Publications by authors named "Shunsuke Sato"

143 Publications

Survival of Floquet-Bloch States in the Presence of Scattering.

Nano Lett 2021 Jun 3. Epub 2021 Jun 3.

Institute for Experimental and Applied Physics, University of Regensburg, Regensburg 93040, Germany.

Floquet theory has spawned many exciting possibilities for electronic structure control with light, with enormous potential for future applications. The experimental demonstration in solids, however, remains largely unrealized. In particular, the influence of scattering on the formation of Floquet-Bloch states remains poorly understood. Here we combine time- and angle-resolved photoemission spectroscopy with time-dependent density functional theory and a two-level model with relaxation to investigate the survival of Floquet-Bloch states in the presence of scattering. We find that Floquet-Bloch states will be destroyed if scattering-activated by electronic excitations-prevents the Bloch electrons from following the driving field coherently. The two-level model also shows that Floquet-Bloch states reappear at high field intensities where energy exchange with the driving field dominates over energy dissipation to the bath. Our results clearly indicate the importance of long scattering times combined with strong driving fields for the successful realization of various Floquet phenomena.
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http://dx.doi.org/10.1021/acs.nanolett.1c00801DOI Listing
June 2021

Hepatitis B Surface Antigen Decline During Sofosbuvir and Ribavirin Therapy in Hepatitis B Inactive Carriers Who were co-infected with Hepatitis C.

Intern Med 2021 May 14. Epub 2021 May 14.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Japan.

Direct-acting antiviral (DAA) therapy carries a potential risk of inducing hepatitis B virus (HBV) reactivation. However, the HBV kinetics during and after DAA therapy in patients co-infected with hepatitis C virus (HCV) and HBV remain unknown. We retrospectively evaluated the HBV kinetics during and after sofosbuvir/ribavirin therapy in four HBV inactive carriers co-infected with HCV. HCV was eradicated in all patients. Changes in HBV-DNA levels during treatment differed among patients. The hepatitis B surface antigen (HBsAg) levels uniformly decreased (mean -0.530 logIU/mL) by the end of treatment and returned to near the baseline in all patients. Sofosbuvir/ribavirin therapy thus demonstrated a suppressive effect on HBsAg.
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http://dx.doi.org/10.2169/internalmedicine.7337-21DOI Listing
May 2021

Elevated serum tyrosine concentration is associated with a poor prognosis among patients with liver cirrhosis.

Hepatol Res 2021 May 8. Epub 2021 May 8.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.

Aim: Chronic liver insufficiency is often associated with changes in amino acid metabolism. We evaluated whether change in serum amino acid concentrations had prognostic value among patients with liver cirrhosis.

Methods: This retrospective study evaluated 158 patients who had been hospitalized with cirrhosis. Baseline serum concentrations of branched-chain amino acids (BCAAs) and tyrosine, as well as the BCAA-to-tyrosine ratio, were evaluated. Cox proportional hazards analysis was used to calculate the hazard ratios for factors that were associated with mortality or liver transplantation.

Results: Among the 158 patients, baseline measurements showed decreased serum BCAA concentrations for 59 patients (37.3%), elevated serum tyrosine concentrations for 80 patients (50.6%), and a decreased BCAA-to-tyrosine ratio for 114 patients (72.2%). During a median follow-up period of 3.0 years, death or liver transplantation occurred at a rate of 0.136 cases/1 person-year. Multivariable analysis showed that transplant-free survival was independently predicted by older age, male sex, comorbid hepatocellular carcinoma, Child-Turcotte-Pugh score, and serum tyrosine concentration. Receiver operating characteristic curve analysis showed that a serum tyrosine concentration of >110 µmol/L was the optimal cut-off value for predicting transplant-free survival (adjusted hazard ratio 1.89, 95% confidence interval 1.15-3.11, p = 0.012). Kaplan-Meier analysis showed a significant difference in the 5-year transplant-free survival probability between patients with high and low serum tyrosine concentrations (42.1% vs. 60.7%, p < 0.001).

Conclusions: Elevated serum tyrosine concentration, but not changes in serum BCAA concentration or the BCAA-to-tyrosine ratio, may indicate a high risk of death or liver transplantation for patients with liver cirrhosis.
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http://dx.doi.org/10.1111/hepr.13651DOI Listing
May 2021

Simulating Vibronic Spectra without Born-Oppenheimer Surfaces.

J Phys Chem Lett 2021 Apr 22;12(12):3074-3081. Epub 2021 Mar 22.

Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science, Luruper Chaussee 149, 22761 Hamburg, Germany.

We show how linear vibronic spectra in molecular systems can be simulated efficiently using first-principles approaches without relying on the explicit use of multiple Born-Oppenheimer potential energy surfaces. We demonstrate and analyze the performance of mean-field and beyond-mean-field dynamics techniques for the H molecule in one dimension, in the later case capturing the vibronic structure quite accurately, including quantum Franck-Condon effects. In a practical application of this methodology we simulate the absorption spectrum of benzene in full dimensionality using time-dependent density functional theory at the multitrajectory Ehrenfest level, finding good qualitative agreement with experiment and significant spectral reweighting compared to commonly used single-trajectory Ehrenfest dynamics. These results form the foundation for nonlinear spectral calculations and show promise for future application in capturing phenomena associated with vibronic coupling in more complex molecular and potentially condensed phase systems.
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http://dx.doi.org/10.1021/acs.jpclett.1c00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8020382PMC
April 2021

Engineering of Polyhydroxyalkanoate Synthase Through Site-Directed Mutagenesis for Enhanced Polymerization of the 3-Hydroxyhexanoate Unit.

