dynamic brain networks, including temporal variability, temporal clustering and temporal efficiency, were then compared between patients and healthy subjects at both global and local levels.

Results: The group of MDD patients showed significantly higher temporal variability, lower temporal correlation coefficient (indicating decreased temporal clustering) and shorter characteristic temporal path length (indicating increased temporal efficiency) compared with healthy controls (corrected p < 3.14×10). Corresponding local changes in MDD were mainly found in the default-mode, sensorimotor and subcortical areas. Measures of temporal variability and characteristic temporal path length were significantly correlated with depression severity in patients (corrected p < 0.05). Moreover, the observed between-group differences were robustly present in both first-episode, drug-naïve (FEDN) and non-FEDN patients.

Conclusions: Our findings suggest that excessive temporal variations of brain FC, reflecting abnormal communications between large-scale bran networks over time, may underlie the neuropathology of MDD.
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http://dx.doi.org/10.1016/j.nicl.2020.102163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229351PMC
February 2021

Combined Patterns Of Physical Activity And Screen-Related Sedentary Behavior Among Chinese Adolescents And Their Correlations With Depression, Anxiety And Self-Injurious Behaviors.

Psychol Res Behav Manag 2019 11;12:1041-1050. Epub 2019 Nov 11.

Medical Psychological Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, People's Republic of China.

Background And Purpose: There are increasing concern about independent associations between physical activity, screen-based sedentary behavior (SSB), and psychological problems, but only a few studies have attempted to explore combined patterns of physical activity and SSB in adolescents and their correlations with psychological problems. This study was aimed at identifying combined patterns of moderate-to-vigorous physical activity (MVPA) and SSB and examining the prevalence of different combined patterns and their correlations with depression, anxiety, and self-injurious behavior among Chinese adolescents.

Methods: Junior and senior high school students (N = 13,659; mean age 15.18±1.89) were recruited. Latent class analysis was conducted to identify combined patterns of MVPA and SSB. Associations between subgroups of MVPA and SSB and socio-demographic characteristics were assessed by logistic regression. Their correlation with depression, anxiety, and self-injurious behaviors was assessed by analysis of variance with analysis stratified by gender.

Results: Four latent classes were identified: high MVPA/low SSB group (64.7%), low MVPA/low SSB (26.7%), low MVPA/high SSB (4.8%), and low MVPA/moderate SSB (3.9%). Generally, the high MVPA/low SSB class was a relatively healthy group. The low MVPA/high SSB class was at risk of enduring depression, anxiety, and self-injurious behavior, with boys being more at risk than girls.

Conclusion: Four latent subgroups of MVPA and SSB were identified in Chinese adolescents. The findings highlight the potential role of concurrent MVPA and SSB, with gender-specific characteristics in the primary prevention of adolescent depression, anxiety, and self-injurious behaviors.
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http://dx.doi.org/10.2147/PRBM.S220075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857666PMC
November 2019

Neuroticism modulates neural activities of posterior cingulate cortex and thalamus during psychosocial stress processing.

J Affect Disord 2020 02 4;262:223-228. Epub 2019 Nov 4.

Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, China. Electronic address:

Objective: Individuals with higher neuroticism are vulnerable to stress and are prone to develop depression, however, the neural mechanisms underlying it have not been clarified clearly.

Method: The Montreal Imaging Stress Task (MIST) was administered to 148 healthy adults during functional magnetic resonance imaging (fMRI). Whole-brain voxel-wise regression analyses were used to detect associations of neuroticism with neural activity involved in perceiving and processing psychosocial stress. In addition, two-sample t-tests were conducted between the high-neurotic and low-neurotic group in order to supplement the results found in regression analyses.

Results: Higher neuroticism scores were associated with higher activities in the posterior cingulate cortex (PCC)/precuneus and thalamus (p < 0.05, false discovery rate correction). Moreover, two sample t-tests also revealed that the high-neurotic group had higher neural stress responses in precuneus and bilateral thalamus in comparison to the low-neurotic group (p < 0.05, false discovery rate correction).

Limitations: Our study mainly recruited young adults, which may limit the generalizability of our findings.

