Publications by authors named "Shuo Dong"

71 Publications

Metabolic profile of heart tissue in cyanotic congenital heart disease.

Am J Transl Res 2021 15;13(5):4224-4232. Epub 2021 May 15.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College 167A Beilishi Road, Xi Cheng District, Beijing 100037, China.

Background: Cyanotic congenital heart disease (CCHD) is one of the most common birth anomalies, in which chronic hypoxia is the basic pathophysiological process.

Methods: To investigate the heart's metabolic remodeling to hypoxia, we performed an untargeted metabolomic analysis of cardiac tissue from 20 CCHD patients and 15 patients with acyanotic congenital heart disease (ACHD).

Results: A total of 71 (63%) metabolites from 113 detected substances in cardiac tissue differed between the CCHD and ACHD groups. A partial least squares discriminant analysis showed separation between the CCHD and ACHD groups. A pathway enrichment analysis revealed that the most enriched metabolic pathways were amino acid metabolism and energy metabolism. Eleven amino acids were increased in CCHD patients, indicating that protein synthesis was down-regulated. Most of the metabolites in Krebs circle were increased in CCHD patients, suggesting down regulation of aerobic energy metabolism. Hierarchical cluster analysis showed that nicotinamide adenine dinucleotide (NAD) was clustered with Krebs cycle related substrates and its level was significantly higher in CCHD than that in ACHD patients. These analyses suggest that NAD might play an important role in response to hypoxia in CCHD patients.

Conclusion: Our data showed a significantly different metabolic profile in CCHD patients compared to ACHD patients, including reduced protein synthesis and aerobic energy production, and the increased level of NAD in the myocardium may be a response mechanism to hypoxia.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205768PMC
May 2021

Efficacy and safety of massage therapy for autism spectrum disorders: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(19):e25874

The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.

Background: Autism spectrum disorder is a neurodevelopmental disorder with increasing incidence. At present, the global incidence of the disease is on the rise, and the cause is unknown. There is no specific treatment for this disease at present, mainly education and training. Traditional Chinese medicine treatment has a certain effect on the improvement of the symptoms of the disease. The treatment methods are mainly oral Chinese medicine and acupuncture, but children are often not easy to cooperate. As a safe and effective green therapy, massage is easy to be accepted by children.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating autism spectrum disorders: Wanfang and PubMed Database, China National Knowledge Infrastructure Database, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, and Excerpta Medica database. Each database will be searched from inception to March 2021. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with autism spectrum disorders. The outcomes will include changes in autism spectrum disorder relief and adverse effect.

Conclusion: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with autism spectrum disorders.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis have been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.
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http://dx.doi.org/10.1097/MD.0000000000025874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133180PMC
May 2021

Two-stage Arterial Switch for Transposition of the Great Vessels in Older Children.

Ann Thorac Surg 2021 May 18. Epub 2021 May 18.

National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P.R. China. Electronic address:

Background: This study investigated a two-stage arterial switch operation (ASO) to treat transposition of the great arteries with intact ventricular septum (TGA-IVS) in late referral patients.

Methods: From February 2007 to August 2018, we retrospectively analyzed patients with TGA-IVS or TGA with restricted ventricular septal defects who had undergone two-stage ASO at our institution. Forty-one patients were included: 21 (51.2%) who had undergone long-term two-stage ASO and 20 (48.8%) who had undergone rapid two-stage ASO.

Results: The long-term two-stage group was older at ASO (3.5 versus 25 months; p < 0.001). The intensive care unit time, mechanical ventilation time, and length of stay were more satisfactory in the long-term group than in the rapid group (P=0.004, P=0.004, and P=0.007, respectively). No in-hospital mortality occurred in the long-term group, and the postoperative course was more manageable in the long-term group than in the rapid group. However, the risk of significant neoaortic regurgitation was lower in the rapid group, which also had a better left ventricular ejection fraction.

Conclusion: The long-term group achieved better early-term outcomes than the rapid group. However, a high risk of neoaortic regurgitation and myocardial dysfunction was also noted.
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http://dx.doi.org/10.1016/j.athoracsur.2021.04.081DOI Listing
May 2021

Ultrafast dynamical Lifshitz transition.

Sci Adv 2021 Apr 21;7(17). Epub 2021 Apr 21.

Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, Berlin 14195, Germany.

