Shu-Han Sun

Shu-Han Sun

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Shu-Han Sun

Publications by authors named "Shu-Han Sun"

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83Publications

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The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome.

BMC Med Genet 2018 Aug 9;19(1):141. Epub 2018 Aug 9.

Department of Gastroenterology, Airforce General Hospital of PLA, Beijing, 100142, China.

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August 2018

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.

J Hepatol 2018 Jun 31;68(6):1214-1227. Epub 2018 Jan 31.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. Electronic address:

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June 2018

Overactivated neddylation pathway in human hepatocellular carcinoma.

Cancer Med 2018 May 30. Epub 2018 May 30.

Department of Medical Genetics, Second Military Medical University, Shanghai, China.

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May 2018

A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.

Medicine (Baltimore) 2017 Dec;96(49):e8591

aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.

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December 2017

CTGF secreted by mesenchymal-like hepatocellular carcinoma cells plays a role in the polarization of macrophages in hepatocellular carcinoma progression.

Biomed Pharmacother 2017 Nov 12;95:111-119. Epub 2017 Sep 12.

Department of Medical Genetics, Second Military Medical University,No. 800 Xiang-Yin Road, Shanghai, 200433, China. Electronic address:

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November 2017

A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.

Dig Dis Sci 2017 11 6;62(11):3014-3020. Epub 2017 Oct 6.

Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.

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November 2017

Genomic Characteristics of Gender Dysphoria Patients and Identification of Rare Mutations in RYR3 Gene.

Sci Rep 2017 Aug 21;7(1):8339. Epub 2017 Aug 21.

Center of Reproductive Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

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August 2017

The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1.

Nat Cell Biol 2017 Jul 29;19(7):820-832. Epub 2017 May 29.

Department of Medical Genetics, Second Military Medical University, Shanghai 200433, China.

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July 2017

An alternative POLDIP3 transcript promotes hepatocellular carcinoma progression.

Biomed Pharmacother 2017 May 24;89:276-283. Epub 2017 Feb 24.

Department of Medical Genetics, Second Military Medical University, No. 800 Xiang-Yin Road, Shanghai 200433, China. Electronic address:

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May 2017

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N -methyladenosine-dependent primary MicroRNA processing.

Hepatology 2017 02 24;65(2):529-543. Epub 2016 Dec 24.

Department of Medical Genetics, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

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February 2017

Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma.

Oncotarget 2016 Oct;7(43):70045-70057

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

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October 2016

EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs.

Oncotarget 2016 Apr;7(16):21887-99

The Department of Medical Genetics, Second Military Medical University, Shanghai, China.

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April 2016

Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1.

Hepatology 2016 Feb 22;63(2):499-511. Epub 2015 Jul 22.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China.

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February 2016

Aldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma.

Mol Cancer 2015 Sep 17;14:170. Epub 2015 Sep 17.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, 200438, Shanghai, P.R. China.

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September 2015

Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma.

J Cancer Res Clin Oncol 2015 Jul 16;141(7):1195-203. Epub 2014 Dec 16.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China.

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July 2015

Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer.

PLoS One 2014 9;9(7):e100340. Epub 2014 Jul 9.

Department of Obstetrics and Gynaecology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

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March 2015

MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells.

FEBS Lett 2015 Mar 7;589(6):702-9. Epub 2015 Feb 7.

Department of Obstetrics & Gynaecology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

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March 2015

Exposure to bisphenol A at physiological concentrations observed in Chinese children promotes primordial follicle growth through the PI3K/Akt pathway in an ovarian culture system.

Toxicol In Vitro 2014 Dec 7;28(8):1424-9. Epub 2014 Aug 7.

Reproductive Center, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

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December 2014

Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2.

Hepatology 2014 Oct 25;60(4):1278-90. Epub 2014 Aug 25.

Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China; Center of Reproductive Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.

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October 2014

Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma.

Cancer Lett 2014 Jul 2;349(1):87-94. Epub 2014 Apr 2.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China. Electronic address:

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July 2014

Low CADM2 expression predicts high recurrence risk of hepatocellular carcinoma patients after hepatectomy.

J Cancer Res Clin Oncol 2014 Jan 17;140(1):109-16. Epub 2013 Nov 17.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China.

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January 2014

H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U-actin complex.

Biochim Biophys Acta 2013 Oct 27;1830(10):4899-906. Epub 2013 Jun 27.

