Publications by authors named "Shuang Song"

388 Publications

Detection of microwave ablation coagulation areas using ultrasound Nakagami imaging based on Gaussian pyramid decomposition: A feasibility study.

Ultrasonics 2022 May 13;124:106758. Epub 2022 May 13.

Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, China. Electronic address:

In this paper, we explored the feasibility of using ultrasound Nakagami-m parametric imaging based on Gaussian pyramid decomposition (GPD) to detect microwave ablation coagulation areas. Monte Carlo simulation and phantom simulation results demonstrated that a 2-layer GPD model was sufficient to achieve the same m parameter estimation accuracy, smoothness and resolution as 3-layer and 4-layer. The performances of GPD, moment-based estimator (MBE) and window-modulated compounding (WMC) algorithms were compared in terms of parameter estimation, smoothness, resolution and contrast-to-noise (CNR). Results showed that the m parameter estimation obtained by GPD algorithm was better than that of MBE and WMC algorithms except the small window size (27 × 5). When using a window size of >3 pulse lengths, GPD algorithm could achieve better smoothness and CNR than MBE and WMC algorithms, but there was a certain loss of axial resolution. The computation time of GPD algorithm was less than that of WMC algorithm, while about 2.24 times that of MBE algorithm. Experimental results of porcine liver microwave ablation ex vivo (n = 20) illustrated that the average areas under the operating characteristic curve (AUCs) of Nakagami m, m and m parametric imaging and homodyned-K (HK) α and k parametric imaging to detect coagulation areas were significantly improved by polynomial approximation (PAX). Kruskal-Wallis test showed that the accuracy of coagulation area detection obtained by PAX imaging of m parameter had no significant difference with that of m, m, HK_α and HK_k parameters. This preliminary study suggested that Nakagami imaging based on GPD algorithm may have the potential to detect microwave ablation coagulation areas.
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http://dx.doi.org/10.1016/j.ultras.2022.106758DOI Listing
May 2022

Covalent Triazine Frameworks with Defective Accumulation Sites: Exceptionally Modulated Electronic Structure for Solar-Driven Oxidative Activation of Peroxymonosulfate.

Environ Sci Technol 2022 May 25. Epub 2022 May 25.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, P. R. China.

Precisely tailoring the electronic structure and surface chemistry of metal-free covalent triazine frameworks (CTFs) for efficient photoactivation of oxyanions is environmentally desirable but still challenging. Of interest to us in this work was to construct artificial defective accumulation sites into a CTF network (CTF-SD) to synchronously modulate both thermodynamic (e.g., band structure) and kinetic (e.g., charge separation/transfer/utilization and surface adsorption) behaviors and probe how the transformation affected the subsequent activation mechanism of peroxymonosulfate (PMS). With the incorporation of terminal cyano (-CN) groups and boron (B) dopants, the delocalized CTF-SD underwent a narrowed electronic energy gap for increased optical absorption as well as a downshifted valence band position for enhanced oxidation capacity. Moreover, the localized charge accumulation regions induced by the electron-withdrawing -CN groups facilitated the exciton dissociation process, while the adjacent electron-deficient areas enabled strong affinity toward PMS molecules. All of these merits impelled the photoactivation reaction with PMS, and a 15-fold enhancement of bisphenol-A (BPA) removal was found in the CTF-SD/PMS/vis system compared with the corresponding pristine CTF system. Mechanistic investigations demonstrated that this system decomposed organics primarily through a singlet oxygen-mediated nonradical process, which originated from PMS oxidative activation over photoinduced holes initiated by an electron transfer process, thereby opening a new avenue for designing an efficient PMS activation strategy for the selective oxidation of organic pollutants.
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http://dx.doi.org/10.1021/acs.est.2c00126DOI Listing
May 2022

The membrane associated NAC transcription factors ANAC060 and ANAC040 are functionally redundant in the inhibition of seed dormancy in Arabidopsis thaliana.

J Exp Bot 2022 May 23. Epub 2022 May 23.

Wageningen Seed Science Centre, Laboratory of Plant Physiology, Wageningen University, 6708 PB Wageningen, The Netherlands.

The NAC family of transcription factors is involved in plant development and various biotic and abiotic stresses. The Arabidopsis thaliana ANAC proteins ANAC060, ANAC040 and ANAC089 are highly homologous based on protein and nucleotide sequence similarity. These three genes are predicted to be membrane bound transcription factors (MTFs) containing a conserved NAC domain but divergent C-terminal regions. The anac060 mutant shows increased dormancy levels when compared to wild type. Mutations in ANAC040 lead to higher seed germination under salt stress and a premature stop codon in ANAC089 Cvi allele results in seeds exhibiting insensitivity to high concentrations of fructose. Thus, these three homologous MTFs confer distinct functions, although all related to germination. To investigate whether the differences in function are caused by a differential spatial or temporal regulation or are the results of differences in the coding sequence (CDS), swapping experiments have been performed in which the promoter and CDS of the three MTFs have been exchanged. Seed dormancy and salt and fructose sensitivity analyses of transgenic swapping lines in mutant backgrounds show that there is functional redundancy between ANAC060 and ANAC040, but not between ANAC060 and ANAC089.
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http://dx.doi.org/10.1093/jxb/erac232DOI Listing
May 2022

Predicting lesion shrinkage in eyes with myopic choroidal neovascularization from features on optical coherence tomography angiography.

Retina 2022 May 11. Epub 2022 May 11.

Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China (the institution where the study was performed).

Purpose: To identify baseline morphological predictors of lesion shrinkage in eyes with myopic choroidal neovascularization (mCNV) treated with anti-vascular endothelial growth factor (VEGF).

Methods: This retrospective study included 46 eyes (41 consecutive patients) with active mCNV receiving anti-VEGF treatment. Optical coherence tomography angiography (OCTA) was performed at baseline and 1 year after treatment. Quantitative features were obtained from OCTA images using AngioTool software. Eyes were classified as "high-shrinkage" or "low-shrinkage" according to the median relative change in lesion area. Baseline quantitative morphological features associated with mCNV shrinkage were identified in univariate and multivariate analyses.

