Shumpei Ishikawa

Shumpei Ishikawa

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Shumpei Ishikawa

Publications by authors named "Shumpei Ishikawa"

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The first case of gastric carcinoma with NTRK rearrangement: identification of a novel ATP1B-NTRK1 fusion.

Gastric Cancer 2020 Mar 18. Epub 2020 Mar 18.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s10120-020-01061-9DOI Listing
March 2020

In vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model.

Oncol Rep 2019 Nov 3;42(5):1745-1754. Epub 2019 Sep 3.

Department of Research, Forerunner Pharma Research Co., Ltd., Komaba Open Laboratory, The University of Tokyo, Tokyo 153‑8904, Japan.

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http://dx.doi.org/10.3892/or.2019.7300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775816PMC
November 2019

Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis Leads to Barrier Disruption.

J Invest Dermatol 2019 Sep 21;139(9):1867-1875.e7. Epub 2019 Mar 21.

Department of Dermatology, the University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jid.2019.02.030DOI Listing
September 2019

Machine learning approaches for pathologic diagnosis.

Virchows Arch 2019 Aug 20;475(2):131-138. Epub 2019 Jun 20.

Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s00428-019-02594-wDOI Listing
August 2019

Difference in morphology and interactome profiles between orthotopic and subcutaneous gastric cancer xenograft models.

J Toxicol Pathol 2018 Oct 13;31(4):293-300. Epub 2018 Aug 13.

Forerunner Pharma Research Co., Ltd., Komaba Open Laboratory, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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https://www.jstage.jst.go.jp/article/tox/31/4/31_2018-0020/_
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http://dx.doi.org/10.1293/tox.2018-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206286PMC
October 2018

HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.

Int J Mol Sci 2018 Jul 24;19(8). Epub 2018 Jul 24.

Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.3390/ijms19082158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121890PMC
July 2018

Frequent fusion in highly metastatic diffuse-type gastric cancer with relatively early onset.

Oncotarget 2018 Jun 29;9(50):29336-29350. Epub 2018 Jun 29.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047683PMC
June 2018

DGC-specific mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.

Oncotarget 2018 May 1;9(33):23198-23207. Epub 2018 May 1.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955407PMC
May 2018

Machine Learning Methods for Histopathological Image Analysis.

Comput Struct Biotechnol J 2018 9;16:34-42. Epub 2018 Feb 9.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.csbj.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158771PMC
February 2018

Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.

Cancer Sci 2017 Feb;108(2):256-266

Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329163PMC
February 2017

Genomic pathobiology of gastric carcinoma.

Pathol Int 2017 Feb 22;67(2):63-71. Epub 2016 Dec 22.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://doi.wiley.com/10.1111/pin.12493
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http://dx.doi.org/10.1111/pin.12493DOI Listing
February 2017

CASTIN: a system for comprehensive analysis of cancer-stromal interactome.

BMC Genomics 2016 11 9;17(1):899. Epub 2016 Nov 9.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1186/s12864-016-3207-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103609PMC
November 2016

Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis.

Hum Pathol 2016 10 21;56:74-80. Epub 2016 Jun 21.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.06.002DOI Listing
October 2016

RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases.

Gastric Cancer 2016 Apr 1;19(2):403-411. Epub 2015 Apr 1.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1007/s10120-015-0493-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824805PMC
April 2016

Opposite RHOA functions within the ATLL category.

Authors:
Shumpei Ishikawa

Blood 2016 Feb;127(5):524-5

TOKYO MEDICAL AND DENTAL UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2015-12-683458DOI Listing
February 2016

The in vivo evaluation of the therapeutic potential of human adipose tissue-derived mesenchymal stem cells for acute liver disease.

Methods Mol Biol 2014 ;1213:57-67

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/978-1-4939-1453-1_6DOI Listing
May 2015

Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.

Hum Pathol 2014 Jul 28;45(7):1397-405. Epub 2014 Feb 28.

Molecular Pathology Laboratory, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.humpath.2014.02.013DOI Listing
July 2014

Prognostic significance of CD204-positive macrophages in upper urinary tract cancer.

Ann Surg Oncol 2014 Jun 4;21(6):2105-12. Epub 2014 Feb 4.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1245/s10434-014-3503-2DOI Listing
June 2014

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.

Nat Genet 2014 Jun 11;46(6):583-7. Epub 2014 May 11.

1] Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. [2] Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. [3] Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1038/ng.2984DOI Listing
June 2014

A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.

Hum Pathol 2014 May 23;45(5):1045-56. Epub 2014 Jan 23.

Division of Pathology, The Cancer Institute, The Cancer Institute Hospital, Japanese Foundation for Cancer Research (JFCR), Tokyo 135-8550, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2014.01.001DOI Listing
May 2014

Clinicopathological and prognostic significance of EZH2 expression in upper urinary tract carcinoma.