Fermi surface is at the heart of our understanding of metals and strongly correlated many-body systems. An abrupt change in the Fermi surface topology, also called Lifshitz transition, can lead to the emergence of fascinating phenomena like colossal magnetoresistance and superconductivity. While Lifshitz transitions have been demonstrated for a broad range of materials by equilibrium tuning of macroscopic parameters such as strain, doping, pressure, and temperature, a nonequilibrium dynamical route toward ultrafast modification of the Fermi surface topology has not been experimentally demonstrated. Combining time-resolved multidimensional photoemission spectroscopy with state-of-the-art TDDFT+ simulations, we introduce a scheme for driving an ultrafast Lifshitz transition in the correlated type-II Weyl semimetal -MoTe We demonstrate that this nonequilibrium topological electronic transition finds its microscopic origin in the dynamical modification of the effective electronic correlations. These results shed light on a previously unexplored ultrafast scheme for controlling the Fermi surface topology in correlated quantum materials.
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http://dx.doi.org/10.1126/sciadv.abd9275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059938PMC
April 2021

An open-source, end-to-end workflow for multidimensional photoemission spectroscopy.

Sci Data 2020 Dec 17;7(1):442. Epub 2020 Dec 17.

Fritz Haber Institute of the Max Planck Society, 14195, Berlin, Germany.

Characterization of the electronic band structure of solid state materials is routinely performed using photoemission spectroscopy. Recent advancements in short-wavelength light sources and electron detectors give rise to multidimensional photoemission spectroscopy, allowing parallel measurements of the electron spectral function simultaneously in energy, two momentum components and additional physical parameters with single-event detection capability. Efficient processing of the photoelectron event streams at a rate of up to tens of megabytes per second will enable rapid band mapping for materials characterization. We describe an open-source workflow that allows user interaction with billion-count single-electron events in photoemission band mapping experiments, compatible with beamlines at 3 and 4 generation light sources and table-top laser-based setups. The workflow offers an end-to-end recipe from distributed operations on single-event data to structured formats for downstream scientific tasks and storage to materials science database integration. Both the workflow and processed data can be archived for reuse, providing the infrastructure for documenting the provenance and lineage of photoemission data for future high-throughput experiments.
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http://dx.doi.org/10.1038/s41597-020-00769-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746702PMC
December 2020

Effects and safety of massage therapy for patients with metatarsal pain: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(49):e23484

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Metatarsalgia refers to localized or generalized forefoot pain in the region of the metatarsal heads. Often this pain is plantar, beneath the metatarsal heads, and arises from either mechanical or iatrogenic causes. The treatment of metatarsalgia remains controversial. A thorough understanding of the biomechanics of the forefoot and the underlying pathology of the particular type of metatarsalgia affecting the patient is a prerequisite to selecting the proper treatment. In recent years, massage therapy has been increasingly accepted by patients due to its lower costs, fewer unwanted side effects, and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with metatarsal pain.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating metatarsal pain: Wanfang and PubMed Database, CNKI, CENTRAL, CINAHL, and EMBASE. Each database will be searched from inception to October 2020. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with metatarsal pain. The outcomes will include changes in metatarsal pain relief and adverse effect.

Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with metatarsalgia.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.

Osf Registration Number: DOI 10.17605/OSF.IO/C6KFJ.
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http://dx.doi.org/10.1097/MD.0000000000023484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717819PMC
December 2020

Effects of massage therapy for patients with thoracic facet joint disorders: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(49):e23480

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Thoracic facet joint disorder is a common thoracic disorder in clinic, inducing pain and discomfort at the dislocated thoracic vertebrae, radiating to pain of the neck and back. The incidence of thoracic facet joint disorder is higher than the facet disorder of the cervical and lumbar vertebrae. Therefore, an ideal strategy to relieve thoracic facet joint disorder is urgently needed. In recent years, massage therapy has been increasingly accepted by thoracic facet joint disorder patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with thoracic facet joint disorder.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness of massage therapy in treating thoracic facet joint disorder: Wanfang and PubMed Database, CNKI, CENTRAL, CINAHL and EMBASE. Each database will be searched from inception to October 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.

Results: This proposed study will evaluate the effectiveness of massage therapy for patients with thoracic facet joint disorder.

Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with thoracic facet joint disorder.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.

Osf Registration Number: DOI 10.17605/OSF.IO/XMEJD.
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http://dx.doi.org/10.1097/MD.0000000000023480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717749PMC
December 2020

Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs).

Drug Des Devel Ther 2020 18;14:5087-5096. Epub 2020 Nov 18.

Department of Cardiovascular Medicine Ward 2, Zibo Central Hospital, Zibo, Shandong 255020, People's Republic of China.