Results: The mCNV area was significantly smaller after 1 year (P=0.013), with a median relative change of -16.5%. The relative change in mCNV area was -48.3% in high-shrinkage eyes (n=23) and -5.2% in low-shrinkage eyes (n=23). High-shrinkage eyes had a smaller mCNV area (P=0.013), shorter total vessel length (P=0.023), and higher endpoint density (P<0.001). Multivariate analysis showed significant associations of high shrinkage with endpoint density (β=-0.037, P=0.043) and previous anti-VEGF treatment (β=0.216, P=0.029).

Conclusion: Morphological features of neovascularization detected by OCTA can predict lesion shrinkage in eyes with mCNV receiving anti-VEGF therapy. Higher endpoint density contributed to shrinkage, particularly of treatment-naive lesions.
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http://dx.doi.org/10.1097/IAE.0000000000003526DOI Listing
May 2022

Anti-obesity effects of fucoidan in high-fat diet-fed mice vary with the gut microbiota structure.

Food Funct 2022 May 20. Epub 2022 May 20.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

Previous studies have indicated that fucoidan could resist high-fat-diet (HFD)-induced obesity by modulating the composition of gut microbiota. However, the outcome of dietary intervention may differ between individuals due to large inter-individual variability in gut microbiota. Thus, the present study aimed to investigate the possible discrepancy of the anti-obesity effects of fucoidan supplementation in HFD-fed mice models with different gut microbiota communities. In the present study, the anti-obesity effects of fucoidan isolated from (Fuc) on normal mice and microbiota-altered mice treated with penicillin or metronidazole were compared and investigated. The 16S rRNA sequencing revealed the differences of gut microbiota among penicillin-treated, metronidazole-treated and normal groups, and mice treated with penicillin were characterized by greater relative abundance of the phylum Bacteroidetes and the families Muribaculaceae and Bacteroidaceae. Furthermore, Fuc ameliorated HFD-induced body weight gain, fat accumulation, serum lipid profiles, insulin resistance, hepatic steatosis and adipocyte hypertrophy in penicillin-treated and untreated mice, while no effects were observed in metronidazole-treated mice. Overall, mice with different initial gut microbiota responded differently to Fuc supplementation on a high-fat diet, and metronidazole-sensitive gut bacteria negatively correlated with obesity symptoms and were required for the anti-obesity effects of Fuc. Moreover, the anti-obesity effects were not dependent on the utilization of Fuc by gut microbiota to produce SCFAs. These findings indicate that evaluation of the gut microbiota structure before dietary interventions is helpful for enhancing the beneficial outcomes of dietary fiber supplementation and provide a rationale for the further application of dietary fucoidan in a personalized way.
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http://dx.doi.org/10.1039/d2fo00480aDOI Listing
May 2022

Oxidized PUFAs Increase Susceptibility of Mice to Infection by Diminishing Host's Innate Immune Responses.

J Agric Food Chem 2022 May 19. Epub 2022 May 19.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

Dietary ω-3 PUFAs are highly prone to oxidation, and this may potentially limit their application in the health-promoting field. Here, we sought to investigate whether and how oxidized PUFAs modulate the susceptibility of mice to (. Tm) infection. Algae oil (AO) and oxidized algae oil (ox-AO) were administered to the C57BL/6 mice prior to . Tm infection. Compared to the . Tm group, ox-AO increased bacterial burden in systemic and intestinal tissues, downregulated host anti-infection responses, and developed worse colitis. In macrophages, ox-AO decreased both phagocytosis of . Tm and clearance of intracellular bacteria and dampened the activation of mitogen-activated protein kinase (MAPK), NF-κB, and autophagy pathways. Furthermore, ox-AO diminished LPS-induced inflammatory cytokine production and . Tm induced NLRC4 inflammasome activation. This study reveals that oxidized PUFAs may contribute to the development of enteric infections and regular monitoring of the oxidation status in commercial PUFA supplements to prevent their potential adverse impact on human health.
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http://dx.doi.org/10.1021/acs.jafc.2c00099DOI Listing
May 2022

Feasibility of Remediation of Heavy-Metal-Contaminated Marine Dredged Sediments by Active Capping with Biochar.

Int J Environ Res Public Health 2022 Apr 19;19(9). Epub 2022 Apr 19.

Marine Engineering Environmental Supervision Technology Room, National Marine Environmental Monitoring Center, Dalian 116023, China.

biochar (BC) has been proposed as a potential absorbent in the marine environments. This study attempts to understand the process of active capping using BC to prevent the release of heavy metals (Pb and Cd) from contaminated marine dredged sediments. The capping efficiency was assessed with a series of lab-scale column experiments. Results showed that the BC exhibits rough pore structure and higher specific surface area, as well as more surface organic functional groups, which is favorable for its adsorption capacity and selectivity towards heavy metals. The capping thickness of 2 cm for BC was sufficient to prevent the release of heavy metals from sediments, with the capping efficiency of 47% for Pb and 62% for Cd. Kinetic studies showed that heavy metals released into the overlying water can be described by a three-parameter sigmoidal kinetic model. Importantly, the fractions of heavy metals in the dredged sediments below the capping layer were analyzed to reveal the capping remediation mechanism. The outcomes of the present study indicate that capping with BC is a promising method to regulate the water environment by preventing the release of heavy metals from the contaminated dredged sediments.
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http://dx.doi.org/10.3390/ijerph19094944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103734PMC
April 2022

Effects of Dopamine-Modified and Organic Intercalation on the Thermophysical Properties of Octadecane/Expanded Vermiculite Composite Phase Change Materials.

ACS Omega 2022 Apr 12;7(16):13538-13545. Epub 2022 Apr 12.

