Shunichi Takeda

Shunichi Takeda

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Shunichi Takeda

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Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells.

Environ Mol Mutagen 2020 Apr 3. Epub 2020 Apr 3.

Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1002/em.22371DOI Listing
April 2020

Nonhomologous end joining and homologous recombination involved in luteolin-induced DNA damage in DT40 cells.

Toxicol In Vitro 2020 Mar 10;65:104825. Epub 2020 Mar 10.

Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2020.104825DOI Listing
March 2020

Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition.

iScience 2020 Feb 9;23(2):100821. Epub 2020 Jan 9.

Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.isci.2020.100821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976935PMC
February 2020

The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks.

Cell Rep 2020 Jan;30(4):1235-1245.e4

Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069250PMC
January 2020

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.

Genes (Basel) 2019 10 30;10(11). Epub 2019 Oct 30.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.3390/genes10110868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895833PMC
October 2019

Applicability Domain of Active Learning in Chemical Probe Identification: Convergence in Learning from Non-Specific Compounds and Decision Rule Clarification.

Molecules 2019 Jul 26;24(15). Epub 2019 Jul 26.

Kyoto University Graduate School of Medicine, Department of Molecular Biosciences, Life Science Informatics Research Unit, Kyoto, Sakyo, Yoshida, Konoemachi, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.3390/molecules24152716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696588PMC
July 2019

Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage.

Int J Mol Med 2019 Jun 11;43(6):2491-2498. Epub 2019 Apr 11.

Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4164
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http://dx.doi.org/10.3892/ijmm.2019.4164DOI Listing
June 2019

A screening for DNA damage response molecules that affect HIV-1 infection.

Biochem Biophys Res Commun 2019 05 30;513(1):93-98. Epub 2019 Mar 30.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.03.168DOI Listing
May 2019

Genistein-induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells.

J Cell Physiol 2019 03 2;234(3):2683-2692. Epub 2018 Aug 2.

State Key Laboratory of Biotherapy, West China Hospital, and Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1002/jcp.27082DOI Listing
March 2019

SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines.

Proc Natl Acad Sci U S A 2018 12 28;115(50):12793-12798. Epub 2018 Nov 28.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan

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http://dx.doi.org/10.1073/pnas.1716349115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294928PMC
December 2018

SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells.

DNA Repair (Amst) 2018 08 18;68:50-57. Epub 2018 Jun 18.

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2018.06.003DOI Listing
August 2018

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.

Environ Mol Mutagen 2018 07 15;59(6):529-538. Epub 2018 May 15.

Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto, 606-8501, Japan.

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http://dx.doi.org/10.1002/em.22201DOI Listing
July 2018

Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.

PLoS One 2018 6;13(2):e0192421. Epub 2018 Feb 6.

Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minami-osawa, Hachioji, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800655PMC
April 2018

Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families.

ChemMedChem 2018 03 5;13(6):511-521. Epub 2018 Feb 5.

Laboratory for Molecular Biosciences, Kyoto University Graduate School of Medicine, Yoshida-konoemachi Building E, 606-8501, Kyoto, Sakyo, Japan.

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http://dx.doi.org/10.1002/cmdc.201700677DOI Listing
March 2018

Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.

Int J Radiat Biol 2018 01 12;94(1):88-96. Epub 2017 Dec 12.

a Particle Radiation Biology, Division of Radiation Life Science , Research Reactor Institute, Kyoto University , Kumatori-cho, Osaka , Japan.

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http://dx.doi.org/10.1080/09553002.2018.1409443DOI Listing
January 2018

TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.

Mol Cancer Ther 2017 11 11;16(11):2543-2551. Epub 2017 Aug 11.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971110PMC
November 2017

Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.

Nucleic Acids Res 2017 Sep;45(17):10079-10088

Genome Integrity and Structural Biology Laboratory, DNA Repair and Nucleic Acid Enzymology Group, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/nar/gkx654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622373PMC
September 2017

Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage.

Toxicol In Vitro 2017 Aug 19;42:130-138. Epub 2017 Apr 19.

Department of Pharmacology, Key Laboratory of Drug Targeting and Drug Delivery Systems of Education Ministry, West China School of Pharmacy, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.04.017DOI Listing
August 2017

SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation.

Cell Struct Funct 2017 Jul 26;42(2):81-94. Epub 2017 May 26.

Department of Biophysics, Graduate School of Science, Kyoto University.

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http://dx.doi.org/10.1247/csf.17007DOI Listing
July 2017

Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.

Chem Res Toxicol 2017 02 27;30(2):699-704. Epub 2016 Dec 27.

Division of Radiation Life Science, Research Reactor Institute, Kyoto University , 2 Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00417DOI Listing
February 2017

Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels.

Chemosphere 2016 Dec 28;164:106-112. Epub 2016 Aug 28.

Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2016.08.092DOI Listing
December 2016

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Mol Cell 2016 11;64(3):580-592

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.10.011DOI Listing
November 2016

Chemical-Space-Based de Novo Design Method To Generate Drug-Like Molecules.

