Shuhua Xu

Shuhua Xu

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PGG.Han: the Han Chinese genome database and analysis platform.

Nucleic Acids Res 2020 Jan;48(D1):D971-D976

Key Laboratory of Computational Biology, Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1093/nar/gkz829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943055PMC
January 2020

Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys.

Nat Commun 2019 Dec 4;10(1):5525. Epub 2019 Dec 4.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.

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http://dx.doi.org/10.1038/s41467-019-13481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892871PMC
December 2019

Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations.

BMC Genomics 2019 Nov 12;20(1):842. Epub 2019 Nov 12.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1186/s12864-019-6226-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852992PMC
November 2019

Sex difference in kidney electrolyte transport II: impact of K intake on thiazide-sensitive cation excretion in male and female mice.

Am J Physiol Renal Physiol 2019 Oct 7;317(4):F967-F977. Epub 2019 Aug 7.

Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1152/ajprenal.00125.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843050PMC
October 2019

PGG.SNV: understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations.

Genome Biol 2019 10 22;20(1):215. Epub 2019 Oct 22.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, CAS, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-019-1838-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805450PMC
October 2019

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.

Nat Commun 2019 10 25;10(1):4892. Epub 2019 Oct 25.

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China.

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http://dx.doi.org/10.1038/s41467-019-12801-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814821PMC
October 2019

MultiWaver 2.0: modeling discrete and continuous gene flow to reconstruct complex population admixtures.

Eur J Hum Genet 2019 01 11;27(1):133-139. Epub 2018 Sep 11.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, CAS, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41431-018-0259-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303267PMC
January 2019

Combined surgical-orthodontic treatment of patients with cleidocranial dysplasia: case report and review of the literature.

Orphanet J Rare Dis 2018 12 4;13(1):217. Epub 2018 Dec 4.

Department of Oral and Craniomaxillofacial Science, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No 500, Quxi Road, Shanghai, Shanghai, China.

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
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http://dx.doi.org/10.1186/s13023-018-0959-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280340PMC
December 2018

Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences.

Eur J Hum Genet 2018 11 10;26(11):1687-1696. Epub 2018 Jul 10.

MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 20043, China.

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http://dx.doi.org/10.1038/s41431-018-0211-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189043PMC
November 2018

Regulation of renal Na transporters in response to dietary K.

Am J Physiol Renal Physiol 2018 10 20;315(4):F1032-F1041. Epub 2018 Jun 20.

Department of Physiology and Biophysics, Weill Medical College of Cornell University , New York, New York.

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https://www.physiology.org/doi/10.1152/ajprenal.00117.2018
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http://dx.doi.org/10.1152/ajprenal.00117.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230734PMC
October 2018

Mechanisms of CO Incorporation into Propargylic Amine Catalyzed by Ag(I)/Amine Catalysts.

J Org Chem 2018 Oct 18;83(19):11896-11904. Epub 2018 Sep 18.

State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers, and Esters, and Department of Chemistry, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China.

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http://pubs.acs.org/doi/10.1021/acs.joc.8b01767
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http://dx.doi.org/10.1021/acs.joc.8b01767DOI Listing
October 2018

AncestryPainter: A Graphic Program for Displaying Ancestry Composition of Populations and Individuals.

Genomics Proteomics Bioinformatics 2018 10 22;16(5):382-385. Epub 2018 Nov 22.

CAS Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China; Human Phenome Institute, Fudan University, Shanghai 201203, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364040PMC
October 2018

Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction.

J Genet Genomics 2018 08 16;45(8):419-432. Epub 2018 Aug 16.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, CAS, Shanghai 200031, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16738527183014
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http://dx.doi.org/10.1016/j.jgg.2018.07.009DOI Listing
August 2018

Inference of multiple-wave admixtures by length distribution of ancestral tracks.

Heredity (Edinb) 2018 07 23;121(1):52-63. Epub 2018 Jan 23.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai, China.

