Publications by authors named "Shuai Zhang"

1,598 Publications

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Is robotic-assisted technology still accurate in total hip arthroplasty for fibrous-fused hips?

J Arthroplasty 2022 Aug 5. Epub 2022 Aug 5.

Senior Department of Orthopedics, the Forth Medical Center of Chinese PLA General Hospital, No.51 Fucheng Road, Haidian District, Beijing, China; National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, No.28 Fuxing Road, Haidian District, Beijing, China. Electronic address:

Background: Total hip arthroplasty (THA) for fibrous-fused hips is technically demanding. This study aimed to evaluate the precision and accuracy, as well as rate of conversion of robotic-assisted THA in such difficult patients.

Methods: We retrospectively analyzed 67 patients (84 hips) who underwent THA with fibrous-fused hips between August 2018 and June 2021 at our institution. Demographics, acetabular cup positionings, leg length discrepancies (LLDs), and postoperative Harris Hip Scores (HHS) were recorded for all patients. Thirty-six patients (44 hips) who underwent robotic-assisted THA and 31 patients (40 hips) who underwent manual THA were enrolled in this study.

Results: The robot accurately executed the preoperative plan, and there were no statistically significant differences between the preoperative planned anteversion, inclination, and the postoperative measurements. In the robotic group, the percentage of acetabular cups in the safety zone was significantly higher than in the manual group (87.2 vs 55%, respectively, p=0.042). The rate of conversion to manual THA for various reasons in the robotic-assisted THA group was 11.4% (5/44). Compared with manual THA, the mean increase in operative time for conversion from robotic-assisted to manual THA was 24 minutes (p<0.001).

Conclusions: In patients who have fibrous-fused hips, preoperative planning can be accurately executed by robotic-assisted technology. Compared with manual THA, robotic-assisted THA had a significant advantage in improving the frequency of achieving cup positioning within the target zone. Overall, robotic-assisted technology was helpful in such difficult cases, and the approximately 11.4% of cases converted to manual THA are reminders that surgeons should be thoroughly prepared preoperatively.
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http://dx.doi.org/10.1016/j.arth.2022.07.023DOI Listing
August 2022

Simple Phenotypic Sensor for Visibly Tracking HO Fluctuation to Detect Plant Health Status.

J Agric Food Chem 2022 Aug 8. Epub 2022 Aug 8.

College of Horticulture Science and Engineering, Shandong Agricultural University, Taian 271018, Shandong, China.

Hydrogen peroxide (HO), as a main component of reactive oxygen species (ROS), serves as a key signaling molecule relevant to plant stress response and health status. Many strategies have been developed for detecting or quantifying HO concentration. However, reports on simply, visibly tracking HO fluctuation in vivo are limited. Here, for visibly tracking the plant HO wave, a green fluorescent phenotypic probe was designed by merging a HO-sensitive tertiary amine moiety with the core fluorophore tetraphenylethene skeleton. The green fluorescence emission is quenched up to 52% by HO with good sensitivity, selectivity, and reversibility within the plant physiological range of 10-100 μM HO. In response to various abiotic stresses, including mechanical damage, high salt, strong light and drought, fluorescence fluctuations, response to HO concentration alterations in vivo was visible to the naked eye under irradiation of commercially available UV light (365 nm) after simple injection of this HO probe solution into seedling leaves. This phenotypic fluorescent HO probe illustrates great potential as early sensors of plant health under stress without the aid of skillful operation and specialized equipment.
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http://dx.doi.org/10.1021/acs.jafc.2c02170DOI Listing
August 2022

Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models.

Phytomedicine 2022 Jul 28;105:154366. Epub 2022 Jul 28.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Background: AMP-activated protein kinase (AMPK) is an effective target for treating diabetes. However, successful drug development is delayed due to issues including toxicity. Plant-derived natural product AMPK activators have emerged as a new way to treat diabetes due to its potential low safety risks. Here, we studied the effect of hernandezine (HER), a natural product derived from Thalictrum, in activating AMPK and treating T2D in mouse models.

Method: We tested HER in various cells and tissues, including primary hepatocytes, skeletal myotubes cell lines, as well as major metabolic tissues from diabetic (db/db) and diet-induced obesity (DIO) model mice. The effect of HER on glucose uptake via AMPK in vitro and in vivo was confirmed utilizing cell transfection and adenovirus interference analysis. Tissue staining assessed the effect of HER on adipogenesis. Real-time quantitative polymerase chain reaction (real-time PCR) was applied to verify the effect of HER on transcription factors. Western blot analysis was used to determine the activation of phosphorylated AMPK and ACC pathways.

Results: Biochemically, we found that HER prevented pAMPK from dephosphorylation to prolong its activity, disproving previous direct activation model and providing a new model to explain HER-mediated AMPK activation. HER could be orally delivered to animals and has a 3-fold long half-life in vivo as compared to metformin. Importantly, long-term oral HER treatment potently reduced body weight and blood glucose in both type 2 diabetes mullitus (T2DM) mouse models by increasing glucose disposal and reducing lipogenesis, and appeared not to induce cardiac hypertrophy.

Conclusion: Natural product HER indirectly activates AMPK by suppressing its dephosphorylation. Oral HER effectively alleviated hyperglycemia and reduced body weight in T2D mouse models, appeared to have a low risk of causing cardiac hypertrophy, and might be a potential therapeutic option for T2DM.
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http://dx.doi.org/10.1016/j.phymed.2022.154366DOI Listing
July 2022

Adsorption coupling photocatalytic removal of gaseous n-hexane by phosphorus-doped g-CN/TiO/Zn(OAc)-ACF composites.

Environ Sci Pollut Res Int 2022 Aug 5. Epub 2022 Aug 5.

College of Chemical Engineering, China University of Petroleum, Qingdao, 266580, People's Republic of China.