Conclusions: Our findings highlight the crucial role of PCC/precuneus and thalamus in the association between neuroticism and stress and may provide insight into the cognitive model of depression.
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http://dx.doi.org/10.1016/j.jad.2019.11.003DOI Listing
February 2020

Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia.

Front Psychiatry 2019 18;10:756. Epub 2019 Oct 18.

Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, China.

The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characteristics leads to inconsistent findings in healthy adult and also schizophrenia. This study aims to develop an integrated striatal model and reveal the altered functional connectivity pattern of the striatum in schizophrenia. Two data-driven approaches, task-dependent meta-analytic connectivity modeling (MACM) and task-independent resting-state functional connectivity (RSFC), were used for seven anatomical connectivity-based striatum subregions to provide an integrated striatal model. Then, RSFC analyses of seven striatal subregions were applied to 45 first-episode schizophrenia (FES) and 27 healthy controls to examine the difference, based on the integrated model, of functional connectivity pattern of striatal subregions. MACM and RSFC results showed that striatum subregions were associated with discrete cortical regions and involved in distinct cognitive processes. Besides, RSFC results overlapped with MACM findings but showed broader distributions. Importantly, significantly reduced functional connectivity was identified between limbic subregion and thalamus, medial prefrontal cortex, anterior cingulate cortex, and insula and also between executive subregions and thalamus, supplementary motor area, and insula in FES. Combing functional and structural connectivity information, this study provides the integrated model of corticostriatal subcircuits and confirms the abnormal functional connectivity of limbic and executive striatum subregions with different networks and thalamus, supporting the important role of the corticostriatal-thalamic loop in the pathophysiology of schizophrenia.
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http://dx.doi.org/10.3389/fpsyt.2019.00756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813199PMC
October 2019

Psychometric properties of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10) in Chinese undergraduates and depressive patients.

J Affect Disord 2020 01 12;261:211-220. Epub 2019 Oct 12.

Medical Psychological Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China. Electronic address:

Backgrouds: The 10-item Connor-Davidson Resilience Scale (CD-RISC-10) is a widely self-report questionnaire to assess resilience in different populations, including adolescents, elderly individuals and psychiatric patients. Considering the application of the CD-RISC-10 in depression patients, the present study aimed to evaluate the psychometric properties, especially the measurement invariance, of the CD-RISC-10 in depressive patient sample.

Methods: A total of 2230 undergraduates from Hunan Province and 293 patients with major depressive disorder (MDD) from psychological clinics participated in our study. Confirmatory factor analysis (CFA) was conducted to evaluate the single-factor model of the CD-RISC-10 and the measurement equivalence of the CD-RISC-10 across the clinical (MDD) and non-clinical (undergraduate) samples, as well as gender invariance in the non-clinical sample.

Results: The findings implied that the CD-RISC-10 showed good reliability and validity, including favorable internal consistency and criterion-related validity. The CFA results showed that the strong model fit for a unidimensional structure of the CD-RISC-10 was supported in the clinical (eg., CFI >0.910, TLI >0.900, RMSEA < 0.080) and non-clinical (eg., CFI >0.950, TLI >0.940, RMSEA < 0.060) groups, respectively. Moreover, the scalar invariance of the CD-RISC-10 was supported across the clinical and non-clinical samples (eg., △CFI < 0.009, △TLI < 0.005, ΔRMSEA < 0.003). Similarly, the strict gender invariance was also established in the male (n = 1035) and female (n = 1195) undergraduate samples (eg., △CFI < 0.008, △TLI < 0.004, ΔRMSEA < 0.002).

Limitations: The inclusion of Chinese individuals only and the absence of depressive patients with comorbidities were our major limitations.

Conclusions: Overall, these psychometric findings not only supported the stability and validity of the CD-RISC-10 for application with different samples in resilience study, but also indicated that the CD-RISC-10 could be an effective instrument for research in depression.
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http://dx.doi.org/10.1016/j.jad.2019.10.018DOI Listing
January 2020

Structural and Functional Connectivity of the Anterior Cingulate Cortex in Patients With Borderline Personality Disorder.