Front Bioeng Biotechnol 2021 3;9:627082. Epub 2021 Mar 3.

Biotechnology Research Laboratories, Kaneka Corporation, Hyogo, Japan.

Polyhydroxyalkanoate (PHA) synthase is an enzyme that polymerizes the acyl group of hydroxyacyl-coenzyme A (CoA) substrates. PHA synthase (PhaC) is an important biocatalyst for the synthesis of a useful PHA copolymer, poly[()-3-hydroxybutyrate--()-3-hydroxyhexanoate] [P(3HB--3HHx)]. Previously, a PhaC mutant with double mutations in asparagine 149 (replaced by serine [N149S]) and aspartate 171 (replaced by glycine [D171G]) was generated to synthesize a 3HHx-rich P(3HB--3HHx) and was named PhaC NSDG. In this study, to further increase the 3HHx fraction in biosynthesized PHA, PhaC was engineered based on the three-dimensional structural information of PHA synthases. First, a homology model of PhaC was built to target the residues for site-directed mutagenesis. Three residues, namely tyrosine 318 (Y318), serine 389 (S389), and leucine 436 (L436), were predicted to be involved in substrate recognition by PhaC. These PhaC NSDG residues were replaced with other amino acids, and the resulting triple mutants were expressed in the engineered strain of for application in PHA biosynthesis from palm kernel oil. The S389T mutation allowed the synthesis of P(3HB--3HHx) with an increased 3HHx fraction without a significant reduction in PHA yield. Thus, a new workhorse enzyme was successfully engineered for the biosynthesis of a higher 3HHx-fraction polymer.
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http://dx.doi.org/10.3389/fbioe.2021.627082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966705PMC
March 2021

Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in urological malignancies: a multi-center retrospective study.

J Bone Miner Metab 2021 Mar 11. Epub 2021 Mar 11.

Departments of Urology, Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Introduction: We evaluated the incidence and risk factors for antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in prostate and kidney cancer patients.

Materials And Methods: We retrospectively reviewed the clinical data of 547 patients from 13 hospitals. Prostate and kidney cancer patients with bone metastases who were treated with a bone-modifying agent (BMA) between January 2012 and February 2019 were enrolled. Exclusion criteria were BMA use for hypercalcemia, a lack of clinical data, a follow-up period of less than 28 days and a lack of evaluation by dentists before BMA administration. The diagnosis and staging of ARONJ were done by dentists.

Results: Two-hundred eighteen patients were finally enrolled in the study, including 168 prostate cancer patients and 50 kidney cancer patients. Of them, 49 (29%) prostate cancer patients and 18 (36%) kidney cancer patients needed tooth extraction prior to BMA initiation. The mean follow-up period after BMA initiation was 552.9 ± 424.7 days (mean ± SD). In the cohort, 23% of the patients were diagnosed with ARONJ in the follow-up period. The 1-year cumulative incidences of ARONJ were 9.4% and 15.4% in prostate and kidney cancer patients, respectively. Multivariate analysis indicated that kidney cancer, tooth extraction before BMA and a body mass index (BMI) ≥ 25 kg/m were significant predictors for ARONJ.

Conclusion: ARONJ is not a rare adverse event in urological malignancies. Especially, kidney cancer, high BMI patients and who needed tooth extraction before BMA were high risk for developing ARONJ.
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http://dx.doi.org/10.1007/s00774-021-01207-4DOI Listing
March 2021

A case of disseminated carcinomatosis of the bone marrow from gastric cancer developing rapidly after a gastrectomy.

Surg Case Rep 2021 Feb 16;7(1):49. Epub 2021 Feb 16.

Department of Surgery, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8524, Japan.

Background: Disseminated carcinomatosis of the bone marrow (DCBM) is often associated with disseminated intravascular coagulation (DIC) and a poor prognosis. Moreover, the timing of the diagnosis varies. We presented herein the first report of a case of DCBM from gastric cancer that developed rapidly after a gastrectomy.

Case Presentation: A 42-year-old male patient was referred to us for gastric cancer. Preoperative laboratory tests were normal. Abdominal computed tomography (CT) revealed no obvious bone metastasis, and he underwent a laparoscopic distal gastrectomy. On postoperative day (POD) 1, laboratory data indicated severe thrombocytopenia. Postoperative bleeding requiring reoperation was found. Afterwards, he complained of lower back pain. His ALP and LDH gradually became elevated. On POD 8, DIC was diagnosed. CT and bone scintigraphy showed multiple, widespread bone metastases. Based on these findings, DCBM from gastric cancer was diagnosed. Systemic chemotherapy was started on POD 12. The DIC subsided during the first course, and he was discharged on POD 21. The patient died of tumor progression 7 months later.