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http://dx.doi.org/10.1038/s41437-017-0041-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997750PMC
July 2018

A genome-wide characterization of copy number variations in native populations of Peninsular Malaysia.

Eur J Hum Genet 2018 06 23;26(6):886-897. Epub 2018 Feb 23.

Chinese Academy of Sciences (CAS), Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41431-018-0120-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974366PMC
June 2018

Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations.

Hereditas 2018 6;155:19. Epub 2018 Apr 6.

1Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 China.

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http://dx.doi.org/10.1186/s41065-018-0057-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889524PMC
April 2018

Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.

Am J Physiol Regul Integr Comp Physiol 2018 03 1;314(3):R334-R341. Epub 2017 Nov 1.

Department of Cellular and Molecular Physiology, Yale University, School of Medicine , New Haven, Connecticut.

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http://dx.doi.org/10.1152/ajpregu.00315.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899254PMC
March 2018

Genome-wide comparison of allele-specific gene expression between African and European populations.

Hum Mol Genet 2018 03;27(6):1067-1077

Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China.

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http://dx.doi.org/10.1093/hmg/ddy027DOI Listing
March 2018

PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations.

Nucleic Acids Res 2018 01;46(D1):D984-D993

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China.

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http://dx.doi.org/10.1093/nar/gkx1032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753384PMC
January 2018

A metagenomic approach to dissect the genetic composition of enterotypes in Han Chinese and two Muslim groups.

Syst Appl Microbiol 2018 Jan 10;41(1):1-12. Epub 2017 Nov 10.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China. Electronic address:

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http://dx.doi.org/10.1016/j.syapm.2017.09.006DOI Listing
January 2018

A missense point mutation in COL10A1 identified with whole-genome deep sequencing in a 7-generation Pakistan dwarf family.

Heredity (Edinb) 2018 01 10;120(1):83-89. Epub 2017 Nov 10.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41437-017-0021-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837121PMC
January 2018

Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia.

Mol Biol Evol 2017 10;34(10):2572-2582

Chinese Academy of Sciences Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China.

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http://dx.doi.org/10.1093/molbev/msx177DOI Listing
October 2017

Assessing genome-wide copy number variation in the Han Chinese population.

J Med Genet 2017 10 13;54(10):685-692. Epub 2017 Jul 13.

Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai, China.

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http://dx.doi.org/10.1136/jmedgenet-2017-104613DOI Listing
October 2017

Gender difference in kidney electrolyte transport. I. Role of AT receptor in thiazide-sensitive Na-Cl cotransporter activity and expression in male and female mice.

Am J Physiol Renal Physiol 2017 Aug 31;313(2):F505-F513. Epub 2017 May 31.

Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut;

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http://dx.doi.org/10.1152/ajprenal.00087.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582908PMC
August 2017

Adaptation of human skin color in various populations.

Authors:
Lian Deng Shuhua Xu

Hereditas 2018 15;155. Epub 2017 Jun 15.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai, 200031 China.

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http://dx.doi.org/10.1186/s41065-017-0036-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502412PMC
August 2017

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

PLoS One 2016 28;11(6):e0158269. Epub 2016 Jun 28.

Department of Internal Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158269PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924846PMC
July 2017

CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data.

J Genet Genomics 2017 07 11;44(7):367-370. Epub 2017 Jul 11.

Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai 200438, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.07.001DOI Listing
July 2017

Differentiated demographic histories and local adaptations between Sherpas and Tibetans.

Genome Biol 2017 06 15;18(1):115. Epub 2017 Jun 15.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s13059-017-1242-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472941PMC
June 2017

Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium.

Sci Rep 2017 02 23;7:43054. Epub 2017 Feb 23.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/srep43054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322361PMC
February 2017

Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait.

J Genet Genomics 2016 12 14;43(12):702-704. Epub 2016 Oct 14.

Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2016.10.003DOI Listing
December 2016

Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.

Hum Genet 2016 Nov 3;135(11):1279-1286. Epub 2016 Aug 3.

Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 YueYang Road, Shanghai, 200031, China.

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http://dx.doi.org/10.1007/s00439-016-1718-yDOI Listing
November 2016

Precision Medicine: What Challenges Are We Facing?

Genomics Proteomics Bioinformatics 2016 10 13;14(5):253-261. Epub 2016 Oct 13.

CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093857PMC
October 2016

Ancestral Origins and Genetic History of Tibetan Highlanders.

Am J Hum Genet 2016 09 25;99(3):580-594. Epub 2016 Aug 25.

Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30273-7.pdf
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http://dx.doi.org/10.1016/j.ajhg.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011065PMC
September 2016

Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus.

Oncotarget 2016 Jul;7(27):42216-42224

Department of Immunology, Genetics and Pathology, Science for Life Laboratory Uppsala, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.18632/oncotarget.9916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173129PMC
July 2016

Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data.

PLoS One 2015 8;10(6):e0129023. Epub 2015 Jun 8.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology,Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, ShanghaiTec University, Shanghai, China; Collaborative Innovation Center of Genetics and Development, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460046PMC
March 2016

Ancestry variation and footprints of natural selection along the genome in Latin American populations.

Sci Rep 2016 Feb 18;6:21766. Epub 2016 Feb 18.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/srep21766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757894PMC
February 2016

EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects.

Hum Genet 2016 Jan 24;135(1):99-108. Epub 2015 Nov 24.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, 200031, Shanghai, China.

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http://dx.doi.org/10.1007/s00439-015-1618-6DOI Listing
January 2016

Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations.

Sci Rep 2016 Jan 5;6:18755. Epub 2016 Jan 5.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/srep18755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700420PMC
January 2016

Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference.

Sci Rep 2016 Jan 28;6:20048. Epub 2016 Jan 28.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS, Shanghai 200031, China.

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http://dx.doi.org/10.1038/srep20048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730239PMC
January 2016

Reintroduction of a Homocysteine Level-Associated Allele into East Asians by Neanderthal Introgression.

Mol Biol Evol 2015 Dec 21;32(12):3108-13. Epub 2015 Sep 21.

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China

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http://dx.doi.org/10.1093/molbev/msv176DOI Listing
December 2015

A probabilistic method for testing and estimating selection differences between populations.

Genome Res 2015 Dec 13;25(12):1903-9. Epub 2015 Oct 13.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences-Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1101/gr.192336.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665011PMC
December 2015

Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity.

Mol Genet Genomics 2015 Oct 3;290(5):1741-52. Epub 2015 Apr 3.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1007/s00438-015-1032-8DOI Listing
October 2015

Dissecting the genetic structure and admixture of four geographical Malay populations.

Sci Rep 2015 Sep 23;5:14375. Epub 2015 Sep 23.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/srep14375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585825PMC
September 2015

A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence.

Am J Hum Genet 2015 Jul 11;97(1):54-66. Epub 2015 Jun 11.

Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572470PMC
July 2015

Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies.

Hum Genomics 2015 Jul 22;9:16. Epub 2015 Jul 22.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1186/s40246-015-0039-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509480PMC
July 2015

Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups.

Eur J Hum Genet 2015 Apr 16;23(4):536-42. Epub 2014 Jul 16.

1] Max Planck Independent Research Group on Population Genomics Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China [2] Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/ejhg.2014.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666576PMC
April 2015

The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.

Hepatology 2015 Apr 23;61(4):1251-60. Epub 2015 Feb 23.

Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory of Liver Diseases, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.27608DOI Listing
April 2015

Quantitating and dating recent gene flow between European and East Asian populations.

Sci Rep 2015 Apr 2;5:9500. Epub 2015 Apr 2.

1] Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max-Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2] School of Life Science and Technology, ShanghaiTec University, Shanghai 200031, China [3] Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China.

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http://dx.doi.org/10.1038/srep09500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382708PMC
April 2015

Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations.

Sci Rep 2015 Apr 30;5:9658. Epub 2015 Apr 30.

1] Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2] School of Life Science and Technology, ShanghaiTec University, Shanghai 200031, China [3] Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China.

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http://dx.doi.org/10.1038/srep09658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386188PMC
April 2015

Analysis of genome-wide RNA-sequencing data suggests age of the CEPH/Utah (CEU) lymphoblastoid cell lines systematically biases gene expression profiles.

Sci Rep 2015 Jan 22;5:7960. Epub 2015 Jan 22.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max-Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/srep07960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302305PMC
January 2015

The influence of admixture and consanguinity on population genetic diversity in Middle East.

J Hum Genet 2014 Nov 25;59(11):615-22. Epub 2014 Sep 25.

Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max-Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/jhg.2014.81DOI Listing
November 2014

Variation and signatures of selection on the human face.

J Hum Evol 2014 Oct 1;75:143-52. Epub 2014 Sep 1.

CAS-MPG Partner Institute and Key Laboratory for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Yueyang Road 320, Shanghai 200031, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhevol.2014.08.001DOI Listing
October 2014

The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia.

Hum Genet 2014 Sep 11;133(9):1169-85. Epub 2014 Jun 11.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1007/s00439-014-1459-8DOI Listing
September 2014

Genetic architectures of ADME genes in five Eurasian admixed populations and implications for drug safety and efficacy.

J Med Genet 2014 Sep 29;51(9):614-22. Epub 2014 Jul 29.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2014-102530
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http://dx.doi.org/10.1136/jmedgenet-2014-102530DOI Listing
September 2014

Neanderthal origin of the haplotypes carrying the functional variant Val92Met in the MC1R in modern humans.

Mol Biol Evol 2014 Aug 10;31(8):1994-2003. Epub 2014 Jun 10.

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, ChinaCAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China

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http://dx.doi.org/10.1093/molbev/msu180DOI Listing
August 2014

A new method for modeling coalescent processes with recombination.

BMC Bioinformatics 2014 Aug 11;15:273. Epub 2014 Aug 11.

Institute of Applied Mathematics, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.

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http://dx.doi.org/10.1186/1471-2105-15-273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137079PMC
August 2014

Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping.

Eur J Hum Genet 2014 Jul 20;22(7):930-7. Epub 2013 Nov 20.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/ejhg.2013.265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060116PMC
July 2014

Fully printed, rapid-response sensors based on chemically modified graphene for detecting NO2 at room temperature.

ACS Appl Mater Interfaces 2014 May 16;6(10):7426-33. Epub 2014 May 16.

Joint Lab with Wuhu Token for Graphene Electrical Materials and Application, Department of Physics, Shanghai Normal University , Guilin Road 100, Shanghai 200234, China.

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http://dx.doi.org/10.1021/am500843pDOI Listing
May 2014

Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for pharmacogenomics.

BMC Genet 2014 May 1;15:52. Epub 2014 May 1.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1186/1471-2156-15-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021503PMC
May 2014

Neanderthal introgression at chromosome 3p21.31 was under positive natural selection in East Asians.

Mol Biol Evol 2014 Mar 13;31(3):683-95. Epub 2013 Dec 13.

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/molbev/mst260DOI Listing
March 2014

A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese.

Eur J Hum Genet 2014 Feb 29;22(2):248-53. Epub 2013 May 29.

1] Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Shanghai, China [2] Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/ejhg.2013.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895631PMC
February 2014

Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses.

Helicobacter 2014 Feb 4;19(1):37-47. Epub 2013 Nov 4.

Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China; Department of Gastroenterology, The Affiliated Hospital, College of Medicine, Ningbo University, Ningbo, 315020, China.

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http://dx.doi.org/10.1111/hel.12102DOI Listing
February 2014

A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression.

Am J Physiol Gastrointest Liver Physiol 2014 Jan 21;306(2):G154-62. Epub 2013 Nov 21.

Children's Hospital Colorado, Univ. of Colorado School of Medicine, 13123 E. 16th Ave., B065 Aurora, CO 80045.