Front Neurosci 2019 13;13:971. Epub 2019 Sep 13.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

Background: Emerging evidences supported the hypothesis that emotional dysregulation results from aberrant connectivity within the fronto-limbic neural networks in patients with borderline personality disorder (BPD). Considering its important role in emotional regulation, the anterior cingulate cortex (ACC) has not yet been fully explored in BPD patients. Therefore, using the seed-based resting state functional connectivity (rsFC) and probabilistic fiber tracking, we aimed to explore the alterations of functional and structural connectivity (SC) of the ACC in patients with BPD.

Methods: A cohort of 50 unmedicated, young BPD patients and 54 sex-, age-, and education-matched healthy controls (HCs) completed psychological tests and underwent rs-fMRI and diffuse tensor imaging (DTI) scanning. Rs-FC analysis and probabilistic fiber tracking were used to plot SC and FC of the ACC.

Results: With the left ACC selected as a seed, BPD patients exhibited increased rsFC and abnormal SC with the right middle frontal gyrus (MFG), and decreased rsFC with the left middle temporal gyrus (MTG), compared with HCs. Additionally, negative cognitive emotion regulation and depressive symptoms both correlated negatively with the rsFC of the left ACC in BPD patients.

Conclusion: Abnormal SC and FC of the ACC underlie the deficient emotional regulation circuitry in BPD patients. Such alterations may be important biomarkers of BPD and thus could point to potential BPD treatment targets.
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http://dx.doi.org/10.3389/fnins.2019.00971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753388PMC
September 2019

Three dimensional convolutional neural network-based classification of conduct disorder with structural MRI.

Brain Imaging Behav 2020 Dec;14(6):2333-2340

Computer Vision Institute, School of Computer Science and Software Engineering, Shenzhen University, Shenzhen, People's Republic of China.

Conduct disorder (CD) is a common child and adolescent psychiatric disorder with various representative symptoms, and may cause long-term burden to patients and society. Recently, an increasing number of studies have used deep learning-based approaches, such as convolutional neural network (CNN), to analyze neuroimaging data and to identify biomarkers. In this study, we applied an optimized 3D AlexNet CNN model to automatically extract multi-layer high dimensional features of structural magnetic resonance imaging (sMRI), and to classify CD from healthy controls (HCs). We acquired high-resolution sMRI from 60 CD and 60 age- and gender-matched HCs. All subjects were male, and the age (mean ± std. dev) of participants in the CD and HC groups was 15.3 ± 1.0 and 15.5 ± 0.7, respectively. Five-fold cross validation (CV) was used to train and test this model. The receiver operating characteristic (ROC) curve for this model and that for support vector machine (SVM) model were compared. Feature visualization was performed to obtain intuition about the sMRI features learned by our AlexNet model. Our proposed AlexNet model achieved high classification performance with accuracy of 0.85, specificity of 0.82 and sensitivity of 0.87. The area under the ROC curve (AUC) of AlexNet was 0.86, significantly higher than that of SVM (AUC = 0.78; p = 0.046). The saliency maps for each convolutional layer highlighted the different brain regions in sMRI of CD, mainly including the frontal lobe, superior temporal gyrus, parietal lobe and occipital lobe. The classification results indicated that deep learning-based method is able to explore the hidden features from the sMRI of CD and might assist clinicians in the diagnosis of CD.
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http://dx.doi.org/10.1007/s11682-019-00186-5DOI Listing
December 2020

State-independent and -dependent structural alterations in limbic-cortical regions in patients with current and remitted depression.

J Affect Disord 2019 11 30;258:1-10. Epub 2019 Jul 30.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China; China National Clinical Research Center on Mental disorders (Xiangya), Changsha, Hunan 410011, China. Electronic address:

Background: The high recurrence of major depressive disorder (MDD) may derive from underlying state-independent structural alterations.

Methods: First-episode drug-naïve currently depressed (cMDD) patients (N = 97), remitted depressed (RD) patients (N = 72), and healthy controls (HCs, N = 100) underwent structural magnetic resonance imaging (MRI). Group differences in cortical thickness (CT), surface area (SA), and local gyrification index (lGI) were analyzed in FreeSurfer.