Conclusion: When thrombocytopenia is observed immediately after a gastrectomy for gastric cancer, the possibility of DCBM should be considered.
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http://dx.doi.org/10.1186/s40792-021-01135-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887103PMC
February 2021

Unravelling the intertwined atomic and bulk nature of localised excitons by attosecond spectroscopy.

Nat Commun 2021 Feb 15;12(1):1021. Epub 2021 Feb 15.

Department of Physics, Politecnico di Milano, 20133, Milano, Italy.

The electro-optical properties of most semiconductors and insulators of technological interest are dominated by the presence of electron-hole quasi-particles, called excitons. The manipulation of excitons in dielectrics has recently received great attention, with possible applications in different fields including optoelectronics and photonics. Here, we apply attosecond transient reflection spectroscopy in a sequential two-foci geometry and observe sub-femtosecond dynamics of a core-level exciton in bulk MgF single crystals. Furthermore, we access absolute phase delays, which allow for an unambiguous comparison with theoretical calculations. Our results show that excitons surprisingly exhibit a dual atomic- and solid-like character, which manifests itself on different time scales. While the former is responsible for a femtosecond optical Stark effect, the latter dominates the attosecond excitonic response. Further theoretical investigation reveals a link with the exciton sub-femtosecond nanometric motion and allows us to envision a new route to control exciton dynamics in the close-to-petahertz regime.
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http://dx.doi.org/10.1038/s41467-021-21345-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884782PMC
February 2021

Climate Change Implications of Bio-Based and Marine-Biodegradable Plastic: Evidence from Poly(3-hydroxybutyrate--3-hydroxyhexanoate).

Environ Sci Technol 2021 03 15;55(5):3380-3388. Epub 2021 Feb 15.

Bioproducts Research Group, Biotechnology Research Laboratories, Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, 1-6 Miyamae-cho, Takasago-cho, Takasago, Hyogo 676-8688, Japan.

Poly(3-hydroxybutyrate--3-hydroxyhexanoate), PHBH or PHBHHx, is a novel bio-based polymer that is biodegradable in both soil and marine environments. While bio-based and biodegradability are often celebrated features to mitigate environmental problems of plastics, their life cycle environmental impacts contain uncertainties that are yet to be fully understood. To develop effective introduction schemes for PHBH, this study assessed the life cycle climate change implications of PHBH. We computed the life cycle greenhouse gas emissions (GHG) and fossil resource consumption of produce bags and spoons composed of PHBH and their fossil-based alternatives based on industrial-scale data. The products were assessed against 10 end-of-life scenarios for commercial plastics. As a result, the cradle-to-gate GHG of PHBH ranged between 0.32 and 16.5 kgCOe/kg-PHBH depending on the land-use change assumed for the biomass production. The product-based comparative analysis presented that PHBH spoons have lower cradle-to-grave GHG emissions over their fossil-based alternatives but not with produce bags because PHBH spoons have a smaller GHG per functional unit than that of its fossil counterpart. The end-of-life scenario analysis conveyed that PHBH should be introduced to a region with a plastic waste management system that avoids methane generation and facilitates energy recovery.
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http://dx.doi.org/10.1021/acs.est.0c06612DOI Listing
March 2021

A multi-center, prospective study on the progression rate of asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on magnetic resonance imaging to idiopathic normal pressure hydrocephalus.

J Neurol Sci 2020 Dec 3;419:117166. Epub 2020 Oct 3.

Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Yamagata, Japan. Electronic address:

Introduction: Our previous community-based study demonstrated that some individuals with AVIM [asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus (iNPH) on magnetic resonance imaging (MRI)] progressed to iNPH in several years. In this hospital-based study, we investigated the progression rate from AVIM to iNPH and its possible predictors.

Methods: We conducted a prospective study of participants with AVIM from several medical institutions/hospitals in Japan. AVIM is defined as "asymptomatic ventriculomegaly with features of iNPH on MRI"; in the present study, asymptomatic was defined as "0 (no symptoms) or 1 (presence of only subjective, but not objective, symptoms) on the iNPH Grading Scale (iNPH-GS)." We also measured possible predicting factors for AVIM-to-iNPH progression, including age, sex, body weight, blood pressure, diabetes mellitus, dyslipidemia, history of mental disease/head injury/sinusitis/smoking/alcohol-intake, Evans index, and the presence of DESH (disproportionately enlarged subarachnoid-space hydrocephalus) findings on brain MRI, and analyzed these potential predictive values.

Results: In 2012, 93 participants with AVIM were registered and enrolled in the study. Of these, 52 participants were able to be tracked for three years (until 2015). Of the 52 participants, 27 (52%) developed iNPH during the follow-up period (11 definite, 6 probable, and 10 possible iNPH), whereas 25 participants remained asymptomatic in 2015. Among the possible predictive factors examined, the baseline scores of iNPH-GS predicted the AVIM-to-iNPH progression.

Conclusions: The multicenter prospective study demonstrated that the progression rate from AVIM to iNPH was ~17% per year, and the baseline scores of iNPH-GS predicted the AVIM-to-iNPH progression.
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http://dx.doi.org/10.1016/j.jns.2020.117166DOI Listing
December 2020

Direct Measurement of Electron-Phonon Coupling with Time-Resolved ARPES.