Background And Purpose: Endothelium exerts an important role in releasing vasoactive substances, maintaining the blood flow, regulating the growth of vessels, moderating the process of coagulation, and the balance of fibrinolytic system, the dysfunction of which is reported to result in arterial stiffness. The present study aimed to investigate the effects of loxoprofen sodium against HUVECs injury induced by angiotensin II.

Methods: The injury model on HUVECs was established through incubation with angiotensin II. The expression levels of AT2R, NOX-4, Bax, Bcl-2, and caspase-3 were evaluated using qRT-PCR and Western Blot. DCFH-DA assay was used to detect the production of ROS and ELISA assay was used to evaluate the level of reduced glutathione. Mitochondrial membrane potential (MMP) was measured using dihydrorhodamine 123 assay. MTT and LDH assays were utilized to determine the proliferation ability of HUVECs. The apoptosis rate of HUVECs was evaluated using flow cytometry.

Results: Loxoprofen sodium suppressed endothelial AT2R elevation by angiotensin II. Loxoprofen ameliorated Angiotensin II-induced production of ROS, reduced GSH, and NOX-2 and NOX-4 expression. Furthermore, Loxoprofen mitigated Angiotensin II, reduced mitochondrial membrane potential and improved cell viability, and suppressed LDH release by angiotensin II. Importantly, loxoprofen showed a beneficial role in protecting endothelial apoptosis by mitigating apoptotic machinery including the balanced expression of Bax, Bcl-2, and caspase-3 cleavage.

Conclusion: Loxoprofen sodium might alleviate the high ROS levels and apoptosis induced by angiotensin II in HUVECs.
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http://dx.doi.org/10.2147/DDDT.S266175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680688PMC
November 2020

Efficacy of massage therapy for postprandial distress syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Nov;99(48):e23473

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Postprandial distress syndrome (PDS), characterized by the presence of prevalently meal-related early satiation and fullness, is a highly prevalent condition with major socioeconomic and healthcare impact. To date, there is a lack of pharmacological treatment proven value for PDS. Therefore, an ideal strategy to relieve PDS is urgently needed. In recent years, massage therapy has been increasingly accepted by PDS patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with postprandial distress syndrome.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating postprandial distress syndrome: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL, and EMBASE. Each database will be searched from inception to October 2020. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with postprandial distress syndrome. The outcomes will include changes in PDS relief and adverse effect.

Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with postprandial distress syndrome.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.

Osf Registration Number: DOI 10.17605/OSF.IO/9WRX8.
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http://dx.doi.org/10.1097/MD.0000000000023473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710185PMC
November 2020

Efficacy and safety of massage therapy for chronic atrophic gastritis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Nov;99(47):e23347

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Chronic atrophic gastritis (CAG) is an established precursor of gastric carcinoma with high prevalence worldwide. It is a typical complex gastro-intestinal disease with multiple influence factors, of which exact mechanisms remain unelucidated. Therefore, an ideal strategy to relieve CAG is urgently needed. In recent years, massage therapy has been increasingly accepted by CAG patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating chronic atrophic gastritis: Wanfang and Pubmed Database, China National Knowledge Infrastructure Database, Cochrane Central register of controlled trials, Cumulative Index of Nursing and Allied Health Literature, and Excerpta Medica database. Each database will be searched from inception to September 2020. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

Result: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis. The outcomes will include changes in CAG relief and adverse effect.

Conclusion: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.
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http://dx.doi.org/10.1097/MD.0000000000023347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676512PMC
November 2020

High-purity foam-like micron-sized gold cage material with tunable plasmon properties.

Sci Rep 2020 Oct 6;10(1):16555. Epub 2020 Oct 6.

Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang, 621900, Sichuan, China.

Herein, by growing mono dispersed gold nanoparticles (MNPAu) on the surface of polystyrene (PS)/nanogold (Au) core-shell composites ([email protected]), we successfully synthesized a micron-sized gold cage (2.6-10.7 μm), referred to as [email protected]@MNPAu for the first time. The new micron-gold cage materials exhibit broadband absorption range from near-ultraviolet to near-infrared, which is unlike the conventional nanogold core-shell structure. The uniform growth of MNPAu on the surface forms a new photonic crystal spectrum. The strong coupling of the spectra causes anomalous absorption in the ultraviolet-near infrared band (400-900 nm). Furthermore, by removing the PS core, a nanogold cavity structure referred to as [email protected] was prepared. This structure demonstrated a high purity (> 97 wt%), low density (9-223 mg/cm), and high specific surface area (854 m/g). As the purification process progressed, the MNPAu coupling on the surface of the micro-gold cage strengthened, resulting in the formation of peaks around 370 nm, plasma resonant peaks around 495 nm, and structural bands of photonic crystal peaks around 850 nm. The micron-sized gold cage provides hybridized and tunable plasmonic systems. The theoretical simulations indicate that this plasmon anomalous absorption phenomena can be understood as the novel form of the topological structural transitions near the percolation threshold, which is consistent experimental measurements.
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http://dx.doi.org/10.1038/s41598-020-72831-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538574PMC
October 2020

Observation of an Excitonic Mott Transition through Ultrafast Core-cum-Conduction Photoemission Spectroscopy.