China University of Geosciences, Beijing School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, P.R. China.

For phase change materials (PCMs) confined in porous structure, the interface interaction between the PCM and the porous skeleton is the key factor to determine the thermal storage performance of PCM. In this study, the modified expanded vermiculite (EVM) was prepared by dopamine modification and DTA intercalation method and a series of EVM-based composite phase change materials with form shape (fs-CPCMs) were prepared by physical impregnation using -octadecane as PCMs. The heat storage performance of the composite phase change materials were improved obviously, and the encapsulation ratio is increased to 84.7% and 83.1%. The nonisothermal crystallization process of prepared composite phase change material were further studied. The effects of dopamine modification and organic intercalation on the encapsulation performance of EVM-based fs-CPCMs were analyzed. The results of XRD, FT-IR, thermal cycle, and TGA tests showed that EVM-based composite phase change materials had good chemical compatibility, thermal reliability, and thermal stability. This study provides a theoretical basis for the preparation of EVM-based fs-CPCMs with high thermal stability and good heat storage performance.
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http://dx.doi.org/10.1021/acsomega.1c06815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088795PMC
April 2022

Urban blue-green space landscape ecological health assessment based on the integration of pattern, process, function and sustainability.

Sci Rep 2022 May 11;12(1):7707. Epub 2022 May 11.

College of Landscape Architecture, Northeast Forestry University, Harbin, 150000, China.

Landscape ecological health (LEH) assessment of blue-green space is vital for the management and restoration of the urban environment. At present, existing LEH assessment research has mainly focused on the single measurement of landscape pattern or external ecological service function, ignoring the effect mechanism. Moreover, there is a lack of targeted assessment of urban blue-green space LEH. In this study, we constructed an urban blue-green space LEH assessment framework based on the integration of pattern, process, function and sustainability, and conducted an empirical analysis in Harbin, a megacity in Northeastern China. The results showed that the spatial changes in the four assessment units of landscape ecological pattern, process, function and sustainability were not coordinated in the study area. From 2011 to 2020, the overall condition of blue-green space LEH in the study area improved but still at an unhealthy level, and the spatial difference increased. Grassland, water and wetland suffered from the widespread degradation of LEH in the study area, and the LEH level improvement type had the largest area proportion, and the stabilization type had the smallest. Moreover, based on the spatial autocorrelation analysis, we clarified the LEH spatial correlation characteristics of the study area and proposed targeted optimization suggestions. Our assessment framework will extend the LEH assessment scope and methodology, and the research results can provide significant references for urban blue-green space protection and management.
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http://dx.doi.org/10.1038/s41598-022-11960-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095597PMC
May 2022

Research on permeable pores in collapse column fillings with different gradation structures.

Sci Rep 2022 May 7;12(1):7518. Epub 2022 May 7.

Information Institute, Ministry of Emergency Management of the PRC, Beijing, 100029, China.

Particle loss is an important cause of water inrush catastrophes in collapsed columns. In order to study the relationship between the lost particles of different graded rock samples and the pore structure of the subsidence column filling, experiments were designed and the changes of the seepage parameters of graded rock samples during the particle migration process under different permeable water pressures P and axial loads F were determined. The results show that: (1) There will be obvious collapse, silting and particle loss behaviors in the sample during different loading processes, and the rock samples with gradation values of n = 0.3 and n = 0.5 are dominant; (2) The relationship between porosity φ and bearing pressure The exponential function can be used to fit the loads F well, and the porosity decreases with the increase of the bearing load. The water surging characteristics before and after 1.2 MPa are mainly in the turbulent water gushing stage, accompanied by instantaneous slurry. Possibility of splashing and indenter sliding; (3) After infiltration, the condition of the remaining skeleton rock samples in the cylinder generally shows a trend of first decreasing rapidly, then increasing slowly, and then decreasing; (4) The gradation value n of the sample and the bottom There is a good correlation between the damaged area and the mean value S of the maximum area of the top water inrush channel. The maximum area increase of the damaged area and the maximum area increase of the water inrush channel show an opposite trend. The permeable pores of the graded samples can be divided into There are three situations of digging and collapse, water inrush gap and scouring hole, and the pore seepage process can be divided into 4 stages of inoculation of water seepage, rapid adjustment, rapid scour and steady flow.
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http://dx.doi.org/10.1038/s41598-022-11372-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079057PMC
May 2022

[email protected] inorganic-organic core-shell skeleton supported Pd nanodots for enhanced electrocatalytic hydrodechlorination.

J Hazard Mater 2022 Aug 22;435:128998. Epub 2022 Apr 22.

Department of Applied Chemistry, Zhejiang University of Technology, Hangzhou 310032, PR China; State Key Laboratory Breeding Base of Green Chemistry Synthesis Technology, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

The development of catalysts with high atom utilization and activity is the biggest challenge for electrocatalytic hydrodechlorination (EHDC) technology. Herein, a design strategy of [email protected] inorganic-organic core-shell skeleton for loading lower dosage of noble palladium (Pd) with robust activity is reported. The self-supported [email protected] nanorod arrays provides exposed surface area for anchoring Pd and PDA as interlayer controls the Pd nucleation to form nanodots with high dispersion, realizing high atom utilization. Moreover, the strong interaction between PDA and Pd realizes the coexistence of electron-rich and deficient Pd species with suitable proportion, which facilitate the H* formation and the C-Cl bond activation, respectively, resulting in the promoted activity. The optimal [email protected]/Pd electrode exhibits a low dosage of Pd (0.093 mg cm) and excellent activity for 4-chlorophenol reduction with a mass activity (MA) of 23.96 ming, which is 3.31 times as high as that of TiO/Pd. The design scheme with inorganic-organic core-shell skeleton as support is benefit for developing highly efficient and lower price elctrocatalysts for EHDC.
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http://dx.doi.org/10.1016/j.jhazmat.2022.128998DOI Listing
August 2022

Insights into the Crucial Role of Electron and Spin Structures in Heteroatom-Doped Covalent Triazine Frameworks for Removing Organic Micropollutants.