VOCs emission reduction in the petroleum and petrochemical industry is a hot and difficult topic at present. The single method may not be able to meet the actual treatment status. Therefore, the adsorption coupled photocatalytic degradation technology was used to remove VOCs. Phosphorus-doped carbon nitride (PCN) and PCN/TiO were prepared by hydrothermal synthesis and sol-gel method, and then PCN/TiO/Zn(OAc)-ACF composites were prepared by ultrasonic impregnation on zinc acetate modified activated carbon fibers (Zn(OAc)-ACF). The removal efficiency of n-hexane by composite materials was explored in a self-made reactor, and the factors affecting removal efficiency, removal mechanism, and possible ways of degradation were investigated. The results showed that under the optimum reaction conditions (initial concentration of n-hexane 200 mg/m, space velocity 1000 h, light intensity 24 W, mass fraction of doped PCN 6%, loading twice, calcination temperature 450 °C), PCN/TiO/Zn(OAc)-ACF composite has the highest removal efficiency of n-hexane (90.2%). The adsorption capacity of the composites after doping the P element was 215.3 mg/g, which did not enhance the adsorption performance compared with that before doping, but the removal rate of n-hexane was higher. This showed that doping P element was helpful to enhance the photocatalytic activity of the composites.
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http://dx.doi.org/10.1007/s11356-022-22382-5DOI Listing
August 2022

Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest-Induced Brain Injury via Neuroinflammation Regulation.

Transl Stroke Res 2022 Aug 3. Epub 2022 Aug 3.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Cardiac arrest (CA) is common and devastating, and neuroprotective therapies for brain injury after CA remain limited. Neuroinflammation has been a target for two promising but underdeveloped post-CA therapies: neural stem cell (NSC) engrafting and glibenclamide (GBC). It is critical to understand whether one therapy has superior efficacy over the other and to further understand their immunomodulatory mechanisms. In this study, we aimed to evaluate and compare the therapeutic effects of NSC and GBC therapies post-CA. In in vitro studies, BV2 cells underwent oxygen-glucose deprivation (OGD) for three hours and were then treated with GBC or co-cultured with human NSCs (hNSCs). Microglial polarization phenotype and TLR4/NLRP3 inflammatory pathway proteins were detected by immunofluorescence staining. Twenty-four Wistar rats were randomly assigned to three groups (control, GBC, and hNSCs, N = 8/group). After 8 min of asphyxial CA, GBC was injected intraperitoneally or hNSCs were administered intranasally in the treatment groups. Neurological-deficit scores (NDSs) were assessed at 24, 48, and 72 h after return of spontaneous circulation (ROSC). Immunofluorescence was used to track hNSCs and quantitatively evaluate microglial activation subtype and polarization. The expression of TLR4/NLRP3 pathway-related proteins was quantified via Western blot. The in vitro studies showed the highest proportion of activated BV2 cells with an increased expression of TLR4/NLRP3 signaling proteins were found in the OGD group compared to OGD + GBC and OGD + hNSCs groups. NDS showed significant improvement after CA in hNSC and GBC groups compared to controls, and hNSC treatment was superior to GBC treatment. The hNSC group had more inactive morphology and anti-inflammatory phenotype of microglia. The quantified expression of TLR4/NLRP3 pathway-related proteins was significantly suppressed by both treatments, and the suppression was more significant in the hNSC group compared to the GBC group. hNSC and GBC therapy regulate microglial activation and the neuroinflammatory response in the brain after CA through TLR4/NLRP3 signaling and exert multiple neuroprotective effects, including improved neurological function and shortened time of severe neurological deficit. In addition, hNSCs displayed superior inflammatory regulation over GBC.
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http://dx.doi.org/10.1007/s12975-022-01047-yDOI Listing
August 2022

Real-time fluorescent cholangiography with indocyanine green in laparoscopic cholecystectomy: a randomized controlled trial to establish the optimal indocyanine green dose within 30 min preoperatively.

Surg Today 2022 Aug 3. Epub 2022 Aug 3.

Department of Surgery, Guangzhou First People's Hospital, No. 1 Panfu Road, Yuexiu District, Guangzhou, 510180, Guangdong, China.

Purpose: To establish the optimal dose of indocyanine green (ICG) to administer intravenously 30 min before laparoscopic cholecystectomy (LC).

Methods: In this randomized controlled trial (RCT), patients undergoing LC for cholecystitis, cholelithiasis, and/or cholecystic polyps were randomized into four groups given four different ICG doses (0.025, 0.1, 0.25, 2.5 mg). Using OptoMedic endoscopy combined with a near-infrared fluorescent imaging system, we evaluated the fluorescence intensity (FI) of the common bile duct and liver at three timepoints: before surgical dissection of the cystohepatic triangle, before clipping of the cystic duct, and before closure. The bile duct-to-liver ratio (BLR) of the FI was analyzed to assess the cholangiography effect.

Results: Sixty-four patients were allocated to one of four groups, with 40 patients included in the final analysis. Generally, with increasing ICG doses, the levels of FI in the bile duct and liver increased gradually at each of the three timepoints. Before surgical dissection of the cystohepatic triangle, 0.1-mg ICG showed the highest BLR (F = 3.47, p = 0.0259). Before clipping the cystic duct and before closure, the 0.025- and 0.1-mg groups showed a higher BLR than the 0.25- and 2.5-mg groups (p < 0.05). When setting the ideal cholangiography at a BLR ≥ 1, ≥ 3, or ≥ 5, the 0.1-mg group showed the highest qualified case number at the three timepoints.

Conclusions: The intravenous administration of 0.1-mg ICG, 30 min before LC, is significantly better for fluorescent cholangiography of the extrahepatic biliary structures before dissection and clipping of the cystohepatic triangle.

Trial Registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR) (ChiCTR2200057933).
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http://dx.doi.org/10.1007/s00595-022-02563-yDOI Listing
August 2022

Analysis of the auricles and auricular shape types for ear-related wearables: A study of mainland Chinese sample aged 15-79.

Work 2022 Jul 23. Epub 2022 Jul 23.

Key Laboratory of Industrial Design and Ergonomics, Ministry of Industry and Information Technology, Xi'an, China.

Background: Comprehension of the complex shape of the auricle and how it differs in terms of factors such as sex, age, and side have become an imperative aspect of the fabrication and service delivery of products that are natural, functional, and healthy for users.

Objective: This study was aimed at providing a clear understanding of the anthropometric characteristics based on age, sex, size, and side and shape type of the auricles of mainland Chinese samples.