Phys Rev Lett 2020 Aug;125(9):096401

Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, 14915 Berlin, Germany.

Time-resolved soft-x-ray photoemission spectroscopy is used to simultaneously measure the ultrafast dynamics of core-level spectral functions and excited states upon excitation of excitons in WSe_{2}. We present a many-body approximation for the Green's function, which excellently describes the transient core-hole spectral function. The relative dynamics of excited-state signal and core levels clearly show a delayed core-hole renormalization due to screening by excited quasifree carriers resulting from an excitonic Mott transition. These findings establish time-resolved core-level photoelectron spectroscopy as a sensitive probe of subtle electronic many-body interactions and ultrafast electronic phase transitions.
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http://dx.doi.org/10.1103/PhysRevLett.125.096401DOI Listing
August 2020

Pediatric massage therapy for restoring pediatric lung function from COVID-19: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Aug;99(33):e21581

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: The novel coronavirus disease 2019 (COVID-19) has caused an international outbreak of a respiratory illness and grown to be a global public health emergency since patients were first detected in Wuhan, China. Given the rapidly growing pandemic and the overwhelmed medical system, there is an urgent need of alternative medicine to help children relieve symptoms during self-quarantine, and possibly to help increase their chances of survival and recovery from COVID-19. By using various manual techniques at specified locations on the surface of the body, pediatric massage manipulation can unblock meridians, promote the circulation of qi and blood and strengthen resistance to pathogens.

Methods: We will search the following electronic databases: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL, EMBASE and MEDLINE. Each database will be searched from inception to June 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.

Results: This systematic review will evaluate the existing evidence of pediatric massage therapy for restoring pediatric lung function from COVID-19. The outcomes will include the improvement of pulmonary function and adverse effect.

Conclusion: This proposed systematic review will evaluate the existing evidence and explore the potential role of pediatric massage therapy on the effectiveness and safety in pulmonary function of COVID-19 convalescent children.

Prospero Registration Number: CRD42020193396.
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http://dx.doi.org/10.1097/MD.0000000000021581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437764PMC
August 2020

Luminescent molecules towards precise cellular event regulation.

Chem Commun (Camb) 2020 Sep 4;56(70):10231-10234. Epub 2020 Aug 4.

Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang link, 637371, Singapore.

A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission of the complex can successfully modulate the activities of light-gated membrane channels and regulate the ion flux in vivo.
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http://dx.doi.org/10.1039/d0cc01923bDOI Listing
September 2020

Tuina (massage) therapy for diarrhea in COVID-19: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jul;99(28):e21293

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: In the beginning of December 2019, the novel coronavirus pneumonia was first detected in Wuhan, China. Its widespread infectivity and strong pathogenicity has posed a great threat to public health, seriously affecting social production and life. Accumulating evidence suggests that gastrointestinal symptoms, such as diarrhea, are common among patients with COVID-19. Tuina (massage) therapy is 1 of the widely employed complementary and alternative medicine interventions in the world. It can act on the subcutaneous muscular layer, enhance the local blood circulation and tissue metabolism of the skin, thus exert its effects on digestive systems and alleviate aversive diarrhea symptoms. This systematic review and meta-analysis will summarize the current evidence of tuina (massage) used as an intervention for diarrhea symptoms in COVID-19.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating exercise-induced fatigue: China National Knowledge Infrastructure, Wanfang and Pubmed Database, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, Excerpta Medica database and MEDLINE. Each database will be searched from inception to June 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.

Results: This proposed study will evaluate the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients. The outcomes will include the improvement of diarrhea symptoms and adverse effect.

Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients.Dissemination and ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.
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http://dx.doi.org/10.1097/MD.0000000000021293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360276PMC
July 2020

Clinical massage therapy for patients with exercise-induced fatigue: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20870

Dongfang Hospital.