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http://ajpgi.physiology.org/cgi/doi/10.1152/ajpgi.00138.2013
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http://dx.doi.org/10.1152/ajpgi.00138.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920074PMC
January 2014

Identification of functional mutations in GATA4 in patients with congenital heart disease.

PLoS One 2013 23;8(4):e62138. Epub 2013 Apr 23.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062138PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633926PMC
November 2013

Dissimilarity of contemporary and historical gene flow in a wild carrot (Daucus carota) metapopulation under contrasting levels of human disturbance: implications for risk assessment and management of transgene introgression.

Ann Bot 2013 Nov 19;112(7):1361-70. Epub 2013 Sep 19.

Plant Ecology and Phytochemistry, Institute of Biology Leiden, Leiden University, PO Box 9505, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1093/aob/mct208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806537PMC
November 2013

Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study.

Sci Rep 2013 ;3:2147

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China.

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http://dx.doi.org/10.1038/srep02147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701898PMC
September 2013

Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis.

J Med Genet 2013 Aug 4;50(8):534-42. Epub 2013 Jun 4.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1136/jmedgenet-2012-101501DOI Listing
August 2013

Genome-wide landscapes of human local adaptation in Asia.

PLoS One 2013 22;8(1):e54224. Epub 2013 Jan 22.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551950PMC
July 2013

Principal component analysis reveals the 1000 Genomes Project does not sufficiently cover the human genetic diversity in Asia.

Front Genet 2013 4;4:127. Epub 2013 Jul 4.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences Shanghai, China.

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http://dx.doi.org/10.3389/fgene.2013.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701331PMC
July 2013

Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation.

Mol Pharmacol 2013 May 5;83(5):1078-86. Epub 2013 Mar 5.

Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1124/mol.113.084772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920091PMC
May 2013

Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments.

Am J Hum Genet 2012 Nov 25;91(5):849-62. Epub 2012 Oct 25.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1016/j.ajhg.2012.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487126PMC
November 2012

Human Organic Solute Transporter (hOST): protein interaction and membrane sorting process.

Int J Biochem Mol Biol 2012 25;3(3):290-301. Epub 2012 Sep 25.

Department of Pediatrics, University of Colorado Denver School of Medicine Aurora, CO 80045.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476788PMC
October 2012

Human population admixture in Asia.

Authors:
Shuhua Xu

Genomics Inform 2012 Sep 28;10(3):133-44. Epub 2012 Sep 28.

Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.5808/GI.2012.10.3.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492649PMC
September 2012

A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.

Hepatology 2012 Jun 25;55(6):1901-11. Epub 2012 Apr 25.

Liver Center, Yale University School of Medicine, New Haven, CT06520-8019, USA.

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http://dx.doi.org/10.1002/hep.25523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319652PMC
June 2012

Identification of close relatives in the HUGO Pan-Asian SNP database.

PLoS One 2011 29;6(12):e29502. Epub 2011 Dec 29.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248454PMC
May 2012

A systematic characterization of genes underlying both complex and Mendelian diseases.

Hum Mol Genet 2012 Apr 20;21(7):1611-24. Epub 2011 Dec 20.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddr599DOI Listing
April 2012

Genome-wide detection of natural selection in African Americans pre- and post-admixture.

Genome Res 2012 Mar 29;22(3):519-27. Epub 2011 Nov 29.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1101/gr.124784.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290787PMC
March 2012

Genetic dating indicates that the Asian-Papuan admixture through Eastern Indonesia corresponds to the Austronesian expansion.

Proc Natl Acad Sci U S A 2012 Mar 6;109(12):4574-9. Epub 2012 Mar 6.

Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society, CAS-MPG, Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://www.picb.ac.cn/picb-dynamic/admin/pic/PNAS-2012-Xu-11
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http://www.pnas.org/cgi/doi/10.1073/pnas.1118892109
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http://dx.doi.org/10.1073/pnas.1118892109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311340PMC
March 2012