Publications

Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study).
Ann Rheum Dis 2018 Mar 30;77(3):348-354. Epub 2017 Nov 30.
Department of Molecular Regulation for Intractable Disease, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.



Increased Serum B Cell Activating Factor and a Proliferation-inducing Ligand Are Associated with Interstitial Lung Disease in Patients with Juvenile Dermatomyositis.
J Rheumatol 2015 Dec 15;42(12):2412-8. Epub 2015 Oct 15.
From the Department of Pediatrics, and Department of Infection and Host Defense, Graduate School of Medicine, Shinshu University School of Medicine, Matsumoto; Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama; Department of Rheumatology, Tokai University School of Medicine, Isehara; Department of Immunology and Infectious Diseases, Aichi Children's Health and Medical Center, Ohbu, Japan.N. Kobayashi, MD, PhD, Department of Pediatrics, Shinshu University School of Medicine; I. Kobayashi, MD, PhD, Department of Pediatrics, Hokkaido University Graduate School of Medicine; M. Mori, MD, PhD, Department of Pediatrics, Yokohama City University Graduate School of Medicine; S. Sato, MD, PhD, Department of Rheumatology, Tokai University School of Medicine; N. Iwata, MD, Department of Immunology and Infectious Diseases, Aichi Children's Health and Medical Center; T. Shigemura, MD, PhD, Department of Pediatrics, Shinshu University School of Medicine; K. Agematsu, MD, PhD, Department of Infection and Host Defense, Graduate School of Medicine, Shinshu University; S. Yokota, MD, PhD, Department of Pediatrics, Yokohama City University Graduate School of Medicine; K. Koike, MD, PhD, Department of Pediatrics, Shinshu University School of Medicine.

Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis.
Rheumatology (Oxford) 2015 May 6;54(5):784-91. Epub 2014 Oct 6.
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Department of Immunology and Infectious Diseases, Aichi Children's Health and Medical Center, Ohbu, Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Department of Pediatrics, Ehime University Graduate School of Medicine, Matsuyama, Department of Allergy & Immunology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Department of Pediatrics, University of the Ryukyus, Naha, Department of Pediatrics, Osaka Medical College, Takatsuki, Department of Pediatrics, Kurume University School of Medicine, Kurume, Department of General Pediatrics, Miyagi Children's Hospital, Sendai, Division of Infection, Immunology and Rheumatology, Kanagawa Children's Medical Center, Yokohama, Department of Infection and Host Defense, Shinshu University Graduate School of Medicine, Matsumoto, Department of Rheumatology, Tokai University School of Medicine, Isehara, Department of Rheumatology, Keio University School of Medicine, Tokyo and School of Health Science, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab.
J Rheumatol 2015 Apr 15;42(4):712-22. Epub 2015 Feb 15.
From The Safety Evaluation Committee of Tocilizumab for JIA; Department of Pediatrics, Nippon Medical School; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU) Graduate School of Medical and Dental Sciences; Chugai Pharmaceutical Co. Ltd., Tokyo; Department of Pediatrics, Yokohama City University School of Medicine, Kanagawa; Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama; Division of Rheumatology and Clinical Immunology, Jichi Medical School, Tochigi, Japan.S. Yokota, MD, PhD, the Safety Evaluation Committee of Tocilizumab for JIA, and the Department of Pediatrics, Yokohama City University School of Medicine; Y. Itoh, MD, the Safety Evaluation Committee of Tocilizumab for JIA, and the Department of Pediatrics, Nippon Medical School; T. Morio, MD, the Safety Evaluation Committee of Tocilizumab for JIA, and the Department of Pediatrics and Developmental Biology, TMDU Graduate School of Medical and Dental Sciences; N. Sumitomo, MD, the Safety Evaluation Committee of Tocilizumab for JIA, and the Department of Pediatric Cardiology, Saitama Medical University International Medical Center; K. Daimaru, BS, Chugai Pharmaceutical Co. Ltd.; S. Minota, MD, the Safety Evaluation Committee of Tocilizumab for JIA, and the Division of Rheumatology and Clinical Immunology, Jichi Medical School.