Methods: Casting and 3D scanning were employed to obtain eighteen auricular measurement variables from 1120 subjects (aged 15-79). Examination of sex-related and bilateral differences were conducted. Furthermore, factor analysis was employed to establish the factors associated with the variations in auricular shape. Also, hierarchical cluster analysis was performed to classify the auricular shapes of individuals.

Results: The auricular inclination angle, conchal depth and tragal height did not exhibit any specific trend across the age groups. No significant bilateral difference was observed in both genders. The auricular shapes were classified into five types according to six major factors.

Conclusions: It was observed that measurement variables of the Chinese auricles changed continuously with age, with most of the linear variables exhibiting a steady increase. The apparent strong association between the auricular types and age groups indicate that a person's auricular shape may change with age.
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http://dx.doi.org/10.3233/WOR-210799DOI Listing
July 2022

Five-Year Outcomes After Endovascular Treatment for Large Vessel Occlusion Stroke.

Front Neurosci 2022 13;16:920731. Epub 2022 Jul 13.

Department of Neurology, The Third People's Hospital of Zigong, Zigong, China.

Background: The long-term outcomes of acute large vessel occlusion (LVO) in anterior circulation treated by endovascular treatment (EVT) remains to be determined. The aim of this study was to assess the 5-year outcomes of patients with LVO who underwent EVT.

Methods: This study was an observational, nationwide registry of consecutive patients with acute LVO who received EVT in 28 comprehensive stroke centers in China. The primary outcome was the proportion of favorable outcome [modified Rankin Scale score (mRS) 0-2] at 5 years. Secondary outcomes included proportions of patients with excellent outcome (mRS 0-1), all-cause mortality and risk of stroke recurrence at 5 years.

Results: A total of 807 patients were included into the study and had 90-day follow-up data, 657 patients had 5-year follow-up data. At 90 days, 218 patients (27.0%) had an excellent outcome, 349 patients (43.2%) had a favorable functional outcome. 199 patients (24.7%) died. At 5 years, 190 patients (28.9%) had an excellent outcome, 261 patients (39.7%) had a favorable functional outcome, 317 patients (48.2%) died and 129 (28.2%) had stroke recurrence. Because of missing 5-year follow-up data, among available 269 patients who achieved functional independence at 90 days, 208 (77.3%) maintained favorable outcome, 19 (7.1%) had disability (mRS 3-5) and 42 (15.6%) died at 5 years. Furthermore, among available 189 patients with mRS 3-5 at 90 days, 53 (28.0%) patients achieved favorable functional outcome, 60 (31.7%) patients maintained unfavorable functional outcome and 76 (40.2%) patients died within 5 years. Multivariate analyses identified that younger age [odds ratio (OR): 0.96; 95% CI, 0.93-0.99; = 0.009], lower mRS at 90 days (OR: 0.15; 95% CI, 0.10-0.23; < 0.001) and absence of stroke recurrence (OR: 0.001; 95% CI, 0.000-0.006; < 0.001) were significantly associated with favorable outcome at 5 years. Advanced age (OR: 1.06, 95% CI, 1.04-1.08; < 0.001), higher mRS at 90 days (OR: 0.84; 95% CI, 0.73-0.98; = 0.021) and atrial fibrillation (OR: 1.63; 95% CI, 1.02-2.60; = 0.04) were independent factors for stroke recurrence.

Conclusion: Our results indicated that the beneficial effect of EVT in patients with acute LVO can be sustained during the course of at least 5 years. Reducing the risk of stroke recurrence by anticoagulation for atrial fibrillation may be a crucial strategy to improve long-term outcome.
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http://dx.doi.org/10.3389/fnins.2022.920731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326078PMC
July 2022

Robotic-assisted versus manual total hip arthroplasty in obese patients: a retrospective case-control study.

J Orthop Surg Res 2022 Jul 30;17(1):368. Epub 2022 Jul 30.

Senior Department of Orthopedics, the Forth Medical Center of Chinese PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing, 100853, China.

Aims: The objective of this study was to evaluate the accuracy of acetabular cup positioning in the obese patients when using robotic-assisted technology during total hip arthroplasty (THA).

Methods: Data were retrospectively collected from patients who underwent primary (THA) with a body mass index (BMI) ≥ 28 kg/m and ≥ 1 year of follow-up between January 2018 and December 2019. Their demographics, diagnosis, acetabular cup positioning, American Society of Anesthesiologists (ASA) score, Harris Hip Score (HHS), and Forgotten Joint Score (FJS) at the final follow-up were recorded for analysis.

Results: There were no statistically significant differences between the two groups in height, weight, BMI, ASA score, or preoperative Harris Hip Score (HHS). Also, there was no difference in inclination angle between the two groups (R-THA: 41.29° ± 3.04°; manual THA (M-THA): 40.47° ± 5.46°; P = 0.312). However, the mean anteversion angle was greater in the R-THA group (20.71° ± 1.98° vs. 19.08° ± 4.04°; P < 0.001). Compared to M-THA, R-THA more frequently achieved an acetabular cup angle within 5° of the target (anteversion, 98.1% vs. 78.1% P = 0.001; inclination, 88.5% vs. 53.1%, P < 0.001). The R-THA group was more advantageous in restoring the hip center of rotation (COR) and leg length difference (LLD). There was no statistical difference in postoperative HHS (P = 0.404) or FJS (P = 0.497) between the two groups.

Conclusions: Compared to manual technique, robotic-assisted technique provided more precise acetabular cup positioning and better leg length restoration for obese patients. The robotic-assisted technique was more advantageous in recovering the center of rotation position and achieved a higher proportion of the acetabular cup placed in the target safety zone. Further studies are needed to confirm the clinical outcomes of surgeries in obese patients using robotic-assisted technology.
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http://dx.doi.org/10.1186/s13018-022-03263-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338672PMC
July 2022

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases.

Front Pharmacol 2022 12;13:920113. Epub 2022 Jul 12.