Background: Exercise-induced fatigue (EF) has been a major area of interest within the field of sports and clinical medicine. Implemented on people's skin, muscles, and joints as an important part of complementary and alternative medicine , massage therapy has a positive effect on the recovery of EF and sports injuries. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with EF.

Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating EF: China National Knowledge Infrastructure, Wanfang and PubMed Database, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, Excerpta Medica database, and Medical Literature Analysis and Retrieval System Online. Each database will be searched from inception to May 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.

Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with EF. The outcomes will include change in fatigue relief and adverse effect.

Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with EF.

Dissemination And Ethics: The results of this review will be disseminated through peer-reviewed publication. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process.
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http://dx.doi.org/10.1097/MD.0000000000020870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328973PMC
June 2020

Significance and Transformation of 3-Alkyl-2-Methoxypyrazines Through Grapes to Wine: Olfactory Properties, Metabolism, Biochemical Regulation, and the HP-MP Cycle.

Molecules 2019 Dec 16;24(24). Epub 2019 Dec 16.

College of Enology, Heyang Viti-Viniculture Station, Northwest A&F University, Yangling 712100, China.

3-Alkyl-2-methoxypyrazines (MPs) contribute to the herbaceous flavor characteristics of wine and are generally considered associated with poor-quality wine. To control the MPs in grapes and wine, an accurate understanding of MP metabolism is needed. This review covers factors affecting people in the perception of MPs. Also, the history of -methyltransferases is revisited, and the present review discusses the MP biosynthesis, degradation, and biochemical regulation. We propose the existence of a cycle between MPs and 3-alkyl-2-hydropyrazines (HPs), which proceeds via -(de)methylation steps. This cycle governs the MP contents of wines, which make the cycle the key participant in MP regulation by genes, environmental stimuli, and microbes. In conclusion, a comprehensive metabolic pathway on which the HP-MP cycle is centered is proposed after gaining insight into their metabolism and regulation. Some directions for future studies on MPs are also proposed in this paper.
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http://dx.doi.org/10.3390/molecules24244598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943733PMC
December 2019

The surgical treatment of anomalous origin of one pulmonary artery from the ascending aorta.

J Cardiothorac Surg 2019 Apr 27;14(1):82. Epub 2019 Apr 27.

Department of Pediatric Cardiac Surgery, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, 100037, People's Republic of China.

Objective: This study sought to summarize the clinical experience of surgical treatment of anomalous origin of pulmonary arteries from the ascending aorta (AOPA) in Fuwai hospital.

Methods: Fifty-two patients (28 males, 17.2 ± 27.2 months old and 8.7 ± 10.2 Kg weight) who have AOPA undertook surgical treatment between 1998 and 2017 were reviewed in this study, 47 out of 52 are anomalous origin of the right pulmonary artery (AORPA), among the rest of the patients are anomalous origin of left pulmonary artery (AOLPA). 27 out of 52 associate with simple cardiac abnormalities, 20 out of 52 associate with complex cardiac malformations, the remaining 5 patients without cardiac abnormalities. Among all patients who underwent surgical treatment, the direct end-to-side anastomosis strategy was applied in 26 patients, autologous pericardial-homograft patch and aortic flap were employed in 20 patients, and synthetic graft was used in 6 patients.

Results: No patient died during the perioperative period. 50 out of 52 patients were followed-up for 100.1 ± 70.9 months. The rate of pulmonary arterial free restenosis for 2 years, 5 years, and 10 years is 98.0, 96.0 and 92.0%, respectively.

Conclusions: The correct diagnosis and appropriate surgical treatment for AOPA could obtain excellent early and medium-term result.
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http://dx.doi.org/10.1186/s13019-019-0904-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487052PMC
April 2019

Chinese herbal medicine for postpartum constipation: a protocol of systematic review and meta-analysis.

BMJ Open 2019 01 15;9(1):e023941. Epub 2019 Jan 15.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Introduction: Constipation is one of the most common gastrointestinal symptoms in postpartum mothers. The choice of treatments for postpartum constipation remains a challenging clinical problem. Chinese herbal medicine has become increasingly popular as an alternative therapy for constipation. This systematic review aims to evaluate the efficacy and safety of Chinese herbal medicine for postpartum constipation.

Methods And Analysis: We will search PubMed (1946 to present), EMBASE (1974 to present), Cochrane Central Register of Controlled Trials (all years), Web of Science (1900 to present), Chinese Biomedical Literatures Database (1978 to present), China National Knowledge Infrastructure (1979 to present) and WANFANG data (1998 to present) to identify any eligible study. No restriction will be put on the language, publication date or status of the study. The primary outcome will be the spontaneous bowel movement. Secondary outcomes will be stool consistency, quality of life, transit time, relief of constipation symptoms and adverse events. We will perform the meta-analysis when more than one trial examines the same intervention and outcomes with comparable methods in similar populations. If the heterogeneity is not significant statistically (p>0.10 or I<50%), the fixed-effect model will be built to estimate the overall intervention effects. Otherwise, the random-effect model will be used to provide more conservative results.