Environ Sci Technol 2022 May 27;56(10):6699-6709. Epub 2022 Apr 27.

College of Environment, Zhejiang University of Technology, Hangzhou 310032, P. R. China.

The water shortage crisis, characterized by organic micropollutants (OMPs), urgently requires new materials and methods to deal with it. Although heteroatom doping has been developed into an effective method to modify carbon nanomaterials for various heterogeneous adsorption and catalytic oxidation systems, the active source regulated by intrinsic electron and spin structures is still obscure. Here, a series of nonmetallic element-doped (such as P, S, and Se) covalent triazine frameworks (CTFs) were constructed and applied to remove organic pollutants using the adsorption-photocatalysis process. The external mass transfer model (EMTM) and the homogeneous surface diffusion model (HSDM) were employed to describe the adsorption process. It was found that sulfur-doped CTF (S-CTF-1) showed a 25.6-fold increase in saturated adsorption capacity (554.7 μmol/g) and a 169.0-fold surge in photocatalytic kinetics (5.07 h), respectively, compared with the pristine CTF-1. A positive correlation between electron accumulation at the active site (N1 atom) and adsorption energy was further demonstrated with experimental results and theoretical calculations. Meanwhile, the photocatalytic degradation rates were greatly enhanced by forming a built-in electric field driven by spin polarization. In addition, S-CTF-1 still maintained a 98.3% removal of 2,2',4,4'-tetrahydroxybenzophenone (BP-2) micropollutants and 97.6% regeneration after six-cycle sequencing batch treatment in real water matrices. This work established a relation between electron and spin structures for adsorption and photocatalysis, paving a new way to design modified carbon nanomaterials to control OMPs.
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http://dx.doi.org/10.1021/acs.est.2c01781DOI Listing
May 2022

Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation.

Am J Hum Genet 2022 May 13;109(5):802-811. Epub 2022 Apr 13.

Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA. Electronic address:

Heritability is a fundamental concept in genetic studies, measuring the genetic contribution to complex traits and bringing insights about disease mechanisms. The advance of high-throughput technologies has provided many resources for heritability estimation. Linkage disequilibrium (LD) score regression (LDSC) estimates both heritability and confounding biases, such as cryptic relatedness and population stratification, among single-nucleotide polymorphisms (SNPs) by using only summary statistics released from genome-wide association studies. However, only partial information in the LD matrix is utilized in LDSC, leading to loss in precision. In this study, we propose LD eigenvalue regression (LDER), an extension of LDSC, by making full use of the LD information. Compared to state-of-the-art heritability estimating methods, LDER provides more accurate estimates of SNP heritability and better distinguishes the inflation caused by polygenicity and confounding effects. We demonstrate the advantages of LDER both theoretically and with extensive simulations. We applied LDER to 814 complex traits from UK Biobank, and LDER identified 363 significantly heritable phenotypes, among which 97 were not identified by LDSC.
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http://dx.doi.org/10.1016/j.ajhg.2022.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118121PMC
May 2022

Time point-independent tumor positivity of Ga-PSMA-PET/CT pre- and post-biopsy in high-risk prostate cancer.

Ann Nucl Med 2022 Jun 1;36(6):523-532. Epub 2022 Apr 1.

Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.

Objective: Prostate-specific membrane antigen (PSMA)-PET/CT imaging has gained increasing clinical importance for the detection and staging of high-risk primary prostate cancer (PCa). However, it is unclear whether the routine practice of prostate biopsy obscures the image finding of PSMA-PET/CT. This study aimed to compare the tumor positivity rate of PSMA-PET/CT performed pre- (PSMA-PET/CT) and post-biopsy (PSMA-PET/CT) in high-risk PCa patients.

Patients And Methods: We matched 58 PSMA-PET/CT with 58 PSMA-PET/CT studies for primary detection of high-risk PCa according to clinical characteristics. Three subgroups of PSMA-PET/CT were defined by the intervals after biopsy (≤ 1 week, 1 ~ 2 weeks, and 2 ~ 5 weeks). Tumor positivity rates were determined, and SUVmax of primary tumors were compared separately for the two main groups and the related subgroups. Malignant prostate tissues from 20 of these patients were examined by immunohistochemical analysis of PSMA. In addition, the values of PSMA-PET/CT and PSMA-PET/CT in assessing seminal vesicle invasion (SVI) were evaluated in patients who underwent radical prostatectomy.

Results: All the primary tumors were positive on PSMA-PET/CT and PSMA-PET/CT imaging, resulting in a patient-based positivity rates of 100% (58/58) in both groups. All examined IHC results (20/20) confirmed the high-level expression of PSMA. SUVmax of primary tumors did not differ between the two main groups (16.1, IQR 9.8-26.6 vs. 16.5, IQR 11.0-26.7, p > 0.05). Subgroup analysis of PSMA-PET/CT (≤ 1 week, 1 ~ 2 weeks, and 2 ~ 5 weeks) also showed no significant difference in tumor SUVmax (15.8, IQR 9.5-22.2; 17.8, IQR 9.8-29.2; and 15.4, IQR 10.1-30.3. p > 0.05). PSMA-PET/CT and PSMA-PET/CT exhibited similar value in SVI detection as well.

Conclusions: The tumor positivity rate was consistently high for PSMA-PET/CT pre- and post-biopsy. A prior biopsy does not seem to affect the tumor positivity rate of PSMA-PET/CT in high-risk PCa.
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http://dx.doi.org/10.1007/s12149-022-01732-wDOI Listing
June 2022

Noninvasive estimation of aortic pressure waveform based on simplified Kalman filter and dual peripheral artery pressure waveforms.

Comput Methods Programs Biomed 2022 Jun 17;219:106760. Epub 2022 Mar 17.

Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom.

Background And Objective: Aortic pressure (P) is important for the diagnosis of cardiovascular disease. However, its direct measurement is invasive, not risk-free, and relatively costly. In this paper, a new simplified Kalman filter (SKF) algorithm is employed for the reconstruction of the P waveform using dual peripheral artery pressure waveforms.

Methods: P waveforms obtained in a previous study were collected from 25 patients. Simultaneously, radial and femoral pressure waveforms were generated from two simulation experiments, using transfer functions. In the first, the transfer function is a known finite impulse response; and in the second, it is derived from a tube-load model. To analyze the performance of the proposed SKF algorithm, variable amounts of noise were added to the observed output signal, to give a range of signal-to-noise ratios (SNRs). Additionally, central aortic, brachial and femoral pressure waveforms were simultaneously collected from 2 Sprague-Dawley rats and the measured and reconstructed P waveforms were compared.

Results: The proposed SKF algorithm outperforms canonical correlation analysis (CCA), which is the current state-of-the-art blind system identification method for the non-invasive estimation of central aortic blood pressure. It is also shown that the proposed SKF algorithm is more noise-tolerant than the CCA algorithm over a wide range of SNRs.

Conclusion: The simulations and animal experiments illustrate that the proposed SKF algorithm is accurate and stable in the face of low SNRs. Improved methods for estimating central blood pressure as a measure of cardiac load adds to their value as a prognostic and diagnostic tool.
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http://dx.doi.org/10.1016/j.cmpb.2022.106760DOI Listing
June 2022

An acidic polysaccharide from Patinopecten yessoensis skirt prevents obesity and improves gut microbiota and metabolism of mice induced by high-fat diet.

Food Res Int 2022 04 11;154:110980. Epub 2022 Feb 11.

National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.

The prevention of obesity is an urgent need for worldwide public health. The scallop (Patinopecten yessoensis) skirt is the by-product of adductor processing. In order to explore the value of the scallop skirt, the present study isolated an acidic polysaccharide from the skirt of P. yessoensis (SPYP) and evaluated its anti-obesity effect. SPYP was characterized as an acidic heteropolysaccharide with a molecular weight of 13.58 kDa. Through stepwise acid hydrolysis followed by HPLC-MS analysis, two core chains in SPYP was determined as heparin-like → 4)β-GlcA(1 → 4)α-GlcNAc → and chondroitin sulfate-like → 4)β-GlcA(1 → 3)β-GalNAc →. SPYP could effectively reduce body weight, decrease fat accumulation and prevent high blood lipids induced by a high-fat diet (HFD) in mice. Further 16S ribosomal ribonucleic acid (rRNA) sequencing analysis revealed that the anti-obesity effect of SPYP was notably associated with its modulation on gut microbiota. The short-chain fatty acids were also restored by SPYP supplementation compared to the HFD group. Moreover, liquid chromatography-high resolution accurate mass spectrometry (LC-HRMS) analysis demonstrated that metabolite profiles of HFD-fed mice were altered by SPYP supplementation, especially the lipid metabolism in serum and amino acid metabolism in cecal content, which may contribute to the anti-obesity effect of SPYP. The present study offers the basis for processing and application of P. yessoensis skirt.
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http://dx.doi.org/10.1016/j.foodres.2022.110980DOI Listing
April 2022

H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading.

Nucleic Acids Res 2022 04;50(7):3852-3866

State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Crucial mechanisms are required to restrict self-propagating heterochromatin spreading within defined boundaries and prevent euchromatic gene silencing. In the filamentous fungus Neurospora crassa, the JmjC domain protein DNA METHYLATION MODULATOR-1 (DMM-1) prevents aberrant spreading of heterochromatin, but the molecular details remain unknown. Here, we revealed that DMM-1 is highly enriched in a well-defined 5-kb heterochromatin domain upstream of the cat-3 gene, hereby called 5H-cat-3 domain, to constrain aberrant heterochromatin spreading. Interestingly, aberrant spreading of the 5H-cat-3 domain observed in the dmm-1KO strain is accompanied by robust deposition of histone variant H2A.Z, and deletion of H2A.Z abolishes aberrant spreading of the 5H-cat-3 domain into adjacent euchromatin. Furthermore, lysine 56 of histone H3 is deacetylated at the expanded heterochromatin regions, and mimicking H3K56 acetylation with an H3K56Q mutation effectively blocks H2A.Z-mediated aberrant spreading of the 5H-cat-3 domain. Importantly, genome-wide analyses demonstrated the general roles of H3K56 deacetylation and H2A.Z deposition in aberrant spreading of heterochromatin. Together, our results illustrate a previously unappreciated regulatory process that mediates aberrant heterochromatin spreading.
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http://dx.doi.org/10.1093/nar/gkac196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023284PMC
April 2022

Preparation of Low-Molecular-Weight Fucoidan with Anticoagulant Activity by Photocatalytic Degradation Method.

Foods 2022 Mar 13;11(6). Epub 2022 Mar 13.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

It is a challenge to degrade sulfated polysaccharides without stripping sulfate groups. In the present study, a photocatalytic method was applied to degrade fucoidan, a sulfated polysaccharide from brown algae. The degradation with varying addition amounts of HO and TiO were monitored by high performance gel permeation chromatography (HPGPC) and thin layer chromatography (TLC), and fucoidan was efficiently degraded with 5% TiO and 0.95% HO. A comparison of the chemical compositions of 2 products obtained after 0.5 h and 3 h illumination, DF-0.5 (average Mw 90 kDa) and DF-3 (average Mw 3 kDa), respectively, with those of fucoidan indicates the photocatalytic degradation did not strip the sulfate groups, but reduced the galactose/fucose ratio. Moreover, 12 oligosaccharides in DF-3 were identified by HPLC-ESI-MS and 10 of them were sulfated. In addition, DF-0.5 showed anticoagulant activity as strong as fucoidan while DF-3 could specifically prolong the activated partial thromboplastin time. All samples exerted inhibition effects on the intrinsic pathway FXII in a dose-dependent manner. Thus, photocatalytic degradation demonstrated the potential to prepare sulfated low-molecular-weight fucoidan with anticoagulant activity.
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http://dx.doi.org/10.3390/foods11060822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954839PMC
March 2022

Responses of the gut microbiota and metabolite profiles to sulfated polysaccharides from sea cucumber in humanized microbiota mice.