J Chem Inf Model 2016 10 30;56(10):1885-1893. Epub 2016 Sep 30.

Department of Chemical Systems Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1021/acs.jcim.6b00038DOI Listing
October 2016

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

Nucleic Acids Res 2016 09 16;44(15):7242-50. Epub 2016 May 16.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto 606-8501, Japan

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009730PMC
September 2016

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.

Oncotarget 2016 Sep;7(37):59795-59808

Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.

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http://dx.doi.org/10.18632/oncotarget.10928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312349PMC
September 2016

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.

Cell Cycle 2016 Aug 26;15(15):1997-2008. Epub 2016 May 26.

a Department of Chemistry , Graduate School of Science and Engineering, Tokyo Metropolitan University , Hachioji-shi, Tokyo , Japan.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1
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http://dx.doi.org/10.1080/15384101.2016.1191711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968974PMC
August 2016

The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.

J Radiat Res 2016 Aug 15;57 Suppl 1:i25-i32. Epub 2016 Jun 15.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1093/jrr/rrw034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990115PMC
August 2016

Genetic Evidence for Genotoxic Effect of Entecavir, an Anti-Hepatitis B Virus Nucleotide Analog.

PLoS One 2016 22;11(1):e0147440. Epub 2016 Jan 22.

Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723259PMC
July 2016

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

ACS Chem Biol 2016 07 11;11(7):1925-33. Epub 2016 May 11.

Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acschembio.5b01047DOI Listing
July 2016

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations.

Oncotarget 2016 May;7(18):25377-90

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.18632/oncotarget.8298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041911PMC
May 2016

Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation.

Chemosphere 2016 Feb 11;144:1901-7. Epub 2015 Nov 11.

Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo 192-0397, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2015.10.085DOI Listing
February 2016

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Mutagenesis 2016 Jan 4;31(1):69-81. Epub 2015 Aug 4.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC: 3375 Bethesda, MD 20892, USA and

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http://dx.doi.org/10.1093/mutage/gev055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723671PMC
January 2016

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.

Cell Rep 2015 Dec 17;13(12):2728-40. Epub 2015 Dec 17.

Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.054DOI Listing
December 2015

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells.

Mutagenesis 2015 Nov 17;30(6):821-8. Epub 2015 Jun 17.

Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA,

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http://dx.doi.org/10.1093/mutage/gev042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723676PMC
November 2015

Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells.

Radiat Res 2015 Oct 2;184(4):442-8. Epub 2015 Oct 2.

a  Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo 192-0397, Japan; and.

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http://dx.doi.org/10.1667/RR14117.1DOI Listing
October 2015

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining.

Nucleic Acids Res 2015 Jul 18;43(13):6359-72. Epub 2015 Jun 18.

Department of Radiation Genetics, Kyoto University, Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan

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http://dx.doi.org/10.1093/nar/gkv621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513880PMC
July 2015

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity.

Cell Rep 2015 Jun 4;11(11):1749-59. Epub 2015 Jun 4.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481157PMC
June 2015

Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.

PLoS Genet 2015 Apr 2;11(4):e1005065. Epub 2015 Apr 2.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan.

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http://dx.doi.org/10.1371/journal.pgen.1005065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383526PMC
April 2015

Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish.

J Parkinsons Dis 2014 ;4(2):301-10

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.3233/JPD-130289DOI Listing
December 2014

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.

Genes Cells 2014 Oct 10;19(10):743-54. Epub 2014 Sep 10.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, 606-8501, Japan; Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.

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http://dx.doi.org/10.1111/gtc.12173DOI Listing
October 2014

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.

PLoS One 2014 23;9(1):e87203. Epub 2014 Jan 23.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900704PMC
September 2014

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.

DNA Repair (Amst) 2014 Sep 29;21:177-82. Epub 2014 Apr 29.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125495PMC
September 2014

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.

J Cell Biol 2014 Aug;206(3):347-56

Department of Biophysics, Graduate School of Science, and Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8502, Japan

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http://dx.doi.org/10.1083/jcb.201404075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121980PMC
August 2014

Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines.

Genes Cancer 2014 Jul;5(7-8):285-92

Division of Radiation Life Science, Research Reactor Institute, Kyoto University, Kumatori, Osaka 590-0494, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162141PMC
http://dx.doi.org/10.18632/genesandcancer.26DOI Listing
July 2014

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.

J Pharmacol Exp Ther 2014 Jun 20;349(3):408-16. Epub 2014 Mar 20.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research (Ju.M., J.H.D., Y.P.), National Clinical Target Validation Laboratory (Y.Z., J.J.), and Division of Cancer Treatment and Diagnosis (Jo.M., J.H.D.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo-ku, Kyoto, Japan (Ju.M., S.T.).

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.113.21014
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http://dx.doi.org/10.1124/jpet.113.210146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019318PMC
June 2014

Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.

J Radiat Res 2014 May 22;55(3):391-406. Epub 2013 Dec 22.

Kyoto University, 17-12 Shironosato, Nagaokakyo-shi, Kyoto 617-0835, Japan.