Ethics And Dissemination: No ethical issues are foreseen because no primary data will be collected. The results will be published in a peer-reviewed scientific journal.

Prospero Registration Number: CRD42018093741.
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http://dx.doi.org/10.1136/bmjopen-2018-023941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340430PMC
January 2019

Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant.

Urology 2018 Jul 30;117:142-144. Epub 2018 Mar 30.

Department of Ultrasound, Tianjin Children's Hospital, Tianjin, China.

Yolk sac tumor (YST) is a rare malignancy typically occurring in children. However, bilateral testicular YSTs are a quite rare situation, which can occur metachronously or synchronously with same histologic type, as well as different histology. We present a case of synchronous YST of the left testis and mature teratoma of the right in a 7-month-old infant treated with testis-sparing surgery at right testis and high radical orchiectomy at left. By follow-up of 28th month, no atrophy, or residual tumor in right testis and no recurrence or evidence of disease in left scrotum was found.
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http://dx.doi.org/10.1016/j.urology.2018.03.025DOI Listing
July 2018

Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia.

Haematologica 2017 08 18;102(8):e300-e304. Epub 2017 May 18.

Leukemia and Stem Cell Biology Group, Department of Haematological Medicine, Division of Cancer Studies, King's College London, UK

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http://dx.doi.org/10.3324/haematol.2016.161406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643733PMC
August 2017

Pump-Power Dependence of Coherent Acoustic Phonon Frequencies in Colloidal CdSe/CdS Core/Shell Nanoplatelets.

Nano Lett 2017 05 27;17(5):3312-3319. Epub 2017 Apr 27.

Division of Chemistry and Biological Chemistry, and Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University , 21 Nanyang Link, Singapore 637371, Singapore.

Femtosecond optical pump-probe spectroscopy resolves hitherto unobserved coherent acoustic phonons in colloidal CdSe/CdS core/shell nanoplatelets (NPLs). With increasing pump fluence, the frequency of the in-plane acoustic mode increases from 5.2 to 10.7 cm, whereas the frequency of the out-of-plane mode remains at ∼20 cm. Analysis of the oscillation phases suggests that the coherent acoustic phonon generation mechanism transitions from displacive excitation to subpicosecond Auger hole trapping with increasing pump fluence. The measurements yield Huang-Rhys parameters of ∼10 for both acoustic modes. The weak electron-phonon coupling strengths favor the application of NPLs in optoelectronics.
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http://dx.doi.org/10.1021/acs.nanolett.7b01394DOI Listing
May 2017

MicroRNA-98 plays a critical role in experimental myocarditis.

Int J Cardiol 2017 Feb 23;229:75-81. Epub 2016 Nov 23.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing 100037, China. Electronic address:

Background And Aims: Myocarditis is inflammation in the heart; its pathogenesis is to be further investigated. Activities of micro RNAs (miR) are associated with immune inflammation. This study tests a hypothesis that miR-98 is involved in the development of myocarditis.

Methods: BALB/c mice were immunized with cardiac α-myosin heavy chain peptides (MyHC-α) to induce myocarditis. The effects of miR-98 on regulation of interleukin (IL)-10 were assessed by real time RT-PCR.

Results: Mice immunized with MyHC-α showed myocarditis and lower frequency of IL-10 B cells (B10 cell) in the hearts. Expression of miR-98 was higher, IL-10 was lower, in B cells isolated from the mouse hearts with myocarditis, which was negatively correlated with each other. Exposure to tumor necrosis factor-α up regulated miR-98 expression in B cells. Over-expression of miR-98 suppressed IL-10 expression in B cells. Blocking miR-98 or adoptively transplanting B10 cells attenuated experimental myocarditis.

Conclusions: miR-98 suppresses IL-10 expression in B cells in the heart, which plays an important role in myocarditis. MiR-98 may be a therapeutic target in the treatment of myocarditis.
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http://dx.doi.org/10.1016/j.ijcard.2016.11.263DOI Listing
February 2017

Jahn-Teller-induced femtosecond electronic depolarization dynamics of the nitrogen-vacancy defect in diamond.

