Publications by authors named "Shun Lei"

5 Publications

  • Page 1 of 1

Facile Synthesis of P-Doped Carbon Nanosheets as Janus Electrodes of Advanced Potassium-Ion Hybrid Capacitor.

ACS Appl Mater Interfaces 2021 Jun 15;13(25):29511-29521. Epub 2021 Jun 15.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, China.

Potassium-ion hybrid capacitors (PIHCs) shrewdly integrate the merits of the high energy density of battery-type anode and the high power density of capacitor-type cathode, promising prospects for potential application in a diversity of fields. Here, we report the synthesis of P-doped porous carbon nanosheets (P-PCNs) with favorable features as electrochemical storage materials, including ultrahigh specific surface area and rich activity sites. The P-PCN as Janus electrodes show highly attractive electrochemical properties of high capacity and remarkable stability for fast K storage and manifest high capacitance for PF adsorption. The P-PCNs are applied as both anode and cathode materials to set up dual-carbon PIHCs, which show the capability to deliver a high energy/power density (165.2 Wh kg and 5934.4 W kg) as well as remarkable long-life capability.
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http://dx.doi.org/10.1021/acsami.1c04278DOI Listing
June 2021

Hierarchical Multicavity Nitrogen-Doped Carbon Nanospheres as Efficient Polyselenide Reservoir for Fast and Long-Life Sodium-Selenium Batteries.

Small 2020 Dec 4;16(48):e2005534. Epub 2020 Nov 4.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.

Sodium-selenium (Na-Se) battery has been emerging as one of the most prospective energy storage systems owing to their high volumetric energy density and cost effectiveness. Nevertheless, the shuttle effect of sodium polyselenide (NaPSe) and sluggish electrochemical reaction kinetics present the main bottlenecks for its practical implementation. Herein, a new Se host of 3D nitrogen-doped hierarchical multicavity carbon nanospheres (3D NHMCs) is designed and synthesized via a facile self-sacrifice templating strategy. The 3D NHMCs are verified to hold a favorable structure of a hollow macropore core and numerous micro/mesopores hollow shell for hosting Se, which can not only maximize Se utilization and alleviate the volumetric expansion but also promote the electrical/ionic conductivity and electrolyte infiltration. Moreover, the abundant self-functionalized surfaces as an efficient NaPSe scavenger via robust physical-chemical dual blocking effects demonstrate high-efficiency in situ anchoring-diffusion-conversion of NaPSe, rendering rapid reaction kinetics and remarkable suppressive shuttle effect, as evidenced by systematic experimental analysis and density functional theory calculations. As a result, the high-Se-loading 3D NHMCs/Se cathode exhibits an ultrahigh volumetric capacity (863 mAh cm ) and rate capability (377 mAh g at 20 C) and unexceptionable stability over 2000 cycles at 2 C.
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http://dx.doi.org/10.1002/smll.202005534DOI Listing
December 2020

Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.

Mol Med Rep 2019 Oct 1;20(4):3224-3232. Epub 2019 Aug 1.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.

