Publications




Maximum BMI and microvascular complications in a cohort of Japanese patients with type 2 diabetes: the Japan Diabetes Complications Study.
J Diabetes Complications 2016 Jul 2;30(5):790-7. Epub 2016 Mar 2.
Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, 1-757 Asahi-machi, Chuo-ku, Niigata, Japan. Electronic address:

Effects of K-877, a novel selective PPARα modulator (SPPARMα), in dyslipidaemic patients: A randomized, double blind, active- and placebo-controlled, phase 2 trial.
Atherosclerosis 2016 Jun 26;249:36-43. Epub 2016 Feb 26.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
J Pharmacol Exp Ther 2015 Nov 3;355(2):299-307. Epub 2015 Sep 3.
Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan (T.O., M.O., T.N., D.M., H.T.); Department of Medicine, Jichi Medical University, Tochigi, Japan (T.O., H.Y., S.I.); and Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina (T.O., M.A.D., L.L.R.)

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.
Biochem Biophys Res Commun 2015 Oct 14;466(3):536-40. Epub 2015 Sep 14.
Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin.
Sci Rep 2015 Sep 15;5:14041. Epub 2015 Sep 15.
Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Yakushiji 3311-1, Shimotsuke, Tochigi 329-0498, Japan.

Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver.
J Lipid Res 2015 May 9;56(5):998-1005. Epub 2015 Mar 9.
Division of Endocrinology and Metabolism, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.

Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages.
J Lipid Res 2014 Oct 27;55(10):2033-40. Epub 2014 May 27.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.

Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
J Lipid Res 2014 Oct 2;55(10):2082-92. Epub 2014 Jun 2.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.

Lipoprotein subfractions highly associated with renal damage in familial lecithin:cholesterol acyltransferase deficiency.
Arterioscler Thromb Vasc Biol 2014 Aug 29;34(8):1756-62. Epub 2014 May 29.
From the Department of Genome Research and Clinical Application, Graduate School of Medicine (M.K., S.A., Y.A., H.B.) and Center for Advanced Medicine, Chiba University Hospital (M.K.), Chiba University, Chiba, Japan; Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (A.G.H., E.S.G.S.); Department of Nephrology in Internal Medicine, Kitasato University Hospital, Sagamihara, Japan (K.K.); Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Japan (S.Y.); Division of Endocrinology and Metabolism, Department of Medicine, Diabetes Center, Jichi Medical University, Shimotsuke, Japan (S.I.); Chiba University, Chiba, Japan (Y.S.); and Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, Sakura, Japan (H.B.).
















Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
Arterioscler Thromb Vasc Biol 2012 Aug 14;32(8):1824-31. Epub 2012 Jun 14.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.



Pegylated interferon-α2b and ribavirin combination therapy induces Hashitoxicosis followed by type 1 diabetes mellitus.
Diabetes Res Clin Pract 2012 Mar 10;95(3):e52-4. Epub 2011 Dec 10.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.

Background to discuss guidelines for control of plasma HDL-cholesterol in Japan.
J Atheroscler Thromb 2012 12;19(3):207-12. Epub 2012 Jan 12.
Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Kasugai, Japan.

Diagnosis and management of type I and type V hyperlipoproteinemia.
J Atheroscler Thromb 2012 1;19(1):1-12. Epub 2011 Dec 1.
Department of Clinical and Molecular Epidemiology, 22nd Century Medical and Research Center, University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.


Molecular analysis of a novel LCAT mutation (Gly179 → Arg) found in a patient with complete LCAT deficiency.
J Atheroscler Thromb 2011 20;18(8):713-9. Epub 2011 May 20.
Division of Endcrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.
Arterioscler Thromb Vasc Biol 2011 May 10;31(5):1108-15. Epub 2011 Mar 10.
Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.





Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes.
Diabetes Res Clin Pract 2010 Jul 7;89(1):52-7. Epub 2010 May 7.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.




Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
J Lipid Res 2010 Feb 10;51(2):274-85. Epub 2009 Jul 10.
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.


Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding.
Am J Physiol Endocrinol Metab 2009 Nov 25;297(5):E1115-24. Epub 2009 Aug 25.
Third Dept. of Internal Medicine, Univ. of Fukui, Faculty of Medical Science, Fukui 910-1193, Japan.




RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.
Cardiovasc Res 2009 May 28;82(2):371-81. Epub 2009 Jan 28.
Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment (ICMRT), Kobe University Graduate School of Medicine, Kobe, Japan.

Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.
Biochem Biophys Res Commun 2008 Nov 30;376(1):111-5. Epub 2008 Aug 30.
Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.



Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target.
J Atheroscler Thromb 2008 Jun;15(3):116-21
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.

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