Food Funct 2022 Apr 4;13(7):4171-4183. Epub 2022 Apr 4.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, P. R. China.

Sea cucumber has been consumed as functional food traditionally in Asia, and its sulfated polysaccharide (SCSPsj) demonstrates health-promoting effects in rodents which are related to the regulation of the gut microbiota. However, little is known about the response of the human gut microbiota to SCSPsj. Therefore, the present study aimed to study the response of the donor microbiota to SCSPsj through a humanized microbiota mice model, which was constructed by antibiotic treatment combined with fecal microbiota transplant. The results revealed that the SCSPsj supplement could positively interact with the specific donor microbiota. It could significantly regulate the gut microbiota community, especially the abundance of . In addition, SCSPsj could modulate the metabolites in serum and cecal contents of mice, including short-chain fatty acids (SCFAs) and lactic acid, and the changes of some bioactive metabolites were associated with the gut microbiota enriched by SCSPsj. Furthermore, experiments demonstrated that the strains isolated could not be proliferated directly by SCSPsj, but SCSPsj significantly promoted biofilm formation and mucus binding of spp., which contributed to the enrichment of . The present study could provide insight into the application of SCSPsj as microbiota-directed food.
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http://dx.doi.org/10.1039/d1fo04443eDOI Listing
April 2022

Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.

BMC Pharmacol Toxicol 2022 03 22;23(1):16. Epub 2022 Mar 22.

Dong Medicine Key laboratory of Hunan Province, Department of Laboratory Medicine, Hunan University of Medicine, Huaihua, 418000, China.

Background: Arsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food Safety Authority. Lentinan, a beta-1,6;1,3-glucan extracts from Lentinus edodes, which has the properties of antioxidant and immunomodulation, present study explored the pharmacological effects of Lentinan on arsenic induced hepatotoxicity in mice.

Methods: Mice experiments were performed by sodium arsenite (SA) treatment or Lentinan intervention, then histopathology, ELISA, Flow Cytometry, or Western-Blotting were applied to evaluate hepatic injury, oxidative stress, CD4 type 17 helper T (Th17) cells, CD4CD25Foxp3 regulatory T cells (Tregs), T cells receptor OX40/CD134, IL-17A, NLRP3, Nrf2, and NQO1.

Results: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention. Further, immunoblotting experiments showed that Lentinan intervention downregulated the levels of OX40, IL-17A, and NLRP3 signals, while elevated the levels of anti-oxidative Nrf2, NQO1 signals compared to arsenic treatment group. For Tregs, Lentinan intervention showed no significant difference from SA treatment group.

Conclusion: Lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.
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http://dx.doi.org/10.1186/s40360-022-00557-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939159PMC
March 2022

Design and Control of a Magnetically-Actuated Capsule Robot with Biopsy Function.

IEEE Trans Biomed Eng 2022 Mar 8;PP. Epub 2022 Mar 8.

Objective: Wireless capsule endoscopy has been well used for gastrointestinal (GI) tract diagnosis. However, it can only obtain images and cannot take samples of GI tract tissues. In this study, we designed a magnetically-actuated biopsy capsule (MABC) robot for GI tract diagnosis.

Methods: The proposed robot can achieve locomotion and biopsy functions under the control of external electromagnetic actuation (EMA) system. Two types of active locomotion can be achieved, plane motion refers to the robot rolling on the surface of the GI tract with a rotating uniform magnetic field. 3D motion refers to the robot moving in 3D space under the control of the EMA system. After reaching the target position, the biopsy needle can be sprung out for sampling and then retracted under a gradient magnetic field.

Results: A pill-shaped robot prototype (15mm 32mm) has been fabricated and tested with phantom experiments. The average motion control error is 0.32mm in vertical direction, 3.3mm in horizontal direction, and the maximum sampling error is about 5.0mm. The average volume of the sampled tissue is about 0.35mm3.

Conclusion: We designed a MABC robot and proposed a control framework which enables planar and 3D spatial locomotion and biopsy sampling.

Significance: The untethered MABC robot can be remotely controlled to achieve accurate sampling in multiple directions without internal power sources, paving the way towards precision sampling techniques for GI diseases in clinical procedures.
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http://dx.doi.org/10.1109/TBME.2022.3157451DOI Listing
March 2022

Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA.

J Nanobiotechnology 2022 Mar 5;20(1):110. Epub 2022 Mar 5.

Department of Implant Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Background: Periodontitis is characterized by progressive inflammation and alveolar bone loss resulting in tooth loss finally. Macrophages including pro-inflammatory M1-like macrophages and reparative M2-like macrophages play a vital role in inflammation and tissue homeostasis in periodontitis. Among them, reparative M2-like macrophages have been shown to promote tissue repair and prevent bone loss. However, the mechanism of reparative M2 macrophages-induced osteoprotective effect remains elusive.

Results: Exosomes from reparative M2-like macrophages (M2-Exos) were isolated and identified successfully. M2-Exos could promote bone marrow stromal cells (BMSCs) osteogenic differentiation while suppressing bone marrow derived macrophage (BMDM) osteoclast formation, and prohibit pathological alveolar bone resorption because of the intercellular communication via exosomes. High expression level of IL-10 mRNA was detected not only in reparative M2-like macrophages but also in M2-Exos. Meanwhile, IL-10 expression level in BMSCs or BMDM was also upregulated significantly after co-culturing with M2-Exos in a concentration-dependent manner. In vitro, recombinant IL-10 proteins had the ability to selectively promote osteogenic differentiation of BMSCs and hinder osteoclast differentiation of BMDM. Moreover, after treatment with M2-Exos and IL-10R antibody together, the capacity of promoting osteogenesis and suppressing osteoclastogenesis of M2-Exos was significantly reversed. In vivo experiments further showed that M2-Exos reduced alveolar bone resorption in mice with periodontitis via IL-10/IL-10R pathway.

