Publications



IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Sci Rep 2016 Jan 12;6:19174. Epub 2016 Jan 12.
Division of Rare Cancer Research, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.
Stem Cell Reports 2016 Jan;6(1):64-73
Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:


Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer.
Mol Endocrinol 2014 Dec;28(12):2012-24
Departments of Anti-Aging Medicine (K.T., T.U., S.I.) and Geriatric Medicine (K.T., T.U., S.I.) and Department of Urology (T.F., Y.H.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Pathology (T.S.), Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan; Genome Science Division (Sh.T., H.A.), Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan; Department of Urology (Sa.T.), Nihon University School of Medicine, Itabashi-ku, Tokyo 173-0032, Japan; and Division of Gene Regulation and Signal Transduction (S.I.), Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.




The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells.
Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1604-9. Epub 2014 Jan 13.
Laboratory for Stem Cell Competency, Research Center for Allergy and Immunology (RCAI), RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Suehirocho, Tsurumi-ku, Yokohama 230-0045, Japan.

GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation.
Genes Cells 2013 Nov 1;18(11):921-33. Epub 2013 Aug 1.
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.


CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
Proc Natl Acad Sci U S A 2012 Dec 29;109(50):20584-9. Epub 2012 Oct 29.
Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.





Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.
Hum Mol Genet 2011 Jul 19;20(14):2710-21. Epub 2011 Apr 19.
Genome Science Division, Research Center for Advanced Science and Technology and Department of Pathology, University of Tokyo, Tokyo, Japan.

Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter.
Mol Cell Biol 2011 Jun 4;31(11):2196-209. Epub 2011 Apr 4.
Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.



A wave of nascent transcription on activated human genes.
Proc Natl Acad Sci U S A 2009 Oct 13;106(43):18357-61. Epub 2009 Oct 13.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.


COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.
Mol Cell Biol 2009 Jan 27;29(1):172-86. Epub 2008 Oct 27.
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan.






A meta-clustering analysis indicates distinct pattern alteration between two series of gene expression profiles for induced ischemic tolerance in rats.
Physiol Genomics 2005 Apr 15;21(2):274-83. Epub 2005 Feb 15.
Intelligent Cooperative System, Department of Information Systems, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

Distinct chromosomal bias of gene expression signatures in the progression of hepatocellular carcinoma.
Cancer Res 2004 Oct;64(20):7263-70
Genome Science Division, Intelligent Cooperative Systems Division, Research Center for Advanced Science and Technology, and Hepato-Biliary-Pancreatic Surgery Division, The University of Tokyo, Tokyo, USA.

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