Phys Rev Lett 2020 Sep;125(13):136401

Max Planck Institute for the Structure and Dynamics of Matter and Center for Free Electron Laser Science, 22761 Hamburg, Germany.

Time- and angular- resolved photoelectron spectroscopy is a powerful technique to measure electron dynamics in solids. Recent advances in this technique have facilitated band and energy resolved observations of the effect that excited phonons, have on the electronic structure. Here, we show with the help of ab initio simulations that the Fourier analysis of the time-resolved measurements of solids with excited phonon modes enables the determination of the band- and mode-resolved electron-phonon coupling directly from the experimental data without any additional input from theory. Such an observation is not restricted to regions of strong electron-phonon coupling and does not require strongly excited or hot phonons, but can be employed to monitor the dynamical renormalization of phonons in driven phases of matter.
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http://dx.doi.org/10.1103/PhysRevLett.125.136401DOI Listing
September 2020

Study of Excited States and Electron Transfer of Semiconductor-Metal-Complex Hybrid Photocatalysts for CO Reduction by Using Picosecond Time-Resolved Spectroscopies.

Chemistry 2021 Jan 3;27(3):1127-1137. Epub 2020 Dec 3.

Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8550, Japan.

A semiconductor-metal-complex hybrid photocatalyst was previously reported for CO reduction; this photocatalyst is composed of nitrogen-doped Ta O as a semiconductor photosensitizer and a Ru complex as a CO reduction catalyst, operating under visible light (>400 nm), with high selectivity for HCOOH formation of more than 75 %. The electron transfer from a photoactive semiconductor to the metal-complex catalyst is a key process for photocatalytic CO reduction with hybrid photocatalysts. Herein, the excited-state dynamics of several hybrid photocatalysts are described by using time-resolved emission and infrared absorption spectroscopies to understand the mechanism of electron transfer from a semiconductor to the metal-complex catalyst. The results show that electron transfer from the semiconductor to the metal-complex catalyst does not occur directly upon photoexcitation, but that the photoexcited electron transfers to a new excited state. On the basis of the present results and previous reports, it is suggested that the excited state is a charge-transfer state located between shallow defects of the semiconductor and the metal-complex catalyst.
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http://dx.doi.org/10.1002/chem.202004068DOI Listing
January 2021

Mucinous Cystadenocarcinoma of the Pancreas with Cyst Infection in a Male Patient.

Intern Med 2020 1;59(19):2383-2389. Epub 2020 Oct 1.

Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Japan.

Follow-up computed tomography revealed a 40-mm pancreatic tail cyst in a 59-year-old man with type 1 diabetes mellitus. An intraductal papillary mucinous neoplasm was suspected; mucinous cystic neoplasm (MCN) was not considered because the patient was a man. During follow-up, cyst infection occurred but was improved by conservative treatment. At the 24-month follow up examination, cyst nodules had developed, corresponding to an increase in the carbohydrate antigen 19-9 level. Mucinous cystadenocarcinoma (MCC) was diagnosed pathologically based on distal pancreatectomy. A diagnosis of male MCN/MCC is often delayed, which may lead to a poor prognosis. MCN infection is also rare and poorly recognized. We observed an atypical male case of MCN/MCC.
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http://dx.doi.org/10.2169/internalmedicine.4937-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644490PMC
November 2020

Eosinophilic Gastroenteritis in an Ulcerative Colitis Patient During Treatment with Tumor Necrosis Factor-alpha Antagonist.

Intern Med 2020 15;59(16):1977-1981. Epub 2020 Aug 15.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Japan.

A 45-year-old man with steroid-dependent ulcerative pancolitis was hospitalized with frequent diarrhea, abdominal pain and distension 3 months after induction of golimumab, a tumor necrosis factor-alpha antagonist. Computed tomography showed wall thickening from the stomach to the colon and massive ascites. Peripheral blood test revealed eosinophilia. A large number of eosinophils were observed in the ascites fluid. Although esophagogastroduodenoscopy showed no abnormal findings and colonoscopy showed ulcerative colitis with a Mayo endoscopic subscore of 1, eosinophil infiltration was histologically observed. Based on these findings, we diagnosed him with eosinophilic gastroenteritis and started prednisolone. Consequently, his eosinophil counts and abdominal symptoms dramatically improved.
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http://dx.doi.org/10.2169/internalmedicine.4554-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492116PMC
January 2021

Pulsatile tinnitus caused by pneumocephalus after Janneta surgery.

Auris Nasus Larynx 2021 Aug 22;48(4):793-796. Epub 2020 Jun 22.

Sen-En Rifu Otological Surgery Center, Miyagi, Japan.

Pulsatile tinnitus of nonvascular origin is rare. We herein present a case of pulsatile tinnitus complicated with Jannetta surgery due to a communication created between the drilled mastoid cells and epidural space. She was successfully cured by otological surgery where the mastoid tip was packed with bone cement. A 68-year-old woman was referred to the previous hospital with complaints of right autophony, aural fullness, hyperacusis to her footsteps, and pulsatile tinnitus for the past three years. She had received Jannetta surgery for right hemifacial spasm seven years before. The computed tomography (CT) of the right temporal bone showed bony dehiscence between the mastoid cells and posterior cranial fossa. She underwent otological surgery to obliterate the tip of the mastoid cavity with artificial bone cement (BIOPEX) under general anesthesia. Her annoying aural symptoms were immediately abolished and she has been free from symptoms at ten months after surgery. It is critical to ensure the closure of any communication created between the middle ear and epidural space during surgeries in order to prevent the occurrence of pulsatile tinnitus.
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http://dx.doi.org/10.1016/j.anl.2020.05.024DOI Listing
August 2021

Room Temperature Terahertz Electroabsorption Modulation by Excitons in Monolayer Transition Metal Dichalcogenides.