Innovation Center of Nursing Research, West China School of Nursing, Department of Gastrointestinal Surgery, National Clinical Research Center for Geriatrics, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway in mammals. It is of great significance in the metabolic homeostasis and cell survival via synthesizing nicotinamide mononucleotide (NMN) through enzymatic activities, serving as a key protein involved in the host's defense mechanism. The NAMPT metabolic pathway connects NAD-dependent sirtuin (SIRT) signaling, constituting the NAMPT-NAD-SIRT cascade, which is validated as a strong intrinsic defense system. Neurodegenerative diseases belong to the central nervous system (CNS) disease that seriously endangers human health. The World Health Organization (WHO) proposed that neurodegenerative diseases will become the second leading cause of human death in the next two decades. However, effective drugs for neurodegenerative diseases are scant. NAMPT is specifically highly expressed in the hippocampus, which mediates cell self-renewal and proliferation and oligodendrocyte synthesis by inducing the biosynthesis of NAD in neural stem cells/progenitor cells. Owing to the active biological function of NAMPT in neurogenesis, targeting NAMPT may be a powerful therapeutic strategy for neurodegenerative diseases. This study aims to review the structure and biological functions, the correlation with neurodegenerative diseases, and treatment advance of NAMPT, aiming to provide a novel idea for targeted therapy of neurodegenerative diseases.
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http://dx.doi.org/10.3389/fphar.2022.920113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322656PMC
July 2022

Bacteria-derived outer membrane vesicles engineered with over-expressed pre-miRNA as delivery nanocarriers for cancer therapy.

Nanomedicine 2022 Jul 25;45:102585. Epub 2022 Jul 25.

School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address:

Outer membrane vesicles (OMVs) of Escherichia coli as nanoscale spherical vesicles have been recently used in cancer therapy as drug carriers. However, most of them need complicated methods to load cargos. Herein, we proposed an inexpensive and potentially mass-produced method for the preparation of OMV engineered with over-expressed pre-miRNA. In this work, we found that OMV can be released and inherit over-expressed tRNA from mother E. coli that directly used for the tumor therapy. The eukaryotic cells infection experiments revealed that the over-expressed pre-miRNA inside OMV could be released and processed into mature miRNAs with the aid of the camouflage of "tRNA scaffold". Moreover, the group in vivo treated with targeted OMV obviously inhibited the expression of target oncogenic CXCR4, and significantly restrain the proliferation of breast cancer tissues. Together, these findings indicated that the OMV-based platform is a versatile and powerful strategy for personalized tumor therapy directly and specificity.
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http://dx.doi.org/10.1016/j.nano.2022.102585DOI Listing
July 2022

Effect of fungal pellets on denitrifying bacteria at low carbon to nitrogen ratio: Nitrate removal, extracellular polymeric substances, and potential functions.

Sci Total Environ 2022 Jul 25;847:157591. Epub 2022 Jul 25.

School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China; Shaanxi Key Laboratory of Environmental Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China.

This research aims to elucidate the effect of fungal pellets (FP) on denitrifying bacteria regarding nitrate (NO-N) removal, extracellular polymeric substances (EPS), and potential functions at a low carbon to nitrogen (C/N) ratio. A symbiotic system of FP and denitrifying bacteria GF2 was established. The symbiotic system showed 100% NO-N removal efficiency (4.07 mg L h) at 6 h and enhanced electron transfer capability at C/N = 1.5. The interactions between FP and denitrifying bacteria promoted the production of polysaccharides (PS) in EPS. Both the increased PS and the PS provided by FP as well as protein and humic acid-like substances in EPS could be consumed by denitrifying bacteria. FP acted as a protector and provided habitat and nutrients for denitrifying bacteria as well as improved the ability of carbohydrate metabolism, amino metabolism, and nitrogen metabolism of denitrifying bacteria. This study provides a new perspective on the relationship between FP and denitrifying bacteria.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157591DOI Listing
July 2022

Series arc fault detection based on continuous wavelet transform and DRSN-CW with limited source data.

Sci Rep 2022 Jul 27;12(1):12809. Epub 2022 Jul 27.

School of Safety Engineering, Shenyang Aerospace University, Shenyang, 110136, China.

When a series arc fault occurs in an indoor power distribution system, the temperature of arc combustion can be as high as thousands of degrees, which can lead to an electrical fire. Deep learning has developed rapidly in recent years and is widely used in fault diagnosis. The problem is that the sourced data is challenging to obtain, and few public data sources affect the application of deep learning models in arc fault diagnosis. In order to solve this problem, an arc fault detection method based on continuous wavelet transform and deep residual shrinkage network with the channel-wise threshold (DRSN-CW) is proposed. First, the grayscale images of source data features are obtained by continuous wavelet transform. Then, the feature images are data enhanced to construct the dataset. Finally, the DRSN-CW model is constructed and used to detect arc fault. The results show that the highest accuracy of arc fault detection is 98.92%, and the average accuracy is 97.72%. This method has excellent performance, which provides a new idea for arc fault detection.
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http://dx.doi.org/10.1038/s41598-022-17235-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329434PMC
July 2022

An Oversampling Method of Unbalanced Data for Mechanical Fault Diagnosis Based on MeanRadius-SMOTE.

Sensors (Basel) 2022 Jul 10;22(14). Epub 2022 Jul 10.

School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

With the development of machine learning, data-driven mechanical fault diagnosis methods have been widely used in the field of PHM. Due to the limitation of the amount of fault data, it is a difficult problem for fault diagnosis to solve the problem of unbalanced data sets. Under unbalanced data sets, faults with little historical data are always difficult to diagnose and lead to economic losses. In order to improve the prediction accuracy under unbalanced data sets, this paper proposes MeanRadius-SMOTE based on the traditional SMOTE oversampling algorithm, which effectively avoids the generation of useless samples and noise samples. This paper validates the effectiveness of the algorithm on three linear unbalanced data sets and four step unbalanced data sets. Experimental results show that MeanRadius-SMOTE outperforms SMOTE and LR-SMOTE in various evaluation indicators, as well as has better robustness against different imbalance rates. In addition, MeanRadius-SMOTE can take into account the prediction accuracy of the overall and minority class, which is of great significance for engineering applications.
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http://dx.doi.org/10.3390/s22145166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324964PMC
July 2022

Mechanical Characterization and Modelling of Subcellular Components of Oocytes.

Micromachines (Basel) 2022 Jul 8;13(7). Epub 2022 Jul 8.

The Tianjin Key Laboratory of Intelligent Robotics, Institute of Robotics and Automatic Information System, Nankai University, Tianjin 300350, China.