Department of Medical Genetics, Second Military Medical University, Shanghai, China.

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October 2013

Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma.

Carcinogenesis 2013 Mar 7;34(3):577-86. Epub 2012 Dec 7.

Department of Medical Genetics, Second Military Medical University, Shanghai, China.

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March 2013

Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.

Mol Cell 2013 Mar 7;49(6):1083-96. Epub 2013 Feb 7.

Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China.

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March 2013

An in vivo molecular imaging probe (18)F-Annexin B1 for apoptosis detection by PET/CT: preparation and preliminary evaluation.

Apoptosis 2013 Feb;18(2):238-47

PET Center, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

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February 2013

Phage-based molecular directed evolution yields multiple tandem human IgA affibodies with intramolecular binding avidity.

J Biotechnol 2012 Apr 8;158(3):120-7. Epub 2011 Jan 8.

Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai 200433, China.

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April 2012

Dexamethasone protects airway epithelial cell line NCI-H292 against lipopolysaccharide induced endoplasmic reticulum stress and apoptosis.

Chin Med J (Engl) 2011 Jan;124(1):38-44

Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

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January 2011

A preliminary study on the activation and antigen presentation of hepatitis B virus core protein virus-like particle-pulsed bone marrow-derived dendritic cells.

Mol Biosyst 2010 Nov 27;6(11):2192-9. Epub 2010 Aug 27.

Department of Medical Genetics, The Second Military Medical University, Shanghai 200433, P R China.

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November 2010

N-glycan based models improve diagnostic efficacies in hepatitis B virus-related hepatocellular carcinoma.

Int J Cancer 2010 Jul;127(1):148-59

Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China.

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July 2010

Identification of an HLA-A*0201-restricted CD8(+) T-cell epitope encoded within Leptospiral immunoglobulin-like protein A.

Microbes Infect 2010 May 1;12(5):364-73. Epub 2010 Feb 1.

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Xiangyin Road 800, Shanghai 200433, China.

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May 2010

Expression, purification, and characterization of a novel Ca(2+)- and phospholipid-binding protein annexin B2.

Mol Biol Rep 2010 Mar 20;37(3):1591-6. Epub 2009 May 20.

Department of Medical Genetics, Second Military Medical University, Shanghai, China.

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March 2010

Expression of annexin a5 is associated with higher tumor stage and poor prognosis in colorectal adenocarcinomas.

J Clin Gastroenterol 2009 Oct;43(9):831-7

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Changhai Hospital, Shanghai, PR China.

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October 2009

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis.

EMBO J 2009 Sep 20;28(18):2719-32. Epub 2009 Aug 20.

Institute of Genetics, Second Military Medical University, Shanghai, China.

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September 2009

Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7.

J Hepatol 2009 Jul 17;51(1):29-38. Epub 2009 Apr 17.

Department of Medical Genetics, Second Military Medical University, 800 Xiang'Yin Road, 200433 Shanghai, China.

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July 2009

Screen of multifunctional monoclonal antibodies against hepatitis B core virus-like particles.

Microbiol Immunol 2009 Jun;53(6):340-8

Department of Gastroenterology, Changhai Hospital, and Department of Medical Genetics, the Second Military Medical University, Shanghai, China.

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June 2009

Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma.

Hepatology 2009 May;49(5):1492-502

Department of Medical Genetics, The Second Military Medical University, Shanghai, People's Republic of China.

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May 2009

Safety evaluation of a canine hepatitis DNA vaccine.

Vaccine 2008 Dec 23;26(52):6925-8. Epub 2008 Oct 23.

Department of Molecular Biology, Hebei Key Lab of Laboratory Animal, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.

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December 2008

Calcium-dependent proapoptotic effect of Taenia solium metacestodes annexin B1 on human eosinophils: a novel strategy to prevent host immune response.

Int J Biochem Cell Biol 2008 23;40(10):2151-63. Epub 2008 Feb 23.

Institute of Medical Genetics, Second Military Medical University, Shanghai 200433, PR China.

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October 2008

Preparation and bioevaluation of (99m)Tc-HYNIC-annexin B1 as a novel radioligand for apoptosis imaging.

Apoptosis 2008 Apr;13(4):600-8

Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China.

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April 2008

Clinical features and mismatch repair genes analyses of Chinese suspected hereditary non-polyposis colorectal cancer: a cost-effective screening strategy proposal.