Nano Lett 2020 Jul 24;20(7):5214-5220. Epub 2020 Jun 24.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

The interaction between off-resonant laser pulses and excitons in monolayer transition metal dichalcogenides is attracting increasing interest as a route for the valley-selective coherent control of the exciton properties. Here, we extend the classification of the known off-resonant phenomena by unveiling the impact of a strong THz field on the excitonic resonances of monolayer MoS. We observe that the THz pump pulse causes a selective modification of the coherence lifetime of the excitons, while keeping their oscillator strength and peak energy unchanged. We rationalize these results theoretically by invoking a hitherto unobserved manifestation of the Franz-Keldysh effect on an exciton resonance. As the modulation depth of the optical absorption reaches values as large as 0.05 dB/nm at room temperature, our findings open the way to the use of semiconducting transition metal dichalcogenides as compact and efficient platforms for high-speed electroabsorption devices.
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http://dx.doi.org/10.1021/acs.nanolett.0c01134DOI Listing
July 2020

[Coping and Supporting Patients and Families of Frontotemporal Lobar Degeneration].

Brain Nerve 2020 Jun;72(6):623-632

Department of Psychiatry, Osaka University Graduate School of Medicine.

Frontotemporal lobar degeneration (FTLD) is a comprehensive term encompassing a group of clinically overlapping but heterogeneous conditions with selective frontal and temporal lobar neurodegeneration. Among the three clinical subtypes of FTLD, behavioral variant frontotemporal dementia (bvFTD) and semantic dementia (SD) were specified as "designated intractable diseases" by the Japanese Ministry of Health, Labor and Welfare in 2015. Under this designation system, relatively young patient with bvFTD or SD of certain severities can receive partial financial support from the Japanese local government. Here we introduce financial and social support for FTLD, including utilization of the designated intractable disease system and other support available in Japan. In addition, we describe the methods for coping and care of prominent symptoms in FTLD. Lastly, we address the current status of a nationwide Japanese FTLD study cohort named FTLD-J.
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http://dx.doi.org/10.11477/mf.1416201572DOI Listing
June 2020

Successful Management of Hemosuccus Pancreaticus due to Pancreatic Adenocarcinoma by Chemoradiotherapy.

Intern Med 2020 Sep 2;59(17):2135-2141. Epub 2020 Jun 2.

Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Japan.

Management of hemosuccus pancreaticus (HP) due to pancreatic adenocarcinoma is problematic. This is the first report of the successful management of HP caused by pancreatic adenocarcinoma by chemoradiotherapy, which is a treatment option for cases with a high surgical risk that are not suitable for interventional radiology. In the present case, bloody pancreatic juice was detected in the main pancreatic duct, and anemia worsened without repeated blood transfusions. The patient ultimately underwent chemoradiotherapy comprising radiation of 3 Gy in 15 fractions concomitant with systemic chemotherapy of S-1. After the treatments, the anemia improved, and the patient was discharged on day 45.
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http://dx.doi.org/10.2169/internalmedicine.4372-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516308PMC
September 2020

Photocatalytic CO Reduction Using a Robust Multifunctional Iridium Complex toward the Selective Formation of Formic Acid.

J Am Chem Soc 2020 Jun 1;142(23):10261-10266. Epub 2020 Jun 1.

Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

A highly efficient tetradentate PNNP-type Ir photocatalyst, Mes-IrPCY2, was developed for the reduction of carbon dioxide. The photocatalyst furnished formic acid (HCOH) with 87% selectivity together with carbon monoxide to achieve a turnover number of 2560, which is the highest among CO reduction photocatalysts without an additional photosensitizer. Mes-IrPCY2 exhibited outstanding photocatalytic CO reduction activity in the presence of the sacrificial electron source 1,3-dimethyl-2-phenyl-2,3-dihydro-1-benzo[]imidazole (BIH) in CO-saturated ,-dimethylacetamide under irradiation with visible light. The quantum yield was determined to be 49% for the generation of HCOH and CO. Electron paramagnetic resonance and UV-vis spectroscopy studies of Mes-IrPCY2 with a sacrificial electron donor revealed that the one-electron-reduced species is the key intermediate for the selective formation of HCOH.
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http://dx.doi.org/10.1021/jacs.0c03097DOI Listing
June 2020

Identification and characterization of a novel extracellular polyhydroxyalkanoate depolymerase in the complete genome sequence of Undibacterium sp. KW1 and YM2 strains.

PLoS One 2020 5;15(5):e0232698. Epub 2020 May 5.

Biotechnology Laboratories, Pharma & Supplemental Nutrition Solutions Vehicle, Kaneka Corporation, Takasago, Hyogo, Japan.