The early steps of embryogenesis are controlled exclusively by the quality of oocyte that linked closely to its mechanical properties. The mechanical properties of an oocyte were commonly characterized by assuming it was homogeneous such that the result deviated significantly from the true fact that it was composed of subcellular components. In this work, we accessed and characterized the subcellular components of the oocytes and developed a layered high-fidelity finite element model for describing the viscoelastic responses of an oocyte under loading. The zona pellucida (ZP) and cytoplasm were isolated from an oocyte using an in-house robotic micromanipulation platform and placed on AFM to separately characterizing their mechanical profiling by analyzing the creep behavior with the force clamping technique. The spring and damping parameters of a Kelvin-Voigt model were derived by fitting the creeping curve to the model, which were used to define the shear relaxation modulus and relaxation time of ZP or cytoplasm in the ZP and cytoplasm model. In the micropipette aspiration experiment, the model was accurate sufficiently to deliver the time-varying aspiration depth of the oocytes under the step negative pressure of a micropipette. In the micropipette microinjection experiment, the model accurately described the intracellular strain introduced by the penetration. The developed oocyte FEM model has implications for further investigating the viscoelastic responses of the oocytes under different loading settings.
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http://dx.doi.org/10.3390/mi13071087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319074PMC
July 2022

IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis.

Front Immunol 2022 8;13:915246. Epub 2022 Jul 8.

Department of Pathology and Laboratory Medicine, Davis Health, University of California, Sacramento, CA, United States.

Cytokines and cytokine receptors are important mediators in immunity and cancer development. Interleukin 22 (IL22) is one of the most important cytokines which has protumor effect. Given that common and specific roles of cytokines/receptors in multiple cancers, we conducted a pan-cancer study to investigate the role of IL22RA1 in cancer using The Cancer Genome Atlas (TCGA) database. Notably, we found IL22RA1 transcript was upregulated in 11 cancer types compared with their corresponding control. The mRNA expression level of IL22RA1 was highest in the pancreas among tumor tissues. The higher expression of IL22RA1 was associated with worse overall survival rate in patients. A total of 30 IL22RA1-correlated genes (e.g. , , , , , and ) are involved in the JAK/STAT pathway which promotes tumor progression. The upregulation of IL22RA1 in tumors was correlated with immune cell infiltration level. Higher expression of IL22RA2, IL20RB, IL10RA, IL10RB, TSLP, TYK2, STAT1 and STAT3 was associated with decreased overall survival rate in patients. IL22RA1 mutation was observed more in uterine cancer and melanoma compared with the other cancer types. Deactivation of IL22RA1 induced a lot of changes in gene expression. IL22RA1 mutants had upregulated DNA damage/repair genes in uterine cancer, whereas downregulated genes in the FoxO signaling pathway. In melanoma, mutation of IL22RA1 can upregulate the HIF signaling pathway but downregulate metabolic pathways. Our study suggests that IL22RA1/JAK/STAT signaling can be an important target for cancer treatment.
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http://dx.doi.org/10.3389/fimmu.2022.915246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304570PMC
July 2022

Epidemiology-based Analysis of Characteristics of Dual Infection of Tuberculosis /Acquired Immune Deficiency Syndrome (AIDS) and Drug Resistance Mechanism of Related Genes.

Cell Mol Biol (Noisy-le-grand) 2022 Feb 28;68(2):109-118. Epub 2022 Feb 28.

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This research was to explore the population characteristics and drug-resistant gene mutations of tuberculosis (TB) and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) dual infection population, and to provide a reference for clinical screening and prevention of TB/HIV dual infection. TB patients and HIV-infected/AIDS patients registered in Fuzhou Center for Disease Control and Prevention were selected as research subjects. The population characteristics of TB/HIV dual infection and mutation of drug-resistant genes were discussed. It was found that TB patients aged 20-40 years had the highest HIV infection rate, followed by those aged over 40 years. The rate of HIV infection in smear-negative TB patients was higher than that in smear-positive TB patients. HIV/AIDS patients aged 20-40 had the highest TB infection rate. In addition, men had higher rates of HIV than women, and married people had lower rates of HIV than single people. Mycobacterium tuberculosis (MTB) had the highest resistance to isoniazid (42.86%), followed by ofloxacin (34.82%), streptomycin (33.81%), and rifampicin (32.15%). Among the 113 cases of multi-drug resistant strains, 82 cases had mutations in the rpoB gene, with a gene mutation rate of 55.75%. The mutations ranged from codon 511 to codon 569. A total of 31 cases had mutations in the katG/inhA gene. Of which, there were 17 cases of katG single gene mutation, 9 cases of inhA single gene mutation, and 5 cases of combined katG and inhA gene mutation. It was suggested that it was necessary to carry out key TB/HIV two-way screening for TB patients older than 40 years old/smear-negative and male, single, and HIV-infected/AIDS patients aged 20-40. The resistance of MTB to antiTB drugs in this area was generally high, and the drug resistance of retreated patients was significantly higher than that of newly treated patients. Among the resistance genes, the rpoB gene had the highest mutation frequency, followed by the katG gene and inhA gene.
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http://dx.doi.org/10.14715/cmb/2022.68.2.16DOI Listing
February 2022

Nanozyme-Based Artificial Organelles: An Emerging Direction for Artificial Organelles.

Small 2022 Jul 22:e2202294. Epub 2022 Jul 22.

CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Artificial organelles are compartmentalized nanoreactors, in which enzymes or enzyme-mimic catalysts exhibit cascade catalytic activities to mimic the functions of natural organelles. Importantly, research on artificial organelles paves the way for the bottom-up design of synthetic cells. Due to the separation effect of microcompartments, the catalytic reactions of enzymes are performed without the influence of the surrounding medium. The current techniques for synthesizing artificial organelles rely on the strategies of encapsulating enzymes into vesicle-structured materials or reconstituting enzymes onto the microcompartment materials. However, there are still some problems including limited functions, unregulated activities, and difficulty in targeting delivery that hamper the applications of artificial organelles. The emergence of nanozymes (nanomaterials with enzyme-like activities) provides novel ideas for the fabrication of artificial organelles. Compared with natural enzymes, nanozymes are featured with multiple enzymatic activities, higher stability, easier to synthesize, lower cost, and excellent recyclability. Herein, the most recent advances in nanozyme-based artificial organelles are summarized. Moreover, the benefits of compartmental structures for the applications of nanozymes, as well as the functional requirements of microcompartment materials are also introduced. Finally, the potential applications of nanozyme-based artificial organelles in biomedicine and the related challenges are discussed.
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http://dx.doi.org/10.1002/smll.202202294DOI Listing
July 2022

An Intelligent and Fast Dance Action Recognition Model Using Two-Dimensional Convolution Network Method.