Discrepancy between clinical and radiological responses to tocilizumab treatment in patients with systemic-onset juvenile idiopathic arthritis.
J Rheumatol 2014 Jun 1;41(6):1171-7. Epub 2014 May 1.
From the Department of Orthopedic Surgery, the Department of Pediatrics, and the Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of Orthopedics, Department of Orthopedic Surgery, Yokohama City University.


Longterm safety and effectiveness of the anti-interleukin 6 receptor monoclonal antibody tocilizumab in patients with systemic juvenile idiopathic arthritis in Japan.
J Rheumatol 2014 Apr 15;41(4):759-67. Epub 2014 Mar 15.
From the Department of Pediatrics, Yokohama City University School of Medicine, and Department of Pediatrics, Yokohama City University Medical Center; Yokohama; School of Health Science, Faculty of Medicine, Kagoshima University, Kagoshima; Aichi Children's Health and Medical Center, Aichi; Miyagi Children's Hospital, Miyagi; Department of Pediatrics, Osaka Medical College, Osaka; Kobe Children's Hospital, Kobe; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba; Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Osaka; Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Clinical features of Mycoplasma pneumoniae infections in the 2010 epidemic season: report of two cases with unusual presentations.
Pediatr Neonatol 2013 Dec 20;54(6):402-5. Epub 2013 Jan 20.
Department of Pediatrics, Hiratsuka Kyosai Hospital, Kanagawa, Japan; Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan. Electronic address:

Severity of respiratory signs and symptoms and virus profiles in Japanese children with acute respiratory illness.
Microbiol Immunol 2013 Dec;57(12):811-21
Department of Pediatrics, National Hospital Organization Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-ku, Yokohama, Kanagawa, 245-8575; Department of Pediatrics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004.




Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan.
Mod Rheumatol 2013 May 20;23(3):425-9. Epub 2012 Oct 20.
Department of Pediatrics, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.


A pediatric patient with myopathy associated with antibodies to a signal recognition particle.
Brain Dev 2012 Nov 19;34(10):877-80. Epub 2012 Mar 19.
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.


Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: systemic arthritis and polyarthritis.
Mod Rheumatol 2012 Aug 9;22(4):558-64. Epub 2011 Oct 9.
Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: report of an open-label case series.
J Rheumatol 2012 Apr 15;39(4):864-7. Epub 2012 Feb 15.
Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis.
Mod Rheumatol 2012 Feb 12;22(1):109-15. Epub 2011 Jun 12.
Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.


A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness.
BMC Infect Dis 2011 Jun 10;11:168. Epub 2011 Jun 10.
Department of Pediatrics, National Hospital Organization Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-ku, Yokohama, Kanagawa 245-8575, Japan.


Nationwide survey of severe respiratory syncytial virus infection in children who do not meet indications for palivizumab in Japan.
J Infect Chemother 2011 Apr 25;17(2):254-63. Epub 2010 Sep 25.
Department of Pediatrics, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis.
J Rheumatol 2011 Apr 15;38(4):769-74. Epub 2011 Jan 15.
Department of Pediatrics, Yokohama City University Graduate School of Medicine; and the CNV Laboratory, DNA Chip Research Institute, Yokohama, Japan.



Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.
Circ Res 2010 Jun 29;106(12):1882-92. Epub 2010 Apr 29.
Department of Life Science and Medical Bioscience, Waseda University Graduate School of Advanced Science and Engineering, 2-2, Wakamatsu-cho, TWIns, Shinjuku-ku, Tokyo 162-8480, Japan.




Health related quality of life measure in systemic pediatric rheumatic diseases and its translation to different languages: an international collaboration.
Pediatr Rheumatol Online J 2014 25;12:49. Epub 2014 Nov 25.
Department of Pediatrics, Alberta Children's Hospital Research Institute Faculty of Medicine, University of Calgary, Calgary, AB Canada.

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