Conclusion: In conclusion, our results demonstrate that the reparative M2-like macrophages could promote osteogenesis while inhibiting osteoclastogenesis in vitro as well as protect alveolar bone against resorption in vivo significantly. M2-Exos could upregulate the IL-10 cytokines expression of BMSCs and BMDM via delivering exosomal IL-10 mRNA to cells directly, leading to activation of the cellular IL-10/IL-10R pathway to regulate cells differentiation and bone metabolism. These results might partly account for the mechanism of osteoprotective effect of reparative M2-like macrophages and provide a novel perspective and a potential therapeutic approach on improving alveolar resorption by M2-Exos.
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http://dx.doi.org/10.1186/s12951-022-01314-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898524PMC
March 2022

Improving Wastewater Treatment by Triboelectric-Photo/Electric Coupling Effect.

ACS Nano 2022 03 28;16(3):3449-3475. Epub 2022 Feb 28.

School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.

The ability to meet higher effluent quality requirements and the reduction of energy consumption are the biggest challenges in wastewater treatment worldwide. A large proportion of the energy generated during wastewater treatment processes is neglected and lost in traditional wastewater treatment plants. As a type of energy harvesting system, triboelectric nanogenerators (TENGs) can extensively harvest the microscale energies generated from wastewater treatment procedures and auxiliary devices. This harvested energy can be utilized to improve the removal efficiency of pollutants through photo/electric catalysis, which has considerable potential application value in wastewater treatment plants. This paper gives an overall review of the generated potential energies (e.g., water wave energy, wind energy, and acoustic energy) that can be harvested at various stages of the wastewater treatment process and introduces the application of TENG devices for the collection of these neglected energies during wastewater treatment. Furthermore, the mechanisms and catalytic performances of TENGs coupled with photo/electric catalysis (e.g., electrocatalysis, photoelectric catalysis) are discussed to realize higher pollutant removal efficiencies and lower energy consumption. Then, a thorough, detailed investigation of TENG devices, electrode materials, and their coupled applications is summarized. Finally, the intimate coupling of self-powered photoelectric catalysis and biodegradation is proposed to further improve removal efficiencies in wastewater treatment. This concept is conducive to improving knowledge about the underlying mechanisms and extending applications of TENGs in wastewater treatment to better solve the problems of energy demand in the future.
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http://dx.doi.org/10.1021/acsnano.1c10755DOI Listing
March 2022

Haplotype-Resolved Genome Analyses Reveal Genetically Distinct Nuclei within a Commercial Cultivar of .

J Fungi (Basel) 2022 Feb 9;8(2). Epub 2022 Feb 9.

Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada.

is a tetrapolar basidiomycete with two haploid nuclei in each cell during most of their life cycle. Understanding the two haploid nuclei genome structures and their interactions on growth and fruiting body development has significant practical implications, especially for commercial cultivars. In this study, we isolated and assembled the two haploid genomes from a commercial strain of using Illumina, HiFi, and Hi-C technologies. The total genome lengths were 50.93 Mb and 49.80 Mb for the two monokaryons SP3 and SP30, respectively, with each assembled into 10 chromosomes with 99.63% and 98.91% anchoring rates, respectively, for contigs more than 100 Kb. Genome comparisons suggest that two haploid nuclei likely derived from distinct genetic ancestries, with ~30% of their genomes being unique or non-syntenic. Consistent with a tetrapolar mating system, the two mating-type loci A (matA) and B (matB) of were found located on two different chromosomes. However, we identified a new but incomplete homeodomain (HD) sublocus at ~2.8 Mb from matA in both monokaryons. Our study provides a solid foundation for investigating the relationships among cultivars and between cultivars and wild strains and for studying how two genetically divergent nuclei coordinate to regulate fruiting body formation in .
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http://dx.doi.org/10.3390/jof8020167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877449PMC
February 2022

Fabrication of astaxanthin-enriched colon-targeted alginate microspheres and its beneficial effect on dextran sulfate sodium-induced ulcerative colitis in mice.

Int J Biol Macromol 2022 Apr 14;205:396-409. Epub 2022 Feb 14.

School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China. Electronic address:

Astaxanthin (Ax) with a strong antioxidant activity is beneficial to human health, but its application is limited by its highly unsaturated structure and poor water-solubility. Ax-enriched colon targeted alginate particles (Ax-Alg) was prepared by high-pressure spraying and ionic gelation, and most of particles was in the range of 0.5-3.2 μm in a diameter. The in vitro models showed that Ax-Alg can maintain the structural integrity in the different conditions (pH, heat and ion). In addition, Ax-Alg can well tolerate the conditions in the mouth, stomach and small intestine and reach the colon where Ax was released due to fermentation of gut microbiota. Mice experiment showed that Ax-Alg reduced dextran sulfate sodium-induced colitis, involving weight loss, disease activity index, colonic mucosal integrity and inflammation, and oxidative damage. On the other hand, Ax-Alg regulated the gut microbiota composition and reduced the abundances of Bacteroidetes members that had positive correlation with ulcerative colitis. Ax-Alg had better effect on the treatment of ulcerative colitis than oil-in-water emulsion, which can be attributed to the synergistic effect of Ax and alginate. This study can be helpful for the application of colon-targeted delivery system in the foods and treatment of colon diseases.
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http://dx.doi.org/10.1016/j.ijbiomac.2022.02.057DOI Listing
April 2022

Physiological Response of Soybean Plants to Water Deficit.

