Shuo-Chien Ling

Shuo-Chien Ling

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Shuo-Chien Ling

Shuo-Chien Ling

Publications by authors named "Shuo-Chien Ling"

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29Publications

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Elevated FUS levels by overriding its autoregulation produce gain-of-toxicity properties that disrupt protein and RNA homeostasis.

Autophagy 2019 Sep 23;15(9):1665-1667. Epub 2019 Jun 23.

a Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Republic of Singapore.

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http://dx.doi.org/10.1080/15548627.2019.1633162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693452PMC
September 2019

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions.

Authors:
Shuo-Chien Ling

Neural Plast 2018 11;2018:8413496. Epub 2018 Apr 11.

Department of Physiology, National University of Singapore, Singapore 117549.

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http://dx.doi.org/10.1155/2018/8413496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925147PMC
December 2018

Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination.

Proc Natl Acad Sci U S A 2018 11 29;115(46):E10941-E10950. Epub 2018 Oct 29.

Department of Physiology, National University of Singapore, Republic of Singapore 117549;

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http://dx.doi.org/10.1073/pnas.1809821115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243235PMC
November 2018

Ooplasmic flow cooperates with transport and anchorage in oocyte posterior determination.

J Cell Biol 2018 10 23;217(10):3497-3511. Epub 2018 Jul 23.

Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL

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http://dx.doi.org/10.1083/jcb.201709174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168253PMC
October 2018

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.

Acta Neuropathol 2017 06 29;133(6):907-922. Epub 2017 Mar 29.

Ludwig Institute for Cancer Research, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0670, USA.

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http://dx.doi.org/10.1007/s00401-017-1698-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427168PMC
June 2017

FUS-linked essential tremor associated with motor dysfunction in Drosophila.

Hum Genet 2016 Nov 9;135(11):1223-1232. Epub 2016 Jul 9.

National Neuroscience Institute, 20 College Road, The Academia, Level 9 (Discovery Tower), Singapore, 169856, Singapore.

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http://link.springer.com/10.1007/s00439-016-1709-z
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http://dx.doi.org/10.1007/s00439-016-1709-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052300PMC
November 2016

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):E6993-7002. Epub 2015 Nov 30.

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093; Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1073/pnas.1520639112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687558PMC
December 2015

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

Acta Neuropathol Commun 2015 Jun 25;3:36. Epub 2015 Jun 25.

King's Centre for Neurodegeneration Research, Kings College London, Department of Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AF, UK.

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http://dx.doi.org/10.1186/s40478-015-0212-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479086PMC
June 2015

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.

Neuron 2014 Apr;82(2):295-307

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096235PMC
April 2014

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.

Neuron 2013 Aug;79(3):416-38

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411085PMC
August 2013

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13318-23. Epub 2010 Jul 12.

Ludwig Institute for Cancer Research and Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093-0670, USA.

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http://dx.doi.org/10.1073/pnas.1008227107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922163PMC
July 2010

Microtubule binding by dynactin is required for microtubule organization but not cargo transport.

J Cell Biol 2007 Feb;176(5):641-51

Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1083/jcb.200608128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064022PMC
February 2007

Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.

Proc Natl Acad Sci U S A 2004 Dec 6;101(50):17428-33. Epub 2004 Dec 6.

Neuroscience Program, Department of Cell Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0408114101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC536039PMC
December 2004