Results: Both groups of depressed patients had significantly decreased CT, relative to HCs, in the left precentral gyrus and significantly increased lGI values in the left superior frontal gyrus (SFG) indicative of state-independent alterations. Relative to HCs, the cMDD group had decreased CT of the SFG, caudal middle frontal gyrus (MFG), posterior cingulate cortex (PCC), and lateral occipital regions as well as increased SA or lGI of the superior temporal gyrus, precuneus, and pericalcarine, whereas the RD group had increased SA or lGI of the SFG, caudal MFG, and supramarginal gyrus; these alterations appeared to be state-dependent. SA or lGI values of the fusiform gyrus, inferior temporal gyrus, and superior parietal lobule differed between the cMDD and RD groups, consistent with state-dependent alterations. Beck depression inventory scores correlated with CT or lGI values of the caudal MFG, lateral occipital cortex in depressed patients.

Limitations: The structural features of several subcortical limbic regions were not analyzed.

Conclusions: Left precentral gyrus CT and left SFG gyrification alterations may represent state-independent alterations in MDD.
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http://dx.doi.org/10.1016/j.jad.2019.07.065DOI Listing
November 2019

Measurement equivalence of the SDQ in Chinese Adolescents: A horizontal and longitudinal perspective.

J Affect Disord 2019 10 1;257:439-444. Epub 2019 Jul 1.

Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Background: The Strengths and Difficulties Questionnaire (SDQ) is commonly used in research and clinical settings as a tool for the measurement of mental well-being. The current study evaluated the best-fit factor structure model of the Chinese version of the SDQ (SDQ-C) among Chinese adolescents and evaluated the measurement invariance of the SDQ-C across gender, age and time.

Methods: Participants included 1,134 adolescents from Hunan Province and Hainan Province in China. A confirmatory factor analysis (CFA) was conducted to determine the structure of the SDQ-C on a large scale. Multigroup CFA(N = 1102, 48.5% male, 51.5% female, mean age = 16.2) were utilized to test the measurement invariance of the five subscales included in the SDQ-C, across gender, age and time.

Results: The SDQ-C exhibited strong internal consistency (overall Cronbach's alpha coefficient = 0.927) and moderate test-retest reliability (Pearson's correlation coefficient = 0.719, over a 6-month interval). The CFA showed a valid five-factor model. Measurement invariance of the model across gender was fully supported. However, measurement invariance across age and time was limited.

Limitations: The participants were from Hunan Province and Hainan Province. It may be necessary to expand the sampled population to better represent the Chinese population.

Conclusions: Measurement equivalence of the SDQ-C across gender was established. Measurement equivalence across age and time was moderate. These findings suggest that the use of the SDQ-C in comparing samples across gender is valid but measurement across age and time may be limited.
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http://dx.doi.org/10.1016/j.jad.2019.06.049DOI Listing
October 2019

Factor Structure and Measurement Invariance Across Gender Groups of the 15-Item Geriatric Depression Scale Among Chinese Elders.

Front Psychol 2019 21;10:1360. Epub 2019 Jun 21.

Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha, China.

The 15-item Geriatric Depression Scale (GDS-15) is widely used to screen depression among elders. But the factor structure of the Chinese version GDS-15 remains unclear. This study was conducted to determine the best-fit factor structure of GDS-15 and to assess measurement invariance across gender groups in a sample of Chinese elders recruited from Mainland China (final sample = 2428). The best-fit factor structure was examined by confirmatory factor analysis (CFA). Multigroup CFA was utilized to test the measurement invariance across genders of the factor structure. The results of CFA revealed that a three-factor model, including life satisfaction (four items), general depressive affect (seven items), and withdrawal (three items), fits the structure of the GDS-15 best. Measurement invariance across genders was supported, fully assuming different degrees of invariance.
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http://dx.doi.org/10.3389/fpsyg.2019.01360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598091PMC
June 2019

Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder.

Eur Child Adolesc Psychiatry 2020 Apr 1;29(4):479-488. Epub 2019 Jul 1.