Front Plant Sci 2021 31;12:809692. Epub 2022 Jan 31.

Agronomy College, Northeast Agricultural University, Harbin, China.

Soybean is an important cash crop in the world, and drought is the main reason for the loss of soybean plants productivity, with drought stress during the most water-sensitive flowering period of soybeans. In this article, drought-tolerant variety Heinong 44 (HN44) and drought-sensitive variety Heinong 65 (HN65) were used as experimental materials. Drought treatment was carried out at the early flowering stage. The method of controlling soil moisture content was used to simulate different degrees of drought, and the physiological changes of these two varieties of soybean under different soil moisture contents were studied. The results showed that with a decrease in soil moisture content, the content of malondialdehyde (MDA) in soybean leaves increased significantly; the activities of peroxidase (POD), catalase (CAT), and ascorbic acid peroxidase (APX) increased first and then decreased; the content of proline, soluble sugar, and soluble protein increased; and the total antioxidant capacity (T-AOC) increased significantly. When the soil moisture content was 15.5%, the degree of membrane lipid peroxidation, osmotic regulatory substances, antioxidant enzyme activity, and T-AOC increased the most, and the decrease in drought-tolerant variety HN44 was significantly less than that of drought-sensitive variety HN65. Our research reveals the response law of soybean crops to physiological characteristics under water deficit and provides theoretical basis and guiding significance for drought-resistant cultivation and breeding of soybean.
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http://dx.doi.org/10.3389/fpls.2021.809692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842198PMC
January 2022

Polysaccharides from edible brown seaweed are effective against high-fat diet-induced obesity in mice through the modulation of intestinal microecology.

Food Funct 2022 Mar 7;13(5):2581-2593. Epub 2022 Mar 7.

School of Food Science and Technology; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, P. R. China.

Brown seaweed is rich in polysaccharides including sulfated polysaccharides and alginate, both of which provide health benefits to the host but whose differences have not received sufficient attention. In this study, alginate from (UPA) and sulfated polysaccharides from (UPSP) were isolated, and their action was analyzed in high fat diet-fed mice. UPA and UPSP improved body composition, fat deposition in body tissues and organs, lipid abnormality and inflammatory response in mice, and compound polysaccharides from (UPP: UPA + UPSP) had a better effect on some physiological indexes, which could be attributed to the differences in the gut microbiota. Both UPSP and UPA modulated diet-induced microbiota dysbiosis, and UPP had better effect on changes in the gut microbiota, including an increase in Bacteroidales and reduction in both Clostridiales and Lactobacillales that had positive correlations with the improvement of the physiological status. The model of bacterial culture revealed that the use of on UPA and UPSP was species dependent, and UPP can better maintain the diversity and stability of the Bacteroidales community. This study indicated that polysaccharides from edible brown seaweed can benefit host health by improving the intestinal microecology, which can be helpful for the application of edible brown seaweed in health foods.
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http://dx.doi.org/10.1039/d1fo04012jDOI Listing
March 2022

Construction and performance of exendin-4-loaded chitosan-PLGA microspheres for enhancing implant osseointegration in type 2 diabetic rats.

Drug Deliv 2022 Dec;29(1):548-560

Department of Oral Implants, School of Stomatology, State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, The Fourth Military Medical University, Xi'an, China.

The updating and optimization of drug delivery systems is critical for better behaviors of drugs, as well as for improving impaired implant osseointegration in diabetes. Numerous studies have reported the benefits of exendin-4 on diabetic bone, with the potential to enhance osseointegration in diabetes. To construct an appropriate sustained-release system of exendin-4 targeting implant osseointegration in diabetes, this study fabricated exendin-4-loaded microspheres using poly(lactic-co-glycolic acid) (PLGA) and chitosan. The morphology, size, encapsulation efficiency, and drug release behavior of microspheres were investigated. The bioactivity of drug-loaded microspheres on cell proliferation and osteogenic differentiation of diabetic BMSCs was investigated to examine the pharmacologic action of exendin-4 loaded into chitosan-PLGA microspheres. Further, the influence of microspheres on osseointegration was evaluated using type 2 diabetes mellitus (T2DM) rat implant model. After 4 weeks, the samples were evaluated by radiological and histological analysis. The results of experiments showed that the prepared exendin-4-loaded chitosan-PLGA microspheres have good properties as a drug delivery system, and the chitosan could improve the encapsulation efficiency and drug release of PLGA microspheres. In addition, exendin-4-loaded microspheres could enhance the proliferation and osteogenic differentiation of diabetic BMSCs. The results of experiments showed the exendin-4-loaded microspheres significantly improved the impaired osseointegration and bone formation around implants in T2DM rats without affecting blood glucose levels. Thus, the local application of exendin-4-loaded chitosan-PLGA microspheres might be a promising therapeutic strategy for improving the efficacy of dental implants in T2DM individuals.
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http://dx.doi.org/10.1080/10717544.2022.2036873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856071PMC
December 2022

Positive FAPI PET/CT in a Bilateral Mammary Angiosarcoma Patient With Less Impressive FDG PET/CT Images.

Clin Nucl Med 2022 Feb 8. Epub 2022 Feb 8.

From the Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract: Bilateral primary angiosarcoma of the breast is an extremely rare disease. We describe a case with bilateral angiosarcoma of the breast well visualized on 68Ga-FAPI PET/CT in a 30-year-old woman with a history of right breast-conserving surgery. However, the lesions are less impressive on 18F-FDG PET/CT. No additional findings including lymph node and distant metastases were noted. The patient underwent bilateral mastectomy, and histopathology revealed well-differentiated angiosarcoma that involved bilateral breast parenchyma and the left nipple. Our case illustrates that 68Ga-FAPI PET/CT can be more sensitive in detecting well-differentiated angiosarcoma of the breast.
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http://dx.doi.org/10.1097/RLU.0000000000004089DOI Listing
February 2022
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