Cancer Sci 2008 Apr 27;99(4):770-80. Epub 2008 Feb 27.

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.

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April 2008

Optimization strategy for plasmid DNAs containing multiple-epitopes of foot-and-mouth disease virus by cis-expression with IL-2.

Vaccine 2008 Feb 26;26(6):769-77. Epub 2007 Dec 26.

Nanjing Center for Disease Control and Prevention, 2 Zizhulin Road, Nanjing 210003, China.

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February 2008

Translocation of annexin B1 in response to the stimulation of PMA and ionomycin in cervical cancer cells.

Cell Biol Int 2008 Jan 7;32(1):121-7. Epub 2007 Sep 7.

Institute of Molecular Genetics and Engineering, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China.

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January 2008

A novel, cheap and effective fusion expression system for the production of recombinant proteins.

Appl Microbiol Biotechnol 2007 Nov 1;77(2):483-8. Epub 2007 Sep 1.

Department of Medical Genetics, The Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, People's Republic of China.

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November 2007

Augmented humoral and cellular immune responses induced by canine adenovirus type 1 DNA vaccine in BALB/c mice.

Viral Immunol 2007 Sep;20(3):461-8

Department of Molecular Biology, Hebei Medical University, Shijiazhuang, People's Republic of China.

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September 2007

Screening, purification, and identification of annexin B1 mutants with high phosphatidylserine-binding activity and reduced immunogenicity.

Appl Microbiol Biotechnol 2007 Jun 24;75(3):539-48. Epub 2007 Mar 24.

Department of Medical Genetics, Second Millitary Medical University, Shanghai, 200433, China.

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June 2007

Annexin B1 from Taenia solium metacestodes is a newly characterized member of the annexin family.

Biol Chem 2007 Jun;388(6):601-10

Department of Medical Genetics, The Second Military Medical University, Xiang Yin Road 800, Shanghai 200433, P.R. China.

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June 2007

Combined DNA vaccination against three animal viruses elicits decreased immunogenicity of a single plasmid in mice.

Vaccine 2007 May 30;25(22):4429-36. Epub 2007 Mar 30.

Department of Medical Genetics, Second Military Medical University, 800 Xiang'Yin Road, Shanghai 200433, China.

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May 2007

Annexin B1 at the host-parasite interface of the Taenia solium cysticercus: Secreted and associated with inflammatory reaction.

Acta Trop 2007 Mar 7;101(3):192-9. Epub 2007 Feb 7.

Department of Medical Genetics, The Second Military Medical University, Xiangyin Road 800, Shanghai 200433, China.

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March 2007

Design and characterization of a platelet-targeted plasminogen activator with enhanced thrombolytic and antithrombotic potency.

Biotechnol Appl Biochem 2007 Feb;46(Pt 2):115-25

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, 800 XiangYin Road, Shanghai 200433, People's Republic of China.

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February 2007

Comparative proteomics analysis to annexin B1 DNA and protein vaccination in mice.

Vaccine 2007 Jan 18;25(5):932-8. Epub 2006 Sep 18.

Department of Medical Genetics, Second Military Medical University, 800 Xiang-Yin Road, Yangpu District, Shanghai 200433, China.

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January 2007

Cloning, purification and biochemical characterization of a thrombus-ditargeting thrombolytic agent, comprised of annexin B1, ScuPA-32K and fibrin-adherent peptide.

J Biotechnol 2006 Nov 7;126(3):394-405. Epub 2006 May 7.

Department of Medical Genetics, The Second Military Medical University, Xiangyin Road 800, Shanghai 200433, China.

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November 2006

Single-nucleotide polymorphisms of mismatch repair genes in healthy Chinese individuals and sporadic colorectal cancer patients.

Cancer Genet Cytogenet 2006 Nov;171(1):17-23

Department of Medical Genetics, The Second Military Medical University, Xiangyin Road 800, Shanghai, China.

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November 2006

Biochemical characterization of annexin B1 from Cysticercus cellulosae.

FEBS J 2006 Jul;273(14):3238-47

Institute of Structural & Molecular Biology, School of Biological Sciences, University of Edinburgh, UK.

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July 2006

Effects of epitopes combination and adjuvants on immune responses to anti-Alzheimer disease DNA vaccines in mice.

Alzheimer Dis Assoc Disord 2005 Oct-Dec;19(4):171-7

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, PR China.