Nat Commun 2016 11 16;7:13510. Epub 2016 Nov 16.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Single-photon emission from the nitrogen-vacancy defect in diamond constitutes one of its many proposed applications. Owing to its doubly degenerate E electronic excited state, photons from this defect can be emitted by two optical transitions with perpendicular polarization. Previous measurements have indicated that orbital-selective photoexcitation does not, however, yield photoluminescence with well-defined polarizations, thus hinting at orbital-averaging dynamics even at cryogenic temperatures. Here we employ femtosecond polarization anisotropy spectroscopy to investigate the ultrafast electronic dynamics of the E state. We observe subpicosecond electronic dephasing dynamics even at cryogenic temperatures, up to five orders of magnitude faster than dephasing rates suggested by previous frequency- and time-domain measurements. Ab initio molecular dynamics simulations assign the ultrafast depolarization dynamics to nonadiabatic transitions and phonon-induced electronic dephasing between the two components of the E state. Our results provide an explanation for the ultrafast orbital averaging that exists even at cryogenic temperatures.
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http://dx.doi.org/10.1038/ncomms13510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116094PMC
November 2016

Sub-Picosecond Auger-Mediated Hole-Trapping Dynamics in Colloidal CdSe/CdS Core/Shell Nanoplatelets.

ACS Nano 2016 Oct 21;10(10):9370-9378. Epub 2016 Sep 21.

Division of Chemistry and Biological Chemistry, and Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University , 21 Nanyang Link, Singapore 637371.

Quasi-two-dimensional colloidal nanoplatelets (NPLs) have recently emerged as a class of semiconductor nanomaterials whose atomically precise monodisperse thicknesses give rise to narrow absorption and emission spectra. However, the sub-picosecond carrier dynamics of NPLs at the band edge remain largely unknown, despite their importance in determining the optoelectronic properties of these materials. Here, we use a combination of femtosecond transient absorption spectroscopy and nonadiabatic molecular dynamics simulations to investigate the early time carrier dynamics of CdSe/CdS core/shell NPLs. Band-selective probing reveals sub-picosecond Auger-mediated trapping of holes with an effective second-order rate constant of 3.5 ± 1.0 cm/s. Concomitant spectral blue shifts that are indicative of Auger hole heating are found to occur on the same time scale as the sub-picosecond trapping dynamics, whereas spectral red shifts that emerge at low excitation densities furnish an electron-cooling time scale of 0.84 ± 0.09 ps. Finally, nonadiabatic molecular dynamics simulations relate the observed sub-picosecond Auger-mediated hole-trapping dynamics to a shallow trap state that originates from the incomplete passivation of dangling bonds on the NPL surface.
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http://dx.doi.org/10.1021/acsnano.6b04210DOI Listing
October 2016

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.

J Hematol Oncol 2016 Mar 12;9:24. Epub 2016 Mar 12.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.

Background: Mixed lineage leukemia (MLL) gene translocations are found in ~75% infant and 10% adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 inhibitors against MLL-rearranged leukemia are needed.

Methods: LSD1 inhibitors were examined for their biochemical and biological activities against LSD1 and MLL-rearranged leukemia as well as other cancer cells.

Results: Potent LSD1 inhibitors with biochemical IC50 values of 9.8-77 nM were found to strongly inhibit proliferation of MLL-rearranged leukemia cells with EC50 of 10-320 nM, while these compounds are generally non-cytotoxic to several other tumor cells. LSD1 inhibition increased histone H3 lysine 4 (H3K4) methylation, downregulated expression of several leukemia-relevant genes, induced apoptosis and differentiation, and inhibited self-renewal of stem-like leukemia cells. Moreover, LSD1 inhibitors worked synergistically with inhibition of DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, against MLL-rearranged leukemia. The most potent LSD1 inhibitor showed significant in vivo activity in a systemic mouse model of MLL-rearranged leukemia without overt toxicities. Mechanistically, LSD1 inhibitors caused significant upregulation of several pathways that promote hematopoietic differentiation and apoptosis.

Conclusions: LSD1 is a drug target for MLL-rearranged leukemia, and LSD1 inhibitors are potential therapeutics for the malignancy.
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http://dx.doi.org/10.1186/s13045-016-0252-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789278PMC
March 2016

Observation of an Excitonic Quantum Coherence in CdSe Nanocrystals.

Nano Lett 2015 Oct 14;15(10):6875-82. Epub 2015 Sep 14.

Division of Chemistry and Biological Chemistry, and Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University , 21 Nanyang Link, Singapore 637371, Singapore.