Authors:
Shuai Zhang

J Environ Public Health 2022 9;2022:4713643. Epub 2022 Jul 9.

School of Music, Shanxi Normal University, Taiyuan 030032, China.

In the field of computer vision, action recognition is a very difficult topic to study. This paper suggests a dance movement recognition method based on DL network in accordance with the characteristics of dance movements. The backbone network in this study is a thin network called Mobile Net. The two-dimensional convolution network, which can only extract spatial features, can extract and fuse time domain features and use them for dance movement recognition by combining the time domain modelling strategy of time domain feature transfer between convolution layers. It uses fewer network parameters and less computation than the original multitarget detection model. Using the clustering method to preset the prior frames of human detection with various sizes and numbers also enhances the model's performance. Finally, the experimental findings demonstrate that the algorithm suggested in this paper outperforms the Incision v3 algorithm in F1 by 9.87 percent and outperforms the traditional CNN algorithm in identification accuracy by 6.51 percent and 10.76 percent, respectively. It is evident that the algorithm used in this paper reduces running time and, to a certain extent, improves the accuracy of dance movement recognition. For related research, it offers some references.
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http://dx.doi.org/10.1155/2022/4713643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288280PMC
July 2022

Spatial variation, sources, and potential ecological risk of metals in sediment in the northern South China Sea.

Mar Pollut Bull 2022 Aug 14;181:113929. Epub 2022 Jul 14.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China. Electronic address:

Heavy metals are of great concern to humans because of their persistence, bioaccumulation, and toxicity. A study on the spatial variation, sources, and potential ecological risk of heavy metals in the coastal sedimentary environment are helpful to clarify the pollution history of aquatic systems and effectively manage and control heavy metal pollution. However, most studies are limited to the Pearl River Estuary region. To investigate the spatial distribution characteristics, sources, and potential ecological risks of heavy metals (Cr, Cu, Pb, Ni, Sn, Zn, As, Cd), a total of 41 sediment samples from the northern South China Sea (NSCS) region were analyzed. The results show that Cu, Ni, Pb, and Zn have similar distribution patterns and their migration path in the coastal area is mainly controlled by the coastal current in western Guangdong. Meanwhile, these metals also have similar sources, i.e. natural weathering products. The distribution patterns of Cr, Sn, Cd, and As are not affected by the coastal current, and the sources of these metals are not only natural weathering products but also human inputs such as electroplating and electronic industries and runoff from agricultural sites. Agricultural activities, coal-burning activities, and aerosol precipitation may be another important source of human activities for As. More than half (65.9 %) of the sampling sites were categorized as having low potential ecological risk, 24.4 % for moderate risk, 7.3 % for considerable risk, and 2.4 % for high potential ecological risk, and the potential ecological risk metals of Cr, Cd, and As in NSCS should be more attention.
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http://dx.doi.org/10.1016/j.marpolbul.2022.113929DOI Listing
August 2022

Experimental study of unconventional modified filling energy absorption and control mechanism in high energy storage rock masses.

Sci Rep 2022 Jul 12;12(1):11783. Epub 2022 Jul 12.

College of Energy Science and Engineering, Xi'an University of Science and Technology, X'an, 710054, Shaanxi, China.

Aiming at the problems that it is difficult to predict rock burst accurately in engineering practice and the implementation parameters of rock burst prevention measures depend on some empirical formulas, in order to study the advantages and disadvantages of different in-situ modification mechanisms deeply, determine the applicable conditions of unusual in-situ modification measures, and provide a theoretical basis for forming adaptive in-situ modification control schemes. Two kinds of modified control methods using the same foundation involve engineering scale and indoor scale. With the help of scale transformation, the whole failure process analysis test of bearing rock samples was carried out. The results show that various modification measures can effectively control the properties, and realize "hard-rock softening or soft-rock hardening" by changing the physical and mechanical parameters of the target rock sample. Compared with the control group, the automatic parameters of rocks deteriorated significantly under different modification measures. The evolution law of carrying energy is similar. However, there are obvious diversity between various modification measures in plastic stage and post-peaking phase stage, which provides favorable conditions for rock burst prevention. Based on this, an adaptive modification control system was constructed. At the same time, filling materials is considered to increase the energy of post-peaking phase (non newtonian fluid: energy-absorbing materials), and further slow down the intensity of released energy within post-peaking phase stage. Because rock burst is characterized by rapid release of energy, non newtonian fluid has a good absorption effect on high-speed impact force. Therefore, in the design test, the effect of non newtonian fluid is realized by applying a high loading rate, and the evaluation of energy absorption effect of bearing rock samples filled with non newtonian fluid in borehole is considered.
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http://dx.doi.org/10.1038/s41598-022-15954-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276692PMC
July 2022

The Potential Mechanisms of Cinobufotalin Treating Colon Adenocarcinoma by Network Pharmacology.

Front Pharmacol 2022 23;13:934729. Epub 2022 Jun 23.

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Network pharmacology, as a novel way using bioinformatics to explore drug targets and interactions in cancer, broadens our understanding of drug action, thereby facilitating drug discovery. Here, we utilized network pharmacology to explore the role and mechanism by which cinobufotalin functions in colon adenocarcinoma (COAD). We found that cinobufotalin represses the growth and proliferation of colon cancer cells, and integrated public databases for targets reported to be associated with COAD, together with those predicted to be targets of cinobufotalin. Targets overlapped between COAD-associated proteins and cinobufotalin target proteins were used to filter candidate targets of cinobufotalin in COAD. The following proteins were thought to occupy a key position in COAD-cinobufotalin target networks: SRC, PIK3R1, MAPK1, PIK3CA, HSP90AA1, CTNNB1, GRB2, RHO1, PTPN11, and EGFR. The networks regulated by cinobufotalin were involved mainly in extracellular signal stimulation and transduction, including MAPK signaling pathway, PI3K-AKT signaling pathway, and JAK-STAT signaling pathway. Besides, transcriptome sequencing results also indicated that cinobufotalin inhibits the response of colon cancer cells to extracellular stimulation and promotes cell apoptosis. Molecular docking results showed that cinobufotalin matches in the pocket of the top candidate cinobufotalin target proteins (SRC, PIK3R1, MAPK1 and PIK3CA). These findings demonstrate cinobufotalin can be developed as potential anti-cancer therapeutics.
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http://dx.doi.org/10.3389/fphar.2022.934729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262105PMC
June 2022

Visible Light-Induced Room-Temperature Formaldehyde Gas Sensor Based on Porous Three-Dimensional ZnO Nanorod Clusters with Rich Oxygen Vacancies.