Center of Functional Neuroimaging, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Accumulating evidence suggests that neural abnormalities in conduct disorder (CD) may be subject to genetic influences, but few imaging studies have taken genetic variants into consideration. The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) has emerged as a high-interest genetic variant due to its importance in cortical maturation, and several studies have implicated its involvement in neurodevelopmental disorders. Thus, it is unclear how this polymorphism may influence brain anatomy and aberrant behaviors in CD. A total of 65 male adolescents with CD and 69 gender-, IQ- and socioeconomic status-matched healthy controls (HCs) (age range 13-17 years) were enrolled in this study. Analyses of variance (ANOVAs) were used to assess the main effects of CD diagnosis, BDNF genotype, and diagnosis-genotype interactions on brain anatomy and behaviors. We detected a significant main effect of BDNF genotype on temporal gyrification and antisocial behaviors, but not on CD symptoms. Diagnosis-genotype interactive effects were found for cortical thickness of the superior temporal and adjacent areas. These results suggest that the BDNF Val66Met polymorphism may exert its influence both on neural alterations and delinquent behaviors in CD patients. This initial evidence highlights the importance of elucidating potentially different pathways between BDNF genotype and cortical alterations or delinquent behaviors in CD patients.
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http://dx.doi.org/10.1007/s00787-019-01363-zDOI Listing
April 2020

Factorial Invariance of the 10-Item Connor-Davidson Resilience Scale Across Gender Among Chinese Elders.

Front Psychol 2019 31;10:1237. Epub 2019 May 31.

Department of Nursing, Second Xiangya Hospital, Central South University, Changsha, China.

Resilience plays an important role in the health of the elderly. The 10-item Connor-Davidson Resilience Scale (CD-RISC-10) is widely used to evaluate resilience, but its factorial invariance has not been evaluated in the Chinese elders. In the current study, 1,238 Chinese elders aged 60 years and above completed the Chinese CD-RISC-10, yielding good reliability (Cronbach's  = 0.936, Omega coefficient = 0.83, and test-retest reliability coefficient of 0.665 after 6 months). Confirmatory factor analysis indicated that a single-factor model fitted our CD-RISC-10 data well, both for the total sample and for each gender group. Furthermore, factorial invariance across genders was supported by multigroup confirmatory factor analysis. Finally, the current study revealed greater resilience levels in Chinese elderly women than in Chinese elderly men.
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http://dx.doi.org/10.3389/fpsyg.2019.01237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554443PMC
May 2019

Psychometric properties of the Chinese version of the Childhood Trauma Questionnaire-Short Form (CTQ-SF) among undergraduates and depressive patients.

Child Abuse Negl 2019 05 8;91:102-108. Epub 2019 Mar 8.

Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, 410011, PR China. Electronic address:

Objective: The Childhood Trauma Questionnaire-Short Form (CTQ-SF) is a self-report questionnaire that retrospectively provides screening for a history of childhood abuse and neglect, and which is widely used throughout the world. The current study aimed to examine the psychometric properties of the Chinese version of the CTQ-SF.

Methods: Participants included 3431 undergraduates from Hunan provinces and 234 depressive patients from psychological clinics. Confirmatory factor analysis was performed to examine how well the original five-factor model fit the data and the measurement equivalence of CTQ-SF across gender. Internal consistency was also evaluated.

Results: The five-factor model achieved satisfactory fit (Undergraduate sample TLI = 0.925, CFI = 0.936, RMSEA = 0.034, SRMR = 0.046; depressive sample TLI = 0.912, CFI = 0.923, RMSEA = 0.044, SRMR = 0.062). Measurement invariance of the five-factor model across gender was supported fully assuming different degrees of invariance. The CTQ-SF also showed acceptable internal consistency and good stability.

Conclusion: The current study provides that the Chinese version of the Childhood Trauma questionnaire-short form has good reliability and validity among Chinese undergraduates and depressive samples, which also indicates that the CTQ-SF is a good tool for child trauma assessment.
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http://dx.doi.org/10.1016/j.chiabu.2019.03.009DOI Listing
May 2019

Topologically state-independent and dependent functional connectivity patterns in current and remitted depression.

J Affect Disord 2019 05 5;250:178-185. Epub 2019 Mar 5.

Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Medical Psychological Institute of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, PR China. Electronic address:

Objective: Identification of state-independent and -dependent neural biomarkers may provide insight into the pathophysiology and effective treatment of major depressive disorder (MDD), therefore we aimed to investigate the state-independent and -dependent topological alterations of MDD.