Recent observations of excitonic coherences within photosynthetic complexes suggest that quantum coherences could enhance biological light harvesting efficiencies. Here, we employ optical pump-probe spectroscopy with few-femtosecond pulses to observe an excitonic quantum coherence in CdSe nanocrystals, a prototypical artificial light harvesting system. This coherence, which encodes the high-speed migration of charge over nanometer length scales, is also found to markedly alter the displacement amplitudes of phonons, signaling dynamics in the non-Born-Oppenheimer regime.
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http://dx.doi.org/10.1021/acs.nanolett.5b02786DOI Listing
October 2015

Decreased expression of claudin-3 is associated with a poor prognosis and EMT in completely resected squamous cell lung carcinoma.

Tumour Biol 2015 Aug 28;36(8):6559-68. Epub 2015 Mar 28.

Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Xicheng District, Beijing, 100050, People's Republic of China.

The deregulation of claudin-3 has been reported to correlate with the invasion and metastasis of various cancers, but little is known about its expression level and the prognostic value in squamous cell lung carcinoma (SqCC). The purpose of this study is to determine the expression levels and the prognostic value of claudin-3 in completely resected SqCC tissues, and the potential underlying mechanism. The protein expression of claudin-3, E-cadherin, β-catenin, and vimentin in the tumor tissues from 103 patients with surgically resected SqCC was examined using immunohistochemistry, western blots, as well as semi-quantitative estimation. The claudin-3 protein level was significantly associated with E-cadherin, β-catenin, and vimentin protein expression. A decreased claudin-3 protein level was significantly correlated with TNM stage, lymph node metastasis, and disease recurrence. Similarly, downregulation of E-cadherin was significantly correlated with lymph node metastasis and disease recurrence. Decreased β-catenin expression also had a significant correlation with disease recurrence. Univariate analyses indicated that the T stage, lymph node metastasis, the TNM stage, and the expression of claudin-3, β-catenin, and vimentin were significant predictors for overall survival (OS). Moreover, multivariate analyses demonstrated that the TNM stage and protein levels of claudin-3, β-catenin, and vimentin were independent predictors for OS of SqCC patients. Claudin-3 plays an important role in the epithelial-mesenchymal transition of SqCC and might be used as a potential prognostic factor for SqCC.
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http://dx.doi.org/10.1007/s13277-015-3350-1DOI Listing
August 2015

Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

Dev Cell 2015 Jan 31;32(1):68-81. Epub 2014 Dec 31.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

The H3 histone variant CENP-A is an epigenetic marker critical for the centromere identity and function. However, the precise regulation of the spatiotemporal deposition and propagation of CENP-A at centromeres during the cell cycle is still poorly understood. Here, we show that CENP-A is phosphorylated at Ser68 during early mitosis by Cdk1. Our results demonstrate that phosphorylation of Ser68 eliminates the binding of CENP-A to the assembly factor HJURP, thus preventing the premature loading of CENP-A to the centromere prior to mitotic exit. Because Cdk1 activity is at its minimum at the mitotic exit, the ratio of Cdk1/PP1α activity changes in favor of Ser68 dephosphorylation, thus making CENP-A available for centromeric deposition by HJURP. Thus, we reveal that dynamic phosphorylation of CENP-A Ser68 orchestrates the spatiotemporal assembly of newly synthesized CENP-A at active centromeres during the cell cycle.
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http://dx.doi.org/10.1016/j.devcel.2014.11.030DOI Listing
January 2015

Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.

J Med Chem 2014 Oct 1;57(20):8307-18. Epub 2014 Oct 1.

Department of Pharmacology, ⊥Department of Pediatrics-oncology, ∥Department of Medicine, and ‡Dan L. Duncan Cancer Center, Baylor College of Medicine , 1 Baylor Plaza, Houston, Texas 77030, United States.

Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several 1-hydroxypyridin-2-one compounds were identified to be inhibitors of IDH1(R132H). A total of 61 derivatives were synthesized, and their structure-activity relationships were investigated. Potent IDH1(R132H) inhibitors were identified with Ki values as low as 140 nM, while they possess weak or no activity against WT IDH1. Activities of selected compounds against IDH1(R132C) were found to be correlated with their inhibitory activities against IDH1(R132H), as well as cellular production of D2HG, with R(2) of 0.83 and 0.73, respectively. Several inhibitors were found to be permeable through the blood-brain barrier in a cell-based model assay and exhibit potent and selective activity (EC50 = 0.26-1.8 μM) against glioma cells with the IDH1 R132H mutation.
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http://dx.doi.org/10.1021/jm500660fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207540PMC
October 2014
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