ACS Omega 2022 Jul 21;7(26):22861-22871. Epub 2022 Jun 21.

Research Center for Analysis and Measurement, Kunming University of Science and Technology, and Analytic & Testing Research Center of Yunnan, Kunming 650093, China.

Oxygen vacancy (V) is a kind of primary point defect that extensively exists in semiconductor metal oxides (SMOs). Owing to some of its inherent qualities, an artificial manipulation of V content in one material has evolved into a hot research field, which is deemed to be capable of modulating band structures and surface characteristics of SMOs. Specific to the gas-sensing area, V engineering of sensing materials has become an effective means in enhancing sensor response and inducing light-enhanced sensing. In this work, a high-efficiency microwave hydrothermal treatment was utilized to prepare a V-rich ZnO sample without additional reagents. The X-ray photoelectron spectroscopy test revealed a significant increase in V proportion, which was from 9.21% in commercial ZnO to 36.27% in synthesized V-rich ZnO possessing three-dimensional and air-permeable microstructures. The subsequent UV-vis-NIR absorption and photoluminescence spectroscopy indicated an extension absorption in the visible region and band gap reduction of V-rich ZnO. It turned out that the V-rich ZnO-based sensor exhibited a considerable response of 63% toward 1 ppm HCHO at room temperature (RT, 25 °C) under visible light irradiation. Particularly, the response/recovery time was only 32/20 s for 1 ppm HCHO and further shortened to 10/5 s for 10 ppm HCHO, which was an excellent performance and comparable to most sensors working at high temperatures. The results in this work strongly suggested the availability of V engineering and also provided a meaningful candidate for researchers to develop high-performance RT sensors detecting volatile organic compounds.
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http://dx.doi.org/10.1021/acsomega.2c02613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260931PMC
July 2022

In-Memory Mathematical Operations with Spin-Orbit Torque Devices.

Adv Sci (Weinh) 2022 Jul 10:e2202478. Epub 2022 Jul 10.

School of Optical and Electronic Information & Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China.

Analog arithmetic operations are the most fundamental mathematical operations used in image and signal processing as well as artificial intelligence (AI).  In-memory computing (IMC) offers a high performance and energy-efficient computing paradigm. To date, in-memory analog arithmetic operations with emerging nonvolatile devices are usually implemented using discrete components, which limits the scalability and blocks large scale integration. Here, a prototypical implementation of in-memory analog arithmetic operations (summation, subtraction and multiplication) is experimentally demonstrated, based on in-memory electrical current sensing units using spin-orbit torque (SOT) devices. The proposed structures for analog arithmetic operations are smaller than the state-of-the-art complementary metal oxide semiconductor (CMOS) counterparts by several orders of magnitude. Moreover, data to be processed and computing results can be locally stored, or the analog computing can be done in the nonvolatile SOT devices, which are exploited to experimentally implement the image edge detection and signal amplitude modulation with a simple structure. Furthermore, an artificial neural network (ANN) with SOT devices based synapses is constructed to realize pattern recognition with high accuracy of ≈95%.
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http://dx.doi.org/10.1002/advs.202202478DOI Listing
July 2022

Universal biosensing platform based on polyMn-MOF nanosheets for efficient analysis of foodborne pathogens from diverse foodstuffs.

Food Chem 2022 Nov 2;395:133618. Epub 2022 Jul 2.

College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, PR China. Electronic address:

A universal electrochemical aptasensing strategy was developed for sensitive detection of various pathogenic bacteria (such as Staphylococcus aureus, Escherichia coli O157:H7, and Salmonella enterica) that commonly existed in food products. Diverse categories of pathogenic bacterium-targeting aptamers were separately immobilized over the polyMOF, which was prepared using the polyether polymer ligand containing 1,4-benzenedicarboxylic acid (polyHbdc) units as building block, 4,4'-bipyridine as co-ligand, polyvinyl pyrrolidone as structural regulator, and MnCl as metal centers (represented by polyMn-MOF). The developed polyMn-MOF-based aptasensor illustrated ultralow limits of detection for three kinds of foodborne pathogens (2.6, 1.5, and 3.5 CFU mL for SE, S. aureus, and E. coli, respectively) in a wide linear range of 10 - 1 × 10 CFU mL of pathogenic bacteria concentration by differential pulse voltammetry, accompanying with high selectivity, good stability, and superior reproducibility. Considering these advantages, the fabricated polyMOF-based aptasensor demonstrated wide applications in food safety and analysis and other biosensing fields.
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http://dx.doi.org/10.1016/j.foodchem.2022.133618DOI Listing
November 2022

Electrochemical Performance of Graphene Oxide/Black Arsenic Phosphorus/Carbon Nanotubes as Anode Material for LIBs.

Materials (Basel) 2022 Jun 29;15(13). Epub 2022 Jun 29.

Materials Institute of Atomic and Molecular Science, Shaanxi University of Science and Technology, Xi'an 710021, China.