Method: Brain resting-state functional magnetic resonance imaging (fMRI) data were acquired from 59 patients with unmedicated first episode current MDD (cMDD), 48 patients with remitted MDD (rMDD) and 60 demographically matched healthy controls (HCs). Using graph theory, we systematically studied the topological organization of their whole-brain functional networks at the global and nodal level.

Results: At a global level, both patient groups showed decreased normalized clustering coefficient in relative to HCs. On a nodal level, both patient groups showed decreased nodal centrality, predominantly in cortex-mood-regulation brain regions including the dorsolateral prefrontal cortex, posterior parietal cortex and posterior cingulate cortex. By comparison to cMDD patients, rMDD group had a higher nodal centrality in right parahippocampal gyrus.

Limitations: The present study, an exploratory analysis, may require further confirmation with task-based and experimental studies.

Conclusions: Deficits in the topological organization of the whole brain and cortex-mood-regulation brain regions in both rMDD and cMDD represent state-independent biomarkers.
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http://dx.doi.org/10.1016/j.jad.2019.03.030DOI Listing
May 2019

State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI.

Front Psychol 2019 11;10:245. Epub 2019 Feb 11.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.

Although efforts have been made to identify neurobiological characteristic of major depressive disorder (MDD) in recent years, trait- and state-related biological characteristics of MDD still remains unclear. Using functional magnetic resonance imaging (fMRI), the aim of this study was to explore whether altered spontaneous neural activities in MDD are trait- or state- related. Resting-state fMRI data were analyzed for 72 current MDD (cMDD) patients (first-episode, medication-naïve), 49 remitted MDD (rMDD) patients, and 78 age- and sex- matched healthy control (HC) subjects. The values of amplitude of low-frequency fluctuation (ALFF) were compared between groups. Compared with the cMDD group, the rMDD group had increased ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe. Besides, compared with the HC group, the cMDD group had decreased ALFF values in the left middle occipital gyrus. Further analysis explored that the mean ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe were correlated positively with BDI scores in rMDD patients. Abnormal activity in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe may be state-specific in current (first-episode, medication-naïve) and remitted (medication-naïve) depression patients. Furthermore, the state-related compensatory effect was found in these brain areas.
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http://dx.doi.org/10.3389/fpsyg.2019.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378291PMC
February 2019

Regional Homogeneity Abnormalities in Early-Onset and Adolescent-Onset Conduct Disorder in Boys: A Resting-State fMRI Study.

Front Hum Neurosci 2019 7;13:26. Epub 2019 Feb 7.

Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China.

: Developmental taxonomic theory posits that formation of early-onset conduct disorder (EO-CD), is considered to have a neurodevelopmental etiology and have more severe psychosocial and neuropsychological dysfunction than adolescent-onset CD (AO-CD), which is thought to stem largely from social mimicry of deviant peers. The purpose of the current study was to investigate whether regional homogeneity (ReHo), denoting the spontaneous brain activity, supports developmental taxonomic theory in a resting state (rs). : Rs-functional magnetic resonance imaging (fMRI) examinations were administered to 36 EO-CD patients, 32 AO-CD patients, and 30 healthy controls (HCs). All participants were male adolescents, aged between 12 and 17 years old. A one-way analysis of covariance (ANCOVA), with age and IQ as covariates, was performed to identify regions with significant group differences in ReHo values, followed by a analyses. : Compared with the AO-CD groups, EO-CD had higher ReHo values in the right middle/inferior frontal gyrus. Compared with the HCs, the EO-CD group exhibited lower ReHo values in the left precuneus, left middle occipital gyrus, left cerebellum posterior lobe and the right inferior parietal lobule, as well as higher ReHo values in the right middle frontal gyrus, left insula/inferior frontal gyrus, right postcentral gyrus, and the left anterior cingulate gyrus. Compared with the HCs, the AO-CD group showed lower ReHo values in the bilateral precuneus, left cerebellum posterior lobe, and the right inferior parietal lobule. : Significant differences in ReHo were observed between the EO-CD and AO-CD groups, implying distinct neuropathological mechanisms of the two CD subtypes, consistent with developmental taxonomic theory. CD-associated abnormalities in ReHo may be related to high-order cognitive and low-level perceptual system impairments in CD.
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http://dx.doi.org/10.3389/fnhum.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374554PMC
February 2019