Polyhydroxyalkanoate (PHA) is a biodegradable polymer that is synthesized by a wide range of microorganisms. One of the derivatives of PHA, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) has flexible material properties and low melting temperature. We have previously demonstrated that PHBH is degradable in a freshwater environment via the formation of biofilm on the surface of the PHBH film. Undibacterium sp. KW1 and YM2, which were isolated from the biofilm present on the PHBH film in the freshwater sample, were shown to have PHBH-degrading activity. In this study, the complete genome sequence of KW1 and YM2 revealed that the extracellular PHA depolymerase gene, designated as phaZUD, was present in their chromosomes. Sequence analysis revealed that PhaZUD contained four domains: a signal peptide, catalytic domain, linker domain, and substrate-binding domain. Escherichia coli harboring a PhaZUD-expressing plasmid showed PHBH-degrading activity in LB medium containing 1 wt% PHBH powder. The recombinant His-tagged PhaZUD from KW1 and YM2 was purified from the culture supernatant and shown to have PHBH-degrading activity at the optimum temperature of 35 and 40°C, respectively. When the degradation product in the PHBH solution was treated with PhaZUD and assayed by LC-TOF-MS, we detected various oligomer structures, but no more than pentamers, which consist of 3-hydroxybutyrate and 3-hydroxyhexanoate. These results demonstrated that PhaZUD may have an endo-type extracellular PHA depolymerase activity.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232698PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199957PMC
July 2020

Correction: Aqueous electrocatalytic CO reduction using metal complexes dispersed in polymer ion gels.

Chem Commun (Camb) 2020 Apr 17;56(34):4736. Epub 2020 Apr 17.

The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Correction for 'Aqueous electrocatalytic CO reduction using metal complexes dispersed in polymer ion gels' by Shunsuke Sato et al., Chem. Commun., 2020, DOI: .
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http://dx.doi.org/10.1039/d0cc90165bDOI Listing
April 2020

Octopus, a computational framework for exploring light-driven phenomena and quantum dynamics in extended and finite systems.

J Chem Phys 2020 Mar;152(12):124119

Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, D-22761 Hamburg, Germany.

Over the last few years, extraordinary advances in experimental and theoretical tools have allowed us to monitor and control matter at short time and atomic scales with a high degree of precision. An appealing and challenging route toward engineering materials with tailored properties is to find ways to design or selectively manipulate materials, especially at the quantum level. To this end, having a state-of-the-art ab initio computer simulation tool that enables a reliable and accurate simulation of light-induced changes in the physical and chemical properties of complex systems is of utmost importance. The first principles real-space-based Octopus project was born with that idea in mind, i.e., to provide a unique framework that allows us to describe non-equilibrium phenomena in molecular complexes, low dimensional materials, and extended systems by accounting for electronic, ionic, and photon quantum mechanical effects within a generalized time-dependent density functional theory. This article aims to present the new features that have been implemented over the last few years, including technical developments related to performance and massive parallelism. We also describe the major theoretical developments to address ultrafast light-driven processes, such as the new theoretical framework of quantum electrodynamics density-functional formalism for the description of novel light-matter hybrid states. Those advances, and others being released soon as part of the Octopus package, will allow the scientific community to simulate and characterize spatial and time-resolved spectroscopies, ultrafast phenomena in molecules and materials, and new emergent states of matter (quantum electrodynamical-materials).
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http://dx.doi.org/10.1063/1.5142502DOI Listing
March 2020

Aqueous electrocatalytic CO reduction using metal complexes dispersed in polymer ion gels.

Chem Commun (Camb) 2020 Apr 20;56(32):4440-4443. Epub 2020 Mar 20.

The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

We use fac-[Re(bpy)(CO)Cl] ([Re-Cl]) dispersed in polymer ion gel (PIG) ([Re]-PIG) to carry out electrocatalytic CO reduction in water. Electrolysis at -0.68 V vs. RHE in a CO-saturated KOH and KCO solution produces CO with over 90% Faradaic efficiency. The PIG electrode is readily combined with water oxidation catalysts to generate a full electrochemical cell. Additionally, we provide evidence that the PIG electrode can be implemented with other molecular catalysts.
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http://dx.doi.org/10.1039/d0cc00791aDOI Listing
April 2020

On-treatment Serum Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) Level and Risk of Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis B during Nucleot(s)ide Analogue Therapy.

Int J Mol Sci 2020 Mar 17;21(6). Epub 2020 Mar 17.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka 410-2295, Japan.

We aimed to analyze the serum level of a novel fibrosis marker, Mac-2-binding protein glycosylation isomer (M2BPGi), and its predictive value for hepatocellular carcinoma (HCC) development in chronic hepatitis B (CHB) under nucleot(s)ide analogue (NA) therapy. Serum M2BPGi levels were quantified in 147 CHB patients at baseline, 48 weeks after starting NA therapy, and at the patients' last visit. The serum M2BPGi level serially decreased at each time point. During the median follow-up time of 6.6 years, 14 of 147 patients developed HCC. Multivariate Cox proportional hazard analysis demonstrated that high serum M2BPGi at 48 weeks was an independent risk factor for HCC development. A cutoff value of M2BPGi at 48 weeks > 1.5 showed an adjusted hazard ratio = 34.9 (95% confidence interval, 4.3-284.9). The 3- and 5-year cumulative incidence of HCC in patients with low M2BPGi were 0.9% and 4.2%, respectively, whereas those in patients with high M2BPGi were 10.1% and 25.6%, respectively ( < 0.001). In conclusion, Serum M2BPGi level at 48 weeks is a useful predictor for HCC development in patients with CHB who receive NA therapy.
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http://dx.doi.org/10.3390/ijms21062051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139452PMC
March 2020

[A Case of Gastrointestinal Stromal Tumor Re-Resected Ten Years after the Resection of Its Recurrence].