As a new two-dimensional material, black arsenic phosphorus (B-AsP) has emerged as a promising electrode for lithium-ion batteries (LIBs) due to its large theoretical capacity and ability to absorb large amounts of Li atoms. However, the poor electronic conductivity and large volume expansion during the lithiation/delithiation process have largely impeded the development of B-AsP electrodes. In this study, graphene oxide (GO)/B-AsP/carbon nanotubes (CNTs) with remarkable lithium-storage property were fabricated via CVD and ultrasound-assisted method. The electrochemical behavior of the GO/B-AsP/CNTs was investigated as an anode in lithium-ion batteries. From the results, as a new-type anode for LIBs, GO/B-AsP/CNTs composite demonstrated a stable capacity of 1286 and 339 mA h g at the current density of 0.1 and 1 A g, respectively. The capacity of GO/B-AsP/CNTs was 693 mA h g after 50 cycles, resulting in capacity retention of almost 86%. In addition, the stable P-C and As-C bonds were formed between B-AsP, GO, and CNTs. Thus, volume expansion of B-AsP was alleviated and the capacity was increased due to the confining effect of GO and CNTs.
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http://dx.doi.org/10.3390/ma15134576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267519PMC
June 2022

Mid-long term forecasting of reservoir inflow using the coupling of time-varying filter-based empirical mode decomposition and gated recurrent unit.

Environ Sci Pollut Res Int 2022 Jul 8. Epub 2022 Jul 8.

State Key Laboratory of Hydraulic Engineering Simulation and Safety, Tianjin University, Tianjin, 300072, China.

Accurate and reliable runoff forecast is beneficial to watershed planning and management and scientific operation of water resources system. However, due to the comprehensive influence of climatic conditions, geographical environment, and human activities, the runoff series is nonlinear and non-stationary, and there are still great challenges in mid-long term runoff forecasting. In order to improve the prediction accuracy, a novel model TVF-EMD-PE-PSO-GRU (TEPPG) was proposed in this study. Firstly, several intrinsic mode functions (IMFs) were obtained by decomposing the original runoff series by time-varying filter-based empirical mode decomposition (TVF-EMD). Secondly, the permutation entropy (PE) algorithm was used to calculate the complexity of each IMF, and the IMF with similar complexity was combined. Then, the gated recurrent unit (GRU) model based on particle swarm optimization (PSO) was used to predict each IMF after merging. Finally, the prediction results of each IMF were superimposed to obtain the final results. And compared with three models such as TVF-EMD-PSO-GRU, extreme-point symmetric mode decomposition coupled gated recurrent unit and particle swarm optimization (ESMD-PSO-GRU), complete ensemble empirical mode decomposition with adaptive noise coupled gated recurrent unit, and particle swarm optimization (CEEMDAN-PSO-GRU). The monthly and annual runoff forecasting of Tangnaihai hydrological station in the upper reaches of the Yellow River and Cuntan hydrological station in the upstream of the Yangtze River was taken as examples to test the performance of the model. The results show that, compared with the other three models, the TEPPG model had the highest prediction accuracy and was relatively stable in both monthly and annual runoff forecasts. Thus, the proposed method was developed to support the decision-making of water resource system.
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http://dx.doi.org/10.1007/s11356-022-21634-8DOI Listing
July 2022

Identifying Transformative Sequences in the Psychotherapeutic Interaction With Chinese Adolescents With Depression: A Conversation Analysis Approach.

Front Psychol 2022 20;13:810371. Epub 2022 Jun 20.

School of Foreign Languages and Literature, Shandong University, Jinan, China.

Previous studies seldom touch on aspects of psychotherapeutic encounters between therapists and clients with particular disorders (such as depression). Little attention has been paid to the sequence organization of psychotherapeutic interaction between therapists and clients with depression in Chinese medical settings. By adopting conversation analysis, we investigated the specifics of psychotherapeutic encounters, specifically, the transformative sequences of psychotherapeutic interaction between therapists and Chinese adolescents with depression. We identified the fourth aspect of clients' experience transformed in the Chinese psychotherapeutic interaction with adolescents with depression: cognition, and described how the sequential organization of therapists' actions facilitates the momentary transformation of clients' experience (i.e., the transformation of cognition, referent, emotion, and relation) in the psychotherapeutic processes. This study not only adds to the conversation analytic study on the transformative sequences in psychotherapeutic interaction but also sheds some light on the study of how therapists transform clients' experience in Chinese psychotherapeutic interaction.
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http://dx.doi.org/10.3389/fpsyg.2022.810371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253862PMC
June 2022

Dendritic cell transfer for cancer immunotherapy.

Int Rev Cell Mol Biol 2022 29;370:33-64. Epub 2022 Jun 29.

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France. Electronic address:

Dendritic cells (DCs) play a major role in cancer immunosurveillance as they bridge innate and adaptive immunity by detecting tumor-associated antigens and presenting them to T lymphocytes. The adoptive transfer of antigen loaded DCs has been proposed as an immunotherapeutic approach for the treatment of various types of cancer. Nevertheless, despite promising preclinical data, the therapeutic efficacy of DC transfer is still deceptive in cancer patients. Here we summarize recent findings in DC biology with a special focus on the development of actionable therapeutic strategies and discuss experimental and clinical approaches that aim at improving the efficacy of DC-based immunotherapies, including, but not limited to, optimized DC production and antigen loading, stimulated maturation, the co-treatment with additional immunotherapies, as well as the inhibition of DC checkpoints.
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http://dx.doi.org/10.1016/bs.ircmb.2022.03.003DOI Listing
June 2022

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

Front Immunol 2022 20;13:904156. Epub 2022 Jun 20.

Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.

Alopecia universalis (AU) is an autoimmune disorder characterized by non-scarring hair loss in the scalp, eyebrows, beard, and nearly the entire body, negatively affecting patient prognosis. Available treatments are usually unsatisfactory. The autoimmune attacks of hair follicles induced by CD8+ T cells and the collapse of hair follicle immune privilege are believed to be the leading causes of AU. Additionally, interferon (IFN)-γ plays an important role in triggering the collapse of hair follicle immune privilege and impairing hair follicle stem cells. Furthermore, the upregulation of Janus kinase (JAK)3 and phospho-signal transducer and activator of transcription (pSTAT)3/STAT1 in alopecia areata patients suggest that JAK inhibitors can be a potentially promising choice for AU patients for the reason that JAK inhibitors can interfere with JAK-STAT signaling pathways and inhibit IFN-γ. Herein, we report a case of AU successfully treated with tofacitinib. However, this beneficial response in the patient was accompanied by a remarkable increase in peripheral blood cytokine levels during tofacitinib treatment.
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http://dx.doi.org/10.3389/fimmu.2022.904156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251371PMC
July 2022
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