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http://dx.doi.org/10.1093/jrr/rrt133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014156PMC
May 2014

Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents.

Biochim Biophys Acta 2014 May 10;1843(5):1002-12. Epub 2014 Jan 10.

Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525539PMC
May 2014

Berberine induces double-strand DNA breaks in Rev3 deficient cells.

Mol Med Rep 2014 May 28;9(5):1883-8. Epub 2014 Feb 28.

Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

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http://dx.doi.org/10.3892/mmr.2014.1999DOI Listing
May 2014

Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex.

Cancer Res 2014 Feb 27;74(3):797-807. Epub 2013 Nov 27.

Authors' Affiliations: Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Sakyo-ku; and Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1443DOI Listing
February 2014

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.

Mol Cancer Ther 2014 Feb 19;13(2):433-43. Epub 2013 Dec 19.

Corresponding Author: Yves Pommier, Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Building 37, Room 5068, NIH, Bethesda, MD 20892-4255.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946062PMC
February 2014

A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.

Arch Toxicol 2014 Jan 21;88(1):145-60. Epub 2013 Aug 21.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

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http://dx.doi.org/10.1007/s00204-013-1084-7DOI Listing
January 2014

Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.

Mol Cancer Ther 2014 Jan 15;13(1):214-20. Epub 2013 Oct 15.

Corresponding Authors: Yves Pommier, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD 20892.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919527PMC
January 2014

Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction.

Neurosci Res 2013 Dec 21;77(4):228-33. Epub 2013 Sep 21.

Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2013.09.006DOI Listing
December 2013

Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells.

Chemosphere 2013 Sep 18;93(2):434-40. Epub 2013 Jun 18.

School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea.

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http://dx.doi.org/10.1016/j.chemosphere.2013.05.029DOI Listing
September 2013

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.

Hum Mol Genet 2013 Jun 27;22(12):2423-34. Epub 2013 Feb 27.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1093/hmg/ddt095DOI Listing
June 2013

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

Cancer Res 2012 Nov;72(21):5588-99

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528345PMC
November 2012

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Nucleic Acids Res 2012 Sep 26;40(17):8371-80. Epub 2012 Jun 26.

School of Life Sciences, Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK.

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http://dx.doi.org/10.1093/nar/gks622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458563PMC
September 2012

The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment.

Biochem Biophys Res Commun 2012 Sep 27;426(3):310-6. Epub 2012 Aug 27.

Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, IFOM-IEO campus, Via Adamello 16, 20139 Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1201585
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http://dx.doi.org/10.1016/j.bbrc.2012.08.066DOI Listing
September 2012

The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.

Carcinogenesis 2012 Jun 16;33(6):1203-10. Epub 2012 Apr 16.

Department of Molecular Biology, University of Geneva, Switzerland.

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http://dx.doi.org/10.1093/carcin/bgs149DOI Listing
June 2012

Establishment and characterization of Roberts syndrome and SC phocomelia model medaka (Oryzias latipes).

Dev Growth Differ 2012 Jun;54(5):588-604

Department of Developmental Medicine, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan.

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http://dx.doi.org/10.1111/j.1440-169X.2012.01362.xDOI Listing
June 2012

Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment.

Toxicol Lett 2012 May 17;211(1):70-6. Epub 2012 Mar 17.

School of Public Health, Seoul National University, Seoul 151-742, Republic of Korea.

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http://dx.doi.org/10.1016/j.toxlet.2012.03.003DOI Listing
May 2012

Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish.

Cell Struct Funct 2011 8;36(2):247-59. Epub 2011 Nov 8.

Department of Biophysics, Graduate School of Science, Kyoto University, Japan.

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http://dx.doi.org/10.1247/csf.11036DOI Listing
April 2012

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

J Biol Chem 2012 Apr 27;287(16):12848-57. Epub 2012 Feb 27.

Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1074/jbc.M111.333963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339927PMC
April 2012

Inhibition of homologous recombination by the PCNA-interacting protein PARI.

Mol Cell 2012 Jan 6;45(1):75-86. Epub 2011 Dec 6.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267324PMC
January 2012

SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line.

Cell Struct Funct 2011 20;36(2):187-95. Epub 2011 Aug 20.

Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1247/csf.11018DOI Listing
December 2011

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

J Cell Biol 2011 Dec 19;195(7):1103-13. Epub 2011 Dec 19.

Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, England, UK.

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http://dx.doi.org/10.1083/jcb.201105058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246887PMC
December 2011

Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development.

Dev Biol 2011 Nov 7;359(1):82-94. Epub 2011 Sep 7.

Aquatic Animal Health Division, National Research Institute of Aquaculture, Fisheries Research Agency, 224-1 Hiruta, Tamaki, Mie, 519-0423, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2011.08.027DOI Listing
November 2011

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.

Genes Dev 2011 Sep;25(17):1847-58

Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/gad.17020911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175720PMC
September 2011

The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.

PLoS Genet 2011 Jul 14;7(7):e1002148. Epub 2011 Jul 14.

Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1371/journal.pgen.1002148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136442PMC
July 2011