Gan To Kagaku Ryoho 2019 Dec;46(13):1943-1944

Dept. of Surgery, Chiba Kaihin Municipal Hospital.

The patient was a 75-year-old man who was diagnosed as having jejunal gastrointestinal stromal tumor(GIST)and underwent partial resection of the small intestine including the tumor 12 years ago. Two years after the first resection, recurrence was detected, and a second resection was performed. Ten years after the second resection following recurrence, he took imatinib, and computed tomography(CT)revealed abdominal and liver tumors. We was diagnosed as having GIST recurrence, and a third resection, which included an abdominal tumor resection and partial hepatectomy, was performed. The pathological findings were metastatic abdominal GIST and angiomyolipoma of the liver. The Japanese Clinical Practice Guidelines for GIST suggest a surgical indication only for local recurrence of GIST and resectable liver metastases. Recurrent GIST cannot be completely cured with antineoplastic drugs alone. Multidisciplinary treatment is necessary for long-term survival of patients with recurrent GIST.
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December 2019

[Intraoperative Pancreatoscopy to Assess the Resection Margin in Intraductal Papillary Mucinous Neoplasm-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2521-2523

Dept. of Surgery, Chiba Kaihin Municipal Hospital.

Intraductal papillary mucinous neoplasm(IPMN)of the pancreas often presents with multifocal lesions. Complete resection without residual skip lesions is essential for complete eradication of the disease. We experienced a case of IPMC in which intraoperative pancreatoscopy was used to determine the surgical margin. Intraoperative pancreatoscopy is a useful and easy method to evaluate the remnant duct and exclude residual tumor. A cystic lesion was incidentally detected in the pancreatic head of a 78-year-old man. Ultrasonography, abdominal computed tomography, magnetic resonance imaging, and endoscopic ultrasound revealed enhancing mural nodules in the pancreatic head and dilation of the entire main pancreatic duct. We performed pancreaticoduodenectomy for mixed IPMN. Intraoperative pancreatoscopy, which was performed to rule out skip lesions, showed no mucosal abnormalities in the remnant duct. The pathological diagnosis was non-invasive intraductal papillary-mucinous carcinoma(IPMC). No signs of recurrence were seen for 6 postoperative months.
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December 2019

Elevated serum procalcitonin levels and their association with the prognosis of patients with liver cirrhosis.

Eur J Gastroenterol Hepatol 2020 09;32(9):1222-1228

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital.

Objectives: Bacterial infection is a major complication in patients with liver cirrhosis. Procalcitonin is an early diagnostic marker of bacterial infection. This study aimed to investigate the association between the serum procalcitonin levels and the prognosis of patients with liver cirrhosis.

Methods: We retrospectively analyzed the serum procalcitonin levels in 236 hospitalized patients with liver cirrhosis. The impact of the serum procalcitonin level on their prognoses was evaluated using multivariate Cox proportional hazards analyses and the Kaplan-Meier method.

Results: The serum procalcitonin level was higher (≥0.05 ng/mL) in 151 (64%) patients, and it was significantly higher in the patients with Child-Turcotte-Pugh class C than in those with Child-Turcotte-Pugh classes A/B. Patients with refractory ascites, hepatic encephalopathy, gastrointestinal bleeding, and bacterial infections had elevated serum procalcitonin levels. The multivariate analyses showed a serum procalcitonin level ≥0.05 ng/mL was an independent prognostic factor for liver cirrhosis (hazard ratio = 1.64; 95% confidence interval = 1.07-2.53; P = 0.024). During a median follow-up interval of 2.1 years, the three-year cumulative survival rates for the patients with normal and elevated serum procalcitonin levels were 72.9 and 56.0%, respectively (P < 0.001). The subgroup analyses that stratified the patients according to age, the Child-Turcotte-Pugh classification, and the presence of liver cancer showed the serum procalcitonin level was significantly associated with their prognoses.

Conclusions: The patients with liver cirrhosis had higher serum procalcitonin levels, regardless of local bacterial infections, and higher procalcitonin levels were associated with poor prognoses.
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http://dx.doi.org/10.1097/MEG.0000000000001644DOI Listing
September 2020

Prognostic significance of serum tyrosine concentration in patients with primary biliary cholangitis under ursodeoxycholic acid therapy.

Hepatol Res 2020 Feb 5;50(2):214-223. Epub 2020 Jan 5.

Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Shizuoka, Japan.

Aim: Chronic liver insufficiency is often associated with alteration in amino acid metabolism. We evaluated the prognostic value of changes in serum amino acid concentrations in patients with primary biliary cholangitis.