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March 2006

Enhanced immunogenicity of microencapsulated multiepitope DNA vaccine encoding T and B cell epitopes of foot-and-mouth disease virus in mice.

Vaccine 2006 Mar 1;24(12):2017-26. Epub 2005 Dec 1.

Department of Medical Genetics, The Second Millitary Medical University, No.800 Xiangyin Road, Yangpu District, Shanghai 200433, China.

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March 2006

16S rRNA gene probe quantitates residual host cell DNA in pharmaceutical-grade plasmid DNA.

Vaccine 2006 Mar 27;24(14):2656-61. Epub 2005 Dec 27.

Department of Medical Genetics, Second Military Medical University, 800 Xiang'Yin Road, Shanghai 200433, China.

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March 2006

Non-fusion expression in Escherichia coli: Single-step purification of recombinant human annexin A5 for detection of apoptosis.

Protein Expr Purif 2006 Jan 11;45(1):80-7. Epub 2005 Jul 11.

Department of Medical Genetics, Second Military Medical University, No. 800 Xiang Yin Road, Shanghai 200433, China.

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January 2006

Tissue distribution of a plasmid DNA containing epitopes of foot-and-mouth disease virus in mice.

Vaccine 2005 Dec 15;23(48-49):5632-40. Epub 2005 Aug 15.

Department of Biological Science and Technology and the State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China.

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December 2005

Effects of CpG-ODN on gene expression in formation of foam cells.

Acta Pharmacol Sin 2005 Nov;26(11):1359-64

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.

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November 2005

[Progress on genetic susceptibility to ankylosing spondylitis].

Yi Chuan Xue Bao 2005 Oct;32(10):1108-14

Institute of Medical Biotechnology & Molecular Genetics, Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.

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October 2005

[Cloning and bioinformatics analysis of a thrombin-like enzyme gene from Agkistrodon acutus].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005 Aug;13(4):542-7

Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China.

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August 2005

Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg.

J Gen Virol 2005 Mar;86(Pt 3):601-10

Department of Medical Genetics, The Second Military Medical University, No. 800 Xiangyin Road, Yangpu District, 200433 Shanghai, China.

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March 2005

Augmented humoral and cellular immune responses of a hepatitis B DNA vaccine encoding HBsAg by protein boosting.

Vaccine 2005 Feb;23(14):1649-56

Department of Medical Genetics, Second Military Medical University, Yangpu district, 200433 Shanghai, China.

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February 2005

Improved immunogenicity of a tuberculosis DNA vaccine encoding ESAT6 by DNA priming and protein boosting.

Vaccine 2004 Sep;22(27-28):3622-7

Department of Medical Genetics, The Second Military Medical University, Xiang'Yin Road 800, Shanghai 200433, China.

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September 2004

Protection of pigs against Taenia solium cysticercosis using recombinant antigen or in combination with DNA vaccine.

Vaccine 2004 Sep;22(29-30):3841-7

Department of Medical Genetics, The Second Military Medical University, Shanghai 200433, China.

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September 2004

Non-fusion expression in Escherichia coli, purification, and characterization of a novel Ca2+- and phospholipid-binding protein annexin B1.

Protein Expr Purif 2004 Mar;34(1):68-74

Department of Medical Genetics, The Second Military Medical University, Xiang Yin Road 800, Shanghai 200433, PR China.

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March 2004

Construction, expression, and characterization of a recombinant annexin B1-low molecular weight urokinase chimera in Escherichia coli.

Acta Biochim Biophys Sin (Shanghai) 2004 Mar;36(3):184-90

Department of Medical Genetics, Second Military Medical University, Shanghai 200433, China.

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March 2004

Immune response in mice inoculated with plasmid DNAs containing multiple-epitopes of foot-and-mouth disease virus.

Vaccine 2003 Dec;21(32):4704-7

Department of Medical Genetics, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China.

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December 2003

Protection of tree shrews by pVAX-PS DNA vaccine against HBV infection.

DNA Cell Biol 2003 Jul;22(7):475-8

Department of Medical Genetics, The Second Military Medical University, Shanghai, China.

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July 2003

Immune response and protection elicited by DNA immunisation against Taenia cysticercosis.

Vaccine 2003 Apr;21(15):1672-80

Department of Medical Genetics, The Second Military Medical University, Xiang'Yin Road 800, 200433, Shanghai, China.

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April 2003