Shugui Chen

Shugui Chen

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Shugui Chen

Shugui Chen

Publications by authors named "Shugui Chen"

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16Publications

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Biotherapeutic Antibody Subunit LC-MS and Peptide Mapping LC-MS Measurements to Study Possible Biotransformation and Critical Quality Attributes In Vivo.

J Pharm Sci 2019 04 20;108(4):1415-1422. Epub 2018 Nov 20.

Bioanalysis, Immunogenicity and Biomarkers, In Vitro/In Vivo Translation Platform, R&D Platform Technology & Science, GSK, King of Prussia, Pennsylvania 19406.

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http://dx.doi.org/10.1016/j.xphs.2018.11.019DOI Listing
April 2019

Artificial strain of human prions created in vitro.

Nat Commun 2018 06 4;9(1):2166. Epub 2018 Jun 4.

Department of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH, 44106, USA.

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http://dx.doi.org/10.1038/s41467-018-04584-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986862PMC
June 2018

Structural determinants of phenotypic diversity and replication rate of human prions.

PLoS Pathog 2015 Apr 14;11(4):e1004832. Epub 2015 Apr 14.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397081PMC
April 2015

Interaction between prion protein and Aβ amyloid fibrils revisited.

ACS Chem Neurosci 2014 05 1;5(5):340-5. Epub 2014 Apr 1.

Department of Physiology and Biophysics, Case Western Reserve University , Cleveland, Ohio 44106, United States.

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http://dx.doi.org/10.1021/cn500019cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030797PMC
May 2014

The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein.

FEBS Lett 2013 Sep 24;587(18):2918-23. Epub 2013 Jul 24.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.febslet.2013.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779884PMC
September 2013

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

J Biol Chem 2013 Mar 9;288(9):6116-29. Epub 2013 Jan 9.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA.

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http://dx.doi.org/10.1074/jbc.M112.431312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585049PMC
March 2013

Structure and dynamic regulation of Abl kinases.

J Biol Chem 2013 Feb 11;288(8):5443-50. Epub 2013 Jan 11.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA.

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http://dx.doi.org/10.1074/jbc.R112.438382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581414PMC
February 2013

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Int Rev Phys Chem 2013 Jan;32(1):96-127

Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115 USA.

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http://dx.doi.org/10.1080/0144235X.2012.751175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652491PMC
January 2013

Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.

J Biol Chem 2012 Sep 22;287(40):33104-8. Epub 2012 Aug 22.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.C112.400614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460415PMC
September 2012

Structural polymorphism in amyloids: new insights from studies with Y145Stop prion protein fibrils.

J Biol Chem 2011 Dec 15;286(49):42777-84. Epub 2011 Oct 15.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M111.302539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234922PMC
December 2011

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues.

J Biol Chem 2010 Aug 24;285(34):26377-83. Epub 2010 Jun 24.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.145516
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http://dx.doi.org/10.1074/jbc.M110.145516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924066PMC
August 2010

Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.

J Mol Biol 2008 Nov 23;383(2):414-23. Epub 2008 Aug 23.

Chemistry & Chemical Biology and The Barnett Institute of Chemical & Biological Analysis, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596866PMC
November 2008

Abl N-terminal cap stabilization of SH3 domain dynamics.

Biochemistry 2008 May 2;47(21):5795-803. Epub 2008 May 2.

Chemistry and Chemical Biology, The Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi800446bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423811PMC
May 2008

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.

Protein Sci 2007 Apr 27;16(4):572-81. Epub 2007 Feb 27.

Chemistry and Chemical Biology, The Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1110/ps.062631007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203333PMC
April 2007