Virchows Arch 2014 Apr 21;464(4):463-71. Epub 2014 Jan 21.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s00428-014-1541-6DOI Listing
April 2014

Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.

Virus Res 2013 Jun 22;174(1-2):108-15. Epub 2013 Mar 22.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1016/j.virusres.2013.03.009DOI Listing
June 2013

Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.

J Thorac Oncol 2012 Dec;7(12):1872-1876

Department of Pathology, Division of Integrative Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan. Electronic address:

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http://dx.doi.org/10.1097/JTO.0b013e3182721ed1DOI Listing
December 2012

DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.

PLoS One 2011 7;6(10):e26052. Epub 2011 Oct 7.

Genome Science Division, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026052PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189249PMC
February 2012

N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria.

Exp Parasitol 2011 Nov 13;129(3):318-21. Epub 2011 Jul 13.

Department of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1016/j.exppara.2011.07.003DOI Listing
November 2011

Claudin-18 is an early-stage marker of pancreatic carcinogenesis.

J Histochem Cytochem 2011 Oct 10;59(10):942-52. Epub 2011 Aug 10.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan.

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http://dx.doi.org/10.1369/0022155411420569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201126PMC
October 2011

β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors.

Am J Surg Pathol 2011 Oct;35(10):1429-40

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan.

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http://dx.doi.org/10.1097/PAS.0b013e31822d6c71DOI Listing
October 2011

Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.

Am J Pathol 2010 Nov 7;177(5):2191-204. Epub 2010 Oct 7.

Department of Integrative Pathology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

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http://dx.doi.org/10.2353/ajpath.2010.100217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966779PMC
November 2010

Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.

J Thorac Oncol 2010 Sep;5(9):1317-24

Department of Pathology, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3181e2a409DOI Listing
September 2010

Identification of chromosomal aberrations of metastatic potential in colorectal carcinoma.

Genes Chromosomes Cancer 2010 May;49(5):487-96

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Tokyo, Japan.

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http://dx.doi.org/10.1002/gcc.20759DOI Listing
May 2010

Population-genetic nature of copy number variations in the human genome.

Hum Mol Genet 2010 Mar 5;19(5):761-73. Epub 2009 Dec 5.

Center for Genomic Medicine, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/hmg/ddp541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816609PMC
March 2010

Mutation analysis of SOX9 and single copy number variant analysis of the upstream region in eight patients with campomelic dysplasia and acampomelic campomelic dysplasia.

Am J Med Genet A 2009 Dec;149A(12):2882-5

Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, 2-10-1 Ohkura, Setagaya, Tokyo 157-8535, Japan.

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http://doi.wiley.com/10.1002/ajmg.a.33107
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http://dx.doi.org/10.1002/ajmg.a.33107DOI Listing
December 2009

Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis.

Hepatology 2009 Feb;49(2):513-22

Division of Genome Science, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/hep.22698DOI Listing
February 2009

Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.

Cancer Sci 2008 Jan 22;99(1):14-22. Epub 2007 Oct 22.

Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-0033, Tokyo, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2007.00640.x
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http://dx.doi.org/10.1111/j.1349-7006.2007.00640.xDOI Listing
January 2008

p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis.

Exp Mol Pathol 2007 Dec 10;83(3):367-76. Epub 2007 Apr 10.

Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1016/j.yexmp.2007.03.006DOI Listing
December 2007

Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway.

Cancer Sci 2007 Apr;98(4):506-11

Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00428.xDOI Listing
April 2007

Noise reduction from genotyping microarrays using probe level information.

In Silico Biol 2006 ;6(1-2):79-92

Dependable and High-performance Computing, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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November 2006

Allelic dosage analysis with genotyping microarrays.

Biochem Biophys Res Commun 2005 Aug;333(4):1309-14

Genome Science Division, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0501250
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http://dx.doi.org/10.1016/j.bbrc.2005.06.040DOI Listing
August 2005

Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.

Clin Cancer Res 2005 Mar;11(5):1776-85

Genome Science Division and Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, Graduate School of Medicine, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1238DOI Listing
March 2005

Short report: Lethal malaria in cytosolic phospholipase A2- and phospholipase A2IIA-deficient mice.

Am J Trop Med Hyg 2004 Jun;70(6):645-50

Department of Pathology, The University of Tokyo, Hongo, Tokyo, Japan.

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June 2004

Selective expression of a subset of neuronal genes in oligodendroglioma with chromosome 1p loss.

Brain Pathol 2004 Jan;14(1):34-42

Genome Science Division, Research Center for Advanced Science and Technology, Department of Neurosurgery, University of Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1750-3639.2004.tb00495.xDOI Listing
January 2004

Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine.

J Biol Chem 2003 Oct 15;278(44):43489-95. Epub 2003 Aug 15.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1074/jbc.M306933200DOI Listing
October 2003

Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling.

Int J Cancer 2003 Feb;103(4):455-65

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1002/ijc.10856DOI Listing
February 2003