Alcohol consumption causes liver steatosis in humans. Metabolic disorders of lipids are one of the factors that cause liver steatosis in hepatocytes. Hepatic Niemann‑Pick C1‑like 1 (NPC1L1) regulates lipid homeostasis in mammals. The relationship between NPC1L1 and autophagy in those with a history of alcohol abuse is unclear. The present study aimed to investigate the function of NPC1L1 in the activation of hepatic autophagy in a mouse model with a human (h)NPC1L1 transgene under alcohol feeding conditions. The mice expressing hNPC1L1 (Ad‑L1) or controls (Ad‑null) were created by retro‑orbital adenovirus injection. The Ad‑L1 and Ad‑null mice were fed with alcohol or a non‑alcoholic diet to mimic chronic alcohol consumption in humans. Hepatic autophagy was demonstrated in isolated primary hepatocytes by monitoring autophagic vacuoles under fluorescence microscopy, and by western blotting for autophagic makers. Isolated hepatocytes from the livers of Ad‑L1 mice were treated with different doses of ezetimibe to study the restoration of autophagy. Chronic alcohol feeding caused liver injury and steatosis, shown by significantly higher levels of plasma alanine transaminase and aspartate transaminase activity, and by hematoxylin and eosin staining in Ad‑L1 and Ad‑null mice. Compared to Ad‑null control mice, the microtubule‑associated proteins 1A/1B light chain 3 (LC3) particles in the isolated hepatocytes of Ad‑L1 mice were decreased, both under alcohol and non‑alcoholic feeding. The ratio of LC3II/LC3I was significantly decreased, and the level of p62/sequestosome‑1 protein was significantly increased in Ad‑L1 mice compared with Ad‑null mice after alcohol feeding. Levels of LC3II protein were statistically increased in hepatocytes isolated from Ad‑L1 mice with ezetimibe treatment. The increase in LC3II expression was dose dependent. Within the tested range, it reached its highest level at 40 µM. The livers of Ad‑L1 mice represent a more human‑like state for the study of hepatic autophagy. Hepatic expression of human NPC1L1 resulted in an inhibition of autophagy; it may contribute to alcoholic fatty liver disease in humans.
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http://dx.doi.org/10.3892/mmr.2019.10549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755247PMC
October 2019

The preclinical analysis of TW-37 as a potential anti-colorectal cancer cell agent.

PLoS One 2017 24;12(10):e0184501. Epub 2017 Oct 24.

Department of Oncology and Southwest Cancer Center, Southwest Hospital, the Third Military Medical University, Chong Qing, China.

TW-37 is a novel, potent and non-peptide Bcl-2 small-molecule inhibitor. Its activity in colorectal cancer (CRC) cells is studied. In both HCT-116 cells and primary human colon cancer cells, treatment with TW-37 at only nM concentration efficiently inhibited cell survival and proliferation. TW-37 also induced caspase-3/9 and apoptosis activation in CRC cells. Feedback autophagy activation was observed in TW-37-treated CRC cells. Reversely pharmacological autophagy inhibition or Beclin-1 knockdown by targeted-shRNA potentiated TW-37-induced apoptosis and killing of CRC cells. In vivo, intravenous injection of TW-37 inhibited HCT-116 tumor growth in mice. TW-37's anti-tumor activity was further potentiated against Beclin-1-silenced HCT-116 tumors. Together, targeting Bcl-2 family protein by TW-37 efficiently inhibits CRC cell growth in vitro and in vivo. Inhibition of feedback autophagy activation could further sensitize TW-37.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184501PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655484PMC
November 2017

ROCK is involved in vimentin phosphorylation and rearrangement induced by dengue virus.

Cell Biochem Biophys 2013 ;67(3):1333-42

Department of Microbiology, Third Military Medical University, Chongqing, 400038, People's Republic of China.

Our previous study showed that dengue virus 2 (DENV2) infection induces rearrangement of vimentin into dense structures at the perinuclear area. However, the underlying mechanism of this phenomenon is poorly characterized. In the present work, we found that vimentin and Ser71 phosphorylated vimentin display similar distributions in DENV2-infected cells. DENV2 infection also induced ROCK activation and phosphorylation of vimentin at Ser71 as the DENV2 infection progressed. Furthermore, Ser71 phosphorylation and vimentin rearrangement induced by DENV2 infection were blocked by the ROCK inhibitor Y-27632. In addition, DENV2 led to endoplasmic reticulum (ER) redistribution in the perinuclear region of the host cells, which was partially blocked by pretreatment with Y-27632. Together, these data support indicate that ROCK may have a role in governing regulating vimentin and ER rearrangement during DENV2 infection. We hypothesize that DENV2 infection, via ROCK activation, induces both vimentin rearrangement and ER redistribution around the perinuclear region, which may play a structural role in anchoring DENV2 to replication sites.
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http://dx.doi.org/10.1007/s12013-013-9665-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838595PMC
July 2014
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