Methods: A total of 75 primary biliary cholangitis patients who started urusodeoxycholic acid therapy were retrospectively enrolled. Baseline serum concentrations of branched-chain amino acids and tyrosine, and branched-chain amino acid-to-tyrosine ratio were determined. The hazard ratios of factors associated with liver-related events were analyzed by Cox proportional hazard analysis.

Results: Of the 75 patients enrolled, 12 showed a decrease in serum branched-chain amino acid levels, and 15 showed an increase in serum tyrosine levels. The branched-chain amino acid-to-tyrosine ratio decreased in 16 patients. During a median 5.6-year follow up, liver-related events occurred in 11 patients. Multivariate analysis showed that high serum tyrosine levels at baseline and high alkaline phosphatase levels 48 weeks after starting urusodeoxycholic acid therapy were independent risk factors for event occurrence. From the receiver operator characteristics curve analysis, serum tyrosine concentration >110 μmol/L was identified as a cut-off value with an adjusted hazard ratio of 20.9 (95% confidence interval 4.3-101.5, P < 0.001). Kaplan-Meier analysis showed that the 5-year cumulative incidences of event occurrence in patients with high and low serum tyrosine concentration were 56.5% and 5.5%, respectively (P < 0.001). The 10-year survival probabilities also showed significant differences between patients with high and low serum tyrosine concentration (44.9% vs. 92.0%, P < 0.001).

Conclusion: Elevation of serum tyrosine concentration indicates a high risk of liver-related events in primary biliary cholangitis patients receiving urusodeoxycholic acid therapy.
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http://dx.doi.org/10.1111/hepr.13434DOI Listing
February 2020

Trans-tract electrocoagulation can decrease the need for postoperative nephrostomy tube after endoscopic combined intrarenal surgery.

Int J Urol 2019 12 30;26(12):1144-1147. Epub 2019 Sep 30.

Department of Urology, Miyazaki University Graduate School of Medicine, Miyazaki, Japan.

Aim: To assess the efficacy and safety of trans-tract electrocoagulation at the end of endoscopic combined intrarenal surgery for renal or ureteral stones.

Methods: The present study included patients who underwent endoscopic combined intrarenal surgery from May 2010 to March 2018. After June 2013, the trans-tract electrocoagulation procedure, to coagulate bleeding from the access tract using a resectscope was carried out at the end of the operation. We compared the patients' background and surgical outcomes between patients with and without trans-tract electrocoagulation.

Results: Between the trans-tract electrocoagulation (n = 225) and non-trans-tract electrocoagulation (n = 72) groups, the stone number was significantly smaller (1:2:3 or more, 126:72:27 vs 59:10:3, P = 0.001) and the initial stone-free rates were significantly higher (80% vs 72%, P = 0.006) in the trans-tract electrocoagulation group than in the non-trans-tract electrocoagulation group. Patients experienced a higher nephrostomy tube-free rate (67% vs 26%, P < 0.0001), shorter postoperative catheterization time (2.8 ± 3.8 vs 5.4 ± 5.0 days, P = 0.002) and shorter hospital stay (6.5 ± 3.6 vs 8.8 ± 5.0 days, P = 0.0001) in the trans-tract electrocoagulation group than in the non-trans-tract electrocoagulation group.

Conclusions: Trans-tract electrocoagulation in endoscopic combined intrarenal surgery is a safe and efficient procedure that decreases the need for nephrostomy tube placement after surgery.
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http://dx.doi.org/10.1111/iju.14120DOI Listing
December 2019

Mechanism of forelimb motor function restoration in rats with cervical spinal cord hemisection-neuroanatomical validation.

IBRO Rep 2019 Dec 5;7:10-25. Epub 2019 Jun 5.

Department of Orthopaedic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo, 181-8611, Japan.

Purpose: The purpose of this study is neuroanatomical validation of forelimb motor function restoration in rats with cervical spinal cord injury.

Materials And Methods: We used eight cervical hemisected rats and eight normal rats. We cut in half the C3/4 cervical spinal cord of 18-weeks-old normal rats. We used 24-weeks-old rats that had reached a nearly steady state of forelimb motor function after the hemisection (Hemisection group). Normal 24-week-old rats were used as Control group. To evaluate the corticospinal tracts, neuro-tracing by biotynirated dextran-amine (BDA) was used. BDA was injected into the damaged side of the cerebral primary motor cortex. In order to quantitatively analyze the specimen, we recorded a site where nerve fibers appear in each specimen in the image analysis (1) and defined the increase rate of immunostaining area using ImageJ in the image analysis (2). Based on the evaluation in the image analysis (1) and the image analysis (2), the Hemisection group and the Control group were compared.

Results: In the image analysis (1), a region with robust appearance of aberrant nerve fibers was observed in the cephalad side of the Hemisection site in Hemisection group than Control group. In the spinal cord caudal to the hemisection, such region was generally more in Hemisection group, however, disappeared or reduced appearance was observed in some regions. In the image analysis (2), no statistical significant difference was noted in each level.

Conclusion: There is a high probability that these aberrant nerve fibers beyond the midline could be involved in forelimb motor function restoration in rats with cervical cord hemisection.
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http://dx.doi.org/10.1016/j.ibror.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581651PMC
December 2019